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A decision model for decentralized autonomous organization platform selection: Three industry case studies

Blockchain(Research and Applications) 2023年第2期4卷 82-100页

作者： E.Baninemeh s.Farshidi s.jansen Department of Information and Computer science Utrecht UniversityUtrechtthe Netherlands Department of software Engineering Lappeenranta University of TechnologyLappeenrantaFinland

Context:Decentralized autonomous organizations are a new form of smart contract-based *** autonomous organization platforms,which support the creation of such organizations,are becoming increasingly popular,such as Aragon and *** the best fitting platform is challenging for organizations,as a significant number of decision criteria,such as popularity,developer availability,governance issues and consistent documentation of such platforms,should be ***,decision-makers at the organizations are not experts in every domain,so they must continuously acquire volatile knowledge regarding such ***:supporting decision-makers in selecting the right decentralized autonomous organization platforms by designing an effective decision model is the main objective of this *** aim to provide more insight into their selection process and reduce time and effort significantly by designing a decision ***:This study presents a decision model for the decentralized autonomous organization platform selection *** decision model captures knowledge regarding such platforms and concepts *** model is based on an existing theoretical framework that assists software engineers with a set of multi-criteria decision-making problems in software ***:We conducted three industry case studies in the context of three decentralized autonomous organizations to evaluate the effectiveness and efficiency of the decision model in assisting *** case study participants declared that the decision model provides significantly more insight into their selection process and reduces time and ***:We observe in the empirical evidence from the case studies that decision-makers can make more rational,efficient,and effective decisions with the decision ***,the reusable form of the captured knowledge regarding decentralized autonomous organization platforms can be

关键词： Decentralized autonomous organization Decision model Multi-criteria decision making Decision support system Decentralized autonomous organization platform Case study research

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da silva Madeleen jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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The Association of Night shift Work with the Development of Breast Cancer in Women

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Open Journal of Epidemiology 2015年第1期5卷 14-21页

作者： P. I. J. Moukangoe M. s. jansen van Rensburg Independent Consultants Johannesburg South Africa

Breast cancer is a serious public health concern in south Africa and globally. It is estimated that one in seven south Africans will develop cancer in their lifetime. According to a case-controlled study, 80% of cancer cases are thought to be due to external, non-inherited factors, which could potentially have been prevented. The objectives of the current case-control study were: 1) to determine the relationship between night shift work and the development of breast cancer;2) to explore the relationship between night shift work and other types of cancer;3) to explore any difference between night shift work and breast cancer, and night shift work and other types of cancer. A total of 106 research participants were selected using non-probability, convenience sampling methods and interviewed using a structured questionnaire. seventy-two (68%) of the women who were interviewed were black, while 32% (n = 35) were white. Of the 106 research participants, 82% (n = 87) had a history of being employed, while 18% (n = 19) had never been employed. Analysed data showed that 29% (n = 31) of the women had a history of working night shift. Of the 31 research participants who reported having worked night shift, 90% (n = 28) had actually done rotating shift work, rather than regular night shift work. The odds ratio of working night shift was found to be 1.24 (OR = 1.24, p = 0.615) higher in breast cancer research participants compared to research participants diagnosed with other types of cancer—odds ratio of 0.80 (p = 0.610). For rotational work, the OR was 1.445, indicating a higher risk than for shift work. It is recommended that the relationship between working night shift and breast cancer risk be explored further through cross-sectional and cohort studies.

关键词： Breast Cancer Cancer Night shift Rotating shift Regular Night shift Parity Genetic Predisposition

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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女性正常乳腺组织的动态MR增强模式

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国际医学放射学杂志 2011年第5期 493-494页

作者： s.A.jansen M.L.Giger G.s.Karczmar G.M.Newstead 刘芳 Department of Radiology The University of Chicago5841 South Maryland AvenueMC 2026ChicagoIL 60637USA

目的本研究旨在探讨大样本无临床症状的妇女,在动态增强MRI(DCE-MRI)上正常乳腺组织的血流动力学、形态学特征以及与乳腺组织密度之间的相关性。方法本研

关键词：乳腺MRI 动力学正常筛查

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选择性单新鲜囊胚移植与先冻存随后移植均可提高年轻女性体外受精活产率并降低双胎妊娠率

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 23-24页

作者： Henman M Catt J.W Wood T. R.P.s. jansen 李跃萍 sydney IVF Box 4384 Sydney NSW 2001 Australia

To determine the extent to which embryo selection by blastulation and elective single blastocyst transfer, supported by efficient cryostorage of spare embryos, can reduce multiple pregnancies and maintain or improve on the live birth rate from IVF. Design: Prospective, nonrandomized cohort study. setting: sydney IVF, a private clinic in Australia. Patient(s): In vitro fertilization patients aged s with three or more usable blastocyst, recruited from April 2000 through December 2001, with pregnancies followed up until August 2004. Intervention(s): Blastocysts were cultured and cryostored with stage-specific culture medium and low oxygen conditions. Main Outcome Measure(s): Fetal heart-positive twin pregnancy rate and accumulating “ take-home baby” rate per retrieval leading to blastocyst transfer. Result(s): Among 121 women who elected single fresh blastocyst transfer (but who could elect to have two frozen blastocysts transferred at once), 79 (65.3% ) took home a baby, with a twin pregnancy rate of 7% . Among 285 women who chose two blastocysts for fresh transfer, 184 (64.2% ) took home at least one baby, with a twin pregnancy rate of 34% and five perinatal deaths. Conclusion(s): With technically appropriate blastocyst culture and freezing, and elective single blastocyst transfer in the fresh cycle, the overall multiple pregnancy rate can be reduced by > 75% , permitting in this series a slight increase in the chance of taking home a baby.

关键词：囊胚移植活产率体外受精双胎妊娠囊胚形成取卵受孕情况多胎妊娠胎心搏动低氧条件

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基于全病灶曲线分布数据对MRI首发乳腺肿物进行动力学熵评估:与标准的动力学分析进行比较

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国际医学放射学杂志 2015年第5期 508-509页

作者： A.shimauchi H.Abe D.V.schacht J.Yulei F.D.Pineda s.A.jansen 李倩 Department of Diagnostic Radiology Graduate School of MedicineTohoku University

摘要目的应用计算机辅助评价(CAE)获得全病灶的动力学分布数据,定量分析动态增强MRI首发乳腺肿物的动力学异质性,并与标准的动力学曲线分析进行比较。方法选择2006—2011年间由MRI首发的乳腺肿物,用CAE对临床MR影像进行评估。通过整个... 详细信息

摘要目的应用计算机辅助评价(CAE)获得全病灶的动力学分布数据,定量分析动态增强MRI首发乳腺肿物的动力学异质性,并与标准的动力学曲线分析进行比较。方法选择2006—2011年间由MRI首发的乳腺肿物,用CAE对临床MR影像进行评估。通过整个病灶内6种动力学模型(中等强化流入型、中等强化平台型、中等强化流出型、快速

关键词：乳腺肿物 MRI 恶性肿物病灶动力学进行

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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