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Novel concepts in radiation-induced cardiovascular disease

World Journal of Cardiology 2016年第9期8卷 504-519页

作者： jason r Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub Department of Medicine Medical College of Georgia at Augusta University Department of Medicine Division of CardiologyMedical College of Georgia at Augusta University

radiation-induced cardiovascular disease(rICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(rT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular *** are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great *** refinements in rT dosimetry and shielding will inevitably limit future cases of rICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose rT regimens,will ensure a steady flow of afflicted patients for the foreseeable ***,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment *** characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under *** imaging modalities may serve as powerful screening tools in rICVD,and recent research and expert opinion advocating their use is *** arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic *** and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology.

关键词： radiotherapy radiation Cardiovascular Atherosclerosis Cardiomyopathy Pericarditis Valvular Hodgkin Breast cancer radiation fibrosis

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Piezoelectric resonant ice protection systems–Part1/2:Prediction of power requirement for de-icing a NACA 0024 leading edge

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Chinese Journal of Aeronautics 2024年第3期37卷 92-103页

作者： Valerian PALANQUE jason POTHIN Vale′rie POMMIEr-BUDINGEr Marc BUDINGEr Institut Clement Ader University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISAE-SUPAErO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This paper proposes a numerical method to analyze the ice protection capability and predict the power requirements of a piezoelectric resonant de-icing *** method is based on a coupled electro-mechanical finite element analysis which enables the fast computation of the modes of resonance of interest to de-ice curved surfaces and the estimation of the input voltage and current required for a given configuration(defined by its mode,actuator location,ice deposit,etc.).Eventually,the electric power to be supplied can be also *** method is applied to a NACA 0024 leading edge equipped with piezoelectric ***,two extension modes are analyzed and compared with respect to their efficiency and power ***,tests are carried out in an icing tunnel to verify the effectiveness of the piezoelectric ice protection system and the predictions of the maximal required *** system allows de-icing the leading edge in less than 2 s for a glaze ice deposit.

关键词： Ice protection system Piezoelectric resonance mode Ice fracture Leading edge de-icing

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Naproxen-induced liver injury

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 552-556页

作者： Sharif Ali jason D Pimentel Department of Pathology and Laboratory Medicine Henry Ford Hospital 2799 West Grand Blvd. Detroit MI 48202 USA

BACKGrOUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to induce liver injury. Patterns of the injury usually range from mild elevations of liver enzymes to sometimes severe fulminant hepatic failure. Likewise, naproxen is a propionic acid derivative NSAID that was introduced in 1980 and has been available as an over-the- counter medication since 1994, but has rarely been reported to cause liver injury. METHODS: We treated a 30-year-old woman with jaundice and intractable pruritus that developed shortly after taking naproxen. We reviewed the medical history and liver histopathology of the patient as well as all previously published case reports of naproxen-associated liver toxicity in the English language literature. rESULTS: The liver biochemical profile of the patient revealed a mixed cholestasis and hepatitis pattern. Consecutive liver biopsies demonstrated focal lobular inflammation, hepatocyte drop-out, and a progressive loss of the small interlobular bile ducts (ductopenia). The biopsy performed two years after onset of the disease showed partial recovery of a small number of bile ducts; however, 10 years passed before the biochemical profile returned to near normal. CONCLUSIONS: Naproxen-associated liver toxicity remains a rare entity, but should be considered in any patient presenting with cholestasis shortly after its use. Liver injury is most commonly seen in a mixed pattern characterized by cholestasis and hepatitis. The resulting liver damage may take years to resolve.

关键词： naproxen ductopenia vanishing bile duct syndrome propionic acid liver injury

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Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome studies

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 115-125页

作者： Bingdi Liu Lin Zhang jason H.Knouft Fangqiong Ling Department of Energy Environmental and Chemical EngineeringWashington University in St.LouisSt.LouisMO 63130USA Department of Biology Saint Louis UniversitySt.LouisMO 63103USA National Great rivers research and Education Center East AltonMO 62035USA Department of Computer Science and Engineering Washington University in St.LouisSt.LouisMO 63130USA Division of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63110USA Division of Computational and Data Science Washington University in St.LouisSt.LouisMO 63130USA

Microbial communities inhabiting river ecosystems play crucial roles in global biogeochemical cycling and pollution *** variations in local microbial assemblages are important for detailed understanding of community assembly and developing robust biodiversity sampling ***,we intensely analyzed twenty water samples collected from a one-meter spaced transect from the near-shore to the near-center in the Meramec river in eastern Missouri,USA and examined the microbial community composition with 16S rrNA gene amplicon *** microbiomes across the transect exhibited extremely high similarity,with Pearson’s correlation coefficients above 0.9 for all pairwise community composition ***,despite the high similarity,PErMANOVA revealed significant spatial differences between near-shore and nearcenter communities(p=0.001).Sloan’s neutral model simulations revealed that within-transect community composition variation was largely explained by demographic stochasticity(r^(2)=0.89).Despite being primarily explained by neutral processes,LefSe analyses also revealed taxa from ten families of which relative abundances differed directionally from the bank to the river center,indicating an additional role of environmental ***,the local variations within a river transect can have profound impacts on the documentation of alpha ***-accumulation curves indicated that even twenty samples did not fully saturate the sampling effort at the genus level,yet four,six and seven samples were able to capture 80%of the phylum-level,family-level,and genus-level diversity,*** study for the first time reveals hyperlocal variations in riverine microbiomes and their assembly mechanisms,demanding attention to more robust sampling strategies for documenting microbial diversity in riverine systems.

关键词： Microbiome Freshwater Taxon accumulation curve Community assembly

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Heterogeneous numerical modelling for the auto thermal reforming of crude glycerol in a fixed bed reactor

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Chinese Journal of Chemical Engineering 2022年第2期35卷 261-268页

作者： jason Williams Hussameldin Ibrahim Nima Karimi Kelvin Tsun Wai Ng Clean Energy Technologies research Institute Process Systems EngineeringFaculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada Environmental Systems Engineering Faculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada

A mathematical model for the catalytic autothermal reforming(ATr)reaction of synthetic crude glycerol to hydrogen in a fixed bed tubular reactor(FBTr)and over an in-house developed metal oxide catalyst is presented in this *** heterogeneous model equations account for a two-phase system of solid catalyst and bulk feed ***,the ATr of crude glycerol reaction scheme and intrinsic kinetic rate model over an active,selective,and stable nickel-based catalyst were integrated in the developed ***,the model was validated using experimental data generated in our labs for the ATr of synthetic crude *** modelling results adequately described the detailed gas product composition and distribution,temperature profiles,and conversion propagation in the axial direction of the fixed bed reactor over a wide range of reaction temperature(773–923 K)and mass-time(12.71–158.23 g cat·min·(mol C)^(-1)).The crude glycerol conversion predicted with the model showing a close resemblance to those obtained experimentally with an average absolute deviation(AAD)of less than 8%.The maximum crude glycerol conversion and hydrogen yield were found to be 92%and 3 mol hydrogen/mol crude glycerol,***,the gas product concentration profile in the reactor was adequately described(90%)accuracy with a hydrogen concentration of 39%(volume).

关键词： Hydrogen crude glycerol Autothermal reforming Numerical analysis Fixed-bed reactor

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Approaches to improve quality of care in inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第28期20卷 9281-9285页

作者： rajesh Shah jason K Hou Department of Medicine Baylor College of Medicine Houston VA HSr&D Center of Excellence Michael E DeBakey Veterans Affairs Medical Center

Studies across medical disciplines have shown gaps in the care recommended in evidence based guidelines and the care actually delivered. Quality improvement projects using systematic audit and feedback interventions such as quality measures, will become increasingly important tools to address these gaps in care. These gaps are also apparent in the care of patients with inflammatory bowel disease. Multiple organizations, including the American Gastroenterology Association and the Crohn’s and Colitis Foundation of America, have developed programs designed to implement quality measures to improve the care of inflammatory bowel disease (IBD) patients. Early results show promise of improving quality, but numerous barriers remain. Gastroenterologists need to be aware of these processes to provide the highest care possible to patients with IBD. We review the existing literature on approaches to quality improvement and their potential application and barriers when applied to IBD care.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Quality

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review of hybrid electric powered aircraft,its conceptual design and energy management methodologies

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Chinese Journal of Aeronautics 2021年第4期34卷 432-450页

作者： Ye XIE Al SAVVArISAL Antonios TSOUrDOS Dan ZHANG jason GU Intelligent robot research Centre Zhejiang LabHangzhou311100China School of Aerospace Transport and ManufacturingCranfield UniversityBedford MK430ALUnited Kingdom York University North YorkToronto M3J 1P3Canada Dalhousie University HalifaxNova Scotia B3H 4R2Canada

The paper overviews the state-of-art of aircraft powered by hybrid electric propulsion *** research status of the design and energy management of hybrid aircraft and hybrid propulsion systems are further *** first contribution of the review is to demonstrate that,in the context of relatively underdeveloped electrical storage technologies,the study of mid-scale hybrid aircraft can contribute the most to both theoretical and practical ***,the profits and potential drawbacks of applying hybrid propulsion to mid-scale hybrid airplanes have not been thoroughly ***,as summed in the overview of design methodologies,the multi-objective optimization transcends the single-objective *** potential of the hybrid propulsion system can be thoroughly evaluated in only one optimization run,if several objectives optimized *** there are few researches covering the conceptual design of hybrid aircraft using multi-objective *** review of the most popular energy management strategies discloses the third research gap—current methodologies favoured in hybrid ground vehicles do not consider the aircraft ***,both non-causal and causal energy management are needed for performing a complicated flight mission with several sub-tasks.

关键词： Aircraft Convex optimization Energy management Fuzzy logic control Hybrid electric propulsion system Non-dominated sorting genetic algorithm Sizing

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On visualization techniques comparison for large social networks overview:A user experiment

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Visual Informatics 2020年第4期4卷 23-34页

作者： Bruno Pinaud jason Vallet Guy Melancn University of Bordeaux CNRS UMR 5800 LaBRIFrance

Visualizing social networks,especially an overview emphasizing their structure,i.e.,communities and their interconnections,is known to be a challenging *** this paper,we present a set of design rationales to build such overview visualizations of social networks and our solution called *** evaluate its performances against two of the most wide-spread visualization techniques(matrix and node-link diagram)in a human–computer controlled experiment based on community-related *** none of the techniques emerge as the overwhelming winner,Jasper appears to be one of the best methods for each task;a fact sustained by the marks given by the ***,Jasper can be seen as an all-encompassing solution for quickly producing legible and compact overviews of large social networks on a single modern computer.

关键词： Overview visualization User evaluation Graphs andnetworks Social networks

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risk management in open cut coal mines

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International Journal of Mining Science and Technology 2013年第3期23卷 369-374页

作者： Ismet Canbulat John Hoelle jason Emery Undergrounds Anglo American Metallurgical Coal Brisbane 4000 Australia Open Cut Geotechnical Engineering Group Anglo American Metallurgical Coal Brisbane 4000 Australia

There are a number of geotechnical systems used at open cut operations of Anglo American's Metallurgical Coal business unit in Australia. These systems are mainly mine site specific, based on geological information and used as hazard plans. They are qualitative and reliant upon the experienced judgement of site based engineers and the general workforce. They are not suitable for calculating the associated risks of geological structures and mining responses. A uniform risk rating system that can be used to provide an unbiased, standard and quantifiable assessment of the risk from highwall and lowwall failures is therefore developed using the experience gained with such systems in Anglo American's South African operations. This system is a semi-quantitative risk rating system and takes into account the relative differences in the importance of hazards as experienced at each mine site as a result of different combinations of geotechnical factors and mining conditions. It is based on critical geotechnical and other parameters that have been identified by site mining engineers, geologists and geotechnical engineers. The primary advantage of this risk rating system is that all open cut mines in the Anglo American's Metallurgical Coal operations use a near identical system, which enables the user to compare the risk after each blast and with other mines. The system can be adjusted to meet local mine specific requirements. The implementation of this system, a computer program that automatically calculates the risks and recommends predetermined controls, has been made as practical and as easy to use as possible. This program can be used by personnel from other mining disciplines not directly related to geotechnical engineering.

关键词： Geotechnical Openrisk Semi-quantitative risk management Open cut Ground control

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Using Twitter Bios to Measure Changes in Self-Identity:Are Americans Defining Themselves More Politically Over Time?

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Journal of Social Computing 2021年第1期2卷 1-13页

作者： Nick rogers jason J.Jones Department of Sociology Stony Brook UniversityStony BrookNY 11794USA

Are Americans weaving their political views more tightly into the fabric of their self-identity over time?If so,then we might expect partisan disagreements to continue becoming more emotional,tribal,and *** recent scholarship has speculated that this politicization of Americans’identity is occurring,but there has been little compelling attempt to quantify the phenomenon,largely because the concept of identity is notoriously difficult to *** introduce here a methodology,Longitudinal Online Profile Sampling(LOPS),which affords quantifiable insights into the way individuals amend their identity over *** this method,we analyze millions of“bios”on the microblogging site Twitter over a 4-year span,and conclude that the average American user is increasingly integrating politics into their social *** on the site are adding political words to their bios at a higher rate than any other category of words we measured,and are now more likely to describe themselves by their political affiliation than their religious *** data suggest that this is due to both cohort and individual-level effects.

关键词： identity social identity theory social media ideology political polarization Twitter

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