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Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge Luis Bermudez-Gonzalez Rodrigo Dagio-Cuellar Cristina Villarreal-Guerrero Ana Gilabert-Garcia Luis Angel Ferral-Barbabosa Joaquin Berarducci Jose Luis Siller-nava Jose Antonio Luna-Alvarez-Amezquita javier iván armenta-moreno nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface national Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of national Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognost... 详细信息

Heart diseases are the main cause of mortality in Mexico, being coronary n>heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

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Lesser kestrels of the same colony do not overwinter together

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Current Zoology 2024年第4期70卷 505-512页

作者： Jorge Garcia-Macia Munir Chaouni Sara Morollon javier Bustamante Lina Lopez-Ricaurte Juan Martinez-Dalmau Beatriz Rodriguez-moreno Vicente Urios Grupo de Investigacion Zoologia de Vertebrados Universidad de AlicanteApdo.99E-03080 AlicanteSpain Department of Wetland Ecology Estacion Biologica de Donana(CSIC)C/Americo Vespucio 2641092SevillaSpain GREFA C/MontedelPilarS/NE-28220MajadahondaMadridSpain

Migratory connectivity describes the linkage between breeding and nonbreeding sites,having major ecological implications in birds:1 season influence the success of an individual or a population in the following *** studies on migratory connectivity have used large-scale approaches,often considering regional populations,but fine-scale studies are also necessary to understand colony *** lesser kestrel Falco naumanni,an insectivorous migratory raptor which form colonies during the breeding period,was considered to have strong connectivity based on regional ***,no small-scale studies on migratory connectivity have been ***,we GPS(Global Positioning System)-tracked 40 adult lesser kestrels from 15 different Spanish breeding colonies,estimating the overlap index between home ranges and the distance between their *** was found that lesser kestrels from the same breeding colony placed their nonbreeding areas at 347±281 km(mean±standard deviation)away from each other(range=23-990),and their home ranges over-lapped by 38.4±23.6%.no differences between intra-colony and inter-colony metrics were found,which suggests that lesser kestrels from the same breeding cluster do not overwinter together,but they spread out and mixed independently of the colony belonging throughout the nonbreeding range of the ***,this study highlights the importance of performing connectivity studies using fine-scale approaches.

关键词： Falco naumanni GPS telemetry migratory connectivity nonbreeding raptor spatial ecology wintering.

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极干旱胁迫对雀麦、多年生黑麦草生长和体内水分的影响

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草地学报 2024年

作者：张咏梅胡海英白小明 Matthew Cory García-Favre javier Ordó?ez iván P 甘肃农业大学干旱生境作物学国家重点实验室宁夏大学林业与草业学院甘肃农业大学草业学院农业与环境学院梅西大学坎佩奈克农艺研究所

为研究极端干旱对牧草生长的影响，选择多年生黑麦草（Lolium Perenne）(Lp)和雀麦（Bromus Valdivianus）(Bv)给予80%?85%植物有效水（Plant available water， PAW）和20%?25% PAW 2种水分处理，分析2牧草生长及体内水分状况对干旱胁... 详细信息

为研究极端干旱对牧草生长的影响，选择多年生黑麦草（Lolium Perenne）(Lp)和雀麦（Bromus Valdivianus）(Bv)给予80%?85%植物有效水（Plant available water， PAW）和20%?25% PAW 2种水分处理，分析2牧草生长及体内水分状况对干旱胁迫的响应。研究表明：1)80%?85% PAW充足水分下，2牧草生物量积累、水势（Water potential， WP）、相对含水量（Relative water content， RWC）和净光合速率（net photosynthetic rate， Pn）无明显种间差异。Bv叶片宽而重、蒸腾速率（Transpiration rate， Tr）、CO2总导度(Total conductance to CO2， CndCO2)和气孔导度(Conductance to H2O， Gs)显著高于Lp。而Lp分蘗多、叶多汁；瞬时水分利用效率是Bv的1.63倍。2)20%?25% PAW对2牧草生长影响不完全一致，叶饱和重、干重和叶面积有相反变化趋势，但与充足水分相比差异不显著；Pn，Tr，CndCO2，Gs和RWC则极显著降低，WP极显著降低了1.60 MPa，致使枯叶占比和叶温差的显著升高。总之，雀麦和多年生黑麦草生长相近，水分利用模式不同；遭受极端干旱，不同种的2牧草耐旱机制具有一定的共性，通过增强叶片持水力、降低水分循环、减少蒸腾失水以提高牧草抗旱性。

关键词：干旱胁迫光合作用蒸腾作用生物量积累瞬时水分利用效率水势

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda javier Sierra Manuel Vidal-Sanz María Teresa moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Grouping tree species to estimate basal area increment in temperate multispecies forests in Durango,Mexico

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Forest Ecosystems 2024年第1期11卷 1-13页

作者： Jaime Roberto Padilla-Martínez Carola Paul Kai Husmann Jose javier Corral-Rivas Klaus von Gadow Department of Forest Economics and Sustainable Land-use Planning Faculty of Forest Sciences and Forest EcologyUniversity of GottingenBüsgenweg 137077GottingenGermany Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Boulevard Durango S/N34120DurangoMexico Faculty of Forestry and Forest Ecology Georg-August-UniversitatBüsgenweg 537077GottingenGermany Department of Forestry and Wood Science Faculty of AgriSciencesStellenbosch UniversityStellenbosch Private Bag X1Stellenbosch7602South Africa

Multispecies forests have received increased scientific attention,driven by the hypothesis that biodiversity improves ecological ***,a greater species diversity presents challenges for forest management and *** study aims to develop basal area growth models for tree species *** analysis is based on a dataset of 423 permanent plots(2,500 m^(2))located in temperate forests in Durango,***,we define tree species cohorts based on individual and neighborhood-based variables using a combination of principal component and cluster ***,we estimate the basal area increment of each cohort through the generalized additive model to describe the effect of tree size,competition,stand density and site *** principal component and cluster analyses assign a total of 37 tree species to eight cohorts that differed primarily with regard to the distribution of tree size and vertical position within the *** generalized additive models provide satisfactory estimates of tree growth for the species cohorts,explaining between 19 and 53 percent of the total variation of basal area increment,and highlight the following results:i)most cohorts show a"rise-and-fall"effect of tree size on tree growth;ii)surprisingly,the competition index"basal area of larger trees"had showed a positive effect in four of the eight cohorts;iii)stand density had a negative effect on basal area increment,though the effect was minor in medium-and high-density stands,and iv)basal area growth was positively correlated with site quality except for an oak *** developed species cohorts and growth models provide insight into their particular ecological features and growth patterns that may support the development of sustainable management strategies for temperate multispecies forests.

关键词： Temperate multispecies forests Cluster analysis Basal area increment Generalized additive models

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Feeding Calcium Salts of Linseed Oil on Metabolic Status and Reproductive Traits in Grazing Dairy Cows

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Open Journal of Animal Sciences 2024年第3期14卷 219-233页

作者： Jesica Daniela Iorio Yaliska moreno González Maria Florencia Olmeda Dino Curletto Daniel Edgardo Scandolo Martin Guillermo Maciel Rafael Alejandro Palladino Mauricio javier Giuliodori Eloy Eduardo Salado School of Agriculture of the University of Buenos Aires (FAUBA) Buenos Aires Argentina Faculty of Agricultural Sciences National University of Lomas de Zamora (UNLZ) Lomas de Zamora Argentina Rafaela Agricultural Experiment Station National Institute of Agricultural Technology (INTA) Rafaela Argentina Faculty of Veterinary Science La Plata National University (FCV) La Plata Argentina

This experiment aimed to evaluate the effect of calcium salts of linseed oil (rich in alpha-linolenic acid (ALA, C18:3n-3) on metabolic and reproductive traits in high-producing dairy cows under grazing. Thirty-six Holstein dairy cows were randomly assigned, in a complete block design, to receive ALA supplementation (0.85 kg∙day−1 of calcium salts of linseed oil) or to remain as untreated control (COn). The concentrate was formulated to offer the same amount of energy across treatments (COn cows received an extra kg of corn to compensate for the higher energy density of ALA treatment). A PMR + Alfalfa pasture was offered to all cows at the same time. A fixed time artiﬁcial insemination (FTAI) at 80 DIM, preceded by a Presynch plus Ovsynch protocol was implemented for the first service and later, on return to estrus, heat detection and artiﬁcial insemination (AI) were performed. Pregnancy diagnosis was checked at 30, 42, 60, and 90 d after AI. Blood and milk samples were taken biweekly. Treatment affected plasma cholesterol concentration (160.36 vs. 186.70 mg∙dl−1, p = 0.03, for ALA and COn, respectively) and on size of corpus luteum (CL, 17.6 vs. 13.7 mm, p = 0.02, for ALA and COn, respectively). Supplementation tended (p = 0.136) to increase conception rate by 200 DIM (81.69% vs. 55.43% in ALA and COn cows, respectively). However, treatment had no effect (p > 0.05) on body weight (BW), body condition score (BCS), and circulating levels of beta-hydroxybutyrate (BHBA), glucose, insulin, growth hormone (GH) and insulin-like growth factor (IGF-I). Our results suggest that supplementation with calcium salts of linseed oil could enhance ovarian function without affecting energy metabolism in early lactation dairy cows.

关键词： α-Linolenic Acid Supplementation Reproduction Grazing Dairy Cows

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new advances in hepatocellular carcinoma

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World Journal of Hepatology 2016年第9期8卷 421-438页

作者： Sonia Pascual iván Herrera javier Irurzun Liver Unit Gastroenterology Department Interventional Radiological Unit Hospital General Universitario de Alicante03010 AlicanteSpain

AIM: To determine if gene-specific DnA methylation in prospectively collected blood samples is associated with later development of hepatocellular carcinoma(HCC).METHODS: Comparing genome-wide DnA methylation profiles using Illumina Human methylation 450 K arrays, we previously identified a list of loci that were differentially methylated between tumor and adjacent nontumor tissues. To examine if dysregulation of DnAmethylation patterns observed in tumor tissues can be detected in white blood cell(WBC) DnA, we conducted a prospective case-control study nested within a community-based cancer screening cohort in Taiwan with 16 years of follow up. We measured methylation levels in ninety-six loci that were aberrant in DnA methylation in HCC tumor tissues compared to adjacent tissues. Baseline WBC DnA from 159 HCC cases and 312 matched controls were bisulfite treated and assayed by Illumina Bead Array. We used the χ2 test for categorical variables and student's t-test for continuous variables to assess the difference in selected characteristics between cases and controls. To estimate associations with HCC risk, we used conditional logistic regression models stratified on the matching factors to calculate odds ratios(OR) and 95%CI. RESULTS: We found that high methylation level in cg10272601 in WnK2 was associated with increased risk of HCC, with an OR of 1.91(95%CI: 1.27-2.86). High methylation levels in both cg12680131 in TPO and cg22511877 in MYT1 L, however, were associated with decreased risk. The ORs(95%CI) were 0.59(0.39-0.87) and 0.50(0.33-0.77), respectively, for those with methylation levels of cg12680131 and cg22511877 above the median compared with those with levels below the median. These associations were still statistically significant in multivariable conditional logistic regression models after adjusting for hepatitis B virus infection and alcohol consumption. COnCLUSIOn: These findings support the measurement of methylation markers in WBC DnA as biomarke

关键词： DnA methylation Epigenetics Hepatitis B virus Hepatocellular carcinoma White blood cell DnA

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The short form of the SUR1 and its functional implications in the damaged brain

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neural Regeneration Research 2022年第3期17卷 488-496页

作者： iván Alquisiras-Burgos javier Franco-Pérez Moisés Rubio-Osornio Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the ***8 and Abcc9 genes code for the proteins SUR1 and SUR2,*** SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other *** is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,***8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental ***,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are ***,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the *** evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the *** structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce ***,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(*** stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy Parkinson's disease stroke sulfonylurea receptor 1 SUR1 traumatic brain injury TRPM4

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Specific primers design based on the superoxide dismutase b gene for Trypanosoma cruzi as a screening tool:Validation method using strains from Colombia classified according to their discrete typing unit

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 854-859页

作者： Francisco Olmo javier Escobedo-Ortegón Patricia Palma Manuel Sánchez-moreno Ana Mejía-Jaramillo Omar Triana Clotilde Marín Grupo de Parasitologia Molecular Departmento de Parasitologia Universidad de Granada Laboratorio de Zoonosis y ETV's C.I.R.Dr.Hideyo NoguchiUniversidad Autonoma de YucatanAve.Itzaes #490 x 5997000 MeridaYucatan(Mexico) Grupo Biologiay Control de Enfermedades Infecciosas BCEI-SIU Instituto de BiologiaUniversidad de Antioquia

Objective:To classify 21 new isolates of Trypanosoma cruai(***) according to the Discrete Typing Unit(DTU) which they belong to,as well as tune up a new pair of primers designed to detect the parasite in biological ***:Strains were isolated,DnA extracted,and classified by using three Polymerase Chain Reactions(PCR).Subsequently this DnA was used along with other isolates of various biological samples,for a new PCR using primers ***,the amplified fragments were ***:It was observed the predominance of DTU i in Colombia,as well as the specificity of our primers for detection of ***,while no band was obtained when other species were ***:This work reveals the genetic variability of 21 new isolates of *** in *** primers confirmed their specificity for detecting the presence of ***.

关键词： Trypanosoma cruzi Polymerase chain reaction Colombia Superoxide dismutase gene b-based primers Discrete typing unit

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Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： Jose M Ruiz-moreno javier A Montero Pedro Amat Francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CnV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy

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