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Safety and Diagnostic Image Quality of Ultravist<sup>®</sup>in an Unselected Sub-Set of Chinese Patients: Data Analyses from a Previous Post Marketing Surveillance

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Open Journal of Radiology 2017年第1期7卷 63-74页

作者： Shuixing Zhang Changhong Liang Ziping Li jary wang Department of Radiology Guangdong General Hospital/Guangdong Academy of Medical Sciences Guangzhou China Department of Radiology The First Affiliated Hospital of Sun Yat-sen University Guangzhou China Medical & Scientific Affairs Bayer HealthCare Pharmaceuticals Beijing China

Background: Iopromide (Ultravist®) has been shown to be a very safe CM agent in previous post-marketing surveillance studies on Western and Asian populations. Our study aimed to analyse data pertaining to the safety, tolerability and diagnostic image quality of Iopromide in an unselected sub-set of the Chinese population. Methods: we analysed data for Chinese ambulatory and in-patients who received Iopromide for an imaging procedure (in accordance with the local package insert and routine clinical practice), as part of an international post-marketing surveillance study. Use of premedication was at the discretion of the attending physician. Patient demographics, clinical history, type of examination, contrast quality and tolerability, including pre-specified adverse drug reactions, were recorded. All statistical analyses were descriptive. Results: case report forms for 20,000 Chinese patients (61.3% men) were analysed, of whom 153 patients (0.77%) had risk factors for idiosyncratic contrast media reactions (at-risk group). Use of premedication, most commonly corticosteroids, was recorded for 5658 patients (28.3%) and 86 at-risk patients (56.2% of the at-risk group), respectively. The mean (±standard deviation) dose of iodine administered was 29 ± 5.5 g. During the physician’s evaluation of image parameters, contrast quality was considered to be “good” (64.7%) or “excellent” (29.3%) in the majority of patients. 571 patients (2.9%) experienced at least one adverse drug reaction [most frequently nausea (0.70%) and dysgeusia (0.62%)], which were typically transient and of mild intensity. Two serious adverse drug reactions were reported [edema (n = 1), decreased blood pressure and dyspnea (n = 1)]. The incidence of adverse drug reactions was increased in the at-risk group versus the overall patient population, and tended to reduce with premedication (mainly corticosteroids). Conclusions: Iopromide was well tolerated and proved to be an efficient contrast agent in a lar

关键词： Contrast Media Iopromide Adverse Drug Reaction Chinese Sub-Population Post-Marketing Surveillance

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Design of a low power GPS receiver in 0.18 μm CMOS technology with a ΣΔ fractional-N synthesizer

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 444-449页

作者： Di LI Yin-tang YANG Jiang-an wang Bing LI Qiang LONG jary WEI Nai-di wang Lei wang Qian-kun LIU Da-long ZHANG School of Microelectronics Xidian University Xi 'an 710071 China Huaxun Microelectronics Corporation Xi 'an 710075 China

A 19 mW highly integrated GPS receiver with a ΣΔ fractional-N synthesizer is presented in this ***-N frequency synthesizer architecture was adopted in this work, to provide more degrees of freedom in the synthesizer design.A high linearity low noise amplifier(LNA) is integrated into the *** radio receiver chip was fabricated in a 0.18 μm complementary metal oxide semiconductor(CMOS) process and packaged in a 48-pin 2 mm×2 mm land grid array chip scale *** chip consumes 19 mW(LNA1 excluded) and the LNA1 6.3 *** performances are:noise figure36 dB, and-108 dBc/Hz @ 1 MHz phase noise offset from the *** carrier noise ratio(C/N) can reach 41 dB at an input power of-130 *** chip operates over a temperature range of-40, 120 °C and ±5% tolerance over the CMOS technology process.

关键词： GPS receiver ΣΔ fractional-N synthesizer Image rejection Phase noise

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Role of sex steroid receptors in pathobiology of hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第39期14卷 5945-5961页

作者： Mamta Kalra jary Mayes Senait Assefa Anil K Kaul Rashmi Kaul Department of Biochemistry and Microbiology Oklahoma State University Center for Health SciencesTulsaOklahoma 74107United States

The striking gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of sex hormones in HCC pathogenesis. Though the studies began as early as in 1980s,the precise role of sex hormones and the significance of their receptors in HCC still remain poorly understood and perhaps contribute to current controversies about the potential use of hormonal therapy in HCC. A comprehensive review of the existing literature revealed several shortcomings associated with the studies on estrogen receptor (ER) and androgen receptor (AR) in normal liver and HCC. These shortcomings include the use of less sensitive receptor ligand binding assays and immunohistochemistry studies for ERα alone until 1996 when ERβ isoform was identified. The animal models of HCC utilized for studies were primarily based on chemical-induced hepatocarcinogenesis with less similarity to virus-induced HCC pathogenesis. However,recent in vitro studies in hepatoma cells provide newer insights for hormonal regulation of key cellular processes including interaction of ER and AR with viral proteins. In light of the above facts,there is an urgent need for a detailed investigation of sex hormones and their receptors in normal liver and HCC. In this review,we systematically present the information currently available on androgens,estrogens and their receptors in normal liver and HCC obtained from in vitro,in vivo experimental models and clinical studies. This information will direct future basic and clinical research to bridge the gap in knowledge to explore the therapeutic potential of hormonal therapy in HCC.

关键词：肝细胞癌病理学性别治疗方法

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FOLFOXIRI vs FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 332-346页

作者： Angélique Vienot Hortense Chevalier Clément Bolognini Elisabeta Gherga Elodie Klajer Aurélia Meurisse Marine jary Stefano Kim Christelle d’Engremont Thierry Nguyen Fabien Calcagno Hamadi Almotlak Francine Fein Meher Nasri Syrine Abdeljaoued Anthony Turpin Christophe Borg Dewi Vernerey Department of Medical Oncology Besançon University HospitalBesançon F-25030France University Bourgogne Franche-Comté INSERMEFS BFCUMR1098Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et GéniqueBesançon F-25000France INSERM CIC-1431 Clinical Investigation Center in BiotherapyBesançon University HospitalBesançon F-25030France Department of Medical Oncology Lille University HospitalLille F-59000France Department of Medical Oncology Nord Franche-ComtéHospitalMontbéliard F-25020France Methodological and Quality of Life in Oncology Unit Besançon University HospitalBesançon F-25030France Department of Gastroenterology Besançon University HospitalBesançon F-25030France

BACKGROUND FOLFIRINOX regimen is the first-line reference chemotherapy(L1)in advanced pancreatic ductal adenocarcinoma(aPDAC).FOLFOXIRI,a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil,has demonstrated efficacy and feasibility in colorectal *** To investigate the potential clinical value of FOLFOXIRI in patients with aPDAC in routine clinical *** Analyses were derived from all consecutive aPDAC patients treated in L1 between January 2011 and December 2017 in two French institutions,with either FOLFOXIRI(n=165)or FOLFIRINOX(n=124)*** consisted of irinotecan(165 mg/m2),oxaliplatin(85 mg/m2),leucovorin(200 mg/m2)and 5-fluorouracil(3200 mg/m2 as a 48-h continuous infusion)every 2 ***-six pairs of patients were selected through propensity score matching,and clinical outcomes of the two treatment regimens were *** Median overall survival was 11.1 mo in the FOLFOXIRI and 11.6 mo in the FOLFIRINOX cohorts,*** propensity score matching,survival rates remained similar between the two regimens in terms of overall survival(hazard ratio=1.22;P=0.219)and progression-free survival(hazard ratio=1.27;P=0.120).The objective response rate was 37.1%in the FOLFOXIRI group vs 47.8%in the FOLFIRINOX group(P=0.187).Grade 3/4 toxicities occurred in 28.7%of patients in the FOLFOXIRI cohort vs 19.5%in the FOLFIRINOX cohort(P=0.079).FOLFOXIRI was associated with a higher incidence of grade 3/4 digestive adverse *** growth factors were used after each chemotherapy cycle and the low hematological toxicity rates were below 5%with both *** FOLFOXIRI is feasible in L1 in patients with aPDAC but does not confer any therapeutic benefit as compared with *** low hematological toxicity rates strengthened the relevance of primary prophylaxis with hematopoietic growth factors.

关键词： Advanced pancreatic cancer First-line chemotherapy FOLFOXIRI FOLFIRINOX Propensity score Cohort study

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Lyocell短切纤维在湿法成网水刺非织造布中的应用

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国际纺织导报 2021年第2期49卷 24-26,28页

作者： S.Schlager T.Maier S.jary S.Rahbaran S.Kulka 王宏球(译) 于俊荣(校) 兰精集团(奥地利) 不详

研究展示了含有Lenzing Lyocell短切纤维的湿法成网水刺湿巾的性能,该短切纤维既能满足高性能非织造布的要求,又能实现湿巾的快速分解或分散。

关键词： Lyocell短切纤维非织造布湿强分解性能

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一键上网自己做

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大众电脑 2002年第6期 115-115页

作者： jary

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硅光电倍增管自动增益校正系统设计

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强激光与粒子束 2022年第7期34卷 155-160页

作者：张琦王传伟李洪涛中国工程物理研究院研究生院北京100088 中国工程物理研究院流体物理研究所脉冲功率科学与技术重点实验室四川绵阳621900

温度会使硅光电倍增管的增益产生较大的漂移,进而影响硅光电倍增管的增益精度。为了使硅光电倍增管增益不随温度发生较大变化,设计了硅光电倍增管的自动增益校正系统,包括基于单片机的高压电源设计与采集系统设计。高电压模块精确工作... 详细信息

温度会使硅光电倍增管的增益产生较大的漂移,进而影响硅光电倍增管的增益精度。为了使硅光电倍增管增益不随温度发生较大变化,设计了硅光电倍增管的自动增益校正系统,包括基于单片机的高压电源设计与采集系统设计。高电压模块精确工作的温度范围为−10~60℃,电源噪声约为30 mV,满足硅光电倍增管性能测试的需求。采集系统经过扫频测试与激光照射测试,可以较好地通过60 MHz的交流信号,并将光信号转变为较明显的电信号。该系统可以向京邦公司的硅光电倍增管阵列jary-TP3050-8X8C提供工作电压与采集电路。

关键词： SiPM STM32 自动增益校正 LM2576-ADJ DS18B20

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