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Incidence of T3151 mutation in BCR/ABL-positive CML and ALL patients

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Frontiers in Biology 2016年第5期11卷 404-411页

作者： Fatemeh Norozi javad mohammadi-asl Tina Vosoughi Mohammad Ali Jalali Far Areal Saki Malehi Najmaldin Saki Health Research Institute Thalassemia and Hemoglobinopathy Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Targeted therapy of Philadelphia-positive ALL and CML patients using imatinib （IM） has caused significant changes in treatment course and has increased the survival of patients. A small group of patients show resistance to IM. Acquired mutations in tyrosine kinase domain of BCR-ABL protein are a mechanism for development of resistance. T315I is one of the most common acquired mutations in this domain, which occurs in ATP binding site and inhibits the formation of hydrogen bond with IM. The aim of this study was to evaluate the prevalence of this mutation in BCR/ABL-positive CML and ALL patients. METHODS： To conduct this study, 60 BCR-ABL-positive patients （including 50 CML and 10 ALL patients） who were subject to treatment with IM were selected. After taking the samples, presence of T315I mutation was assessed using ARMS- PCR on cDNA and its polymorphism was evaluated by sequencing. RESULTS： The results showed that among 60 patients, only three patients had T315I mutation, which was detected using ARMS technique. The three patients bearing mutation were afflicted with CML and no significant association was found between blood parameters with duration of treatment in presence of mutation. CONCLUSIONS： The mutation was found in three CML patients, which indicated lower likelihood and diagnostic value of this mutation in ALL patients. Given the negative direct sequencing results in T3151 patients, it can be concluded that ARMS- PCR is a more sensitive technique when the number of cancer cells is low in patients during treatment.

关键词： BCR-ABL T315I mutation imatinib CML ALL

Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

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Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi Ali Amin Asnafi javad mohammadi-Asl Seyed Ahmad Hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

Evaluation Performance of Protocols LEACH, 802.15.4 and CBRP, Using Analysis of QoS in WSNs

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Wireless Sensor Network 2014年第10期6卷 221-236页

作者： Syyed javad mohammadi Baygi Mehran Mokhtari Department of Computer Engineering Islamic Azad University Damghan Branch Damghan Iran

Standards can define the performance and required protocols in different types of nodes in Wireless Sensor Networks (WSNs). In this article we discuss the Quality of Service (QoS) requirements in WSNs and present a survey of some of the QoS multi-parameters metrics in WSNs. Also, it gives the performance of 802.15.4, LEACH, and CBRP protocol considering parameters. The simulation tests were carried out by the simulator NS 2.29;it showed that the performance of 802.15.4 protocol is better than the LEACH. The results have shown that the 802.15.4 standard protocol provides better quality of outperformed service requirements than LEACH protocol. So its performance in WSNs is more effective than LEACH protocol. CBRP protocol simulators NS 2.34, reduce traffics and congestion packet. Finally, the algorithm CBRP offers optimal performance with reduced overhead and delay with respect to the other two protocols. Plus, the strengths and weaknesses of the protocols are specified in relation to the provision of quality of service. It should take effective action to address them.

关键词： 802.15.4 LEACH CBRP QoS WSN

Fast Convergence Resource Allocation in IEEE 802.16 OFDMA Systems with Minimum Rate Guarantee

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China Communications 2016年第12期13卷 120-131页

作者： Mohammad Mostafavi javad Musevi Niya Hosein mohammadi Behzad Mozaffari Tazehkand Faculty of Electrical and Computer Engineering University of Tabriz Faculty of Electrical and Computer Engineering University of Zanjan

Resource allocation in the context of OFDMA-based systems is challenging, given a combinatorial nature of the problem. In the context of IEEE 802.16 systems this problem is further exacerbated by additional constraints that are faced with its two dimensional frame nature. The main challenges associated with resource allocation in these systems are: mapping the allocated bandwidth resources to users in this two dimensional frame, power and frequency allocation, and Qo S guarantee. This optimization problem can usually be solved by an iterative algorithm. The solutions proposed have a constant step size in iterations which causes a long convergence time. For this reason, the solutions proposed are not applicable in IEEE 802.16 systems. In this paper we propose a novel resource allocation algorithm in IEEE 802.16 systems which has an adaptive step size in iterations while taking into account the minimum rate guarantee for users.

关键词： burst pack channel aware la grangian function OFDMA power allocation sub-channel allocation

Solvent extraction of rubidium from gold waste using conventional SX and new CFE methods

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Rare Metals 2015年第11期34卷 818-828页

作者： Mohammad Reza Tavakoli mohammadi Seyed Mohammad javad Koleini Sepideh Javanshir Hossein Abolghasemi Mahmoud Abdollahy Mineral Processing Department Tarbiat Modares University Mining Engineering Department University of Birjand Oil and Gas Center of Excellence School of Chemical Engineering College of Engineering University of Tehran

Solvent extraction（SX） of rubidium（Rb） from leaching filtrate of gold waste（GW） in Mouteh Processing Plant by 18-crown-6（18C6） was studied. High potential of new column flotoextraction（CFE） method in extraction of Rb from dilute solutions was also demonstrated. First, the factors affecting SX of Rb from a synthetic rubidium sulfate solution(containing 100 mg·L-1Rb) were identified.0.05 mol·L-118C6 in kerosene, 0.02 mol·L-1picric acid in aqueous phase, aqueous to organic（A/O） ratio of 1, p H7 and mixing time of 15 min are the optimum values for affective factors. The three-stage precipitation with sodium carbonate, p H adjustment with sulfuric acid and two-stage evaporation and crystallization were conducted to purify the leaching from impurities such as Fe, Al, Mn, Ca and especially competing cations of K and Na. Almost complete extraction of Rb and K from final filtrate containing 0.08 mol·L-1picric acid was performed using 0.2 mol·L-118C6 in kerosene. The Rb and K strippings of 99.12 % and 9.93 %, respectively, are obtained with 2 mol·L-1nitric acid with A/O ratio of 2. Finally, the performance comparison of the CFE and SX methods in similar conditionsshows increased extraction of K and Rb by 16 % and 5 %,respectively, using CFE method.

关键词： Rubidium Gold waste Solvent extraction Column flot

Inhibition of E. coli and bio-preservation of ground beef by Lactobacillus,black pepper extract and EDTA

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Food Bioscience 2022年第3期47卷 1098-1103页

作者： Shadieh mohammadi javad Aliakbarlu Hossein Tajik Leila Manafi Negar Mortazavi Department of Food Hygiene and Quality Control Faculty of Veterinary MedicineUrmia UniversityUrmiaIran Environmental Health Research Center Research Institute for Health DevelopmentKurdistan University of Medical SciencesSanandajIran

The objectives of present study were to evaluate the potential of Lactobacillus reuteri or Lactobacillus casei combined with black pepper extract(BPE)and ethylenediamine tetraacetic acid(EDTA)for controlling the growth of *** O157:H7 and improving the chemical,microbiological and sensory quality of ground beef stored at 10℃ for 12 *** in vitro results indicated that the combination of *** with BPE and EDTA had the most potent antibacterial effect against *** and resulted in 2.7 log CFU/ml *** ground beef,the combination of *** or *** with BPE and EDTA decreased *** and aerobic mesophilic bacteria counts up to 1 and 1.6 log CFU/g,***,this combination significantly reduced the lipid oxidation rate(up to 60%)and improved odor and overall acceptability scores of ground *** was concluded that the combination of *** with BPE and EDTA could be used in ground beef to control microbial proliferation,retard lipid oxidation,and improve sensory quality.

关键词： Lactobacillus Ground beef Black pepper EDTA E.coli

Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami Hamid Reza mohammadi Hossein Mahmoudvand Mohammad Nabi Moradi javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

Genotype×tillage interaction and the performance of winter bread wheat genotypes in temperate and cold dryland conditions

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Journal of Integrative Agriculture 2022年第11期21卷 3199-3215页

作者： Ebrahim ROOHI Reza mohammadi Abdoul Aziz NIANE javad VAFABAKHSH Mozaffar ROUSTAEE Mohammad Reza JALAL KAMALI Shahriar SOHRABI Shahriar FATEHI Hossain TARIMORADI Horticulture and Crop Science Research Department Kurdistan Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation and Extension Organization(AREEO)Sanandaj 66169-36311Iran Dry Land Agricultural Research Institute(DARI) Sararood CampusAREEOKermanshah 67441-61377Iran International Center for Agriculture Research in the Dry Area(ICARDA) Dubai 13979United Arab Emirates Seed and Plant Improvement Research Department Khorasan Razavi Agricultural and Natural Resources Research and Education CenterAREEOMashhad 91859-86111Iran Cereal Research Department DARIAREEOMaragheh 119Iran International Maize and Wheat Improvement Center(CIMMYT) Karaj 31585-4119Iran Kurdistan Jehade Agricultural Organization Sanandaj 66169-35383Iran

Growing concerns for food security and the alleviation of hunger necessitate knowledge-based crop management technologies for sustainable crop *** this study,13 winter bread wheat genotypes(old,relatively old,modern,and breeding lines)were evaluated under three different tillage systems,i.e.,conventional tillage(CT,full tillage with residue removed),reduced tillage(RT,chisel tillage with residue retained)and no-tillage(NT,no-tillage with residue retained on the soil surface)in farmer’s fields under rainfed conditions using strip-plot arrangements in a randomized complete block design with three replications in the west of Iran(Kamyaran and Hosseinabad locations)over two cropping seasons(2018–2019 and 2019–2020).The main objectives were to investigate the effects of tillage systems and growing conditions on the agronomic characteristics,grain yield and stability performance of rainfed winter bread wheat ***(P<0.01)genotype×tillage system interaction effects on grain yield and agronomic traits suggested that the genotypes responded differently to the different tillage *** number of grains per spike and plant height were positively(P<0.0)associated with grain yield under the NT system,so they may be considered as targeted traits for future wheat *** statistical models,the modern cultivars(“Sadra”and“Baran”)were identified as high yielding and showed yield stability across the different tillage *** per each tillage system,genotype“Sadra”followed by“Zargana-6//Dari 1-7 Sabalan”exhibited higher adaption to CT;while cultivars“Jam”and“Azar2”showed better performance under the RT system;and cultivars“Varan”and“Baran”tended to have better performance expression in the NT *** increased grain yields achieved in combination with lower costs and greater profits from conservation agriculture suggest that adapted cultivar and NT systems should be evaluated and promoted more widely to farmers in the west of Iran as an a

关键词： bread wheat no-tillage reduced tillage grain yield yield stability

Aperture Efficiency Study of Square Reflect Array Antennas

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Wireless Engineering and Technology 2018年第3期9卷 66-78页

作者： javad Nourinia Changiz Ghobadi Bahman mohammadi Farzad Alizadeh Department of Electrical Engineering Urmia University Urmia Iran

This paper presents a detailed study of square reflect array (RA) antenna aperture efficiency (ηa). Effects of quantization-phase and limited phase-range errors on radiation pattern, half-power beam width (HPBW) and ηa for different feed locations are investigated. Results show an in-crease in side-lobe levels (SLLs) and a slightly reduction in ηa with quantization-phase augmentation or element phase-range reduction, however, the effects on HPBW are negligible. Nevertheless, the degradation in ηa is negligible when the quantization-phase is lower than 30° or phase-range is more than 300°. Parametric studies have been carried out to provide design guidelines to maximize ηa. It is perceived that the offset-angle plays an important role to determine ηa, especially for feed with narrow beam width.

关键词： Aperture Efficiency Limited Phase-Range Error Quantization-Phase Error Reflect array Antennas Square Aperture