检索结果-南通市图书馆

World Journal of Gastroenterology 2005年第37期11卷 5751-5756页

作者： Aron Altorjay Balazs Paal Nicolette Sohar janos Kiss Imre Szanto Istvan Sohar Department of Surgery Saint George University Teaching Hospital Székesfehérvár Seregélyesi u. 3. H-8000 Hungary Center for Advanced Biotechnology and Medicine UMDNJ Piscataway NJ USA National Medical Center Department of Surgery Budapest Szabolcs u.33-35. H-1135 Hungary

AIM： To establish whether there are fundamental differences in the biochemistries of adenocarcinomas of the gastroesophageal junction （GEJ） and the squamous cell carcinomas of the lower third of the esophagus （LTE）. METHODS： Between February 1, 1997 and February 1, 2000, we obtained tissue samples at the moment of resection from 54 patients for biochemical analysis. The full set of data could be comprehensively analyzed in 47 of 54 patients＇ samples （81%）. Of these, 29 were adenocarcinomas of the GEJ Siewert type Ⅰ （n = 8）, type Ⅱ （n = 12）, type Ⅲ （n = 9）, and 18 presented as squamous cell carcinomas of the LTE. We evaluated the mean values of 11-lysosomal enzyme and 1-cytosol protease activities of the tumorous and surrounding mucosae as well as their relative activities, measured as the ratio of activity in tumor and normal tissues from the same patient. These data were further analyzed to establish the correlation with tumor localization, TNM stage （lymph-node involvement）, histological type （papillary, signet-ring cell, tubular）, state of differentiation （good, moderate, poor）, and survival （≤24 or ≥24 mo）. RESULTS： In adenocarcinomas, the activity of α-mannosidase （AMAN）, cathepsin B （CB） and dipeptidyl-peptidase Ⅰ （DPP Ⅰ） increased significantly as compared to the normal gastric mucosa. In squamous cell carcinomas of the esophagus, we also found a significant difference in the activity of cathepsin L and tripeptidyl-peptidase Ⅰ in addition to these three. There was a statistical correlation of AMAN, CB, and DPP Ⅰ activity between the level of differentiation of adenocarcinomas of the GEJ and lymph node involvement,because tumors with no lymph node metastases histologically confirmed as well-differentiated, showed a significantly lower activity. The differences in CB and DPP Ⅰ activity correlated well with the differences in survival rates, since the CB and DPP Ⅰ values of those who died within 24 mo following surgical intervention were significantly higher tha

关键词： Prognostic value Lysosomal enzymes Cardiac adenocarcinomas Siewert classification Esophageal squamous cell carcinoma

Improved Culture Media for Embryogenic Callus Generation in Sorghum [Sorghum bicolor (L.) Moench]

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2020年第1期89卷 111-119页

作者： Paul Chege Andrea Palagyi Csaba Lantos Erzsebet Kiss janos Pauk Szent Istvan University Doctoral School of Plant ScienceGodolloPater K.u.1.H-2103Hungary Cereal Research Non-profit Ltd. Department of BiotechnologySzegedAlsokikotosor 9.H-6701Hungary

Many attempts on optimization of sorghum[Sorghum bicolor(L.)Moench]tissue culture induction media have been made,but the culture system remains with some bottlenecks compared to that of other *** study aimed at assessing the suitability of various induction media to produce embryogenic callus(yellow and friable)with high induction rates and reduced phenolic *** six culture medium modifications:3 based on Murashige and Skoog(MS)medium and one each based on Chu N6,Gamborg B5 and 190-2 media respectively were applied in the culture of mature embryos from 10 sorghum *** there was a genotype influence on the attainment of a yellow callus,friability of the callus was determined to be dependent on the culture medium and not the *** strength MS medium with 0.2 mg/l 2,4-D with 2.8 g/l Gelrite®as the gelling agent modified with 1.0 g/l KH_(2)PO_(4),1.0 g/l L-proline,1.0 g/l L-asparagine and 0.16 mg/l CuSO_(4)·5H_(2)O(type E)was found to be the most effective resulting in about 60%yellow coloured callus induction with 25%*** of CuSO_(4)·5H_(2)O,KH_(2)PO_(4),L-proline and L-asparagine significantly reduced the phenolic *** strength MS medium was observed to contribute to quality callus production when compared to full strength MS media modified with the *** half strength MS medium was also observed to suppress phenolic *** 190-2 produced the highest regeneration frequency(40%)among the 3-regeneration media *** results provide information on a suitable sorghum callus induction medium necessary for embryogenesis.

关键词： Sorghum medium embryogenic callus half-strength MS

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第10期11卷 1489-1495页

作者： Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci 1st Department of Medicine Laszlo Lakatos Department of Internal Medicine 4 2nd Department of Medicine Semmelweis University 2nd Department of MedicineSemmelweis UniversityBudapest:Laszlo PronaiAnnamaria NemethPal Miheller Erzsebet Hospital 1st Department of MedicineBudapest: Agota KovacsLaszlo Bene Szent janos Hospital 1st Department of Medicine:Gyorgy Szekely University of Pecs 1st Department of MedicinePecs:Beata Gasztonyi University of Szeged 1st Department of MedicineSzeged:Ferenc NagyJanos Lonovics Semmelweis Hospital 1st Department of MedicineMiskolc:Laszlo Ujszaszy University of Debrecen 2nd Department of MedicineDebrecen:Istvan AltorjaiKaroly Palatka Kenezi Gy. County Hospital 2nd Department of MedicineDebrecen: Gyula G. Kiss County Hospital 2nd Department of MedicineZalaegerszeg Ferenc Tarnok Markusovszky Hospital2nd Department of MedicineSzombathely:Zoltan Dobronte Csolnoky F. County Hospital 1st Department of MedicineVeszprem:Zsuzsanna ErdelyiTunde PandurGabor Mester

AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. RESULTS: NOD2/CARD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%,P<0.0001). SNP8/R702W (10.8% vs 6%, P= 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P= 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vs controls: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet=1.71, 95%CI=1.12-2.6, P= 0.0001, ORtwo-risk alleles = 25.2, 95%CI =4.37- ,P<0.0001), early disease onset (carrier: 26.4 years vs non-carrier: 29.8 years, P=0.0006), ileal disease (81.9% (?) 69.5%, OR = 1.99, 95%CI = 1.29-3.08, P= 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs 64.8%), stricturing behavior (OR = 1.69,95%CI = 1.13-2.55, P= 0.026) and increased need for resection (OR=1.71, 95%CI: 1.13-2.62, P= 0.01), but not with duration, extra-intestinal manifestations, familial disease or smoking. TLR4 exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P = 0.06), in NOD2mut/wt: 26.7 years. CONCLUSION: These results confirm that variant NOD2/ CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4 mutation carriers tended to present at earlier age.

关键词： Crohn's disease NOD2 CARD15 TLR4 Extraintestinal manifestation Phenotype

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不断改进轮对设计,适应国际市场需求

西铁科技 2014年第1期 51-53页

作者： Petr janos Rasim Zlma 宋文伟捷克Bonatrans集团公司

为保证诸如轮对这样关键安全构件设计的整体需要，欧洲制造标准经历了不断改进与完善的过程。这有助于欧洲供应商开拓车轴、车轮及轮对的国际市场。

关键词：国际市场需求构件设计轮对供应商欧洲

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

智能仪器(上)

仪表工业 1990年第6期 33-36页

作者： janos Sztipanovits 崔连德段剑弓美国田纳西州纳什维尔市Vanderbilt 大学

计算机技术的进步是推动仪器仪表工程发展的主要动力;目前,以人工智能为基础的软件方法为测量系统的设计人员提供了良好的机遇。本文着重探讨智能仪器的新功能及其设计、操作过程中的一般技术问题;由被测量对象的定性、定量模型和仪器... 详细信息

计算机技术的进步是推动仪器仪表工程发展的主要动力;目前,以人工智能为基础的软件方法为测量系统的设计人员提供了良好的机遇。本文着重探讨智能仪器的新功能及其设计、操作过程中的一般技术问题;由被测量对象的定性、定量模型和仪器本身构成的‘知识级’已经被证明是智能测量系统的最重要特征;同时还分析了知识级的一般结构及其实现方法。

关键词：智能仪器仪器

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

对Fields奖有非议吗？

数学译林 2015年第3期34卷 265-270页

作者： janos Kollar 李灵芝陆柱家普林斯顿大学不详

你会多么担心获得Fields（菲尔兹）奖可能会毁掉你的研究事业？这个问题似乎是荒唐的，但最近由两位经济学家George Borjas和Kirk Doran写的一篇文章[BD14]提出，这是我们——数学界和科学界应该考虑的一个问题．令人高兴的是，40岁以... 详细信息

你会多么担心获得Fields（菲尔兹）奖可能会毁掉你的研究事业？这个问题似乎是荒唐的，但最近由两位经济学家George Borjas和Kirk Doran写的一篇文章[BD14]提出，这是我们——数学界和科学界应该考虑的一个问题．令人高兴的是，40岁以上的读者们不必担心，但也许年轻的研究人员要认真对待这个问题．当然，Fields奖获得者如此之少，以至于被击中的可能性实际上几乎为零．然而，该奖也并非随机地乱碰．

关键词：经济学家研究人员获得者

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

络合平衡的分析应用

1987年

作者：（匈）亚诺什（janos I.）刘士斌译

本书据英译本《Analytical applications of complex equilibria》转译:本书著者原题无汉译名:书名原文∶Analytical applicatins of complex equilibria:本书以统一的处理方法讨论了络合平衡和其它平衡问题以及络合物稳定常数和质子化... 详细信息

ISBN: (纸本)7560100503

本书据英译本《Analytical applications of complex equilibria》转译:本书著者原题无汉译名:书名原文∶Analytical applicatins of complex equilibria:本书以统一的处理方法讨论了络合平衡和其它平衡问题以及络合物稳定常数和质子化常数的测定方法等。

关键词：络合滴定

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

中子束流相空间标定技术介绍

中子束流相空间标定技术介绍

第三届全国核技术与应用学术研讨会

作者：王姝驭李润东唐彬 janos Fuzi 中国工程物理研究院核物理与化学研究所

为了在中子射线装置调试与安装过程中了解上游部件或者中子源情况,应用中子束流相空间标定技术进行了相关的研究,通过采用二维位敏探测器,小孔与飞行时间装置相结合的办法,可以得到中子束流的发散、源强度分布以及上游部件的安装情况,...

为了在中子射线装置调试与安装过程中了解上游部件或者中子源情况,应用中子束流相空间标定技术进行了相关的研究,通过采用二维位敏探测器,小孔与飞行时间装置相结合的办法,可以得到中子束流的发散、源强度分布以及上游部件的安装情况,为下游部件的设计、安装与调试提供必要输入参数。实验装置如图1,主要包括三个主要部件:斩波器、带针孔的隔板与探测器。其中斩波器与探测器可以通过商业购买得到,而小孔装置是非标件,需要仔细考虑与设计。针孔的隔板制作材料用B比较好,细孔的直径在毫米量级,与斩波器距离不能超过20mm,在此范围内越近越好。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中子束流相空间标定技术研究

中子束流相空间标定技术研究