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Prostate-specific antigen （PSA） screening： has the pendulum swung too far？

Asian Journal of Andrology 2011年第5期13卷 655-656页

作者： jason m phillips e david crawford Department of Urology University of Colorado HealthSciences Center Aurora CO 80045 USA

Prostate-specific antigen （PSA） along with digital rectal exam has been the standard for prostate cancer screening in the United States for the past 20 years.1 During this time period, the improved detection of prostate cancer decreased related mortality more than 30%.2 In fact, metastases and their comorbidities have decreased more than 75% since the early 1990s, resulting in a higher incidence of early organ-confined disease. While it is clear that prostate cancer mortality statistics have improved, it is unclear whether men are overscreened.

关键词： Diseases Phenotypic screening

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Value within otolaryngology:Assessment of the cost-utility analysis literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第1期2卷 -页

作者： Krupa R. Patel david J. phillips jason m. Leibowitz Theresa Scognamiglio Victoria e. Banuchi William I. Kuhel david I. Kutler marc A. Cohen Weill Cornell medical College New York NY 10065 USA Department of 0tolaryngology-Head and Neck Surgery New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA Department of 0tolaryngology-Head and Neck Surgery University of Miami Miami FL 33136 USA Department of Pathology&Laboratory medicine New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA

Objective:To assess the characteristics and quality of cost utility analyses (CUA) related to otolaryngology within the CeA registry and to summarize their collective results. methods:All cost-utility analyses published between 1976 and 2011 contained in the Cost-effectiveness Analysis Registry (CeA Registry) were evaluated. Topics that fall within the care of an otolaryngologist were included in the review regardless of the presence of an otolaryn-gologist author. Potential associations between various study characteristics and CeA registry quality scores were evaluated using the Pearson product moment correlation coefficient. Results:Sixty-one of 2913 (2.1%) total CUA publications screened were related to otolaryn-gology. eighteen of 61 (29.5%) publications included an otolaryngologist as an author. Fourteen studies agreed on the cost effectiveness of at least unilateral cochlear implantation and six of seven (85.7%) studies demonstrated the cost effectiveness of continuous positive airway pres-sure (CPAP) for obstructive sleep apnea (OSA). Forty-six percent (28 of 61) of all manuscripts were published between 2008 and 2011. A more recent publication year was associated with a higher CeA registry quality score while the presence of an otolaryngologist author and journal impact factor had no significant correlation with the quality of the CUA. Conclusion:Based on current evidence in the CeA registry, unilateral cochlear implantation for hearing loss and CPAP for OSA are both cost-effective therapeutic interventions. Although CUAs in otolaryngology have increased in quantity and improved in quality in more recent years, there is a relative lack of CUAs in otolaryngology in comparison to other subspecialties. Copyright a 2016 Chinese medical Association. Production and hosting by elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-SA license (http://***/licenses/by-nc-sa/4.0/).

关键词： Cost-utility analysis

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