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Pandanus amaryllifoliusleaf extract improves insulin sensitivity in high-fat diet-induced obese mice

中国药理学与毒理学杂志 2015年第S1期29卷 70-70页

作者： SuphaketSAENTAWEESUK jarinyapornnaowaboot NuntiyaSOMPARN Department of Preclinical Science Faculty of Medicine Thammasat University Pathum Thani 12120 Thailand

OBJECTIVE To investigate the effect of Pandanus amaryllifolius leaf in high-fat diet-induced insulin resistance in mice *** To induce obesity,male ICR mice were fed with a high-fat diet(45%fat)for six *** mice were divided into four groups(n=8):non-obese control mice were treated with 5% gum arabic and obese mice were treated with Pandanus amaryllifolius(125and 250mg·kg-1·d-1),or 5% gum *** six weeks of treatments,the fasting blood glucose,serum insulin,OGTT and fat cell protein expression of glucose transporter 4(GLUT4)were *** Administration of Pandanus amaryllifolius showed significantly(P<0.05)reduced the high blood glucose,inhibited the abnormal increase in blood glucose level during OGTT,and decreased the high level of serum ***,it is interesting that the protein expression of GLUT4 was effectively increased by Pandanus *** These findings demonstrate that the extract from Pandanus amaryllifolius leaf possesses antihyperglycemic action in obese mice by improving insulin sensitivity and stimulating GLUT4 expression in adipose tissue.

关键词： Pandanus amaryllifolius insulin resistance obesity

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Improvement of lipid profile and atherogenic index in rat treated with Cymbopogon citratus Stapf water extract

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中国药理学与毒理学杂志 2015年第S1期29卷 30-30页

作者： NuntiyaSOMPARN SuphaketSAENTHAWEEUK jarinyapornnaowaboot AtcharapornTHAEOMOR Department of Preclinical Science Faculty of Medicine Thammasat University Rangsit Campus Pathm Thani 12120 Thailand School of Biology Institute of Science Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

OBJECTIVE To investigate the effects of Cymbopogon citratus Stapf water extract(CCS)on lipid profile,atherogenic index and antioxidant enzymes in Sprague-Dawley *** Rats aged eight weeks(250±20)g were orally administered with CCS at 250 and 500mg·kg-1·d-1 for one *** Administration of CCS extract to rats caused significant decrease of serum total cholesterol,triglycerides and LDL levels,whereas,the HDL level was increased compared with untreated rats(P<0.05).Moreover,the CCS extract showed a significant decreased atherogenic index in comparison with untreated rats(P<0.05).Furthermore,serum activities of superoxide dismutases and catalase were also improved in rats treated with *** was consistent with decrease of serum thiobarbituric acid reactive *** The present study provides evidence that CCS water extract provides a benefit effect on serum lipid and atherogenic index and exhibits antioxidant effect in vivo.

关键词： Cymbopogon citratus Stapf lipid atherogenic index

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