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Chemistry and Pharmacology of 4-Hydroxylonchocarpin:A Review

Chinese Journal of Integrative Medicine 2013年第6期19卷 475-480页

作者： Victor kuete jaures a.k.noumedem Frederic Nana Department of Biochemistry Faculty of ScienceUniversity of DschangCameroon Department of Organic Chemistry Faculty of ScienceUniversity of Yaounde ICameroon

4-hydroxylonchocarpin （LCP） or 2＇,4-dihydroxy-3＇,4＇-（2,2-dimethylchromene） chalcone is a chalcone of the class flavonoid, with a molecular weight of 322 g/mol mostly isolated in the family Moraceae and Leguminosae. LCP was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular, antimalarial, anti-inflammatory, ornitnine decarboxylase activity and antioxidant. The hemisynthesis of the compound has been described. The present review was undertaken to bring out together the knowledge on LCP, and can serve as the start point for future reseamh and valorization accomplishments.

关键词： 4-hydroxylonchocarpin biosynthesis synthesis pharmacology

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Antibacterial and Antibiotic-Potentiation Activities of Some Cameroonian Food Plants against Multi-Drug Resistant Gram-Negative Bacteria

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Chinese Journal of Integrative Medicine 2014年第7期20卷 546-554页

作者： Simplice B.Tankeo Stephen T.Lacmata jaures a.k.noumedem Jean P.Dzoyem Jules R kuiate Victor kuete kuiate and Victor Kuete Department of BiochemistryFaculty of ScienceUniversity of Dschang Department of Biochemistry Faculty of ScienceUniversity of Dschang

Objective： To evaluate the in vitro antibacterial properties and the ability to potentiate some common antibiotics effects of the methanol extracts of 11 Cameroonian food plants on 29 Gram-negative bacteria expressing multidrug resistant （MDR） phenotypes. Methods： The antimicrobial activity of the extracts was performed using the broth microdilution method. The phytochemical screening of these extracts was also performed using standard methods. Resalts： Ocimum basilicum, Gnetum africanum and Eucalyptus robusta extracts possessed an antibacterial activity against all the 29 studied bacteria. The extracts from G. africanum and E. robusta were the most active with the lowest minimal inhibitory concentration of 64 p, g/mL on Escherichia coil AG100A for both extracts and also against klebsiella pneumoniae k24 for G. africanum. When tested in the presence of phenylalanine-arginine 13 -Naphtylamide （PA 13 N）, an efflux pump inhibitor, the extract of Thymus vulgafis and E. Robusta showed the best activities on most tested strains. E. Robusta extract showed good synergistic effects, improving the activity of commonly used antibiotics in about 85% of cases. Coaclasion： The overall results obtained provide the baseline information for the use of the tested plants in the treatment of bacterial infections.

关键词： food plants Cameroon multidrug resistant Gram-negative bacteria efflux pumps

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