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胰岛素样生长因子-1和血小板源性生长因子-α对人类脂肪源性基质细胞成骨分化的调节作用

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中国美容整形外科杂志 2011年第7期22卷 I0003-I0003页

作者： Benjamin Levi Aaron W. James Derrick c. Wan jason P. glotzbach george W. commons Michael T. Longaker 魏峰(译) 高景恒(译) 张晨(译) 美国加利福尼亚州斯坦福斯坦福大学医学院整形再造外科中心外科部Hagey儿科再生研究室《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景人类脂肪源性基质细胞有巨大的用于组织工程的潜能。作者的实验室致力于研究人类脂肪源性基质细胞对骨骼组织的再生作用，并识别那些可增强人类脂肪源性基质细胞成骨性分化的因子。作者假设胰岛素样生长因子（insulin-like growth f... 详细信息

背景人类脂肪源性基质细胞有巨大的用于组织工程的潜能。作者的实验室致力于研究人类脂肪源性基质细胞对骨骼组织的再生作用，并识别那些可增强人类脂肪源性基质细胞成骨性分化的因子。作者假设胰岛素样生长因子（insulin-like growth factor，IgF）和血小板源性生长因子（platelet-derived growth factor，PDgF）可以刺激人类脂肪源性基质细胞骨生成，且IgF可刺激脂肪形成。方法从人脂肪抽吸组织中获取脂肪源性基质细胞，首先，采用微阵列分析法检测成骨性分化过程中的基因表达。获取标本中添加重组体IgF-1和PDgF-α的方式是：分别单独添加，二者联合添加。利用碱性磷酸酶、茜素红、油红O进行染色，并利用定量实时多聚酶链式反应（RUNX2，ALP，OcN，IgFl，PPARg，LPL，AP2，and gcP1）评估骨生成和脂肪形成。最后，评估IgF和PDgF信号途径的交叉点。结果所有标记物均可观察到IgF-1可增加成骨性分化作用（P〈0．01）。然而，初始时单独加入PDgF-α并不能影响骨生成标记物。PDg-α可上调IgF-1的转录活性。PDgF-α与IgF-1联合添加或在添加IgF-1前添加PDgF-α对骨生成的增加作用均大于单独加入任一种因子。IgF-1可增加人类脂肪源性基质细胞的脂肪生成，而PDgF-α的作用相反。结论IgF信号可显著增强人类脂肪源性基质细胞的骨生成，可以在组织工程中使用。PDgF和IgF联合使用对脂肪源性基质细胞骨生成的促进作用强于单独使用任一种。未来的体内应用将关注脂肪源性基质细胞，仿生支架和重组体IgF的结合。

关键词：血小板源性生长因子胰岛素样生长因子-1 脂肪形成基质细胞人类成骨分化 PDgF-α IgF-1

干扰素下游分子25-羟基胆固醇抑制IL-1诱导产生的炎症

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中国肿瘤生物治疗杂志 2015年第1期22卷 46-46页

作者：陈坤刘书逊 Andrea R Dang EV Jeffrey g 不详

美国加州大学圣弗朗西斯科分校的微生物与免疫学系的jason教授和他的研究团队发现,干扰素(interferon,IFN)诱导基因25-胆固醇羟化酶(cholesterol 25-hydroxylase,ch25h)通过代谢产生的25羟基胆固醇(oxysterol 25-hydroxycholesterol,25Hc)负向调节IL-1诱导发生的炎症反应,该研究成果发表在2014年8月8日的Science杂志上。IFN在抗病毒反应中发挥着重要的作用,并且越来越多的研究表明IFN具有抑制免疫应答过度活化的功能,

关键词：胆固醇羟化酶 IL-1 hydroxylase 负向调节过度活化免疫应答 interferon 抗病毒 cholesterol 研究成果

脑动静脉畸形的处理：美国心脏协会／美国卒中协会对医疗卫生专业人员发布的科学声明

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国际脑血管病杂志 2017年第8期25卷 684-708页

作者： colin P. Derdeyn gregory J. Zipfel Felipe c. Albuquerque Daniel L. cooke Edward Feldmann jason P. Sheehan James c. Tomer 盖延廷王威简新革檀书斌李彦江彭方强刘旻谛宋冬雷不详冬雷脑科医生集团上海200040

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过Pu... 详细信息

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过PubMed、Medline或Embase完成各自相关章节的文献检索，时间截止到2015年1月底。声明草稿由同行评议专家以及卒中委员会科学监督委员会和卒中委员会领导委员会进行预先审查。结果本科学声明的重点细分为流行病学、诊断、自然史、治疗方案（包括开颅手术、立体定向放射外科和栓塞治疗的作用）以及破裂和未破裂bAVMs的处理，并且确定了需要更多证据支持的领域。结论bAVMs是一种相对少见但非常重要的出血性卒中病因，尤其是在年轻成人中。本声明描述了目前关于破裂和未破裂bAVMs的自然史和治疗方法的知识现状，同时提供了处理建议以及对将来研究的提示。

关键词： AHA科学声明动静脉畸形脑出血诊断栓塞治疗颅内出血神经外科放射外科

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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chinese Physics c 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem 安丰鹏安琪 giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael cabrera Barbara caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo callegari Antonio cammi Agustin campeny 曹传亚曹国富曹俊 Rossella caruso cédric cerna chi chan 常劲帆 Yun chang 陈国明陈平平 Po-An chen 陈少敏 Xurong chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu chin cheng Alexey chetverikov Davide chiesa Pietro chimenti Artem chukanov gérard claverie catia clementi Barbara clerbaux Selma conforti Di Lorenzo Daniele corti Flavio Dal corso Olivia Dalager christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 Li-cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto garfagnini Arsenii gavrikov Marco giammarchi Nunzio giudice Maxim gonchar 龚光华宫辉 Yuri gornushkin Alexandre göttel Marco grassi Vasily gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio guardone 郭聪郭竞渊郭万磊 Xinheng guo 郭宇航 Paul Hackspacher caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad católica de chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina china Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North china Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of chinese Academy of Sciences BeijingChina Jilin University ChangchunChina college of Electronic Science and Engineering National University of Defense TechnologyChangshaChina chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of china HefeiChina The Radiochemistry and Nuclear chemistry group in University of South china HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina guangxi University NanningChina East china University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

多源雷达高度计全球典型湖泊水位变化数据集(2002-2016)

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全球变化数据学报（中英文） 2018年第3期2卷 295-302,184-191页

作者：廖静娟沈国状赵云中国科学院遥感与数字地球研究所数字地球重点实验室北京100094 海南省地球观测重点实验室三亚572029 中国科学院大学北京100049

湖泊水位是反映区域和全球环境变化的重要指标。基于ENVISAT/RA-2、cryosat-2/SIRAL、jason-2三种星载雷达高度计的gDR(geophysical Data Record)数据和MODIS影像数据经湖泊边界提取、水位计算、水位异常值剔除、高斯滤波去噪、高程系... 详细信息

湖泊水位是反映区域和全球环境变化的重要指标。基于ENVISAT/RA-2、cryosat-2/SIRAL、jason-2三种星载雷达高度计的gDR(geophysical Data Record)数据和MODIS影像数据经湖泊边界提取、水位计算、水位异常值剔除、高斯滤波去噪、高程系统转换等过程,提取了全球118个面积大于400km2的湖泊2002-2016年的水位变化数据集。每个湖泊的2002-2016年水位年平均变化率采用简单线性回归计算得到。数据结果分别采用青海湖、鄱阳湖和北美五大湖的实测水位进行了水位提取精度验证,提取精度可达分米-厘米级。该数据集涉及的118个湖泊,位于亚欧大陆57个,北美洲31个,非洲14个,南美洲10个,大洋洲6个。数据集内容包括:(1)118个湖泊的2002-2016年水位变化数据,包括湖泊的日观测水位、月平均水位和年平均水位。(2)118个湖泊的2002-2016年水位变化率数据。数据存储为.xlsx、.shp格式,由126个数据文件组成,数据量为3.71 MB(压缩为1个数据文件,3.48 MB)。

关键词：湖泊水位变化全球多源雷达高度计

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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chinese Physics c 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An guangpeng An Qi An giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael cabrera Hao cai Xiao cai Yanke cai Zhiyan cai Antonio cammi Agustin campeny chuanya cao guofu cao Jun cao Rossella caruso cédric cerna Jinfan chang Yun chang Pingping chen Po-An chen Shaomin chen Shenjian chen Xurong chen Yi-Wen chen Yixue chen Yu chen Zhang chen Jie cheng Yaping cheng Alexander chepurnov Davide chiesa Pietro chimenti Artem chukanov Anna chuvashova gérard claverie catia clementi Barbara clerbaux Selma conforti Di Lorenzo Daniele corti Salvatore costa Flavio Dal corso christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan gan Feng gao Alberto garfagnini Alexandre göttel christoph genster Marco giammarchi Agnese giaz Nunzio giudice Franco giuliani Maxim gonchar guanghua gong Hui gong Oleg gorchakov Yuri gornushkin Marco grassi christian grewing Maxim gromov Vasily gromov Minghao gu Xiaofei gu Yu gu Mengyun guan Nunzio guardone Maria gul cong guo Jingyuan guo Wanlei guo Xinheng guo Yuhang guo Paul Hackspacher caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade catolica do Rio de Janeiro RioBrazil Pontificia Universidad católica de chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina china Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North china Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of chinese Academy of Sciences BeijingChina Jilin University ChangchunChina college of Electronic Science and Engineering National University of Defense TechnologyChangshaChina chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of china HefeiChina The Radiochemistry and Nuclear chemistry group in University of South china HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina guangxi University NanningChina East china University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

小胶质细胞在脊髓背角突触可塑性和慢性疼痛中的重要作用

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科学新闻 2020年第2期 110-110页

作者：谈智刘先国武龙军 Li-Jun Zhou Jiyun Peng Ya-Nan Xu Wei-Jie Zeng Jun Zhang Xiao Wei chun-Lin Mai Zhen-Jia Lin Yong Liu Madhuvika Murugan Ukpong B.Eyo Anthony D.Umpierre Wen-Jun Xin Tao chen Mingtao Li Hu i Wang jason R.Richardson 中山大学中山医学院美国罗格斯大学和梅奥诊所

文章简介本研究发现,用强度为10 V的强直电刺激作用于小鼠的坐骨神经可引起脊髓背角c纤维突触LTP和持续至少35天的慢性疼痛,但不会引起传入神经元的损伤和炎症。为了排除强直电刺激引起的其他效应可能导致慢性疼痛,研究预先用利多卡因(... 详细信息

文章简介本研究发现,用强度为10 V的强直电刺激作用于小鼠的坐骨神经可引起脊髓背角c纤维突触LTP和持续至少35天的慢性疼痛,但不会引起传入神经元的损伤和炎症。为了排除强直电刺激引起的其他效应可能导致慢性疼痛,研究预先用利多卡因(钠通道阻断剂)阻断传入神经的动作电位,或阻断脊髓背角的NMDA受体,发现二者都可完全阻断强直电刺激引起的脊髓背角LTP和慢

关键词：慢性疼痛强直电刺激小胶质细胞突触可塑性重要作用

一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统

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科学新闻 2019年第2期 33-33页

作者： Daniel S.Kermany Michael goldbaum Wenjia cai carolina c.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu christina Li Sierra Hewett jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu cindy Wen Edward D. Zhang charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康美国加州大学圣地亚哥分校人类基因组医学研究所

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜... 详细信息

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OcT(光学相干断层扫描)

关键词： AI 深度学习

JUNO sensitivity on proton decay p→νK^(+)searches

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chinese Physics c 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael cabrera Barbara caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo callegari Antonio cammi Agustin campeny 曹传亚曹国富曹俊 Rossella caruso cédric cerna 常劲帆 Yun chang 陈平平 Po-An chen 陈少敏陈旭荣 Yi-Wen chen 陈义学陈羽陈长程捷程雅苹 Alexey chetverikov Davide chiesa Pietro chimenti Artem chukanov gérard claverie catia clementi Barbara clerbaux Selma conforti Di Lorenzo Daniele corti Flavio Dal corso Olivia Dalager christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng gao Alberto garfagnini Arsenii gavrikov Marco giammarchi Agnese giaz Nunzio giudice Maxim gonchar 龚光华宫辉 Yuri gornushkin Alexandre göttel Marco grassi christian grewing Vasily gromov 顾旻皓谷肖飞古宇关梦云 Nunzio guardone Maria gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad católica de chile SantiagoChile IPHc Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN catania and Dipartimento di Fisica e Astronomia dell Universitàdi catania CataniaItaly East china University of Science and Technology ShanghaiChina University of Science and Technology of china HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJcLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATEcH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North china Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector