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Adiponectin and the regulation of gastric content volume in the newborn rat

World Journal of Gastroenterology 2021年第33期27卷 5566-5574页

作者： Huanhuan Wang Paul Esemu-Ezewu Jingyi Pan Julijana Ivanovska Estelle B Gauda jaques belik Department of Paediatrics The Hospital for Sick ChildrenToronto M5G 1X8OntarioCanada Department of Paediatrics and Physiology The Hospital for Sick ChildrenToronto M5G 1X8OntarioCanada

BACKGROUND Oral intake is dependent on the gastric ability to accommodate the food ***,neonates have a smaller gastric capacity than adults and this may limit the volume of their milk ***,we previously reported that the newborn rat gastric milk volume is greatest after birth and,when normalized to body weight,decreases with postnatal *** age-dependent changes are not the result of intake differences,but greater gastric accommodation and reduced emptying *** Hypothesizing that breastmilk-derived adiponectin is the factor regulating gastric accommodation in neonates,we comparatively evaluated its effects on the rat fundic muscle tone at different postnatal *** In freshly dispersed smooth muscle cells(SMC),we measured the adiponectin effect on the carbachol-induced length *** Adiponectin significantly reduced the carbachol-stimulated SMC shortening independently of *** the presence of the inhibitor iberiotoxin,the adiponectin effect on SMC shortening was suppressed,suggesting that it is mediated via largeconductance Ca^(2+)sensitive K^(+)channel ***,we comparatively measured the newborn rat gastric milk curd adiponectin content in one-and twoweek-old rats and found a 50%lower value in the *** Adiponectin,a major component of breastmilk,downregulates fundic smooth muscle contraction potential,thus facilitating gastric volume *** rodent’s adaptive response maximizes breastmilk intake volume after birth.

关键词： Gastric emptying Fundus Smooth muscle Breastmilk Potassium channel Development

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