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Encapsulated peracetic acid as a valid broad‑spectrum antimicrobial alternative,leading to beneficial microbiota compositional changes and enhanced performance in broiler chickens

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2128-2142页

作者： Salvatore Galgano Leah conway Nikki dalby Adrian Fellows Jos G.MHoudijk Monogastric Science Research Centre Scotland’s Rural CollegeWest Mains RoadEdinburgh EH93JGScotlandUK Aga2tech Ltd HalifaxUK Centre for Innovation Excellence in Livestock YorkUK

Background Antimicrobial alternatives are urgently needed,including for poultry production *** this study,we tested the potential broad-range antimicrobial alternative peracetic acid,delivered in feed via the hydrolysis of encapsulated precursors through a 28-day study using 375 Ross 308 broiler *** tested two peracetic acid concentrations,30 and 80 mg/kg on birds housed on re-used litter,and we evaluated the impact of both levels on gut microbial communities,bacterial concentration,antimicrobial resistance genes relative abundance and growth performance when compared to control birds housed on either clean or re-used *** Body weight gain and feed conversion ratio improved in peracetic acid fed *** d 28,birds given 30 mg/kg of peracetic acid had a decreased Firmicutes and an increased Proteobacteria abundance in the jejunum,accompanied by an increase in Bacillus,Flavonifractor and Rombustia in the caeca,and a decreased abundance of tetracycline resistance *** given 80 mg/kg of peracetic acid had greater caecal abundance of macrolides lincosamides and streptogramins resistance *** performance on clean litter was reduced compared to reused litter,which concurred with increased caecal abundance of Blautia,decreased caecal abundance of Escherichia/Shigella,Anaerostipes and Jeotgalicoccus,and greater gene abundance of vancomycin,tetracycline,and macrolides resistance *** Peracetic acid could be used as a safe broad-spectrum antimicrobial alternative in *** precursors were able to reduce the bacterial concentration in the jejunum whilst promoting the proliferation of probiotic genera in the caeca,especially at the low peracetic acid concentrations tested,and improve growth ***,our findings offer further insights on potential benefits of rearing birds on re-used litter,suggesting that the latter could be associated with better performance and reduced antimicrobial resistance

关键词： Antimicrobial alternative Antimicrobial resistance Broiler chicken Microbiota Peracetic acid Performance 16S rRNA gene

Quantitative data graphics in 3d desktop-based virtual environments-an evaluation

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International Journal of digital Earth 2015年第8期8卷 623-639页

作者： Susanne Bleisch jason dykes Geomatics Engineering FHNW University of Applied Sciences and Arts Northwestern SwitzerlandMuttenzSwitzerland giCentre City University LondonLondonUK

3d desktop-based virtual environments provide a means for displaying quantitative data in *** that are inherently spatial in three dimensions may benefit from visual exploration and analysis in relation to the environment in which they were collected and to which they *** empirically evaluate how effectively and efficiently such data can be visually analyzed in relation to location and landform in 3d versus 2d *** two experiments,participants performed visual analysis tasks in 2d and 3d visualizations and reported insights and their confidence in *** results showed only small differences between the 2d and 3d visualizations in the performance measures that we evaluated:task completion time,confidence,complexity,and insight ***,we found differences for different datasets and settings suggesting that 3d visualizations or 2d representations,respectively,may be more or less useful for particular datasets and contexts.

关键词： 3d geovisualization quantitative data graphics visual data analysis empirical evaluation

Physiological evidence of integrin-antibody reactive proteins influencing the innate cellular immune responses of larval Galleria mellonella hemocytes

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Insect Science 2020年第2期27卷 239-255页

作者： jason F.Lapointe Connor d.McCarthy Gary B.dunphy Craig A.Mandato department of Anatomy and Cell Biology McGill UniversityMontrealCanada department of Natural Resource Sciences Macdonald CampusSte.Anne De BellevueCanada

Larval Galleria melonella(L.)hemocytes form microaggregates in response to stimulation by Gram-positive bacteria Hemocyte adhesion to foreign materials is mediated by the CAMP/protein kinase A pathway and the B-subunit of cholera toxin using a cAMP-independent *** toxin-induced microaggregation was inhibited by the integrin inhibitory RGdS peptide,implying integrins may be part of the *** on the types of mammalian integrin-antibody reactive proteins affecting hemocyte adhesion and bacterial-induced responses ars,ory,Ai,and B3 subunits occred on both granular cell and plasmatocyte hemocyte subtypes.A fluorescent band representing the binding of rabbit as-integrin subunit antibodies occurred between adhering heterotypic *** frequency of the bands was increased by cholera *** as andβrabbit integrin subunit antibodies inhibited removal of Bacillus subtilis(Cohn)from the hemolymph in vivo,A as ir-specific synthetic peptide blocker similarly diminished hemocyte function whereas the 0v Bs-specific inhibitory peptide and the corresponding integrin subunit antibodies did not influence nonself hemocyte *** blots revealed several proteins reacting with a given integrin-antibody *** integrin-antibody reactive proteins(which may include integrins)with possible as and B epitopes modulate immediate hemocyte *** microscopy established plasmatocyte adhesion to and rosetting over substrata followved by granular cell microaggregate adhesion to plasmatocytes during early stage nodulation.

关键词： hemocyte response integrin-antibody reactive protein

Cytokines from the pig conceptus:roles in conceptus development in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney d Geisert Matthew C Lucy Jeffrey J Whyte jason W Ross daniel J Mathew Animal Sciences Research Center University of Missouri department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： Cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

Embedding in Anisotropic Spheres

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Research in Astronomy and Astrophysics 2022年第4期22卷 62-70页

作者： Alberto K.Mathias Sunil d.Maharaj Jefta M.Sunzu jason M.Mkenyeleye department of Mathematics and Statistics The University of DodomaP.O.Box 338DodomaTanzania Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalDurban 4000South Africa

Exact solutions to the Einstein field equations for class I spacetime symmetry in relativistic stars are *** symmetry provides a relation between the gravitational potentials that lead to generalized solutions of the Einstein field *** choose one of the gravitational potentials on a physical basis,which allows us to obtain the other gravitational potential via an embedding *** is therefore possible to generate a model with astrophysical *** model generated satisfies physical properties like stability,causality,regularity,equilibrium and energy conditions.

关键词： gravitation astroparticle physics relativistic processes

Properties of alkylbenzimidazoles for CO_2 and SO_2 capture and comparisons to ionic liquids

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Science China Chemistry 2012年第8期55卷 1638-1647,1-2页

作者： SHANNON Matthew S. HINdMAN Michelle S. dANIELSEN Scott. P. O. TEdSTONE jason M. GILMORE Ricky d. BARA jason E. department of Chemical & Biological Engineering University of Alabama Tuscaloosa USA NSF-REU Site: Engineering Solutions for Clean Energy Generation Storage and Consumption Department of Chemical & Biological Engineering University of Alabama Tuscaloosa USA department of Chemical & Biomolecular Engineering University of Pennsylvania Philadelphia USA department of Chemical & Biomolecular Engineering Clemson University Clemson USA

To date, few reports have been concerned with the physical properties of the liquid phases of imidazoles and benzimidazoles- potential starting materials for a great number of ionic liquids. Prior research has indicated that alkylimidazole solvents exhibit different, and potentially advantageous physical properties, when compared to corresponding imidazolium-based ionic liquids. Given that even the most fundamental physical properties of alkylimidazole solvents have only recently been reported, there is still a lack of data for other relevant imidazole derivatives, including benzimidazoles. In this work, we have synthesized a se- ries of eight 1-n-alkylbenzimidazoles, with chain lengths ranging from ethyl to dodecyl, all of which exist as neat liquids at ambient temperature. Their densities and viscosities have been determined as functions of both temperature and molecular weight. Alkylbenzimidazoles have been found to exhibit viscosities that are more similar to imidazolium-based ILs than al- kylimidazoles, owed to a large contribution to viscosity from the presence of a fused ring system. Solubilities of CO2 and SO2, two species of concern in the emission of coal-fired power generation, were determined for selected alkylbenzimidazoles to understand what effects a fused ring system might have on gas solubility. For both gases, alkylbenzimidazoles were deter- mined to experience physical, non-chemically reactive, interactions. The solubility of CO2 in alkylbenzimidazoles is 10%-30% less than observed for corresponding ILs and alkylimidazoles. 1-butylbenzimidazole was found to readily absorb at least 0.333 gram SO2 per gram at low pressure and ambient temperature, which could be readily desorbed under an N： flush, a behavior more similar to imidazolium-based ILs than alkylimidazoles. Thus, we find that as solvents for gas separations, benzimidazoles share characteristics with both ILs and alkylimidazoles.

关键词： benzimidazole imidazole ionic liquids carbon dioxide (CO2) capture sulfur dioxide (S02)

Nanotrains and Self-Assembled Two-dimensional Arrays Built from Carboranes Linked by Hydrogen Bonding of dipyridones

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Nano Research 2008年第5期1卷 412-419页

作者： Takashi Sasaki jason M.Guerrero Ashley d.Leonard James M.Tour department of Chemistry Department of Mechanical Engineering and Materials ScienceRice UniversityMS 2226100 Main St.HoustonTexas 77005USA

The strong hydrogen bonding ability of 2-pyridones were exploited to build nanotrains on *** wheels on axles difunctionalized with 2-pyridone hydrogen bonding units were synthesized and displayed spontaneous formation of linear nanotrains by self-assembly on SiO_(2)or mica *** using atomic force microscopy confi rmed linear formations with lengths up to 5μm and heights within the range of the molecular height of the carborance-tipped axles.

关键词： Nanovehicles nanotrains 2-pyridone hydrogen bonding self-assembly

ECMO in major burn patients: feasibility and considerations when multiple modes of mechanical ventilation fail

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Burns & Trauma 2017年第2期5卷 134-139页

作者： jason d. Kennedy Wesley Thayer Reuben Beuno Kelly Kohorst Avinash B. Kumar department of Anesthesiology and Critical Care Vanderbilt University Medical Center 121121st Avenue S Suite 526 Nashville TN 37212 USA department of Plastic Surgery Vanderbilt University Nashville TN USA

Background: We report two cases of acute respiratory distress syndrome in burn patients who were successfully managed with good outcomes with extra corporeal membrane oxygenation (ECMO) after failing multiple conventional modes of ventilation, and review the relevant *** presentation: The two patients were a 39-year-old male and 53-year-old male with modified Baux Scores of 79 and 78, respectively, with no known inhalation injury. After the initial modified Parkland-based fluid resuscitation and partial escharotomy, both patients developed worsening hypoxemia and acute respiratory distress *** hypoxemia continued to worsen on multiple modes of ventilation including volume control, pressure regulated volume control, pressure control, airway pressure release ventilation and volumetric diffusive *** both cases, the PaO2 ≤ 50 mm Hg on a FiO2100% during the trial of mechanical ventilation. The deterioration was rapid (decision was made to trial the patients on ECMO. Veno-Venous ECMO (V-V ECMO) was successfully initiated following cannulation-under transesophgeal echo guidance—with the dual lumen Avalon? (Maquet, NJ, USA) cannula. ECMO support was maintained for 4 and 24 days, respectively. Both patients were successfully weaned off ECMO and were discharged to rehabilitation following their complex hospital ***: Early ECMO for isolated respiratory failure in the setting on maintained hemodynamics resulted in a positive outcome in our two burn patients suffered from acute respiratory distress syndrome.

关键词： ARdS Burns Extra corporeal membrane oxygenation Rescue ventilation Conventional ventilation failure Veno-venous ECMO

Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells

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Bone Research 2014年第3期2卷 139-151页

作者： Ping Wang Liang Zhao jason Liu Michael d Weir Xuedong Zhou Hockin H K Xu Biomaterials & Tissue Engineering division Department of Endodontics Prosthodontics and Operative Dentistry University of Maryland Dental School Baltimore MD 21201 USA State Key Laboratory of Oral diseases West China Hospital of Stomatology Sichuan University department of Orthopaedic Surgery Nanfang Hospital Southern Medical University Mechanical Engineering department University of Maryland Baltimore County Baltimore MD 21250 USA Center for Stem Cell Biology and Regenerative Medicine University of Maryland School of Medicine Baltimore MD 21201 USA

Tissue engineering is promising to meet the increasing need for bone regeneration. Nanostructured calcium phosphate （CAP） biomaterials/scaffolds are of special interest as they share chemical/crystallographic similarities to inorganic components of bone. Three applications of nano-CaP are discussed in this review： nanostructured calcium phosphate cement （CPC）; nano-CaP composites; and nano-CaP coatings. The interactions between stem cells and nano-CaP are highlighted, including cell attachment, orientation/ morphology, differentiation and in vivo bone regeneration. Several trends can be seen：（i） nano-CaP biomaterials support stem cell attachment/proliferation and induce osteogenic differentiation, in some cases even without osteogenic supplements; （ii） the influence of nano-CaP surface patterns on cell alignment is not prominent due to non-uniform distribution of nano-crystals; （iii） nano-CaP can achieve better bone regeneration than conventional CaP biomaterials; （iv） combining stem cells with nano-CaP accelerates bone regeneration, the effect of which can be further enhanced by growth factors; and （v） cell microencapsulation in nano-CaP scaffolds is promising for bone tissue engineering. These understandings would help researchers to further uncover the underlying mechanisms and interactions in nano-CaP stem cell constructs in vitro and in vivo, tailor nano-CaP composite construct design and stem cell type selection to enhance cell function and bone regeneration, and translate laboratory findings to clinical treatments.

关键词： CPC Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells stem