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Congenital Heart Disease 2024年第1期19卷 65-68页

作者： Michael A.rebolledo Jane s.Yao jas.n.n.john.on.umar s.bos.on.ben.amin.r.waller iii Division of Pediatric Cardiology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA Division of Pediatric Cardiothoracic surgery Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the *** review the clinical and imaging data that support our *** had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and *** case may represent one example of the experimental surgical work done prior to *** Jatene’s description of theﬁrst successful arterial switch performed in 1975.

关键词： Adult congenital heart disease arterial switch operation great vessel anomaly imaging(all modalities)

Intraoperative application of three-dimensional printed guides in total hip arthroplasty: A systematic review

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World Journal of Orthopedics 2024年第7期15卷 660-667页

作者： Tim P Crone Bart M W Cornelissen Jakob Van Oldenrijk Pieter Koen bos Ewout s Veltman Department of Orthopedic surgery and sports Medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands Department of Oral and Maxillofacial surgery Erasmus Medical CenterRotterdam 3015 GDNetherlands

BACKGrOUnD Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of *** majority of acetabular components are aligned freehand,without the use of navigation *** specific instruments(PsI)and three-dimensional(3D)printing of THA placement guides are increasingly used in primary THA to ensure optimal *** To summarize the literature on 3D printing in THA and how they improve acetabular component *** PubMed was used to identify and access scientific studies reporting on different 3D printing methods used in *** studies with 236 hips in 228 patients were *** studies could be divided into two main categories;3D printed models and 3D printed *** 3D printing in THA helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to *** overarching consensus between the studies is that the use of 3D guidance tools can assist in improving THA cup positioning and reduce the need for revision THA and the associated *** The implementation of 3D printing and PsI for primary THA can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.

关键词： Total hip arthroplasty Three-dimensional printing Hip replacement surgery Three-dimensional planning surgical guides

Knowledge‐based deep learning system for classifying Alzheimer's disease for multi‐task learning

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 805-820页

作者： Amol Dattatray Dhaygude Gaurav Kumar Ameta Ihtiram raza Khan Pavitar Parkash singh renato r.Maaliw iii natrayan Lakshmaiya Mohammad shabaz Muhammad Attique Khan Hany s.Hussein Hammam Alshazly Department of Data science University of WashingtonSeattleWashingtonUSA Department of Computer science&Engineering Parul Institute of TechnologyParul UniversityVadodaraGujaratIndia Department of Computer science Jamia HamdardDelhiIndia Department of Management Lovely Professional UniversityPhagwaraIndia 5 College of Engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of Mechanical Engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia Model Institute of Engineering and Technology JammuJ&KIndia Department of Computer science HITEC UniversityTaxilaPakistan Department of Computer science and Mathematics Lebanese American UniversityBeirutLebanon Electrical Engineering Department College of EngineeringKing Khalid UniversityAbhaSaudi Arabia Electrical Engineering Department Aswan UniversityAswanEgypt Faculty of Computers and Information South Valley UniversityQenaEgypt

Deep learning has recently become a viable approach for classifying Alzheimer's disease(AD)in medical ***,existing models struggle to efficiently extract features from medical images and may squander additional information resources for illness *** address these issues,a deep three‐dimensional convolutional neural network incorporating multi‐task learning and attention mechanisms is *** upgraded primary C3D network is utilised to create rougher low‐level feature *** introduces a new convolution block that focuses on the structural aspects of the magnetOrCID:ic resonance imaging image and another block that extracts attention weights unique to certain pixel positions in the feature map and multiplies them with the feature map ***,several fully connected layers are used to achieve multi‐task learning,generating three outputs,including the primary classification *** other two outputs employ backpropagation during training to improve the primary classification *** findings show that the authors’proposed method outperforms current approaches for classifying AD,achieving enhanced classification accuracy and other in-dicators on the Alzheimer's disease neuroimaging Initiative *** authors demonstrate promise for future disease classification studies.

关键词： classification deep learning

Biomass gasification,catalytic technologies and energy integration for production of circular methanol:new horizons for industry decarbonisation

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Journal of Environmental sciences 2024年第6期140卷 306-318页

作者： Luis F.Bobadilla Lola Azancot Miriam González-Castañ Estela ruíz-López Laura Pastor-Pérez Francisco J.Durán-Olivencia runping Ye Katie Chong Paula HBlanco-sánchez Zenthao Wu Tomás r.reina JoséA.Odriozola Departamento de Química Inorgánica e Instituto de Ciencia de Materiales de sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key Laboratory of Jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts research Institute(EBrI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievement of the zero-emission *** implementation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatement is a critical process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the development of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy Microreactors

Management of obstructed colorectal carcinoma in an emergency setting:An update

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： Efstathios T Pavlidis Ioannis n Galanis Theodoros E Pavlidis 2nd Propedeutic Department of surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced(stage II,iii or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(CT),CT colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed since it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficulties in dissecting the distended colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma Emergency surgery Colectomy Intraluminal metal stents

Evaluation of a Wireless solar Powered Personal Weather station

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Agricultural sciences 2024年第1期15卷 36-53页

作者： robert J. Lascano Timothy s. Goebel Dennis C. Gitz iii john E. stout Cropping systems research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin County, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a Personal Weather station (PWs) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWs and to compare these to measurements obtained with an automatic weather station (AWs). For this purpose, we installed four PWs deployed within 20 m of the Plant stress and Water Conservation Meteorological Tower that was used as our AWs, located at UsDA-Ars Cropping systems research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (rsub>gsub>), air temperature (Tsub>airsub>) and relative humidity (rH), and wind speed (Ws), and calculated values of dewpoint temperature (Tsub>dewsub>). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWs and AWs. Hourly average values of rsub>gsub> measured with the PWs and AWs agreed on clear days, but PWs measurements were higher on cloudy days. There was no statistical difference between PWs and AWs hourly average measurements of Tsub>airsub>, rH, and calculated Tsub>dewsub>. Hourly average measurements of rsub>gsub> and Ws were more variable. We concluded that the PWs we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation sensors Citizen Weather station Mesonet rainfall Weather Variables

Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental sciences 2024年第4期37卷 428-431页

作者： VICTOr Abiola Adepoju OKECHUKWU Innocent Onyezue sAFAYET Jamil OLALEKAn john Okesanya DOn Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by mir-128

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neural regeneration research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-sanchis Pedro AAvila-López Iva Tic David Valle-García Marta ribalta-Vilella Luis Labrador Deb ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance Cnrs UMr5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine n-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,micrornAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,micrornAs,oxidative stress,and *** better understand the biology of G9a,we compared the global micrornA expression between senescence-accelerated mouse-prone 8(sAMP8)control mice and sAMP8 treated with G9a inhibitor *** found a downregulation of mir-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTr)of peroxisome-proliferator activator receptor γ(PPArG)***,Pparg gene expression levels were higher in the sAMP8 group treated with G9a inhibitor than in the sAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPArγby G9a inhibitor could also increase the expression of genes involved in DnA damage responses and *** addition,we also described that the PPArγ/AMPK axis partially explains the regulation of autophagy markers ***,PPArγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPArγ-dependent pathways by mir-128.

关键词： aging cognitive decline epigenetics G9a inhibition micrornAs mir-128 peroxisome-proliferator activator receptorγ(PPArγ) PPArG sAMP8

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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neural regeneration research 2024年第8期19卷 1835-1841页

作者： Irene navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-romero Marta Carretero-rey sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en red de Enfermedades neurodegenerativas(CIBErnED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the rGs14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(OrM),can induce enhancement of *** this study,we demonstrated that the same treatment with rGs14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of OrM in young animals and prevent OrM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDnF).A knockdown of BDnF gene in rGs14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of OrM *** findings suggest that BDnF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in rGs14414-treated rodent models of aging and Alzheimer’s ***,our findings of rGs14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

storylines of family medicine Ⅺ:professional identity formation—nurturing one’s own story

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Family Medicine and Community Health 2024年第S3期12卷 99-108页

作者： William B Ventres Leslie A stone Hamish J Wilson sumi M sexton David J Doukas Jessica P Cerdena David M Kelley Michael D Fetters Jeffrey J Haney john J Frey iii Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA General Practice and rural Health University of Otago Dunedin School of MedicineDunedinNew Zealand Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine Tulane University School of MedicineNew OrleansLouisianaUSA Family Medicine residency Program Middlesex HealthMiddletownConnecticutUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Medical Education and Clinical sciences Washington State UniversitySpokaneWashingtonUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the UsA and elsewhere around the ***‘Ⅺ:professional identity formation—nurturing one’s own story’,authors address the following themes:‘The social construction of professional identity’,‘On becoming a family physician’,‘What’s on the test?—professionalism for family physicians’,‘The ugly doc-ling’,‘Teachers—the essence of who we are’,‘Family medicine research—it starts in the clinic’,‘socially accountability in medical education’,‘Personal philosophy and how to find it’and‘Teaching and learning with storylines of Family Medicine’.May these essays encourage readers to find their own creative spark in medicine.

关键词： own becoming professional