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HCMV-HIV 共感染患者 HCMV gN 基因型分析

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中华微生物学和免疫学杂志 2015年第4期35卷 258-264页

作者：俞俊岭吴建军胡中旺类延花李国兰张文昌赵俊张俊玲甘霖余莉陈敬贤王明丽安徽医科大学微生物学教研室合肥230032 安徽省疾病预防控制中心合肥市疾病预防控制中心阜阳市疾病预防控制中心哥伦比亚大学病理与细胞生物学教研室

目的：了解HIV感染者中人巨细胞病毒（ human cytomegalovirus， HCMV）糖蛋白N （ glycoprotein N， gN）的型别分布；探讨HCMV-HIV共感染对患者疾病进程的影响及不同gN基因型感染与获得性免疫缺陷综合征（ acquired immuno-deficiency... 详细信息

目的：了解HIV感染者中人巨细胞病毒（ human cytomegalovirus， HCMV）糖蛋白N （ glycoprotein N， gN）的型别分布；探讨HCMV-HIV共感染对患者疾病进程的影响及不同gN基因型感染与获得性免疫缺陷综合征（ acquired immuno-deficiency syndrome，AIDS）发病和相关死亡的关系。方法对359例HIV感染者进行HCMV pp65抗原血症检测，利用HCMV gN（UL73）基因巢式PCR扩增HCMV活动性感染患者全血DNA，限制性核酸内切酶MboⅠ、ScaⅠ和SalⅠ对巢式PCR产物进行限制性片段长度多态性分析（ restricted fragment length polymorphism analysis， RFLP），队列随访研究不同型别HCMV感染与AIDS患者发病和死亡的关系。结果 HCMV pp65抗原血症检测发现，359例HIV感染者中HCMV活动性感染患者28例，对其中20例HCMV活动性感染患者的全血DNA样本进行PCR-RFLP分析，结果表明，HIV感染患者中HCMV gN基因型分布如下：gN-3a，4／20（20％）；gN-1，4／20（20％）；gN-4b，1／20（5％）；gN-4d，1／20（5％）；混合感染，10／20（50％）；在随访期内，HCMV UL73基因阳性的HIV感染者更易转变为AIDS患者（RR＝9．78），且gN-1和gN-4型感染者发病和相关死亡风险是其他基因型的4．6倍（P＜0．05）。结论 HCMV活动性感染可能会加速HIV感染者疾病进程，其中以gN-1和gN-4型HCMV活动性感染相对危险度最高。

关键词：人类免疫缺陷病毒人巨细胞病毒限制性片段长度多态性分析

Multi-step in situ interface modification method for emission enhancement in semipolar deep-ultraviolet light emitting diodes

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Photonics Research 2022年第12期10卷 2778-2785页

作者： LI chen JIE SUN WEI GUO jason HOO WEI LIN HANGYANG chen HOUQIANG XU LONG YAN SHIPING GUO JUNYONG KANG JICHUN YE Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China Yongjiang Laboratory Ningbo315201China Advanced Micro-Fabrication Equipment Inc. Shanghai 201201China Department of Physics Xiamen UniversityXiamen361005China University of Chinese Academy of Sciences Bejing100049China

SemipolarⅢ-nitrides have attracted increasing attention in applications of optoelectronic devices due to the much reduced polarization field.A high-quality semipolar AlN template is the building block of semipolar AlGaN-based deep-ultraviolet light emitting diodes(DUV LEDs),and thus deserves special *** this work,a multi-step in situ interface modification technique is developed for the first time,to our knowledge,to achieve high-quality semipolar AlN *** stacking faults were efficiently blocked due to the modification of atomic configurations at the related *** regrown AlGaN layers were obtained on the in situ treated AlN template,and stacking faults were eliminated in the post-grown AlGaN *** strains between AlGaN layers were relaxed through a dislocation glide in the basal plane and misfit dislocations at the *** contrast,high-temperature ex situ annealing shows great improvement in defect annihilation,yet suffers from severe lattice distortion with strong compressive strain in the AlN template,which is unfavorable to the post-grown AlGaN *** strong enhancement of luminous intensity is achieved in in situ treated AlGaN DUV *** in situ interface modification technique proposed in this work is proven to be an efficient method for the preparation of high-quality semipolar Al N,showing great potential towards the realization of high-efficiency optoelectronic devices.

关键词： diodes polarization interface

Does internet use improve the public evaluation of government environmental governance (GEG) in China? An analysis using the Chinese Social Survey, 2013−2017

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Chinese Journal of Population,Resources and Environment 2022年第4期20卷 307-315页

作者： Jinghuan chen jason AJean Yunliang Zhang Yixi Lu Research Institute of Social Development Southwestern University of Finance and EconomicsChengdu611130China

Based on three datasets of the Chinese Social Survey(CSS)2013,2015,and 2017 and the National Statistical Yearbook,this study examined whether and in what ways using the Internet may or may not affect the public evaluation of government environmental governance(GEG).There are three main ***,Internet use has a negative influence on the public evaluation of ***,there has been an urban-rural difference in terms of Internet use;especially for the rural resident,increasing their use of the Internet significantly lowered their evaluation of ***,Internet use affects GEG mainly through political trust,whilst it tends to enhance people’s perception of environmental problems;however,it has little influence on their evaluation of *** finding implies that public evaluation of GEG should be viewed as an important inter-subjective dimension of GEG;especially in the Internet era,it has become increasingly necessary for the government to not only continuously improve the quality of governance by dealing with actual/practical environmental issues,but also enhance its ability to react to the public opinions online effectively and appropriately.

关键词： Internet use Public evaluation Government environmental governance Urban-rural difference Political trust

Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke

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Acta Pharmacologica Sinica 2007年第5期28卷 609-615页

作者： jason TC TZEN Tzyy-rong JINN Hank KH SHE Balance CM chen Vic HSIEH Graduate Institute of Biotechnology Herbal Source Biotechnology Co Tainan CountyTaiwan741 China jason Life Tech Inc National Chung Hsing UniversityTaichungTaiwan 402 China

Aim:To examine if magnesium lithospermate B （MLB） extracted from Danshen,thedried roots of Salvia miltiorrhiza,may act as an active component responsible forthe cardiac therapeutic effect of this traditional Chinese herb via the same molecu-lar mechanism triggered by cardiac glycosides,such as ouabain and ***,we wanted to test if MLB may provide neuroprotection againstischemic stroke as observed for cardiac ***:Similarity in thechemical structure and molecular configuration between MLB and ouabain *** inhibition potency of MLB and ouabain on Na+,K+-ATPase activ-ity of a commercial product,as well as in purified membrane fractions from rat brainand heart tissues,was examined and *** effect of MLBagainst ischemic stroke was also evaluated using a cortical brain slice-basedassay ***:Dose-dependent inhibition on the commercial Na+,K+-ATPase equivalent to that for ouabain was observed for MLB of approximatelyhalf dosage by *** relative potency of ouabain and MLB was alsoobserved for their inhibition on Na+,K+-ATPase activity of plasma membranepurified from rat tissues,although these 2 inhibitors exhibited somewhat lowercompetence in these crude *** ischemic gerbil brains,post-treatment withMLB significantly reduced the infarct size,visualized by 2,3,5-triphenyltetrazoliumchloride staining,by approximately 55% when compared with the control ***:These results evidently suggest that the cardiac therapeutic effect ofDanshen should be at least partly attributed to the effective inhibition of Na+,K+-ATPase by MLB,and that MLB provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion.

关键词： cardiac glycosides magnesium lithospermate B Na~+,K~+-ATPase neuroprotection ouabain Salvia miltiorrhiza

Temperature Responses to Infrared-Loading and Water Table Manipulations in Peatland Mesocosms

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Journal of Integrative Plant Biology 2008年第11期50卷 1484-1496页

作者： Jiquan chen Scott Bridgham jason Keller John Pastor Asko Noormets Jake F.Weltzin Department of Environmental Sciences University of Toledo Center for Ecology and Evolutionary Biology University of Oregon Smithsonian Environmental Research Center Department of Biological Sciences University of Minnesota National Phenology Network

We initiated a multi-factor global change experiment to explore the effects of infrared heat loading （HT） and water table level （WL） treatment on soil temperature （T） in bog and fen peatland mesocosms. We found that the temperature varied highly by year, month, peatland type, soil depth, HT and WL manipulations. The highest effect of HT on the temperature at 25 cm depth was found in June for the bog mesocosms （3.34-4.27 ℃） but in May for the fen mesocosms （2.32-4.33 ℃） over the 2-year study period. The effects of WL in the bog mesocosms were only found between August and January, with the wet mesocosms warmer than the dry mesocosms by 0.48-2.03 ℃ over the 2-year study period. In contrast, wetter fen mesocosms were generally cooler by 0.16-3.87℃. Seasonal changes of temperatures elevated by the HT also varied by depth and ecosystem type, with temperature differences at 5 cm and 10 cm depth showing smaller seasonal fluctuations than those at 25 cm and 40 cm in the bog mesocosms. However, increased HT did not always lead to warmer soil, especially in the fen mesocosms. Both HT and WL manipulations have also changed the length of the non-frozen season.

关键词： global change infrared mesocosm peatlands warming experiment water table.

A CASE FOR SUSTAINABLE SECURITY SYSTEMS ENGINEERING:INTEGRATING NATIONAL,HUMAN,ENERGY AND ENVIRONMENTAL SECURITY

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Journal of Systems Science and Systems Engineering 2009年第4期18卷 385-402页

作者： jason K. LEVY L. Douglas Wilder School of Government and Public Affairs Virginia Commonwealth University

In the wake of the September 11,2001 terrorist attacks, there is a growing sense of insecurity felt by many citizens around the world. Sustainable security, with roots in the sustainable development and human security literature, seeks positive transformations for the co-evolving and mutually dependent human-environmental condition by integrating （and subsuming） national, human, environmental, and energy security concems and capitalizing on opportunities provided by human creativity, diplomatic openings, modernization and environmental change. The field of Sustainable Security Systems Engineering is proposed for protecting, restoring, designing, and implementing a set of integrated natural and man-made processes that equitably and responsibly meet the biophysical needs of human communities, while maintaining long-term security, respecting financial constraints, meeting ecological limits, and improving institutional arrangements for transparent and effective governance. Scenario planning is shown to help promote sustainable security by identifying the preconditions of instability and helping to proactively address them in an increasingly complex and uncertain world. The six papers published in this featured collection cross policy domains, geographic, political, and sectoral boundaries and were discussed at forums sponsored by the Systems Engineering and Global Policy group. Collectively, they demonstrate the quality, breadth and depth of systems engineering methodologies that are used to promote sustainable security.

关键词： Sustainable security systems engineering national security human security environment and energy scenario planning

Finite Element Analysis of Femoral Strains in Older Adults During Stair Ascent and Descent

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Journal of Science in Sport and Exercise 2022年第2期4卷 168-179页

作者： chen Deng jason C.Gillette Timothy R.Derrick Division of Sport Biomechanics School of Sport ScienceBeijing Sport UniversityNo.48Xinxi RoadBeijing 100084People’s Republic of China Department of Kinesiology Iowa State UniversityAmesIAUSA

Purpose Understanding the femur load environment during daily activity is necessary for the understanding of risk of femoral pain,pain related falls,and femoral fractures,which could help the design of osteogenic exercises or the preventa-tive methods for older *** Using the finite element femur analysis,this study was to estimate the femoral strains at 9 cross-sections along the long axis of femur for stair ascent and descent(n=17;age:50-65 years).Motion analysis and inverse dynamics were com-bined with musculoskeletal modelling and optimization,then were used as input to a 3-D femur model to estimate femoral *** at the hip contact force peaks were *** The compressive and tensile strains during stair descent were greater than ascent for all or most cross-sections,especially for the proximal cross-sections of the femur:stair ascent produced−324.0±103.8 to−483.7±191.0μεcompressive strains and descent produced−608.8±288.4 to 1016.0±444.1με;stair ascent produced 336.2±105.4 to 391.8±136.9μεtensile strains and descent produced 546.9±252.8 to 741.7±333.6με.Conclusion Strains represent the material deformation effect on the bone due to the sum of all the bone external *** bone strains could help future studies analyze load conditions in a more comprehensive way for other physical activities,which predicts the risk of stress fractures and tests if alternative methods(gait type change)could reduce stress and strain effectively.

关键词： Femoral cross-sections Finite element method Bone strains Stair ascent and descent Older adults

活性瓷釉涂层钢筋及钢纤维增强混凝土板动、静力学特性研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第5期17卷 366-377页

作者： Dong-ming YAN Shi-kun chen Gen-da chen jason BAIRD School of Civil and Architectural Engineering Zhejiang University Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology

目的:活性瓷釉涂层能够显著增强钢筋的防腐蚀能力,同时明显提升钢筋与混凝土的粘结力。通过对活性瓷釉涂层钢筋以及钢纤维增强混凝土板在动、静力荷载作用下的承载力、变形特性以及破坏特征的研究,为活性瓷釉涂层技术在钢筋混凝土结构... 详细信息

目的:活性瓷釉涂层能够显著增强钢筋的防腐蚀能力,同时明显提升钢筋与混凝土的粘结力。通过对活性瓷釉涂层钢筋以及钢纤维增强混凝土板在动、静力荷载作用下的承载力、变形特性以及破坏特征的研究,为活性瓷釉涂层技术在钢筋混凝土结构中的应用奠定理论基础。创新点:1.对活性瓷釉涂层钢筋混凝土板的动、静力学性能进行系统研究;2.探究活性瓷釉钢纤维在混凝土结构中的作用机理。方法:1.通过对活性瓷釉涂层钢筋混凝土板进行爆炸实验(图3),揭示活性瓷釉涂层钢筋混凝土结构的动力破坏特征(图5和6);2.通过对活性瓷釉涂层钢筋混凝土板进行静力实验(图4),研究在"点"荷载和"线"荷载作用下混凝土板的力学性能;3.通过分析钢纤维在钢筋混凝土结构中的传力机理,提出活性瓷釉涂层钢纤维在钢筋混凝土结构中的设计方法(图13)。结论:1.活性瓷釉涂层能够显著改善钢筋在混凝土结构中的传力性能;在动力荷载作用下,涂层钢筋混凝土结构的破坏程度明显减轻。2.活性瓷釉涂层能够显著改善钢筋混凝土结构的变形特性,大大增强其耗能能力。3.采用活性瓷釉涂层的钢纤维,其纤维长度可适当减小。

关键词：活性瓷釉涂层爆炸荷载破坏特征钢纤维

High performance columnar-like Fe2O3@carbon composite anode via yolk@shell structural design

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Journal of Energy Chemistry 2020年第2期29卷 126-134页

作者： Zhiming Zheng Pei Li jason Huang Haodong Liu Yi Zao Zhongli Hu Li Zhang Huixin chen Ming-Sheng Wang Dong-Liang Peng Qiaobao Zhang Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005FujianChina Department of Nanoengineering University of California San DiegoLa Jolla 92093CAUSA Joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010SichuanChina Soochow Institute for Energy and Materials Innovations(SIEMIS) Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006Jiangsu.China Xiamen Institute of Rare Earth Materials Haixi institutesChinese Academy of SciencesXiamen 361024Fujian.China

Conversion-type reaction anode materials with high specific capacity are attractive candidates to improve lithium ion batteries(LIBs), yet the rapid capacity fading and poor rate capability caused by drastic volume change and low electronic conductivity greatly hinder their practical applications. To circumvent these issues, the successful design of yolk@shell Fe2 O3@C hybrid composed of a columnar-like Fe2O3 core within a hollow cavity completely surrounded by a thin, self-supported carbon(C) shell is presented as an anode for high-performance LIBs. This yolk@shell structure allows each Fe2O3 core to swell upon lithiation without deforming the carbon shell. This preserves the structural and electrical integrity against pulverization, as revealed by in situ transmission electron microscopy(TEM) measurement. Benefiting from these structural advantages, the resulting electrode exhibits a high reversible capacity(1013 m Ah g-1 after80 cycles at 0.2 A g-1), outstanding rate capability(710 m Ah g-1 at 8 A g-1) and superior cycling stability(800 m Ah g-1 after 300 cycles at 4 A g-1). A Li-ion full cell using prelithiated yolk@shell Fe2 O3@C hybrid as the anode and commercial Li CoO2(LCO) as the cathode demonstrates impressive cycling stability with a capacity retention of 84.5% after 100 cycles at 1 C rate, holding great promise for future practical applications.

关键词： Fe2O3 Mesoporous carbon Yolk@shell Lithium ion battery