检索结果-南通市图书馆

Mll5 Contributes to Hematopoietic Stem Cell Fitness and Homeostasis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mll5 Contributes to Hematopoietic Stem Cell Fitness and Home...

Pre-stroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from focal cerebral ischemia in rats

中国遗传学会模式生物与人类健康研讨会

作者：张岩 jasmine wong Mark Klinger Mary T.Tran Kevin M.Shannon Nigel Killeen 中国科学院上海巴斯德研究所 Departments of Pediatrics University of California Departments of Microbiology and Immunology University of California

MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid *** we show that inactivation of the Mll5...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2007年第9期2卷 513-518页

作者： Xingbao Zhu jasmine Lee Jill wong Wan Loo Tan Zhongtang Feng Tinghua Wang Zhicheng Xiao Ivan Ng Department of Neurosurgery Kunming General Hospital of Chinese PLA Kunming 650032 Yunnan Province China Brain Injury Research Laboratory Department of Neurosurgery National Neuroscience Institute Singapore 408433 Institute of Neuroscience Kunming Medical College Kunming 650031 Yunnan Province China Institute of Molecular and Cell Biology Singapore 117608 Department of Anatomy Faculty of Medicine National University of Singapore Singapore 119074 Department of Clinical Research Singapore General Hospital Singapore 169608

BACKGROUND： Inhibitory signals, i.e. neurite growth inhibitors （NGIs）, presenting on central nervous system （CNS） myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the immune repair mechanisms of body. OBJECTIVE： To evaluate the effect of pre-stroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of focal cerebral ischemia. DESIGN： A completely randomized design, and controlled experiment. SETTING： Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS： Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in body mass from 180 to 250 g were provided by the Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1（＋）-neurite growth inhibitors （pcDNA-NGIs） a gift was provided by Dr. Xiao from the Department of Clinical Research, Singapore General Hospital, Singapore. METHODS： The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. ① The involved rats were randomized into 3 groups： model group （group A）, pcDNA3.1（＋） group （group B） and pcDNA-NGIs group （group C）, with 20 rats in each group. Left focal cerebral ischemia was permanently induced through middle cerebral artery occlusion with the assistance of an operating microscope. Successful middle cerebral artery occlusion was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline （PBS） was intramuscularly injected into the tibial muscle once a week before middle cerebral artery occlusion for 6 weeks in group C. As control, pcD

关键词： stroke growth inhibitors cerebral ischemia

Poststroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from local cerebral ischemia in rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2007年第2期2卷 65-69页

BACKGROUND： Inhibitory signals, i.e. neurite growth inhibitors （NGIs）, presenting on central nervous system （CNS） myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the body＇s immune repair mechanisms. OBJECTIVE： To evaluate the effect of poststroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of local cerebral ischemia. DESIGN： Completely randomized grouping design, and controlled experiment. SETTING： Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS： Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in weight from 180 to 250 grams were provided by Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1（＋）-neurite growth inhibitors （pcDNA-NGIs） a gift was provided by Dr. Xiao from Department of Clinical Research, Singapore General Hospital, Singapore. METHODS： The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. （1）The involved rats were randomized into 3 groups： pcDNA-NGIs group （group A）, pcDNA3.1 （＋） group （group B） and model group （group C）, with 20 rats in each group. Left focal cerebral ischemia （FCI） was permanently induced through middle cerebral artery occlusion （MCAO） with the assistance of an operating microscope. Successful MCAO was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline （PBS） was intramuscularly injected into the tibial muscle once a week after MCAO for 6 weeks in group A. As control, pcDNA3.1 （＋） was also administrated in the sam

关键词： stroke(TCM) growth inhibitors, cerebral ischemia

轴突生长抑制因子DNA疫苗免疫促进脑缺血后神经功能恢复

在线全文

学校读者我要写书评

暂无评论

昆明医学院学报 2008年第1期29卷 52-55页

作者：朱兴宝 jasmine LEE Jill wong 肖志成范泉水 Ivan NG 解放军昆明总医院神经外科云南昆明650032 国立神经科学学院神经外科脑损伤研究实验室新加坡408433 分子和细胞生物学研究所成都军区疾病预防控制中心云南昆明650032

目的为进一步证实突生长抑制因子DNA疫苗免疫对局部脑缺血后神经功能恢复的促进作用.方法采用永久性阻断SD大鼠大脑中动脉的方法制备左侧局部脑缺血模型;在中风前或中风后经腓肠肌注射轴突生长抑制因子DNA疫苗免疫动物,每周1次,共6周;... 详细信息

目的为进一步证实突生长抑制因子DNA疫苗免疫对局部脑缺血后神经功能恢复的促进作用.方法采用永久性阻断SD大鼠大脑中动脉的方法制备左侧局部脑缺血模型;在中风前或中风后经腓肠肌注射轴突生长抑制因子DNA疫苗免疫动物,每周1次,共6周;分别采用改良神经病严重程度记分、被动逃避试验和悬臂迷宫试验评价中风后运动功能、认知行为和焦虑样情感的恢复.结果中风前或中风后进行轴突生长抑制因子DNA疫苗免疫,局部脑缺血后都出现明显的运动恢复.认知行为和焦虑样情感障碍则没有明显改善.结论中风前或中风后给予轴突生长抑制因子DNA疫苗免疫可促进脑缺血后的运动功能恢复.

关键词：轴突生长抑制因子 DNA疫苗局部脑缺血行为

轴突生长抑制因子DNA疫苗对大鼠中枢神经系统的影响(英文)

在线全文

学校读者我要写书评

暂无评论

中华神经外科疾病研究杂志 2007年第3期6卷 214-218页

作者：朱兴宝 jasmine Lee Jill wong Wan Loo Tan 冯忠堂肖志成 Ivan Ng 解放军昆明总医院神经外科云南昆明650031 国立神经科学研究所神经外科急性脑损伤研究室新加坡408433 昆明医学院神经科学研究所云南昆明650031 新加坡国立大学医学部解剖学系

目的探讨轴突生长抑制因子DNA疫苗(pcDNA-NGIs)免疫是否会对中枢神经系统造成损害。方法以pcDNA-NGIs免疫成年Sprague-Dawley大鼠,免疫期间进行实验性自动免疫性脑髓鞘炎评分,同时观察实验动物的感觉运动功能和认知行为。结果以pcDNA-N... 详细信息

目的探讨轴突生长抑制因子DNA疫苗(pcDNA-NGIs)免疫是否会对中枢神经系统造成损害。方法以pcDNA-NGIs免疫成年Sprague-Dawley大鼠,免疫期间进行实验性自动免疫性脑髓鞘炎评分,同时观察实验动物的感觉运动功能和认知行为。结果以pcDNA-NGIs免疫的大鼠未出现实验性自动免疫性脑髓鞘炎症状。复合神经病学评分、粘附纸条清除试验和开放场地试验表明,pcDNA-NGIs免疫不会损害实验动物的感觉运动功能。另外,被动回避试验和主动回避试验证明,pcDNA-NGIs免疫不会引起学习和记忆障碍。结论pcDNA-NGIs免疫不会损害实验大鼠中枢神经系统。

关键词： DNA疫苗轴突生长抑制因子实验性自动免疫性脑髓鞘炎感觉运动功能缺陷认知行为

Complications and Costs Associated with Initiation of Anti-coagulation Therapy Using Warfarin--An Observation Study

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2015年第6期3卷 262-267页

作者： jasmine Chiat Ling Ong Seng Han Lim Chai Ling Ong Liping Chen Elicia Purnata Edmund Joo Sheng See Joel Cho-Lun Chiang Vivian Shi Yin wong Loke Khee Siow Jin Shing Hon Ming Chai Kong Chi Keong Ching Department of Pharmacy Singapore General Hospital Outram Road Singapore 169608 Singapore Department of Pharmacy National Heart Centre Singapore 5 Hospital Drive Singapore 16960 Singapore Department of Cardiology National Heart Centre Singapore 5 Hospital Drive Singapore 169609 Singapore

To evaluate the safety and cost of anticoagulation therapy in patients newly initiated on warfarin in two institutions in Singapore. All patients newly started on warfarin between December 2011 and May 2012 were recruited and followed up for a period of 6 months. All hospitalization attributed to complications of warfarin therapy, number of INR （international normalized ratio） greater than 4 and total cost of warfarin therapy were collected and analysed. A total of 321 patients were newly initiated on warfarin for standard indications were recruited. At the end of 6 month period, 8.4% of patients were hospitalized for complication related to warfarin therapy. For patients who had stable INR while on warfarin, this rate was almost 2 times lower （3.8% vs 8.4%）. In our study group, patients started on warfarin as inpatients had higher rates of bleeding （15.1% vs 6.7%） and more 1NRs greater than 4 （0.7 per patient vs 0.11 per patient）. The cost of initating warfarin was USD660 over the first 6 months of therapy. Patients newly initiated on warfarin were at a heightened risk of bleeding complications as compared to patients already stable on warfarin therapy. This also translates to considerable costs of warfarin initiation.

关键词： Anticoagulation warfarin initiation complications cost.

中风后抗轴突生长抑制因子DNA免疫促进局部脑缺血后神经再生(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华神经外科疾病研究杂志 2008年第5期7卷 406-410页

作者：朱兴宝 jasmine Lee Jill wong Wan Loo Tan 王廷华冯忠堂肖志成 Ivan Ng 成都军区昆明总医院神经外科云南昆明650032 新加坡国家神经科学学院神经外科急性脑损伤实验室新加坡408433 昆明医学院神经科学研究所云南昆明650031 国立分子和细胞生物学研究所新加坡117608 新加坡国立大学医学院解剖系新加坡119074 新加坡总医院临床研究所神经生物学实验室新加坡169608

目的评价中风后给予轴突生长抑制因子DNA疫苗对局部脑缺血后神经再生的促进作用。方法采用阻断大脑中动脉血流成功诱导左侧局部脑缺血后,经腓肠肌注射轴突生长抑制因子DNA疫苗。立体定向注射生物素葡聚糖胺追踪皮质红核投射的新生轴突... 详细信息

目的评价中风后给予轴突生长抑制因子DNA疫苗对局部脑缺血后神经再生的促进作用。方法采用阻断大脑中动脉血流成功诱导左侧局部脑缺血后,经腓肠肌注射轴突生长抑制因子DNA疫苗。立体定向注射生物素葡聚糖胺追踪皮质红核投射的新生轴突。结果中风后给予轴突生长抑制因子DNA疫苗可增加跨过中线终止于对侧红核相应区域的生物素葡聚糖胺标记阳性交叉纤维(P<0.05)。结论中风后给予轴突生长抑制因子DNA疫苗可促进局部脑缺血后的轴突再生。

关键词：轴突生长抑制因子 DNA疫苗局部脑缺血神经再生

中风前抗轴突生长抑制因子DNA免疫促进脑缺血功能康复

在线全文

学校读者我要写书评

暂无评论

西南军医 2007年第3期9卷 6-8页

作者：朱兴宝 jasmine Lee Jill wong Wan Loo Tan 王廷华冯忠堂 Xiao Zhicheng Ivan Ng 解放军昆明总医院神经外科昆明650032 Brain Injury Research Lad Department of Neurosurgery National Neuroscience Institute Singapore 408433 昆明医学院神经科学研究所昆明650031 Institute of Molecular and Cell Biology Singapore 117608 Department of Anatomy Faculty of Medicine National University of Singapore Singapore 119074 Department of Chnical Research Singapore General Hospital Singapore 169608

目的证实中风前抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;血清中检测出相关抗体后,采用永久性阻断大脑中动脉的方法制备左侧局部脑缺血模型;分... 详细信息

目的证实中风前抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;血清中检测出相关抗体后,采用永久性阻断大脑中动脉的方法制备左侧局部脑缺血模型;分别采用改良的神经病严重程度记分、被动逃避试验和悬臂迷宫试验评价运动功能、认知行为和焦虑样情感的。结果中风前接受抗轴突生长抑制因子DNA免疫,局部脑缺血后出现明显的运动恢复,但是认知行为和焦虑样情感障碍则没有明显改善。结论中风前抗轴突生长抑制因子DNA免疫可促进脑缺血后的运动功能恢复。

关键词：轴突生长抑制因子 DNA免疫局部脑缺血行为

中风后抗轴突生长抑制因子DNA免疫促进脑缺血功能恢复

在线全文

学校读者我要写书评

暂无评论

西南军医 2007年第4期9卷 2-4页

作者：朱兴宝 jasmine Lee Jill wong Wan Loo Tan 王廷华冯忠堂 Xiao Zhicheng Ivan Ng 解放军昆明总医院神经外科昆明650032 Brain Injury Research Lad Department of Neurosurgery National Neuroseienee Institute Singapore 408433 昆明医学院神经科学研究所昆明650031 Institute of Molecular and Cell Biology Singapore 117608 Department of Anatomy Faculty of Medicine National University of Singapore Singapore 119074 Department of Clinical Research Singapore General Hospital Singapore 169608

目的探讨中风后抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法通过永久性阻断大脑中动脉诱导左侧局部脑缺血后,经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;分别采用改良的神经病严重程度记分、... 详细信息

目的探讨中风后抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法通过永久性阻断大脑中动脉诱导左侧局部脑缺血后,经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;分别采用改良的神经病严重程度记分、被动逃避试验和悬臂迷宫试验来评价运动功能、认知行为和焦虑样情感的恢复。结果中风后接受抗轴突生长抑制因子DNA免疫,局部脑缺血后出现明显的运动功能恢复,但是认知行为和焦虑样情感障碍则没有明显改善。结论中风后抗轴突生长抑制因子DNA免疫可促进脑缺血后的运动功能恢复。

关键词：轴突生长抑制因子 DNA免疫局部脑缺血行为