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Neural Regeneration Research 2021年第6期16卷 1192-1193页

作者： Sara T.Whiteman jason m.Askvig Department of Biology Concordia CollegeMoorheadMNUSA

Thy-1 as an“anti-sprouting”factor:Since the identification of Thy-1(CD-90)in 1964 by Reif and Allen,the precise functions of this glycosyl phosphatidylinositol-anchored surface protein within the central nervous system have been difficult to ***-1 is a 110-amino acid cellular adhesion molecule that plays a role in cell-cell communication by interacting with other cellular adhesion molecules,including integrins(Leyton et al.,2001).While found on a diverse array of cells within the body,Thy-1 is present on the surface of almost every neuron in the brain(morris and Grosveld,1989).

关键词： precise system interacting

Prostate-specific antigen （PSA） screening： has the pendulum swung too far？

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Asian Journal of Andrology 2011年第5期13卷 655-656页

作者： jason m Phillips E David Crawford Department of Urology University of Colorado HealthSciences Center Aurora CO 80045 USA

Prostate-specific antigen （PSA） along with digital rectal exam has been the standard for prostate cancer screening in the United States for the past 20 years.1 During this time period, the improved detection of prostate cancer decreased related mortality more than 30%.2 In fact, metastases and their comorbidities have decreased more than 75% since the early 1990s, resulting in a higher incidence of early organ-confined disease. While it is clear that prostate cancer mortality statistics have improved, it is unclear whether men are overscreened.

关键词： overscreened Prostate-specific

The human gut sterolbiome:bile acid-microbiome endocrine aspects and therapeutics

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Acta Pharmaceutica Sinica B 2015年第2期5卷 99-105页

作者： jason m.Ridlon Jasmohan S.Bajaj Department of microbiology and Immunology Virginia Commonwealth University mcGuire VA medical Center Division of Gastroenterology Hepatology and Nutrition Virginia Commonwealth University

The human body is now viewed as a complex ecosystem that on a cellular and gene level is mainly prokaryotic. The mammalian liver synthesizes and secretes hydrophilic primary bile acids, some of which enter the colon during the enterohepatic circulation, and are converted into numerous hydrophobic metabolites which are capable of entering the portal circulation, returned to the liver, and in humans,accumulating in the biliary pool. Bile acids are hormones that regulate their own synthesis, transport, in addition to glucose and lipid homeostasis, and energy balance. The gut microbial community through their capacity to produce bile acid metabolites distinct from the liver can be thought of as an "endocrine organ"with potential to alter host physiology, perhaps to their own favor. We propose the term "sterolbiome" to describe the genetic potential of the gut microbiome to produce endocrine molecules from endogenous and exogenous steroids in the mammalian gut. The affinity of secondary bile acid metabolites to host nuclear receptors is described, the potential of secondary bile acids to promote tumors, and the potential of bile acids to serve as therapeutic agents are discussed.

关键词： Sterolbiome Gut microbiome Bile acids metabolite Therapeutic agent

Surgical solutions to the problem of massive weight loss

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World Journal of Gastroenterology 2006年第41期12卷 6602-6607页

作者： jason A Spector Steven m Levine Nolan S Karp Division of Plastic Surgery Weill medicine College of Cornell University New YorkNY 10021United States Institute of Reconstructive and Plastic Surgery Division of Plastic SurgeryNew York University School of MedicineNew YorkNY 10016United States

In response to the global rise in obesity, bariatric surgery has become increasingly more popular and successful As a result, the demand for body contouring following massive weight loss is rapidly growing. Although bariatric procedures may produce impressive weight loss, people who achieve massive weight loss are often unhappy with the hanging folds of skin and subcutaneous tissue that remain. This review examines the nature of the post-bariatric deformity in each body region and briefly reviews common approaches to their treatment.

关键词： Weight loss Bariatric surgery Body contour surgery

A longitudinal analysis of the U.S. Air Force Reserve Officers’ Training Corps physical fitness assessment

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military medical Research 2020年第2期7卷 166-173页

作者： Cameron Smackey jason mDe Freitas Applied Neuromuscular Physiology Laboratory Oklahoma State University192 CRCStillwaterOK 74078USA

Background:The *** Force physical fitness assessment(PFA)is used to determine the overall fitness of their *** is currently unknown to what extent the PFA scores of Reserve Officers’Training Corps(ROTC)cadets are affected by mandatory physical *** purpose of this investigation was to longitudinally examine the PFAs of ROTC cadets over a four-year period,evaluate the results across class ranks,and evaluate the sensitivity of the classification of the ***:Air Force ROTC cadets performed the PFAs(abdominal circumference,1-min pushups,1-min sit-ups,and a 1.5-mile run)in both the spring(n=26)and fall(n=22)*** were compiled over a four-year period(Spring 2014–Fall 2017)and were performed in accordance with Air Force Instruction 36–2905.A oneway repeated measures ANOVA was performed separately for the fall and spring groups for each dependent variable across the 4 ***,a one-way between groups ANOVA was performed for each dependent variable during the time point(fall 2015;n=46)with the most recorded cadets for each class ***:Longitudinal assessments revealed a main effect of time(P=0.010)on abdominal circumference;cadets had a smaller abdominal circumference in their freshman year than in their senior year.A main effect of time(P=0.006)was also observed on sit-up quantity;cadets performed more sit-ups in their junior year than in their freshman *** between class ranks during the same year(between-subjects ANOVA)revealed a main effect of class rank on sit-up quantity(P=0.003);the freshmen completed fewer repetitions than the sophomores(P=0.018)and the juniors did(P=0.001).Conclusions:The results indicated that only the sit-up component showed differences between class *** findings suggest that the Air Force PFA may not be sensitive enough to detect changes in physical fitness or distinguish between class ranks regarding physical performance,even after years of *** limitation may b

关键词： Class ranks Fitness assessment military Physical training ROTC

The Jehol Biota (Lower Cretaceous, China): new discoveries and future prospects

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Integrative Zoology 2006年第1期1卷 15-17页

作者： Paul m.BARRETT jason m.HILTON Department of Palaeontology Natural History MuseumLondonUK School of Geography Earth and Environmental SciencesUniversity of BirminghamUK

Continuing work on the paleontology and sedimentology of the Jehol Group(Lower Cretaceous,China)is yielding numerous new insights into the evolution of many mesozoic plant and animal ***,many questions remain unanswered regarding Jehol paleoenvironments,paleobiology and *** of this information will be crucial in providing a detailed reconstruction of this extinct ecosystem.

关键词： climate Jehol Biota paleobotany paleozoology

Androgen deprivation therapy-associated vasomotor symptoms

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Asian Journal of Andrology 2012年第2期14卷 193-197页

作者： jason m Jones manish Kohli Charles L Loprinzi Department of medical Oncology Mayo Clinic Rochester MN 55905 USA

Androgen deprivation therapy （ADT） is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.

关键词： androgen deprivation therapy hot flashes vasomotor symptoms

POLYmERIC NANOPARTICLES FROm SUPERCRITICAL CO_2 mICROEmULSION POLYmERIZATION

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Chinese Journal of Polymer Science 2006年第1期24卷 95-101页

作者： Wei-jun Ye jason S. Keiper Joseph m. DeSimone NSF Science and Technology Center for Environmentally Responsible Solvents and Processes Department of Chemistry University of North Carolina at Chapel Hill CB# 3290 Venable Hall Chapel Hill NC 27599-3290 USA Department of Chemical Engineering North Carolina State University P. O. Box 7905 Raleigh NC 27695-7905 USA

Herein, we reported the microemulsion polymerization in supercritical carbon dioxide. With the aid of an anionic phosphate fluorosurfactant （bis-[2-（F-hexyl）ethyl]phosphate sodium）, water-soluble/CO2-insoluble acryloxyethyltrimethyl ammonium chloride monomer and N,N＇-methylene-bisacrylamide cross-linker were solubilized into CO2 continuous phase via the formation of water-in-CO2 （w/c） microemulsion water pools. Initiated by a CO2-soluble initiator, 2,2＇-azo-bisisobutyronitrile （AIBN）, cross-linked poly（acryloxyethyltrimethyl ammonium chloride） particles were produced and stabilized in these w/c internal water pools. Nano-sized particles with sizes less than 20 nm in diameter and narrow particle size distributions were obtained.

关键词： Supercritical carbon dioxide Nanoparticles microemulsion polymerization.

Sex differences in cognition and their relationship to male mate choice

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Current Zoology 2019年第3期65卷 285-293页

作者： jason KEAGY Ross mINTER Robin m.TINGHITEELLA Department of Animal Biology School of Integrative Biology University of Illinois at Urbana-Champaign Urbana IL USA Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora CO USA Department of Biological Sciences University of DenverDenverCOUSA

male cognition has gained recognition as an important potential player in sexual selection. A number of studies have found positive correlations between male sexual signals and cognitive performance an d/or female pref ere nces for males with better cog nitive performance, although other studies have not fou nd these relati on ships. Sex roles can differ dramatically, and sex differen ces in selection on cog nition likely follow from the different tasks associated with these sex roles. Here, using threespine stickleback Gasterosteus aculeatus, a species with clearly diverge nt sex roles and mutual mate choice, we focus on the cognitive trait inhibitory control because males must differentially respond to reproductive females versus other sticklebacks while defending territories and refrain from eating eggs and fry while performing paternal care. We presented fish with a detour task four times over a period of 7 days, allowing us to assess initial inhibitory control and improvement over time. We ask 1) whether there are sex differences in inhibitory control and 2) whether male mate choice is associated with female inhibitory control. Although males outperformed females on three different measures of detour task performance across four trials, these differences were largely explained by males being less neophobic than females. Females took more trials to successfully solve the detour task, even after accounting for sex differences in neophobia. Female cognitive abilities, however, were unrelated to the vigor with which males courted them. The equivocal results regarding sex differences in cognitive ability suggest further study given the very different selection pressures each sex experiences.

关键词： cognition detour task mutual mate choice sexual selection threespine stickleback