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remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel

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Stroke & Vascular Neurology 2021年第1期6卷 103-108页

作者： jason Philip Appleton Carla richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Stroke Division Nottingham University Hospitals NHS TrustNottinghamUK Platelet Solutions Ltd Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK Platelet research Group Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment *** primary aim was to assess the proportion of patients who are insensitive to *** secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular *** Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were *** function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or ***’general practitioners provided details on recurrent vascular events at least 90 days *** are mean(SD)and median[IQr].resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 ***-parametric descriptors and tests were *** 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and *** of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin ***(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=*** remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed *** significant associations were noted between clopidogrel resistance and recurrent ischaemic events.

关键词： patients cerebral function

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现代装饰 2022年第4期 24-33页

作者： Tiffany ricardo Kelly Dubisar Chad Wyman Marissa Everling Ben Vela Marie Achterhof Miriam Diaz Laura richardson jason O'rear(摄影) 不详

过去两年来,新冠疫情一直严重扰乱着人们的正常工作,大多数公司纷纷放弃充满变数的“重返办公室”计划,转而考虑如何长久地改变利用办公空间的方式。疫情持续的时间越长,员工离回归2020年之前的日常生活就越远。然而,许多绩优公司并未... 详细信息

过去两年来,新冠疫情一直严重扰乱着人们的正常工作,大多数公司纷纷放弃充满变数的“重返办公室”计划,转而考虑如何长久地改变利用办公空间的方式。疫情持续的时间越长,员工离回归2020年之前的日常生活就越远。然而,许多绩优公司并未要求员工居家办公,也未强迫员工重返疫情之前的办公室环境,而是积极调整相关政策和办公空间设计方案,以建立信任和赋能员工,更好地迎接未来。

关键词：办公空间奥马哈绩优公司办公室疫情日常生活重返

jason ATHErTON The outspoken British chef on work, pet hates and Gordon ramsay

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城市漫步（上海版、英文） 2015年第6期 80-80页

作者： BETTY richardson 不详

I was a 27-year'overnight success story.'People go,“Wow,you did this in five years!”–I didn’t do anything in five *** can’t wake up one morning and go‘right,I want to be a chef,’and in five years’time you’ve got 16 successful restaurants around the world or Michelin stars and *** doesn’t work like *** have to start at the bottom,like I did 27 years ago.

关键词： restaurant stars spoken

jason OAKLEY & JOHN LIU In conversation with Scarpetta and Coquille’s leading men

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城市漫步（上海版、英文） 2015年第8期 79-79页

作者： BETH richardson 不详

One of Shanghai’s finest chefs,jason Oakley,formerly of David Laris’restaurant Laris and San Francisco’s The French Laundry,has left his post at the Mandarin Oriental’s Fifty8o grill to head Scarpetta and *** caug... 详细信息

关键词： cooking restaurant ill

SHANGHAI TAVErN Classy Comfort in The Shanghai EDITION

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城市漫步（上海版、英文） 2018年第11期 61-61页

作者： Ned Kelly Betty richardson(Photos) 不详

The Place Shanghai Tavern is the Eastern incarnation of Berner's Tavern in London,Michelin-starred Chef jason Atherton's all-day dining,classic and classy British comfort food *** in a large high-ceilinged dark wood and marble appointed dining room on the ground floor of The Shanghai EDITION,plush green booths line the outskirts while chairs mix with sofas in the *** again,comfy and classy.

关键词： EDIT Comfort Eastern