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World Journal of Gastroenterology 2000年第1期6卷 49-52页

作者： Indaram AVK Nandi s Weissman s Lam s Bailey B Blumstein M Greenberg R Bank s Division of Gastroenterology Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew YorkUSA

AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease *** Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELIsAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s *** Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than *** these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further *** Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess.

关键词： subject headings crohns disease cytokine/analysis intestinal mucosa

Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

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Translational Neurodegeneration 2023年第1期12卷 638-653页

作者： Xavier sánchez-sáez Isabel Ortuño-Lizarán Carla sánchez-Castillo Pedro Lax Nicolás Cuenca Department of Physiology Genetics and MicrobiologyUniversity of AlicanteSan Vicente del RaspeigSpain Alicante Institute for Health and Biomedi-cal Research(IsABIAL) AlicanteSpain Ramón Margalef Institute University of AlicanteSan Vicente del RaspeigSpain.

Background The main clinical symptoms characteristic of Parkinson’s disease(PD)are bradykinesia,tremor,and other motor ***,non-motor symptoms,such as visual disturbances,can be identified at early stages of the *** of these symptoms is the impairment of visual motion ***,we sought to determine if the starburst amacrine cells,which are the main cellular type involved in motion direction selectivity,are degenerated in PD and if the dopaminergic system is related to this *** Human eyes from control(n=10)and PD(n=9)donors were available for this *** immunohistochemistry and confocal microscopy,we quantified starburst amacrine cell density(choline acetyltransferase[ChAT]-positive cells)and the relationship between these cells and dopaminergic amacrine cells(tyrosine hydroxylase-positive cells and vesicular monoamine transporter-2-positive presynapses)in cross-sections and wholemount *** First,we found two different ChAT amacrine populations in the human retina that presented different ChAT immunoreactivity intensity and different expression of calcium-binding *** populations are affected in PD and their density is reduced compared to ***,we report,for the first time,synaptic contacts between dopaminergic amacrine cells and ChAT-positive cells in the human *** found that,in PD retinas,there is a reduction of the dopaminergic synaptic contacts into ChAT *** Taken together,this work indicates degeneration of starburst amacrine cells in PD related to dopaminergic degeneration and that dopaminergic amacrine cells could modulate the function of starburst amacrine *** motion perception circuitries are affected in PD,their assessment using visual tests could provide new insights into the diagnosis of PD.

关键词： Parkinson’s disease Retinal neurodegeneration Human retina ChAT amacrine cells Dopaminergic amacrine cells

sYNTHEsEs AND CHARACTERIZATIONs OF OLIGO(AZOMETHINE ETHER)s DERIVED FROM 2,2'-[1,4-ENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE AND 2,2'-[1,2-PHENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE

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Chinese Journal of Polymer science 2012年第5期30卷 682-693页

作者： Ismet Kaya süleyman Culhaoglu Canakkale Onsekiz Mart University Faculty of Science and ArtsDepartment of ChemistryCanakkale 17020Turkey

The oligo（azomethine ether）s were synthesized via polycondensation of alkyl diamines with aromatic dialdehydes. Two series of dialdehydes, namely 2,2＇-[1,2-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-1,2-（PBMODB）] and 2,2＇- [1,4-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-I,4-（PBMODB）] were prepared from the condensation reactions of salicylaldehyde with o-xylenedibromide and p-xylenedibromide, respectively. The structures of dialdehydes and oligomers were determined by FT-IR, 1H-NMR and 13C-NMR. The thermal analyses of oligomers were conducted by DsC and TG/DTA techniques, respectively. size exclusion chromatography （sEC） technique was also used to determine molecular weights and molecular weight distributions of oligomers. Electrochemical properties of the synthesized products were investigated.

关键词： Polyazomethine Thermal analysis Dialdehyde Oligoazomethine.

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

Expression of L amino acid transport system 1 and analysis of iodine-123-methyltyrosine tumor uptake in a pancreatic xenotransplantation model using fused high-resolution-micro-sPECT-MRI

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Hepatobiliary & Pancreatic Diseases International 2011年第1期10卷 30-37页

作者： Corinna von Forstner Maaz Zuhayra Ole Ammerpohl sanjay Tiwari Olav jansen Holger Kalthoff Eberhard Henze Jan-Hendrik Egberts Department of Nuclear Medicine University Hospital of Schleswig-Holstein Institute for Experimental Cancer Research University Hospital of Schleswig-Holstein Institute of Neuroradiology University Hospital of Schleswig-Holstein Department of General surgery and Thoracic surgery University Hospital of Schleswig-Holstein

BACKGROUND:The specificity in discriminating pancreatitis is limited in the positron emission tomography(PET)using ***,PET is not widely available compared to the single photon emission computed tomography(sPECT).since amino acids play a minor role in metabolism of inflammatory cells,the potential of the sPECT tracer,3-[ 123 I]iodo-L-α-methyltyrosine(123I-IMT),for detecting pancreatic cancer was examined in xenotransplantation models of human pancreatic carcinoma in mice. METHODs: 123 I-IMT was injected to eight mice inoculated with subcutaneous or orthotopic pancreatic *** high-resolution-micro-sPECT(Hi-sPECT)and magnetic resonance imaging were *** gene expression level of L amino acid transport-system 1(LAT1)was analyzed and correlated with tumor uptake of 123 I-IMT. REsULTs:A high uptake of 123 I-IMT was detected in all tumor-bearing *** median tumor-to-background ratio (T/B)was 12.1(2.0-13.2)for orthotopic and 8.4(1.8-11.1)for subcutaneous xenotransplantation,***, the LAT1 expression in transplanted Colo357 cells was increased compared to non-malignant ***:Our mouse model could show a high 123 I-IMT uptake in pancreatic *** MRI scans facilitate precise evaluation of uptake in the specific regions of *** studies are required to confirm these findings in tumors derived from other human pancreatic cancer *** amino acids play a minor role in the metabolism of inflammatory cells,the potential for application of 123 I-IMT to distinguish pancreatic tumor from inflammatory pancreatitis warrants further investigation.

关键词： pancreatic ductal adenocarcinoma iodine-123-methyltyrosine high-resolution-micro-sPECT L amino acid transport-system 1 xenotransplantation model

Neumann＇s method for boundary problems of thin elastic shells

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUsTADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The possibility of using Neumann＇s method to solve the boundary problems for thin elastic shells is studied. The variational statement of the static problems for the shells allows for a problem examination within the distribution space. The convergence of Neumann＇s method is proven for the shells with holes when the boundary of the domain is not completely fixed. The numerical implementation of Neumann＇s method normally requires significant time before any reliable results can be achieved. This paper suggests a way to improve the convergence of the process, and allows for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elastic shell theory Neumann's method variational principle Korn's inequality distribution embedding theorem Green tensor

Influence of Organo-Metal Interactions on Regeneration of Exhausted Clay Mineral sorbents in soil Columns Loaded with Heavy Metals

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Pedosphere 2017年第3期27卷 579-587页

作者： Yasser REFAEY Boris jansen Pim DE VOOGT John R.PARsONs Abdel-Hamid EL-sHATER Abdel-Aziz EL-HADDAD Karsten KALBITZ Institute for Biodiversity and Ecosystem Dynamics (IBED) University of Amsterdam Geology Department Faculty of Science Sohag University soil Resources and Land Use Institute of Soil Science and Site Ecology Faculty of Environmental Sciences Technical University Dresden

Natural clay minerals can play an important role in crude remediation of wastewater polluted with the heavy metals （HMs） Cu, Zn and Ni. The presence and timing of ddition of natural dissolved organic matter （DOM） have a significant effect on the HM removal by clay mineral sorbents. However, the influence of the presence of DOM on the remediation of the used clay mineral sorbents once saturated with HMs is largely unknown. To resolve this, clay mineral-rich soil column of varying composition, loaded （i） with Cu, Zn and Ni only, （ii） first with DOM followed by Cu, Zn and Ni, or （iii） with DOM, Cu, Zn and Ni simultaneously, was used in a set of desorption experiments. The soil columns were leached with 0.001 mol L-1 CaCI2 dissolved in water as control eluent and 0.001 tool L-1 CaC12 dissolved in DOM as treatment eluent. During the preceding loading phase of the sorbent, the timing of DOM addition （sequential or concurrent with HMs） was found to have a significant influence on the subsequent removal of the HMs. In particular when the column was loaded with DOM and HMs simultaneously, largely irreversible co-precipitation took place. Our results indicate that the regeneration potential of clay mineral sorbents in wastewater treatment will be significantly reduced when the treated water is rich in DOM. In contrast, in manured agricultural fields （where HMs enter together with DOM）, HM mobility will be lower than expected from interaction dynamics of HMs and clay minerals.

关键词： dissolved organic matter heavy metal mobility remediation timing of addition wastewater treatment

Fluid dynamics analysis and pyrolysis of brewer’s spent grain in a spouted bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos A.s. Barrozo Lidja D.M.s. Borel Taísa s. Lira Carlos H. Ataíde school of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s spent grain (BsG) is a large-scale agroindustrial waste that could be more efficiently utilized. This waste is composed of lignocellulosic material and so may serve as a good source of biomass for thermochemical conversion. The present study investigated the fluid dynamics behavior of mixtures of sand and BsG in a spouted bed to assess the viability of the thermochemical conversion of this biomass via fast pyrolysis. Fluid dynamics analyses were performed while varying the mass fraction of BsG (6–80%) and the static bed height (6.6–13.4 cm). Empirical equations for predicting the minimum spouting conditions and the mixing index were obtained using a regression technique, and the selected fluid dynamics parameters were employed in the spouted bed pyrolysis. The bio-oil resulting from this process was rich in phenolic compounds, various nitrogenated compounds (representing precursors for pharmaceuticals) and long-chain hydrocarbons. The products obtained from the analytical and spouted bed pyrolysis processes were also compared.

关键词： Brewer’s spent grain Agroindustrial residue spouted bed Fast pyrolysis Particle mixing

simulation of Case Depth of Cementation steels According to Fick’s Laws

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Journal of Iron and steel Research International 2012年第11期19卷 71-78页

作者： s R Elmi Hosseini Faculty of Engineering Department of Materials Science and EngineeringUniversity of Sistan and Baluchestan

The carburizing process is the enrichment of the depth of low carbon steels with carbon. It leads to samples with a combination of high surface hardness and high core toughness and to an impact strength that is required for many engineering parts. The material studied is a low carbon steel. The carbon content is little in this type of steel （wc = 0.2 ~）. The calculation of case depth is very important for cementation steels that are hardened in the carburi- zing process. The effective case depth is defined as the perpendicular distance from the surface to a place at which the hardness is HV 550. Nowadays, a great number of studies have been carried out on the simulation of effective case depth, but no studies have been conducted to determine the numerical relation between the total case depth on one hand and the carburizing time and the effective case depth on the other hand. The steel specimens were subjected to graphite powder. Then, they were heat treated at 925 ~C for about 3, 5, 8 and 12 h, respectively. Then, these parts were quenched in oil. To determine the effective case depth, the micr0hardness test was performed on the cross-section of specimens. Plotting the case depth vs carburizing time, the required conditions for obtaining the specified case depth were determined. Also, the comparison between the case depths in numerical solution and the actual position in pack carburizing was performed.

关键词： cementation steel carburizing case depth Fick's law simulation