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Signal Transduction and Targeted Therapy 2022年第8期7卷 3139-3142页

作者： Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li janusz rak Shihua Wang Robert Chunhua Zhao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China Department of Cell Biology School of Life Sciences Shanghai University 200444 Shanghai China Department of Genetics and Cell Biology Basic medical college Qingdao University 308 Ningxia Road 266071 Qingdao China Research Institute of the McGill University Health Centre Glen Site McGill University Montreal QC H4A 3J1 Canada

In the process of collating the raw data,the authors noticed several inadvertent mistakes occurred in Fig.1b,Fig.2d,f,l,and Supplementary Fig.1b that need to be corrected after online publication of the *** correct data are provided as *** key findings of the article are not affected by these *** original article has been corrected.

关键词： correction finding corrected

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3318-3332页

作者： Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li janusz rak Shihua Wang Robert Chunhua Zhao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Department of Genetics and Cell Biology Basic medical collegeQingdao University308 Ningxia Road266071QingdaoChina Research Institute of the McGill University Health Centre Glen SiteMcGill UniversityMontrealQCH4A 3J1Canada Department of Cell Biology School of Life SciencesShanghai University200444ShanghaiChina

Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src.

关键词： miR wound healing

Anticipating the lifespan: Predicting the durability of an anode-supported solid oxide fuel cell short stack over 50,000 h

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Progress in Natural Science:Materials International 2024年第3期34卷 606-613页

作者： Muhammad Zubair Khan Amjad Hussain Seung-Bok Lee Tak-Hyoung Lim rak-Hyun Song Department of Materials Science & Engineering Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology Hydrogen Energy Research Division Korea Institute of Energy Research Department of Advanced Energy and System Engineering Korea University of Science and Technology (UST)

In the present study, the operational lifetime of a solid oxide fuel(SOFC) short stack is predicted by investigating the performance degradation of both the short stack and its cells throughout 1000 h at 800°C. The short stack and integral cell voltages are continuously measured during the long-term test, with electrochemical impedance spectroscopy(EIS) conducted every 200 h. The short stack voltage decreased rapidly for the initial 200–300 h and afterwards, it decreased at a slow rate due to the increase in the Ohmic and polarization resistances in the same manner. Scanning electron microscopy results show that there is no delamination or cracking among constituent layers of the short-stack cells. The single degradation effects of the Ni coarsening in the anode, cation migration and surface segregation in cathode and oxide scale growth in metallic interconnect mesh are successfully integrated into a comprehensive lifetime prediction model. The experimentally measured voltage degradation data of the short stack fits well with the developed mathematical model and allows the successful prediction of the lifetime up to 50,000 h.

关键词： Degradation Impedance Lifetime SOFC Stack

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英特尔希望超越竞争对手

科技纵览 2024年第1期 32-33,56页

作者： Gwendolyn rak 不详

这家芯片制造商将希望寄托于新型晶体管、供电技术和新的代工业务。过去5年,英特尔在先进芯片制造方面一直落后于台湾积体电路制造公司(以下简称台积电)和三星。现在,为,了重新获得领先地位,该公司正在采取一项大胆而冒险的行动,在用于... 详细信息

这家芯片制造商将希望寄托于新型晶体管、供电技术和新的代工业务。过去5年,英特尔在先进芯片制造方面一直落后于台湾积体电路制造公司(以下简称台积电)和三星。现在,为,了重新获得领先地位,该公司正在采取一项大胆而冒险的行动,在用于台式机和笔记本电脑的Arrow Lake处理器中引入两项新技术,计划于2024年底推出。

关键词：笔记本电脑芯片制造商英特尔供电技术台式机

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MagQuest寻求新的全球地磁图

科技纵览 2024年第1期 12-13页

作者： Gwendolyn rak 不详

全球地磁模型对导航至关重要。该模型将全球各点位磁场的精确测量结果汇编成一张地图,提供不断变化的磁场数据,但目前用于收集这些重要数据的系统已经很陈旧了。美国一家情报机构参与了开发新技术取代陈旧系统的竞赛,现在,竞赛正处于最... 详细信息

全球地磁模型对导航至关重要。该模型将全球各点位磁场的精确测量结果汇编成一张地图,提供不断变化的磁场数据,但目前用于收集这些重要数据的系统已经很陈旧了。美国一家情报机构参与了开发新技术取代陈旧系统的竞赛,现在,竞赛正处于最后的阶段。人们希望将来拥有一个更准确的全球地磁模型。全球地磁模型在手机、飞机和军事应用中非常重要。“我们每天都会用它来判断应该往左还是往右。”

关键词：情报机构地磁模型地磁图精确测量竞赛重要数据

Effectiveness of menstruation hygiene skills training for adolescents with autism

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World Journal of Psychiatry 2023年第11期13卷 958-966页

作者： Meltem Kaydırak Büşra Yılmaz Merve Azak Çiğdem Bilge Department of Women Health and Gynecologic Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye Department of Pediatric Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye Department of Obstetrics and Women's Health Nursing Muğla SıtkıKoçman UniversityFaculty of Health SciencesMuğla 48000Türkiye

BACKGROUND Adolescents with autism spectrum disorder(ASD)may encounter many difficulties with their menstrual *** challenges that adolescents with ASD may face include understanding physical changes,coping with symptoms,emotional sensitivity,communication,personal care,and *** To evaluate the effect of menstrual hygiene skills training given to adolescents with ASD on their menstrual hygiene *** The study was conducted with 15 adolescents diagnosed with ASD by the single group pre-test and post-test model in three special education centers in Tü*** were collected with the Adolescent and Parent Information Form and the Adolescent-Specific Menstrual Hygiene Skill Registration *** While the mean age of adolescents was 16.06±0.88 years,the mean age of individuals responsible for adolescent care was 43.66±5.56 *** 60.0%of the adolescents noticed the onset of bleeding before training,this rate was 93.3%after *** Adolescent-Specific Menstrual Hygiene Skill Registration Form showed a statistically significant increase in the application steps after the *** difference between the menstrual hygiene skill scores of adolescents CONCLUSION The menstrual hygiene skills training given to adolescents with ASD was beneficial in increasing their menstrual hygiene *** individuals must take responsibility during menstruation and independently manage their continuous care activities.

关键词： Autism Adolescent Menstruation Hygiene Training

Surface and Hydrogen Sorption Characteristics of Various Activated Carbons Developed from Rat Coal Mine （Zonguldak） and Anthracite

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Chinese Journal of Chemical Engineering 2011年第6期19卷 931-937页

作者： Atakan Top rak Turkan Kopac Department of Chemistry Zonguldak Karaelmas University 67100 Zonguldak Turkey

激活的碳样品从从一个煤矿获得的煤样品被开发，老鼠(Zonguldak，土耳其) 并且白煤(西伯利亚，俄国) ，在 600900

关键词：氢氧化钾无烟煤活性炭表面积大鼠吸附特性煤矿孔隙结构特性

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Highly dense and ultrathin gadolinia-doped ceria interlayer for enhanced performance of large-area anode-supported solid oxide fuel cell

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Progress in Natural Science:Materials International 2023年第5期33卷 733-741页

作者： Sang Woo Shin Amjad Hussain Muhammad Zubair Khan Dong Woo Joh Tak-Hyung Lim Seung-Bok Lee Jong-Eun Hong Joon Hyung Shim rak-Hyun Song Hydrogen Energy Research Division Korea Institute of Energy Research Department of Mechanical Engineering Korea University Department of Advanced Energy and System Engineering Korea University of Science and Technology(UST) 4. Department of Materials Science & Engineering Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology

The fabrication of a highly dense and ultrathin Gd doped ceria(GDC) interlayer on a large-area, porous electrolyte-coated planar anode support using vacuum slurry coating is studied for application in solid oxide fuel cells(SOFCs). The electrolyte-coated planar anode support body is fabricated by tape casting and pre-sintering is performed at 1100, 1150, and 1200°C. The GDC interlayer is coated onto the pre-sintered electrolyte-coated anode support using a vacuum slurry coating process with different immersion times(30–60 s). A highly dense and ultrathin GDC interlayer with a thickness of 1.48 μm is produced after co-sintering at 1400°C. The 1200°C pre-sintered electrolyte-coated anode support showed a thin and highly dense GDC interlayer which is attributed to a lower shrinkage difference between the coated GDC interlayer and pre-sintered body. The electrochemical performance of a vacuum slurry-coated GDC interlayer cell is 38 % higher compared to that of the screen-printed GDC-coated cell at 700°C due to the greatly reduced Ohmic and electrode polarization resistances. The considerable improvement in the performance is attributed to the ultrahigh GDC density which has prevented the secondary phase formation between the cathode and electrolyte. This study presents the economical, scalable, and reproducible process for the fabrication of highly robust GDC interlayer for the large-area planar anode-supported SOFCs.

关键词： Solid oxide fuel cell Vacuum slurry coating GDC interlayer Sintering Performance

Experimental and Theoretical Spectral(FT-IR,Raman,NMR,UV-Vis and NLO)Analysis of a Potential Anti-Tumor Drug：1-Methyl-6-Nitro-1H-Benzimidazole

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光谱学与光谱分析 2018年第6期38卷 1963-1969页

作者： Halil Oturak Neslihan Kaya Kιnaytürk Cagrι Cιrak DepartmentofPhysics SüleymanDemirelUniversityIsparta32100Turkey ExperimentalandObservationalResearchandApplicationCentre SüleymanDemirelUniversityIsparta32100Turkey DepartmentofPhysics ErzincanUniversityErzincan24100Turkey

In the present work,the experimental and the theoretical spectroscopic properties of 1-Methyl-6-Nitro-1H-Benzimidazole were *** FT-IR(400~4 000cm^(-1))and FT-Raman spectra(100~4 000cm^(-1))of 1-Methyl-6-Nitro-1H-Benzimidazole in the solid phase were ***,experimental NMR and UV spectra of titled molecule were *** interpret the experimental data,geometric parameters,vibrational frequencies,NMR,UV spectra and NLO analysis of the optimized molecule were calculated using ab initio Hartree–Fock(HF)method and density functional theory(B3LYP)method with the 6-31++G(d,p)and 6-311++G(d,p)basis *** bands were assigned based on the potential energy distribution using the VEDA *** theoretical results showed good agreement with the experimental values.

关键词：光谱学英文摘要

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Osteochondral lesion of talus with gout tophi deposition:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3814-3820页

作者： Taeho Kim Young-rak Choi Department of Orthopaedic Surgery CHA Bundang Medical CenterCHA UniversitySeongnam 13497Gyeonggi-doSouth Korea Department of Orthopaedic Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Osteochondral lesion of talus is a broad term used to describe an injury or abnormality of the talar articular cartilage and adjacent *** arises from diverse causes,and although trauma is implicated in many cases,it does not account for the etiology of every *** is a chronic arthritic disease caused by excess levels of uric acid in *** deposition of monosodium urate in the clavicle,femur,patella and calcaneus was reported *** is common disease but rare at a young age,especially during teenage *** lesion caused by intra-articular gouty invasion is very *** SUMMARY We encountered a rare case of a 16-year-old male who has osteochondral lesion of the talus(OLT)with *** had fluctuating pain for more than 2 *** could see intra-articular tophi with magnetic resonance image(MRI)and *** performed arthroscopic exploration,debridement and *** were resolved after operation,and bony coverage at the lesion was seen on postoperative *** had checked image and uric acid levels for 18 *** It is rare to see OLT with gouty tophi in young *** it is challenging,the accuracy of diagnosis can be improved through history taking,MRI and arthroscopy.

关键词： Ankle Gout Osteochondral lesion of the talus Tophi Magnetic resonance image Arthroscope Case report