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Proton pump inhibitors and colorectal cancer:A systematic review

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World Journal of Gastroenterology 2021年第44期27卷 7716-7733页

作者： Agastya Patel Piotr Spychalski Magdalena Antoszewska Jaroslaw Regula jarek Kobiela Department of General Endocrine and Transplant SurgeryMedical University of GdanskGdansk 80-210Poland Department of Dermatology Venereology and AllergologyMedical University of GdanskGdansk 80-210Poland Department of Gastroenterology Hepatology and OncologyCenter of Postgraduate Medical EducationThe Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 01-813Poland

BACKGROUND The use of proton pump inhibitors(PPI)is common worldwide,with reports suggesting that they may be *** studies have found that PPI may affect colorectal cancer(CRC)*** To summarize current knowledge on the relationship between PPI and CRC from basic research,epidemiological and clinical *** This systematic review was based on the patients,interventions,comparisons,outcome models and performed according to PRISMA ***,EMBASE,Scopus,and Web of Science databases were searched from inception until May 17,*** initial search returned 2591 articles,of which,28 studies met the inclusion criteria for this *** studies were categorized as basic research studies(n=12),epidemiological studies(n=11),and CRC treatment studies(n=5).The quality of the included studies was assessed using the Newcastle-Ottawa Scale or Cochrane Risk of Bias 2.0 tool depending on the study *** Data from basic research indicates that PPI do not stimulate CRC development via the trophic effect of gastrin but instead may paradoxically inhibit *** studies also suggest that PPI may have properties beneficial for CRC *** appear to have anti-tumor properties(omeprazole,pantoprazole),and are potential T lymphokine-activated killer cell-originated protein kinase inhibitors(pantoprazole,ilaprazole),and chemosensitizing agents(pantoprazole).However,these mechanisms have not been confirmed in human *** epidemiological studies suggest that there is no causal association between PPI use and increased CRC *** studies show that concomitant PPI and capecitabine use may reduce the efficacy of chemotherapy resulting in poorer oncological outcomes,while also suggesting that pantoprazole may have a chemosensitizing effect with the fluorouracil,leucovorin,oxaliplatin(FOLFOX)*** An unexpected inhibitory effect of PPI on CRC carcinogenesis by way of several potential mechanisms is *** review

关键词： Colorectal cancer Proton pump inhibitor Carcinogenesis Cancer epidemiology Capecitabine Translational medicine

Assessing forest understory biomass in northwest Florida (USA) and its potential to meet the state energy needs

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Forestry Studies in China 2011年第4期13卷 303-310页

作者： Marian MARINESCU Puneet DWIVEDI jarek NOWAK FPInnovations Vancouver British Columbia V6T 1Z4 Canada School of Forest Resources and Conservation University of Florida Gainesville 32601 USA Florida Division of Forestry Tallahassee 32399 USA

A stratified random sampling approach was employed to quantify total biomass across prevalent non-commercial forest understory species found in six counties of northwest Florida, USA. The moisture content （wet basis） and calorific values of these species were also measured. Total green biomass from forest understory species was estimated to be around 12 million metric tons, mostly comprised of Cliftonia monophylla （titi, buckwheat tree） and Cyrilla racemiflora （white titi, swamp titi）. This understory forest biomass would be sufficient to generate about 28.8 million GJ of electricity or 1589.25 million liters of ethanol. A need was identified to determine the inventory of forest understory biomass at the state level and assess the overall sustainability of utilizing forest understory biomass for bioenergy.

关键词： bioenergy biomass Florida United States forest understory moisture content

Image-based surgical planning paradigm for cardiovascular diseases

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中国循环杂志 2016年第Z1期31卷 -页

作者： Zhenglun Alan Wei jarek Rossignac Timothy Slesnick Kirk Kanter Mark Fogel Ajit Yoganathan Walace H. Coulter Department of BiomedicalEngineering Georgia Institute of Technology and Emory University Atlanta GA USA. Schoolof Interactive Computing Georgia Institute of Technology Atlanta GA USA. Division of Cardiology Children’s Hospitalof Philadelphia Philadelphia PA USA. Division of Cardiothoracic Surgery Children’s Healthcare of Atlanta Emory University Schoolof Medicine Atlanta GA USA Department of Pediatrics Division of Cardiology Children’s Healthcare of Atlanta Emory University Schoolof Medicine Atlanta GA USA

Objective Around 0.8% of children are born with congenital heart disease (CHD). These diseases often require complicated pediatric cardiac surgeries where small changes in operating room execution can have drastic effects on patient outcomes. We will introduce an image-based surgical planning paradigm, which has the ability to preoperatively evaluate surgical options, thereby exploring these changes and enhancing patient outcomes。[第一段]

关键词：冠状动脉疾病心血管疾病儿童人类

Verifiable Badging System for scientific data reproducibility

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Blockchain(Research and Applications) 2021年第2期2卷 68-81页

作者： Swapna Krishnakumar Radha Ian Taylor jarek.nabrzysk. Iain Barclay Center for Research Computing University of Notre DameIN46556USA School of Computer Science and Informatics Cardiff UniversityCardiffWalesCF103ATUK

Reproducibility can be considered as one of the basic requirements to ensure that a given research finding is accurate and *** paper presents a new layered approach that allows scientific researchers to provide a)data to fellow researchers to validate research and b)proofs of research quality to funding agencies,without revealing sensitive details associated with the *** conclude that by integrating smart contracts,blockchain technology,and self-sovereign identity into an automated system,it is possible to assert the quality of scientific materials and validate the peer review process without the need of a central authority.

关键词： Blockchain technology Self-sovereign identity Decentralized identifiers Verifiable credentials Smart contracts

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铝工业中阴极碳块的超声波检查

新型炭材料 1990年第4期6卷 62-63页

作者： T.Foosnces S.jarek 郭广庆

一、引言本工作的主要目的是确定超声波技术在检测大的碳块上的结构缺陷如空隙、裂缝等,并且建立量的取舍标准。其次是确定阴极碳块的静态弹性模量和动态弹性模量之间的相互关系。前者由应力应变关系计算得到,后者则通过超声波方法获得。

关键词：铝阴极碳快超声波检查

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爱尔兰都柏林大运河广场剧院

中国建筑装饰装修 2011年第3期 82-89页

作者：丹尼尔.里伯斯金 Ros Kavanagh jarek Matla

主持建筑师：丹尼尔里伯斯金地点：爱尔兰达克兰建筑面积：733．

关键词：爱尔兰都柏林剧院广场建筑面积建筑师

Connecting supplier and DoD blockchains for transparent part tracking

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Blockchain(Research and Applications) 2021年第3期2卷 17-30页

作者： Francis Asuncion Adam Brinckman Dwayne Cole Jeffrey Curtis Matt Davis Timothy Dunlevy Calvin Farmer Andrew Harrison Daniel P.Johnson Joshua Joyce Chris Klubertanz Jonathan Lane John Martin jarek.nabrzysk. Joel Neidig Deysi Olivares Gregory Robinson Gabriel Rodriguez Chris Root Karen Rowand Al Salour Jeff Score David Scott Ian Taylor Chandler Thompson Huy Truong Xiqun Wang Dale Warren NAVAIR USA SIMBA Chain PlymouthIN46563USA Center for Research Computing University of Notre DameNotre DameIN46556USA Indiana Technology and Manufacturing Companies(ITAMCO) PlymouthIN46563USA Boeing Company USA Naval Systems Inc.USA

Blockchains have been around for more than ten years,and since 2015,a plethora of systems have been launched to target more flexible use *** recently,several enterprise blockchain systems,such as Consensys Quorum and Hyperledger Fabric,have been launched to make blockchain simpler to apply in complex organizational *** this paper,we identify a specific Department of Defense use case,extrapolate requirements,and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this *** describe a platform that meets many of these challenges and show how we architected,designed,and implemented a solution for this use case for deployment at *** solution connects transactions from two separate blockchain systems,Consensys Quorum and Hyperledger Fabric,by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks.

关键词： Blockchain Smart contracts Supply chain Department of defense(DoD) GraphQL Enterprise blockchain systems

Early Stage CAD-Compliant Energy Performance Assessment Method

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Journal of Energy and Power Engineering 2013年第9期7卷 1662-1668页

作者： jarek Kumitski Targo Kalamees Teet Tark Faculty of Civil Engineering Tallinn University of Technology Tallinn 12618 Estonia Hevac Ltd. Tallinn 10621 Estonia

A simple calculator for early stage energy performance assessment in residential buildings was developed and partially validated in this study. The calculator is based on the correlation of heat loss and energy need for heating and has fixed internal heat gains as intended for compliance assessment. With the calculator, the effect of any parameter implemented can be immediately seen on delivered and primary energy. Because of simple equations, it is suitable for implementation into CAD (computer aided design) design tools including basic BIM (building information modeling) data. Results showed that the accuracy of the correlation for the cases with practical relevance was not worse than 14% of the energy need of space heating. This applies for passive house insulation level; for less insulated building envelopes, the deviations were smaller. This 14% equals to only 3 kWh/(m2·a), i. e., the percentage difference in the total delivered and primary energy was much lower because of other components in the energy balance. The deviations determined were implemented in the calculator as safety margin. Results prove that simple energy performance assessment based on specific heat loss coefficient is well justified for early stage energy analyses as well as for compliance assessment implemented in Estonian regulation.

关键词：评估方法能源需求早期阶段性能评估 CAD 计算机辅助设计兼容建筑围护结构