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Subsequent bilateral acute carpal tunnel syndrome due to tophaceous infiltration:A case report

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World Journal of Clinical Cases 2024年第2期12卷 418-424页

作者： Soon-Chin Yeoh Wen-Tien Wu Jui-Tien Shih Wen-Chin Su kuang-Ting Yeh School of Medicine Tzu Chi UniversityHualien 970374TaiwanChina Department of Orthopedics Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Department of Orthopaedic Surgery Taoyuan Armed Forces General HospitalTaoyuan 325208TaiwanChina Department of Clinical Education Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Graduate Institute of Clinical Pharmacy Tzu Chi UniversityHualien 970374TaiwanChina

BACKGROUND Acute carpal tunnel syndrome(ACTS)is commonly caused by repetitive strain,trauma,or inflammatory ***,ACTS due to tophaceous gout is a clinical event that remains poorly understood and *** rare manifestation necessitates prompt diagnosis and intervention to prevent irreversible *** SUMMARY A 51-year-old man who had poorly controlled hyperuricemia presented with ACTS secondary to tophaceous *** of rapid symptom progression symptoms and severe median nerve compression within 3 mo,the patient underwent emergency decompression surgery for both wrists at different time ***,he exhibited complete recovery of sensory and motor functions,with no recurrence at long-term *** outcomes were achieved through immediate decompression surgery,anti-inflammatory medications,postoperative active and passive range-of-motion exercises,and intermittent wrist *** diagnosis and surgical intervention,when necessary,are crucial for preventing long-term complications and obtaining favorable outcomes in patients with *** optimal gout management strategy involving pharmacologic therapy and lifestyle modifications may help minimize ACTS recurrence and improve clinical *** Prompt surgical intervention and optimal gout management are crucial for preventing irreversible nerve damage and ACTS recurrence.

关键词： Acute carpal tunnel syndrome Gout Surgical decompression Range-of-motion exercises Case report

Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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Genes & Diseases 2024年第2期11卷 535-538页

作者： Xi Kong Peng Lu Jinyue Zhang Zheng Bao Chenghao kuang Bingqing Xie Jianhua Peng Ning Ma Yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

Diverse nucleotide substitutions in rice base editing mediated by novel TadA variants

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Plant Communications 2024年第8期5卷 104-112页

作者： Man Yu Yongjie kuang Chenyang Wang Xuemei Wu Shaofang Li Dawei Zhang Wenxian Sun Xueping Zhou Bin Ren Huanbin Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Pathology China Agricultural UniversityBeijing 100193China Scientific Observing and Experimental Station of Crop Pests in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment College of Life ScienceState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064China State Key Laboratory of Vegetable Biobreeding National Engineering Research Center for VegetablesBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Gene Editing Technologies(Hainan) Ministry of Agricultural and Rural AffairsSanya 572024China

CRISPR-mediated base editors have been widely used to correct defective alleles and create novel alleles by artificial evolution for the rapid genetic improvement of *** editing capabilities of base editors strictly rely on the performance of various nucleotide modification *** with the welldeveloped adenine base editors(ABEs),cytosine base editors(CBEs)and dual base editors suffer from unstable editing efficiency and patterns at different genomic loci in rice,significantly limiting their ***,we comprehensively examined the base editing activities of multiple evolved TadA8e variants in *** found that both TadA-CDd and TadA-E27R/N46L achieved more robust C-to-T editing than previously reported hyperactive hAID*D,and TadA-CDd outperformed TadA-E27R/N46L.A C-to-G base editor(CGBE)engineered with TadA-CDd and OsUNG performed highly efficient C-to-G editing in rice compared with that of *** addition,a dual base editor constructed with a single protein,TadDE,enabled simultaneous,highly efficient C-to-T and A-to-G editing in ***,our results demonstrate that TadA8e derivatives improve both CBEs and dual base editors in rice,providing a powerful way to induce diverse nucleotide substitutions for plant genome editing.

关键词： CRISPR TadA variants cytosine base editing dual base editor rice

An assessment of the CMIP6 performance in simulating Arctic sea ice volume flux via Fram Strait

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Advances in Climate Change Research 2024年第4期15卷 584-595页

作者： Hui-Yan kuang Shao-Zhe SUN Yu-Fang YE Shao-Yin WANG Hai-Bo BI Zhuo-Qi CHEN Xiao CHENG School of Geospatial Engineering and Science Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China CAS Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of Sciences(CAS)Qingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Numerical models serve as an essential tool to investigate the causes and effects of Arctic sea ice *** the simulation capabilities of the most recent CMIP6 models in sea ice volume flux provides references for model applications and ***,reliable long-term simulation results of the ice volume fux contribute to a deeper understanding of the sea ice response to global climate *** this study,the sea ice volume flux through six Arctic gateways over the past four decades(1979-2014)were estimated in combination of satellite observations of sea ice concentration(SIC)and sea ice motion(SIM)as well as the Pan-Arctic Ice-Ocean Modeling and Assimilation System(PIOMAS)reanalysis sea ice thickness(SIT)*** simulation capability of 17 CMIP6 historical models for the volume flux through Fram Strait were quantitatively *** ice volume flux simulated from the ensemble mean of 17 CMIP6 models demonstrates better performance than that from the individual model,yet IPSL-CM6A-LR and EC-Earth3-Veg-LR outperform the ensemble mean in the annual volume flux,with Taylor scores of 0.86 and 0.50,***6 models display relatively robust capability in simulating the seasonal variations of volume *** them,CESM2-WACCM performs the best,with a correlation coefficient of 0.96 and a Taylor score of ***,NESM3 demonstrates the largest devi-ation from the observation/reanalysis data,with the lowest Taylor score of *** variability of sea ice volume flux is primarily influenced by SIM and SIT,followed by *** extreme large sea ice export through Fram Strait is linked to the occurrence of anomalously low air temperatures,which in turn promote increased SIC and SIT in the corresponding ***,the intensified activity of Arctic cyclones and Arctic dipole anomaly could boost the southward sea ice velocity through Fram Strait,which further enhance the sea ice outflow.

关键词： Sea ice volume flux CMIP6 models Fram Strait Attribution analysis

Multiplexed stimulated emission depletion nanoscopy(mSTED)for 5-color live-cell long-term imaging of organelle interactome

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Opto-Electronic Advances 2024年第7期7卷 17-26页

作者： Yuran Huang Zhimin Zhang Wenli Tao Yunfei Wei Liang Xu Wenwen Gong Jiaqiang Zhou Liangcai Cao Yong Liu Yubing Han Cuifang kuang Xu Liu State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311121China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of Endocrinology and Metabolism Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Precision Instruments Tsinghua UniversityBeijing 100084China College of electronics and information engineering Shanghai University of Electrical PowerShanghai 200090China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200China

Stimulated emission depletion microscopy(STED)holds great potential in biological science applications,especially in studying nanoscale subcellular ***,multi-color STED imaging in live-cell remains challenging due to the limited excitation wavelengths and large amount of laser ***,we develop a multiplexed live-cell STED method to observe more structures simultaneously with limited photo-bleaching and *** separating live-cell fluorescent probes with similar spectral properties using phasor analysis,our method enables five-color live-cell STED imaging and reveals long-term interactions between different subcellular *** results here provide an avenue for understanding the complex and delicate interactome of subcellular structures in live-cell.

关键词： optical nanoscopy phasor analysis multicolor live cell imaging

RDH12-associated retinal degeneration caused by a homozygous pathogenic variant of 146C>T and literature review

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 311-316页

作者： Jin Li Yi-Qun Hu Hong-Bo Cheng Ting Wang Long-Hao kuang Tao Huang Xiao-He Yan Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina

AIM:To describe the clinical,electrophysiological,and genetic features of an unusual case with an RDH12 homozygous pathogenic variant and reviewed the characteristics of the patients reported with the same ***:The patient underwent a complete ophthalmologic examination including best-corrected visual acuity,anterior segment and dilated fundus,visual field,spectral-domain optical coherence tomography(OCT)and electroretinogram(ERG).The retinal disease panel genes were sequenced through chip capture high-throughput sequencing and Sanger sequencing was used to confirm the *** we reviewed the characteristics of the patients reported with the same ***:A 30-year male presented with severe early retinal degeneration who complained night blindness,decreased visual acuity,vitreous floaters and amaurosis *** best corrected vision was 0.04 OD and 0.12 OS,*** fundus photo and OCT showed bilateral macular atrophy but larger areas of macular atrophy in the left *** shows bilateral symmetrical *** revealed that the amplitudes of a-and b-wave were severely *** ERG showed decreased amplitudes in the local macular area.A homozygous missense variant c.146C>T(chr14:68191267)was *** clinical characteristics of a total of 13 patients reported with the same pathologic variant ***:An unusual patient with a homozygous pathogenic variant in the c.146C>T of RDH12 which causes late-onset and asymmetric retinal degeneration are *** clinical manifestations of the patient with multimodal retinal imaging and functional examinations have enriched our understanding of this disease.

关键词： RDH12 gene inherited retinal degeneration homozygous pathogenic variant clinical feature multi-mode imaging

Dinitrophenyl-oxadiazole compounds:Design strategy,synthesis,and properties of a series of new melt-cast explosives

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Defence Technology（防务技术） 2024年第5期35卷 100-107页

作者： Bao-long kuang Ting-wei Wang Cong Li Mou Sun Qamar-un-Nisa Tariq Chao Zhang Zhi-ming Xie Zu-jia Lu Jian-guo Zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China China Wuzhou Engineering Group CO. LTD.Beijing 100053China

Melt-cast explosives are the most widely used energetic materials in military composite explosives,researchers have been unremittingly exploring high-energy and insensitive melt-cast *** this work,a series of dinitrophenyl-oxadiazole compounds were designed and *** compounds have an ideal low melting point(80-97℃),good detonation performance(detonation velocity D=6455-6971 m/s,detonation pressure P=18-19 GPa)and extreme insensitive nature(impact sensitivity≥60 J,friction sensitivity>360 N).All these compounds were well characterized by nuclear magnetic resonance,fourier transform infrared spectroscopy,elemental *** 2,3 were unambiguously confirmed by X-ray single crystal diffraction *** a result,their overall properties are superior to traditional melt-cast explosives trinitrotoluene(TNT)and dinitroanisole(DNAN)which may have excellent potential applications in insensitive melt-cast explosives.

关键词： Dinitrophenyl-oxadiazole Melt-cast explosive Low sensitivity

Application of wastewater-based epidemiological monitoring of COVID-19 for disease surveillance in the city

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 81-87页

作者： Heng Chen Zhenhua Chen Liwen Hu Fengzhu Tang Dan kuang Jiayi Han Yao Wang Xiao Zhang Yue Cheng Jiantong Meng Rong Lu Lan Zhang Chengdu Workstation for Emerging Infectious Disease Control and Prevention Chinese Academy of Medical SciencesChengdu 610047China Chengdu Center for Disease Control and Prevention Chengdu 610047China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Beijing 100050China National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100050China

Wastewater-based surveillance serves as a supplementary approach to clinical surveillance of COVID-19 during the *** study aimed to track the prevalence of the disease and the viral genetic variability through wastewater-based surveillance in the post-epidemic *** January to December 2023,samples were collected from the influent lines of two wastewater treatment plants(WWTPs),concentrated using PEG8000,and subjected to detection of the target genes ORF 1ab and N of SARS-CoV-2 via reverse transcriptional quantitative PCR(RT-qPCR).For next-generation sequencing(NGS),high-quality samples from both wastewater and clinical patients were *** analysis were performed using R software to evaluate the correlation between the SARSCoV-2 RNA concentrations in wastewater and positive rate of reported cases,indicating a positive *** diversity patterns of SARS-CoV-2 in wastewater resembled those in the patient source based on Principal Coordinates Analysis(PCoA)with three clusters for different *** rise of RNA concentration in wastewater indicates the growth of cases and the emergence of new variants,serving as an early warning of potential viral mutations,disease outbreaks even possible ***,the genomic surveillance of wastewater could help identify new variants that may not be captured through population monitoring,especially when sample sizes are ***,surveillance of SARS-CoV-2 in municipal wastewater has emerged as a reliable,earlywarning monitoring system for COVID-19 in the post-epidemic era.

关键词： Wastewater-based epidemiology Monitoring COVID-19 Post-epidemic era

Controlled Synthesis of Proton-Conductive Porous Organic Polymer Gels via Electrostatically Stabilized Colloidal Formation

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CCS Chemistry 2024年第7期6卷 1767-1775页

作者： Bin Chen Yifeng kuang Lu Liu Linkun Cai Zaoming Wang Panchao Yin Liangbin Huang Cheng Gu State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065 Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641 South China Advanced Institute for Soft Matter Science and Technology South China University of TechnologyGuangzhou 510640 Institute for Integrated Cell-Material Sciences Institute for Advanced StudyKyoto UniversityKyoto 606-8501

Porous organic polymers(POPs)have attracted extensive interest due to their structural diversity and predesigned ***,the majority of POPs are synthesized as insoluble and unprocessable powders,which greatly impede their advanced applications because of limited mass transport and inadaptation for device ***,we report a controlled synthetic strategy of macroscopic POP gels by a cation-stabilized colloidal formation mechanism,which is widely adaptable to a large variety of tetra-/tri-amino build blocks for the synthesis of Tröger’s base-linked POP gels,aerogels,and ionic *** POP gels combined the integrated advantages of hierarchically porous structures and tailorable mechanical stiffness,whereas they could load substantial amounts of phosphoric acids and construct unimpeded transport pathways for proton conduction,exhibiting unprecedented proton conductivity at subzero *** strategy offers a new solution to the intractable processing issues of POPs toward device applications with cutting-edge performances.

关键词： porous organic polymers Tröger’s base linkage gels superprotonic conduction subzero temperatures