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The role of gap junctions in cell death and neuromodulation in the retina

Neural Regeneration Research 2021年第10期16卷 1911-1920页

作者： Gergely Szarka marton Balogh Adam J.Tengolics Alma Ganczer Bela Volgyi Tamas Kovacs-Oller janos Szentagothai Research Centre University of PecsPecsHungary Retinal Electrical Synapses Research Group National Brain Research Program(NAP 2.0)Hungarian Academy of SciencesBudapestHungary Department of Experimental Zoology and Neurobiology University of PecsPecsHungary medical School University of PecsPecsHungary

Vision altering diseases,such as glaucoma,diabetic retinopathy,age-related macular degeneration,myopia,retinal vascular disease,traumatic brain injuries and others cripple many lives and are projected to continue to cause anguish in the foreseeable *** junctions serve as an emerging target for neuromodulation and possible regeneration as they directly connect healthy and/or diseased cells,thereby playing a crucial role in *** they are permeable for macromolecules,able to cross the cellular barriers,they show duality in illness as a cause and as a therapeutic *** this review,we take recent advancements in gap junction neuromodulation(pharmacological blockade,gene therapy,electrical and light stimulation)into account,to show the gap junction’s role in neuronal cell death and the possible routes of rescuing neuronal and glial cells in the retina succeeding illness or injury.

关键词： age-related macular degeneration bystander effect connexin diabetic retinopathy gap junction glaucoma neuromodulation retina retinal disease vision

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Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 927-934页

作者： ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel miklós Nyitrai Zsolt Biró Hajnalka Abrahám Department of Ophthalmology University of Pecs Medical School and Clinical CentrePecs 7623Hungary Department of Experimental Zoology and Neurobiology University of PecsPecs 7624Hungary Department of Biophysics University of Pecs Medical School and Clinical CentrePecs 7624Hungary janos Szentagothai Research Centre University of PecsPecs 7624Hungary Optimum Laser Centre Budapest 1124Hungary Gemini Eye Clinics Zlin 76001Czech Republic Department of medical Biology and Central Electron microscopic Laboratory University of Pecs Medical SchoolPecs 7624Hungary

AIm:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).mETHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by *** of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were *** order to map the actin network of cells,fluorescently labeled phalloidin was *** samples were examined using confocal laser scanning ***:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to *** CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological *** the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were *** FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were ***:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells.

关键词： lens epithelial cell cytoskeleton capsulotomy glial fibrillary acidic protein actin

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