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Use of intra-arterial chemotherapy for retinoblastoma:results of a survey

International Journal of Ophthalmology(English edition) 2014年第4期7卷 726-730页

作者： Nathalia Grigorovski Evandro Lucena Clarissa Mattosinho Andreu Parareda Sima Ferman jaume catalá Guillermo Chantada Department of Pediatric Oncology Instituto Nacional de Cncer Ophthalmic Oncology Service Instituto Nacional de Cncer Oncology Service Hospital Sant Joan de Deu Esplugues de Llobregat Ophthalmology Service Hospital Sant Joan de DeuEsplugues de Llobregat

·AIM: To obtain baseline knowledge about the current use of intra-arterial chemotherapy(SSOAIC) in centers worldwide.·METHODS: A survey including questions about the use of SSOAIC was emailed to retinoblastoma experts.·RESULTS:Seventy-nine(response rate 69.9%) doctors from 63 centers in 35 countries responded. Thirty-one centers from 19 countries use SSOAIC. Twelve performed more than 50 procedures. Melphalan is the most commonly used drug but 15 centers use more than one drug. First line therapy for advanced unilateral disease is the most common use of SSOAIC(74.2%). Centers with larger experience(>50 applications) were less likely using melphalan alone(P =0.06) and significantly more likely using SSOAIC in more situations such as second line in preference to radiotherapy P =0.05. Nineteen(61.2%)stated that SSOAIC improved their results and 21(77.8%)reported less toxicity compared to other *** centers reported that SSOAIC did not improve their results. There were regional variations in the use of SSOAIC which is used more frequently as secondary treatment in Europe compared to the USA and *** centers identified cost is the major limiting factor for SSOAIC.· CONCLUSION: SSOAIC is used in an increasing number of centers worldwide with regional *** with more experience in SSOAIC use it in more situations including other drugs than melphalan. The majority of the centers using this technique reportedimproved results and few complications.

关键词： retinoblastoma intra-arterial chemotherapy survey

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The Last Pterosaurs: First Record from the Uppermost Maastrichtian of the Tremp Syncline (Northern Spain)

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1198-1227页

作者： DALLA VECCHIA Fabio M. RIERA Violeta OMS Josep Oriol DINARS-TURELL jaume GAETE Rodrigo GALOBART Angel Institut català de Paleontologia "M. Crusafont" (ICP) Grup de Recerca del Mesozoic Escola Industrial 23E-08201 SabadellSpain Universitat Autònoma de Barcelona Departament de GeologiaCerdanyola del VallèsBarcelonaE-08193Spain Istituto Nazionale di Geofisica e Vulcanologia Laboratorio di PaleomagnetismoVia di Vigna Murata 605I-00143 RomaItaly Museu de la Conca Dellà C/del Museu 4E-25650 IsonaSpain

Pterosaur bones are for the first time reported from the Tremp Syncline （Spain） and the southern Pyrenees. They come from the Torrebilles-2 site （Isona, Lleida Province） in the upper Maastrichtian part of the Tremp Formation, which falls within the C29r magnetochron. Fragmentary long bones are referred to the Pterosauria based on their cortical thinness, micro-architecture, and histological features. They belong to very large to possibly giant individuals. The most complete specimen is possibly a partial right femur. The review of the Maastrichtian pterosaur record shows that only a few specimens can be referred to the C29r （which contains the K/Pg boundary）. The identification of fragmentary remains could improve our knowledge about the abundance and distribution of these flying sauropsids just before the end-Cretaceous mass extinction.

关键词： Pterosauria bone morphology histology latest Maastrichtian European Archipelago,Ibero-Armorican Island Tremp Syncline.

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Clinical characteristics of COVID-19 hospitalized patients associated with mortality:A cohort study in Spain

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Infectious Medicine 2022年第2期1卷 81-87页

作者： Manuel Lozano Adina Iftimi Alvaro Briz-Redon Juanjo Peiró Lara Manyes María Otero Mayte Ballester MDolores de las Marinas Juan Carlos catalá Joséde Andrés Carolina Romero Preventive Medicine and Public Health Food SciencesToxicology and Forensic Medicine DepartmentUniversitat de ValènciaValenciaSpain Epidemiology and Environmental Health Joint Research Unit FISABIO−Universitat Jaume I−Universitat de ValènciaValenciaSpain Department of Statistics and Operations Research University of ValenciaValenciaSpain Statistics Office City Council of ValenciaValenciaSpain Department of Anesthesia Critical Care and Pain UnitUniversity General HospitalValenciaSpain Division of Allergy and Immunology University General HospitalValenciaSpain Anesthesia Unit-Surgical Specialties Department Valencia University Medical SchoolValenciaSpain Division of Research Methodology European UniversityValenciaSpain

Background:The heterogeneity of patients with COVID-19 may explain the wide variation of mortality rate due to the population characteristics,presence of comorbidities and clinical ***:In this study,we analyzed 5342 patients’recordings and selected a cohort of 177 hospitalized patients with a poor prognosis at an early *** assessed during 6 months their symptomatology,coexisting health conditions,clinical measures and health assistance related to *** Cox proportional hazards models were built to identify the associated factors with mortality ***:We observed that cough and kidney failure triplicate the mortality risk and both bilirubin levels and oncologic condition are shown as the most associated with the demise,increasing in four and ten times the risk,*** clinical characteristics such as fever,diabetes mellitus,breathing frequency,neutrophil-lymphocyte ratio,oxygen saturation,and troponin levels,were also related to mortality risk of in-hospital ***:The present study shows that some symptomatology,comorbidities and clinical measures could be the target of prevention tools to improve survival rates.

关键词： COVID-19 SARS-CoV-2 Respiratory insufficiency Mortality Proportional hazard model Pandemics Coronavirus infections Epidemiology

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