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Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi Ali Amin Asnafi javad Mohammadi-Asl Seyed Ahmad hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

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Traumatic myiasis agents in Iran with introducing of new dominant species,Wohlfahrtia magnifica(Diptera:Sarcophagidae)

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Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 451-455页

作者： javad Rafinejad Kamran Akbarzadeh Yavar Rassi Jamasp Nozari Mohammad Mehdi Sedaghat Mostafa hosseini Hamzeh Alipour Abdolmajid Ranjbar Danial Zeinali Department of Medical Entomology School of Public HealthTehran University of Medical Sciences Department of Plant Protection Faculty of Agronomy SciencesCollege of Agriculture and Natural ResourcesUniversity of Tehran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical Sciences Faculty of Public Health and Nutrition Shiraz University of Medical Sciences Agricultural Jihad of Fars province Management of Darab Agricultural Jihad Agricultural Jihad of Fars province.Management of Abadeh Agricultural Jihad

Objective:To study agents of animal wound myiasis in various geographical districts of Fars ***:This study has been done in Fars province,located in the southern part of *** of 10358 domestic animals have been visited from April 2011 to March *** infected wounds in any parts of animal body were sampled by means of ***:About 61%of all animal wound myiasis were caused by larvae of Wohlfahrtia *** most wound myiasis cases due to this species occurred in central part of Fars *** wasn't any significant difference between sheep and goat in infestation with myiasis(P>0.05).The infestation rate of myiasis in cattle community was 0.86%.Conclusions:The infestation rate of livestock was lower than other works in Iran and some other countries like Saudi *** bezziana has been mentioned as main myiasis agent in *** in this study it cleared that similarly to some European countries,the common animal myiasis agent in Iran is Wohlfahrtia *** new species as principal agent for myiasis can help public health and animal husbandry policy makers to prepare sufficient and effective control and/or preventive measures for this disease.

关键词： Traumatic myiasis Wohlfahrtia magnifica Sheep and goats Iran

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Asymptotic Stability of Time Delay Systems with Unknown Uncertainty Bounds Using Adaptive Robust Control

Asymptotic Stability of Time Delay Systems with Unknown Unce...

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2010 Chinese Control and Decision Conference

作者： Mojtaba hosseini Toodeshki javad Askari Saeed Hosseinnia Isfahan University of Technology IsfahanIran

＜正＞The problem of adaptive robust control of uncertain linear systems with multiple time delays in the state variables is considered in this *** essential requirement for the parameter uncertainties is that they satisfy some matching conditions and are norm bounded,whose bounds are *** objective is to design an adaptive robust controller based on a new Lyapunov Krasovskii functional such that the closed loop system is asymptotically stable. The proposed design condition is formulated in terms of linear matrix inequality（LMI） which can be easily solved by LMI Toolbox in ***,two numerical examples are included to illustrate the effectiveness of the derived controller.

关键词： Time delay systems Adaptive robust control linear matrix inequalities(LMIs)

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活体异体结膜缘和羊膜移植治疗化学性眼外伤造成的角膜缘干细胞缺失(英文)

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国际眼科杂志 2008年第6期8卷 1095-1100页

作者： Mehdi hosseini Tehrani Asoo Ali Mahmoudi Hassan Hashe-mi Syed Jafar Oskouee javad Amuzadeh Mohammad Taher Rajabi Masoomeh Taherzadeh Hamideh Shenazandi 伊朗德黑兰大学医学院眼科 Farabi眼科医院眼科研究中心

目的:评价利用活体异体结膜缘和羊膜移植治疗化学性眼外伤造成的角膜缘干细胞缺失的临床效果。方法:从2005-07/2007-12,本研究包括了9名男性化学性眼外伤患者(10眼)。所有患者接受了亲属活体异体结膜缘和羊膜移植,2例眼接受了睑缝术。... 详细信息

目的:评价利用活体异体结膜缘和羊膜移植治疗化学性眼外伤造成的角膜缘干细胞缺失的临床效果。方法:从2005-07/2007-12,本研究包括了9名男性化学性眼外伤患者(10眼)。所有患者接受了亲属活体异体结膜缘和羊膜移植,2例眼接受了睑缝术。用环孢菌素和泼尼松龙进行全身性免疫抑制。结果:在3例眼中观察到完全角膜上皮化(30%),其中1例在术后1.5mo出现免疫排斥,角膜溶解引起穿孔,加大全身性免疫抑制剂量来控制病情。3例眼中植片无法在角膜表面重新形成上皮,被定为原发性失败。其余4眼有部分上皮形成,但上皮细胞无法完全覆盖角膜表面。术前最佳矫正视力从手动到1m处数指,术后最佳矫正视力从光感到20/80。有5眼视力得到改进,不需其他治疗。手术失败的主要原因为干眼症和持续性炎症。结论:对于能控制泪量和眼部炎症的病例,亲属活体异体角膜缘和羊膜移植是治疗化学性眼外伤造成的角膜缘干细胞缺失最佳方法之一。

关键词：眼化学伤活体异体结膜缘移植羊膜移植

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