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mpaired flow-mediated vasodilatation in Asian Indians with erectile dysfunction

Asian Journal of Andrology 2013年第5期15卷 652-657页

作者： Tanuj Bhatia Aditya Kapoor jatinder kumar Archana Sinha Priyadarshi Ranjan Sudeep kumar Naveen Garg Satyendra-Tewari Aneesh Srivastava Rakesh Kapoor Pravin K Goel Departments of Cardiology Sanjay Gandhi PGIMS Lucknow 226014 India Urology and Renal Transplantation Sanjay Gandhi PGIMS Lucknow 226014 India

Endothelial dysfunction is the postulated link between coronary artery disease （CAD） and erectile dysfunction （ED）. Brachial artery flow-mediated vasodilatation （FMD） is a non-invasive surrogate marker for endothelial function assessment. Despite Asian Indians representing a considerable global CAD burden, data on FMD and ED in these patients are lacking. Of the 225 patients undergoing coronary angiography, 72% had ED （assessed using the International Index of Erectile Function （IIEF-5） questionnaire）; ED was moderate to severe in 61% of the patients. ED patients had a higher incidence of severe and diffuse angiographic CAD, a greater number of coronary vessels involved and a lower mean brachial artery FMD （6.40%±4.60% vs. 9.10%±4.87%, P〈0.001） compared to non-ED patients. A progressive reduction in FMD was noted with increasing severity of ED. Impaired FMD （ ≤ 5.5%） was twice as common in ED patients （52% vs. 24% without ED）. Patients with impaired FMD had higher ED prevalence （85% vs. 62%） and lower mean I IEF-5 scores compared to those with normal FMD. Impaired FMD was a significant ED predictor independent of other risk factors （odds ratio, 2.33; 95% confidence interval： 0.59-9.23; P=0.03）. An inverse correlation between FMD and ED severity was observed （r=-0.22; P=0.004）. ED is common among Asian Indians with angiographically documented CAD. Patients with ED have impaired FMD independent of other risk factors, suggesting that endothelial dysfunction is the underlying pathophysiology. Urologists and cardiologists need to be aware of the association between ED, CAD and endothelial dysfunction.

关键词： Asian Indians brachial artery flow mediated vasodilatation erectile dysfunction (ED)

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Glottic foreign bodies in infants: A series of four cases

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Case Reports in Clinical Medicine 2013年第6期2卷 341-344页

作者： Aayush Mittal Rahul Bhargava Sunil kumar jatinder kumar Sahni Department of Otorhinolaryngology-Head & Neck Surgery Hind Institute of Medical Sciences & Shekhar Hospital Lucknow India Department of Otorhinolaryngology-Head & Neck Surgery Lady Hardinge Medical College New Delhi India

Foreign body in glottis especially in infants is rare. Retrieval of foreign body is a rather simple procedure but sharing of the airway with the anaesthetist and impeding complication makes it more challenging and dangerous. Making a diagnosis of foreign body is most challenging in delayed cases. Complete history and detailed physical examination along with high index of suspicion, in cases of persistent cough, fever, nonresolving respiratory infection, are needed to rule out airway especially laryngeal foreign body. This series of 4 cases is being reported because of the rarity of the glottis foreign body in infants.

关键词： Foreign Body Bronchoscopy Infant Glottis

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Isolation, purification and characterization of an N-acetyl-D-lactosamine binding mitogenic and anti-proliferative lectin from tubers of a cobra lily Arisaema utile Schott

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Advances in Bioscience and Biotechnology 2010年第2期1卷 79-90页

作者： Vikram Dhuna Kshitija Dhuna jatinder Singh Ajit kumar Saxena Satyam kumar Agrawal Sukhdev Singh Kamboj 不详

Lectins are the carbohydrate-binding proteins of non-immune origin which have been the subject of intense investigation over the last few decades owing to the variety of interesting biological properties. Most of the lectins which have been purified and characterized from plants have been obtained from dicotyledons. In the present study a lectin was purified from tubers of a monocot plant Arisaema utile (AUL) Schott by affinity chromatography on asialofetuin-linked amino activated silica beads. AUL gave a single band in SDS-PAGE at pH 8.3 corresponding to subunit Mr 13.5 kDa. The native molecular mass of AUL was 54 kDa suggesting a homotetrameric structure. AUL gave multiple bands in isoelectric focusing and in native PAGE at pH 8.3. AUL was inhibited by N-acetyl-D-lactosamine (Lac NAc), a disaccharide and asialofetuin, a complex desialylated serum glycoprotein. When treated with denaturing agents, the lectin was stable in the presence of urea (3 M), thiourea (4 M) and guanidine HCl (4 M). AUL was a glycoprotein with a carbohydrate content of 1.2%. Complete loss of activity was observed upon modification of tryptophan residues of the lectin. The activity was reduced to 25% after modification of tyrosine. Chemical modification of arginine, histidine, serine and cysteine residues of AUL did not affect its activity. Using Far UV CD spectra the estimated secondary structure was 37% α-helix, 25% β-sheet and 38% random contributions. The lectin showed potent mitogenic response towards human lymphocytes. In vitro anti-proliferative assay using 11 human cancer cell lines resulted in 50% inhibition of six cell lines viz. SW-620, HCT-15, SK-N-SH, IMR-32, Colo-205 and HT-29 at 38, 42, 43, 49, 50 and 89 µg/ml, respectively.

关键词： N-acetyl-D-lactosamine Arisaema Utile Affinity Purification Anti-Proliferative Asialofetuin Chemical Modification Lectin Mitogenicity

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Isolation, purification and characterization of an N-acetyl-D-lactosamine binding mitogenic and anti-proliferative lectin from tubers of a cobra lily Arisaema utile Schott

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Advances in Bioscience and Biotechnology（生命科学与技术进展） 2010年第2期

作者： Vikram Dhuna Kshitija Dhuna jatinder Singh Ajit kumar Saxena Satyam kumar Agrawal Sukhdev Singh Kamboj

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