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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Chinese Journal of Cancer Research 2017年第3期29卷 172-178页

作者： Pei-Hung Chang cheng-Hsu Wang Eric Yen-Chao chen Shih-Wei Yang Wen-Chi Chou jason Chia-Hsun Hsieh Feng-Che Kuan Kun-Yun Yeh Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445 TaiwanChina Cancer Center Chang Gung Memorial HospitalKeelung 20445TaiwanChina Department of Radiation Oncology Chang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Otolaryngology Head and Neck SurgeryChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Division of Medical Oncology Department of Internal MedicineChang Gung Memorial Hospital at LinkouTaoyuan 33305TaiwanChina Department of Hematology and Oncology Department of MedicineChang-Gung Memorial HospitalChiayi 61363TaiwanChina

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

关键词： Glasgow prognostic score (GPS) head and neck cancer chemoradiation inflammation cachexia nutrition

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二维纳米材料在渗透汽化脱盐膜中的应用

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化工进展 2023年第3期42卷 1437-1447页

作者：陈仪郭耀励叶海星李宇璇牛青山深圳大学高等研究院广东深圳518000 中国石油大学(华东)重质油国家重点实验室山东青岛266580 中国石油大学(华东)材料科学与工程学院山东青岛266580

渗透汽化(PV)具有预处理要求低,截留率及水回收率高、抗污染性强等优势,在水处理尤其是高盐废水处理方面具有巨大的应用前景。但目前PV脱盐技术的分离效率较低、稳定性差、抗污染性能欠佳的劣势限制了PV膜在分离膜技术的应用和认可。新... 详细信息

渗透汽化(PV)具有预处理要求低,截留率及水回收率高、抗污染性强等优势,在水处理尤其是高盐废水处理方面具有巨大的应用前景。但目前PV脱盐技术的分离效率较低、稳定性差、抗污染性能欠佳的劣势限制了PV膜在分离膜技术的应用和认可。新型膜材料如二维纳米材料的引入使得PV膜从材料到性能都有了较大提升,被认为是提高PV膜脱盐性能的有效手段。本文首先介绍了PV脱盐技术的分离机理,并从3个方面综述了二维纳米材料在制备PV脱盐膜中的应用现状:二维纳米材料的分类与合成方法、PV复合脱盐膜的制备途径与稳定性提高策略以及二维纳米材料对PV膜特性及脱盐性能的影响。文中指出现有的PV传质模型存在较大局限性且新型二维纳米材料的合成方法较难,为了进一步提高PV复合膜的性能并降低制备成本,还需完善PV复合膜的传质机制并优化二维纳米材料的制备工艺。

关键词：渗透汽化二维纳米材料脱盐膜复合材料

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Track forecast:Operational capability and new techniques-Summary from the Tenth International Workshop on Tropical Cyclones(IWTC-10)

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Tropical Cyclone Research and Review 2023年第1期12卷 64-80页

作者： Adam Conroy Helen Titley Rabi Rivett Xiangbo Feng John Methven Kevin Hodges Alan Brammer Andrew Burton Paromita Chakraborty Guomin chen Levi Cowan jason Dunion Abhijit Sarkar Bureau of Meteorology West PerthAustralia Met Office ExeterUK National Centre for Atmospheric Science and Department of Meteorology University of ReadingReadingUK Department of Meteorology University of ReadingReadingUK Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsUSA National Centre for Medium Range Weather Forecasting NoidaIndia Shanghai Typhoon Institute of China Meteorological Administration ShanghaiChina Joint Typhoon Warning Center HonoluluUSA Cooperative Institute for Marine and Atmospheric Studies University of Miamiand Hurricane Research DivisionNOAA/Atlantic Oceanographic and Meteorological LaboratoryMiamiUSA

In this paper,we summarize findings from the Tenth International Workshop on Tropical Cyclones(IWTC-10)subgroup on operational track forecasting techniques and *** rate of improvement in the accuracy of official forecast tracks(OFTs)appears to be slowing down,at least for shorter lead times,where we may be approaching theoretical *** agencies continue to use consensus methods to produce the OFT with most continuing to rely on an unweighted consensus of four to nine NWP *** continues to be limited use of weighted consensus techniques,which is likely a result of the skills and additional maintenance needed to support this *** in the accuracy of ensemble mean tracks is leading to increased use of ensemble means in consensus *** agencies are increasingly producing situation-dependent depictions of track uncertainty,rather than relying on a static depiction of track forecast certainty based on accuracy statistics from the preceding 5 *** trend has been facilitated by the greater availability of ensemble NWP guidance,particularly vortex parameter files,and improved spread in *** improving spread-skill relationships,most ensemble NWP systems remain under *** many operational centers are looking to leverage“super-ensembles”(ensembles of ensembles)to ensure the full spread of location probability is *** is an important area of service development for multi-hazard impact-based warnings as it supports better decision making by emergency managers and the community in the face of uncertainty.©2023 The Shanghai Typhoon Institute of China Meteorological *** services by Elsevier *** behalf of KeAi Communication *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Tropical cyclones Track forecasting Ensembles Track uncertainty

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Combined Pangenomics and Transcriptomics Reveals Core and Redundant Virulence Processes in A Rapidly Evolving Fungal Plant Pathogen

Combined Pangenomics and Transcriptomics Reveals Core and Re...

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中国植物病理学会2023年学术年会

作者： chen Hongxin KING Robert SMITH Dan BAYON Carlos ASHFIELD Tom TORRIANI Stefano KANYUKA Kostya HAMMOND-KOSACK Kim BIERI Stephane RUDD jason Syngenta Crop Protection AG

Studying genomic;variation in rapidly evolving pathogens potentially enables identification of genes supporting their "core biology",being present,functional and expressed by all strains or " flexible biology",varying between *** supporting flexible biology may be considered to be " accessory",whilst the "core" gene set is likely to be important for common features of a pathogen species biology,including virulence on all host *** wheat-pathogenicfungus Zymoseptoria tritici represents one of the most rapidly evolving threats to global food security and was the focus of this ***,we constructed a pangenome of 18 European field isolates,with 12 also subjected to RNAseq transc;ription profiling during *** this data,we predicated a " coreμgene set comprising 9807 sequences which were(1) present in all isolates,(2) lacking inactivating polymorphisms and(3) expressed by all isolates.A large accessory genome,consisting of 45% of the total genes,was also *** classified genetic and genomic polymorphism at both chromosomal and individual gene *** required for essential functions including virulence had lower-than average sequence variability amongst core *** core and accessory genomes encoded many small,secreted candidate effector proteins that likely interact with plant *** vector-mediated transient in planta overexpression of 88 candidates failed to identify any which inducted leaf necrosis characteristic of ***,functional complementation of a non-pathogenic deletion mutant lacking five core genes demonstrated that full virulence was restored by re-introduction of the single gene exhibiting least sequence polymorphism and highest *** data support the combined use of pangenomics and transcriptomics for defining genes which represent core,and potentially exploitable,weaknesses in rapidly evolving pathogens.

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Fine Mapping and Identification of a Novel Locus FwS1 associated with Pea Resistance to Fusarium Wilt

Fine Mapping and Identification of a Novel Locus FwS1 associ...

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中国植物病理学会2023年学术年会

作者： chen Hongxin KING Robert SMITH Dan BAYON Carlos ASHFIELD Tom TORRIANI Stefano KANYUKA Kostya HAMMOND-KOSACK Kim BIERI Stephane RUDD jason Syngenta Crop Protection AG

Pea Fusarium wilt,induced by Fusarium oxysporum ***(Fop),has always been a devastating disease that causes severe yield losses and economic damage in pea-growing regions *** utilization of pea cultivars carrying a resistance gene is the most efficient approach for managing this *** our previous pea accessions screening,we obtained a disease-resistant cultivar Shijiadacaiwan 1(S1) which carries a confirmable disease resistance gene,*** study aimed to finely map and identify FWS1,as well as develop(corresponding functional *** trait loci sequencing(QTL-seq),based on the whole-genome resequencing(WGRS) of S1(resistant),Y4(susceptible),and their extreme susceptible phenotype bulks from a 67 F population,was performed,and a 982-kb genomic region with ASNP-index≥0.9 on chromosome 6 was identified as the FwS1 candidate region in ***,the candidate region was refined to a 16.8-kb region via fine mapping,employing QTL-seq analysis with supplemental extreme resistant phenotype bulks,and expanding the F population to 593 *** SNPs were carried out in the 16.8-kb region among eight pea genotypes using genomic *** specific nonsynonymous SNP was confirmed in an NB-ARC(nucleotide-binding adaptor shared by APAF-1,R proteins,and CED-4) domain by haplotype analysis of 201 accessions,whose corresponding gene was considered to be the candidate ***,one specific SNP marker in this decided loci was successfully developed using KASP(Kompetitive allele specific PCR) assay,and the marker was verified to be specific for *** this study,we employed a genome-based integrative strategy combining WGRS and traditional genetic mapping to identify the candidate gene for FwSl and develop *** results suggest that WGRS is a precise,rapid,and cost-effective method to identify candidate genes and develop diagnostic markers,and it can accelerate the identification of resistance genes to pea Fu

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Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

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The Journal of Biomedical Research 2016年第2期30卷 120-133页

作者： jason D.Whitt Adam B.Keeton Bernard D.Gary Larry A.Sklar Kamlesh Sodani Zhe-Sheng chen Gary A.Piazza Department of Biochemistry University of Mississippi Medical Center Cancer Institute Jackson MS 39216 USA Drug Discovery Research Center Mitchell Cancer Institute University of South Alabama Mobile AL 36604 USA ADT Pharmaceuticals Inc. Orange Beach AL 36561 USA Department of Pathology The University of New Mexico Albuquerque NM87131 USA Department of Pharmaceutical Sciences St. John's University New York NY 11439 USA

ATP-binding cassette（ABC） transporters ABCC1（MRP1）,ABCB1（P-gp）,and ABCG2（BCRP） contribute to chemotherapy *** primary goals of this study were to characterize the efficacy and mechanism of the nonsteroidal anti-inflammatory drug（NSAID）,sulindac sulfide,to reverse ABCC1 mediated resistance to chemotherapeutic drugs and to determine if sulindac sulfide can influence sensitivity to chemotherapeutic drugs independently of drug *** assays were performed to measure resistance of ABC-expressing cell lines to doxorubicin and other chemotherapeutic *** were tested for the ability to restore sensitivity to resistance selected tumor cell lines,as well as a large panel of standard tumor cell *** experiments characterized the mechanism by which sulindac sulfide inhibits ABCC1 substrate and co-substrate（GSH） transport in isolated membrane vesicles and intact *** reversal of multi-drug resistance（MDR）,decreased efflux of doxorubicin,and fluorescent substrates were demonstrated by sulindac sulfide and a related NSAID,indomethacin,in resistance selected and engineered cell lines expressing ABCC 1,but not ABCB 1 or *** sulfide also inhibited transport of leukotriene C_4 into membrane *** sulfide enhanced the sensitivity to doxorubicin in 24 of 47 tumor cell lines,including all melanoma lines tested（7-7）.Sulindac sulfide also decreased intracellular GSH in ABCC1 expressing cells,while the glutathione synthesis inhibitor,BSO,selectively increased sensitivity to sulindac sulfide induced *** sulfide potently and selectively reverses ABCC1-mediated MDR at clinically achievable ***1 expressing tumors may be highly sensitive to the direct cytotoxicity of sulindac sulfide,and in combination with chemotherapeutic drugs that induce oxidative stress.

关键词： multi-drug resistance doxorubicin sulindac MRP1 glutathione

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Impact of androgen-deprivation therapy on the outcome of dose-escalation prostate cancer radiotherapy without elective pelvic irradiation

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Asian Journal of Andrology 2017年第5期19卷 596-601页

作者： Wei-Hsien Hou Chao-Yuan Huang Chia-Chun Wang Keng-Hsueh Lan Chung-Hsin chen Hong-Jen Yu Shih-Ping Liu Ming-Kuen Lai Yeong-Shau Pu jason Chia-Hsien cheng Division of Radiation Oncology Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Urology National Taiwan University Hospital Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Graduate Institutes of Oncology National Taiwan University College of Medicine Taipei Taiwan China Graduate Institutes of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan China

The benefit of androgen-deprivation therapy （ADT） in combination with dose-escalated radiotherapy （DERT） for localized prostate cancer has not been determined in randomized studies. In this study, the benefit of ADT was assessed in patients uniformly treated with dose-escalated intensity-modulated radiation therapy （IMRT） to the prostate and seminal vesicles but not pelvis. In all, 419 patients with localized prostate adenocarcinoma underwent definitive IMRT （cumulative dose 78 Gy）, with 32.6%, 33.1%, 32.1%, and 2.1% having T1 through T4 disease, respectively, and 51.2% having high-risk disease. ADT was given to 76.1% of patients. With a median follow-up of 60 months, 5-year biochemical failure-free, disease-free, and overall survival rates were 87%, 86%, and 87%, respectively. T stage was an independent predictor of all three rates. Five-year pelvic nodal recurrence rate was 2.9%. ADT improved biochemical failure-free and disease-free survival but not overall survival. ADT showed benefit in high-risk disease but not intermediate-risk disease. Late gastrointestinal and genitourinary toxicities ≥ grade 2 occurred in 11.0% and 6.7%, respectively. In conclusion, DERT with 78 Gy yields good disease control and low rate of pelvic nodal recurrence. ADT improves disease-free survival in patients with high-risk but not intermediate-risk disease.

关键词： androgen-deprivation therapy dose-escalation prostate cancer radiotherapy

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Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE Consortium

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Journal of Sport and Health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina Devoto Timothy B.Meier chen Lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.Giza Hyung-Suk Kim Daniel Huber Jaroslaw Harezlak Kenneth L.Cameron Gerald McGinty Jonathan Jackson Kevin M.Guskiewicz jason P.Mihalik Alison Brooks Stefan Duma Steven Rowson Lindsay D.Nelson Paul Pasquina Michael A.McCrea Jessica M.Gill the CARE Consortium Investigators Johns Hopkins School of Nursing and Medicine BaltimoreMD 21205USA National Institutes of Health BethesdaMD 20892USA Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Predictiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Department of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA Departments of Pediatrics and Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA Department of Epidemiology and Biostatistics School of Public Health–Bloomington Indiana UniversityBloomingtonIN 47405USA John A.Feagin Sports Medicine Fellowship Keller Army Community HospitalWest PointNY 10996USA United States Air Force Academy Colorado SpringsCO 80840USA Mathew Gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA Department of Orthopedics Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Medicine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

Background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or ***,more accurate diagnostic markers are needed for sport-related ***:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education Consortium conducted between 2015 and *** blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute *** with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)*** applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related ***:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this *** identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed *** top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPB41)and alpha-synuclein(SNCA)were 0.956 and 0.875,*** combination of EPB41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of ***:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combina

关键词： Biomarkers College athletes Concussion Mild traumatic brain injury Sport injury

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肾脏替代治疗患者中万古霉素使用研究的文献计量和可视化分析

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中国医院用药评价与分析 2024年第5期24卷 513-518,525页

作者：范淑盼谢文敏陈美琪丁楠王卓海军军医大学第一附属医院药剂科上海200433 沈阳药科大学生命科学与生物制药学院沈阳110016

目的:探讨肾脏替代治疗患者中万古霉素使用研究领域的现况和趋势。方法:基于Web of Science Core Collection,对2007年1月1日至2023年10月11日发表的肾脏替代治疗患者中万古霉素使用研究的相关文献进行检索。采用VOSviewer和CiteSpace... 详细信息

目的:探讨肾脏替代治疗患者中万古霉素使用研究领域的现况和趋势。方法:基于Web of Science Core Collection,对2007年1月1日至2023年10月11日发表的肾脏替代治疗患者中万古霉素使用研究的相关文献进行检索。采用VOSviewer和CiteSpace软件进行文献计量学和可视化分析,涉及发表趋势、地理分布特征、作者及机构、期刊分布特征和关键词信息等。结果:共纳入747篇文献。2007年以来,相关领域发文量波动上升,美国(264篇)是发文量最多的国家,其次为澳大利亚(76篇)和中国(71篇)。昆士兰大学(49篇)出版物最多。jason A Roberts(24篇)、David W Johnson (19篇)和Jeffrey Lipman(19篇)是发文量居前3位的作者。《Peritoneal Dialysis International》(47篇)是发表相关文献最多的期刊。近年来的关键词聚焦于急性肾损伤、给药方案、治疗药物监测、群体药动学以及连续肾脏替代治疗等主题。结论:肾脏替代治疗患者中万古霉素的最佳使用剂量尚不清楚。通过治疗药物监测及群体药动学建模等方法,给予患者合适的给药方案,从而达到抗感染疗效并规避不良反应是该领域的热点和趋势。我国的研究机构与国际间缺乏紧密的合作交流。

关键词：肾脏替代治疗万古霉素文献计量学给药剂量治疗药物监测

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Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects

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Cellular & Molecular Immunology 2019年第5期16卷 473-482页

作者： Kai-Yang Tang jason Lickliter Zhi-Hua Huang Zong-Shu Xian Han-Yang chen cheng Huang Chong Xiao Yu-Peng Wang Ying Tan Lin-Feng Xu Yu-Liang Huang Xiao-Qiang Yan Generon(Shanghai)Corporation Ltd. Zhangjiang Hi-Tech ParkShanghaiChina Nucleus Network MelbourneVICAustralia

F-652 is a recombinant fusion protein consisting of two human interleukin-22(IL-22)molecules linked to an immunoglobulin constant region(IgG 2-Fc).IL-22 plays critical roles in promoting tissue repair and suppressing bacterial *** safety,pharmacokinetics(PK),tolerability,and biomarkers of F-652 were evaluated following a single dose in healthy male volunteers in a randomized,double-blind,placebo-controlled *** single-dose subcutaneous(SC)injection of F-652 at 2.0µg/kg into healthy subjects,six out of six subjects experienced delayed injection site reactions,which presented as erythematous and/or discoid eczematous lesions 10 to 17 days post-dosing.F-652 was then administered to the healthy subjects via an intravenous(IV)infusion at 2.0,10,30,and 45µg/*** severe adverse event(SAE)was observed during the *** the IV-dosed cohorts,eye and skin treatment emergent adverse events(TEAEs)were observed in the 30 and 45µg/kg cohorts.F-652 IV dosing resulted in linear increases in C max and AUC(0–t),and the T 1/2 ranged from 39.4 to 206h in the *** IV injection of F-652 induced dose-dependent increases in serum marker serum amyloid A,C-reactive protein,and FIB,and decreased serum *** serum levels of 36 common pro-inflammatory cytokines/chemokines were not altered by the treatment of F-652 at 45μg/*** conclusion,IV administration of F-652 to healthy male volunteers is safe and well-tolerated and demonstrates favorable PK and pharmacodynamic *** results warrant further clinical development of F-652 to treat inflammatory diseases.

关键词： Interleukin-22 F-652 Pharmacokinetics Pharmacodynamics Safety

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