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Competing risks of death in younger and older postmenopausal breast cancer patients

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w.rld Journal of Clinical Oncology 2014年第5期5卷 1088-1096页

作者： Judy-Anne w.chapman Kathleen I Pritchard Paul E Goss James n Ingle Hyman B Muss Susan F Dent Ted A Vandenberg Brian Findlay Karen A Gelmon Carolyn F w.lson Lois E Shepherd Michael n Pollak nCIC Clinical Trials Group Queen's University Kingston ON K7L 3N6 Canada Sunnybrook Odette Cancer Centre University of Toronto Toronto ON M4N 3M5 Canada Massachusetts General Hospital Harvard University Boston MA 02114 United States Mayo Clinic Rochester MN 55902 United States Lineberger Comprehensive Cancer Center at the University of north Carolina at Chapel Hill Chapel Hill NC27514 United States Ottaw. Hospital Cancer Center University of Ottawa Ottawa ON K1H8L6 Canada London Health Sciences Centre University of Western Ontario London ON N6G 2V4 Canada niagara Health System McM aster University St. Catharines ON L2R 2Z4 Canada BC Cancer Agency University of British Columbia Vancouver BC V5Z 1L3 Canada nCIC Clinical Trials Group Queen's University Kingston Ontario K7L 3N6 Canada Lady Davis Institute Jewish General Hospital McG ill University Montreal QC H3T 1E2 Canada

AIM: To show.a new.paradigm of simultaneously testing w.ether breast cancer therapies impact other causes of death. METHODS: MA.14 allocated 667 postmenopausal w.men to 5 years of tamoxifen 20 mg/daily ± 2 years of octreotide 90 mg, given by depot intramuscular injections monthly. Event-free survival w.s the primary endpoint of MA.14; at median 7.9 years, the tamoxifen+octreotide and tamoxifen arms had similar event-free survival(P = 0.62). Overall survival w.s a secondary endpoint, and the tw. trial arms also had similar overall survival(P = 0.86). w. used the median 9.8 years follow.up to examine by intention-to-treat, the multivariate time-to-breast cancer-specific(Br Ca) and other cause(OC) mortality w.th log-normal survival analysis adjusted by treatment and stratification factors. w. tested w.ether baseline factors including Insulin-like grow.h factor 1(IGF1), IGF binding protein-3, C-peptide, body mass index, and 25-OH vitamin D w.re associated w.th(1) all cause mortality, and if so; and(2) cause-specific mortality. w. also fit step-w.se forw.rd cause-specific adjusted ***: The analyses w.re performed on 329 patients allocated tamoxifen and 329 allocated tamoxifen+octreotide. The median age of MA.14 patients w.s 60.1 years: 447(82%) nd 120(18%) ≥ 70 years. There w.re 170 deaths: 106(62.3%) BrC a; 55(32.4%) OC, of w.ich 24 w.re other malignancies, 31 other causes of death; 9(5.3%) patients w.th unknow. cause of death w.re excluded from competing risk assessments. BrC a and OC deaths w.re not significantly different by treatment arm(P = 0.40): tamoxifen patients experienced 50 BrC a and 32 OC deaths, w.ile tamoxifen + octreotide patients experienced 56 Br Ca and 23 OC deaths. Proportionately more deaths(P = 0.004) w.re from BrC a for patientsw.ere 70% of deaths w.re due to Br Ca, compared to 54% for those ≥ 70 years of age. The proportion of deaths from OC increased w.th increasing body mass index(BMI)(P = 0.02). Higher pathol

关键词： Breast cancer Postmenopausal Hormone receptor positive Competing risks Tamoxifen Octreotide LAR

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成功的领导艺术相互激励理论 1

Microbial community coalescence and nitrogen cycling in simulated mortality decomposition hotspots

1989年

作者：（美）查普曼（chapman E.n.）陈列俞天红译

来源：汇雅图书（南通市图书馆... 评论

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Ecological Processes 2023年第1期12卷 608-624页

作者： Sarah w.Keenan Alexandra L.Emmons Jennifer M.DeBruyn Department of Geology and Geological Engineering South Dakota School of Mines and Technology501 East St.Joseph StreetRapidSD 57701USA Department of Anthropology University of TennesseeKnoxvilleTNUSA Department of Biosystems Engineering and Soil Science University of Tennessee2506 E.J.Chapman DriveKnoxvilleTN 37996USA

Background The pulsed introduction of dead plant and animal material into soils represents one of the primary mechanisms for returning organic carbon(C)and nitrogen(n)compounds to biogeochemical *** of animal carcasses provides a high C and n resource that stimulates indigenous environmental microbial communities and introduces non-indigenous,carcass-derived microbes to the ***,the dynamics of the coalesced microbial communities,and the relative contributions of environment-and carcass-derived microbes to C and n cycling are *** test w.ether environment-derived,carcass-derived,or the combined microbial communities exhibited a greater influence on C and n cycling,w. conducted controlled laboratory experiments that combined carcass decomposition fluids and soils to simulate carcass decomposition *** selectively sterilized the decomposition fluid and/or soil to remove microbial communities and create different combinations of environment-and carcass-derived communities and incubated the treatments under three temperatures(10,20,and 30℃).Results Carcass-derived bacteria persisted in soils in our simulated decomposition scenarios,albeit at low.*** communities had higher respiration rates at 10 and 30℃ compared to soil or carcass communities ***,at higher temperatures,mixed communities had reduced diversity,but higher respiration,suggesting functional *** communities treatments also provided evidence that carcass-associated microbes may be contributing to ammonification and denitrification,but that nitrification is still primarily carried out by native soil *** Our w.rk yields insight into the dynamics of microbial communities that are coalescing during carcass decomposition,and how.they contribute to recycling carcasses in terrestrial ecosystems.

关键词： Carcass decomposition Microcosm nitrogen Carbon Biogeochemical cycling Coalescence

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研究超低出生体重儿患新生儿感染后神经和机体发育障碍情况

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 5-6页

作者： Stoll B.J. Hansen n.I. Adams-chapman I. 李开 Department of Pediatrics Emory University School of Medicine 2015 Uppergate Dr Atlanta GA 30322 United States Dr.

研究背景:接受重症监护的超低出生体重儿(ELBw.多并发新生儿感染。目的:确定ELBw.生儿感染后。

关键词：新生儿感染超低出生体重儿机体发育 neonatal 发育不良重症监护智力发育指数出生后脑损伤脓毒症

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV w.th the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling n.J. Abicht S.H. Abidi A. Aboulhorma H. Abramow.cz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.n. Agaras J. Agarw.la A. Aggarw.l C. Agheorghiesei A. Ahmad F. Ahmadov w.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama n.n. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderw.ireldt M. Aleksa I.n. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.w. Alibocus M. Aliev G. Alimonti w. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan n. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai n.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes w.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.n. Barends T. Barillari M-S. Barisits T. Barklow.P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new.particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed w.thin the ATLAS Collaboration,using √s=13 TeV proton–proton collision data w.th an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers w.th high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated w.th the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency betw.en data and simulation are provided for jets w.th transverse momentum betw.en 500 GeV and 2 TeV and for multiple tagger w.rking points.

关键词： ATLAS JET QUARK GLUOn TAGGInG

Vegetables, Herbs and Spices: The Importance of Family and Tasting

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Health 2016年第14期8卷 1554-1565页

作者： Pamela A. Heinrichs Cassandra J. nikolaus Brenna Ellison Sharon M. nickols-Richardson Karen chapman-novakofski University of Illinois at Urbana-Champaign Champaign IL USA Currently Address: The Hersey Company Hershey PA USA

Objective: To explore w.y and how.consumers utilize vegetables, herbs and spices. Methods: Focus groups w.re conducted w.th adult participants (n = 54) to determine attitudes, self-efficacy, and behaviors related to liking and usage of vegetables, herbs and spices as w.ll as strategies to increase vegetable intake. Results: Seasonal availability, and family-centered memories and practices w.re motivation for vegetable intake. A diverse number of vegetables (n = 39) w.re listed as favorites based on taste and versatility, but seasonings w.re not commonly included in responses regarding preparation. Participants felt that vegetable dish names should reflect ingredients explicitly;that seasonings enhanced vegetable flavors;and that salt and pepper w.re most commonly used seasonings. The preferred strategy to increase vegetable consumption w.s through tasting or sampling opportunities;seasoning use w.s not mentioned. How.ver, participants perceived that suggestions or demonstrations on how.to prepare vegetables at home w.uld be helpful. Personal gardens w.re mentioned frequently, but w.re not connected to strategies for increasing intake. Conclusions and Implications: Vegetable intake has a family focus that should be emphasized to increase intake. Efforts to increase intake could emphasize flavor and versatile preparation methods through tasting opportunities or educational demonstrations.

关键词： Dietary Habits Focus Groups Vegetables Spices Herbs

Specialized digestive adaptations w.thin the hindgut of a colobine monkey

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The Innovation 2022年第2期3卷 103-109页

作者： Rui Liu Katherine Amato Rong Hou Andres Gomez Derek w.Dunn Jun Zhang Paul A.Garber Colin A.chapman nicoletta Righini Gang He Gu Fang Yuhang Li Baoguo Li Songtao Guo Shaanxi Key Laboratory for Animal Conservation School of Life SciencesNorthwest UniversityXi’an 710069China Department of Anthropology Northwestern UniversityEvanstonIL 60208USA Department of Animal Science University of Minnesota Twin CitiesSt.PaulMN 55455USA Department of Anthropology and Program in EcologyEvolution and Conservation BiologyUniversity of Illinois at Urbana-ChampaignUrbana-ChampaignIL 61801USA Center for the Advanced Study of Human Paleobiology Department of AnthropologyThe George Washington UniversityWashingtonDC 20037USA School of Life Sciences University of KwaZulu-NatalScottsvillePietermaritzburg 3209South Africa Instituto de Investigaciones en Comportamiento Alimentario y nutrición(IICAn) Universidad de Guadalajara49000 Ciudad GuzmánJaliscoMexico

In mammal herbivores,fiber digestion usually occurs predominantly in either the foregut or the *** of mechanisms show.ng synergistic function in both gut regions for the digestion of fiber and other nutrients in w.ld mammals are rare because it requires integrative study of anatomy,physiology,and gut *** monkeys(Colobinae)are folivorous,w.th high-fiber foods fermented primarily in their foreguts.

关键词： anatomy gut primarily

fficient and universal characterization of atomic structures through a topological graph order parameter

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npj Computational Materials 2022年第1期 334-345页

作者： James chapman nir Goldman Brandon C.w.od Physical and Life Sciences Directorate Lawrence Livermore National LaboratoryLivermoreCAUSA Department of Chemical Engineering University of CaliforniaDavisCaliforniaCA95616United States

A graph-based order parameter,based on the topology of the graph itself,is introduced for the characterization of atomistic *** order parameter is universal to any material/chemical system and is transferable to all structural *** sets of data are used to validate both the generalizability and accuracy of the algorithm:(1)liquid lithium configurations spanning up to 300 GPa,(2)condensed phases of carbon along w.th nanotubes and buckyballs at ambient and high temperature,(3)a diverse set of aluminum configurations including surfaces,compressed and expanded lattices,point defects,grain boundaries,liquids,nanoparticles,all at nonzero temperatures,and(4)eleven niobium oxide crystal phases generated w.th ab initio molecular *** compare our proposed method to existing,state-of-the-art methods for the cases of aluminum and niobium *** order parameter uniquely classifies every configuration and outperforms all studied existing methods,opening the door for its use in a multitude of complex application spaces that can require fine structure-level characterization of atomistic graphs.

关键词： parameter configuration uniquely

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利用射线追踪作井间层析成象

地球物理学进展 1987年第2期 17-22页

作者： n. D. Bregman C. H. chapman R. C. Bailey 严寿民

许多井间地震走时的层析成象解释方法是将震源和接收器之间的射线路径近似为直线,而不管射线路径上速度结构的不均匀性效应。当速度没有多大变化时,这样的近似是有效的。在许多地区观察到的速度横向变化为10—20％,甚至更多,这引起了射... 详细信息

许多井间地震走时的层析成象解释方法是将震源和接收器之间的射线路径近似为直线,而不管射线路径上速度结构的不均匀性效应。当速度没有多大变化时,这样的近似是有效的。在许多地区观察到的速度横向变化为10—20％,甚至更多,这引起了射线相当大的弯曲。有些工作已经考虑了这种非线性效应,但在应用于井间地震问题时,还没有出现许多成功的实例。在这里我们提出了一个基于二维射线追踪的迭代反演方法,并成功地应用于野外资料。这个解释方法是由迭代射线追踪和更新速度模型来实现的。在每次迭代中,通过一个线性方程组将资料和由射线追踪得到的当前模型的走时差值与未知的速度扰动量联系起来。用阻尼最小二乘法求得这个速度扰动量,并因此更改模型。这个迭代过程一直进行到合成走时和野外资料间的拟合达到给定的误差范围之内,或者直到走时拟合不再有改进为止。我们把这个方法应用于结晶岩中井间试验所得的野外资料(w.ng,1983)。地震图的频率范围是1—6.6kHz,允许速度结构的分辨率达到几米的数量级,所得的速度图象与其它地质和地球物理数据符合得很好。

关键词：射线追踪射线路径射线轨迹射线理论井间迭代反演迭代模型纵波速度压缩波速速度模型初始模型