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小单孢菌产生的氨基糖苷类抗生素:化学与微生物学Ⅱ

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国外医药(抗生素分册) 1987年第6期 415-418页

作者： janos berdy ,廖福荣

Fortimicin型由日本协和发酵公司和美国阿波特实验室的研究人员共同发现的fortimicin型抗生素,是一组具有新型结构与作用方式的很有前途的氨基糖苷类。几年后,其它一些实验室也从不同的微生物中发现了类似的化合物。与全部由小单孢菌产... 详细信息

Fortimicin型由日本协和发酵公司和美国阿波特实验室的研究人员共同发现的fortimicin型抗生素,是一组具有新型结构与作用方式的很有前途的氨基糖苷类。几年后,其它一些实验室也从不同的微生物中发现了类似的化合物。与全部由小单孢菌产生的庆大霉素-西索米星型抗生素明显不同,fortimicin型假二糖是由一个脱氧氨糖(如:6-差向绛红糖胺-B)和一个定名为福提霉胺(Ⅲ)的1,4-二氨基环醇或其3,4-差向脱甲基-等衍生物组成,它们不仅由小单孢菌产生(fortimicins,lysinomycin等),而且亦可由链霉菌产生(sannamycins,istamycins),由糖多孢菌产生(sporaricins)及指孢囊菌产生(dacti-micins)。

关键词：庆大霉素生物合成艮他霉素生化反应碳水化合物氨基糖西索米星企业研究所工业实验室链霉菌微生物学抗生素阿司米星产生菌

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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近几年抗生素研究进展及其展望

国外医药(抗生素分册) 1981年第1期 14-28页

作者： janos berdy 蔡顺养匈牙利药物研究所抗生素化学结构分类学家

作者系国际知名的匈牙利药物研究所抗生素化学结构分类学家。目前流行的分类系统就以他的姓氏命名—— berdy系统。他设计的一套检索穿孔卡现已在美国国家癌症研究所协助下制成电子计算机软件。他编辑的十大册“抗生素手册”也即将出版... 详细信息

作者系国际知名的匈牙利药物研究所抗生素化学结构分类学家。目前流行的分类系统就以他的姓氏命名—— berdy系统。他设计的一套检索穿孔卡现已在美国国家癌症研究所协助下制成电子计算机软件。他编辑的十大册“抗生素手册”也即将出版。这篇综述是在国家医药管理总局赴匈医药考察组访问匈牙利药物研究所座谈时由作者推荐并亲自作介绍的。鉴于本文涉及范围较广,取材丰富,内容新颖并附有很多有价值的统计资料。现将全文译出以飨读者。

关键词：抗生素化学结构酞胺类动物饲料添加剂微生物界氨基糖碳水化合物研究进展

Non-crossing Quantile Regression Neural Network as a Calibration Tool for Ensemble Weather Forecasts

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Advances in Atmospheric Sciences 2024年第7期41卷 1417-1437页

作者： Mengmeng SONG Dazhi YANG Sebastian LERCH Xiang'ao XIA Gokhan Mert YAGLI Jamie M.BRIGHT Yanbo SHEN Bai LIU Xingli LIU Martin janos MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin150001China Heidelberg Institute for Theoretical Studies Schloss-Wolfsbrunnenweg 3569118HeidelbergGermany Chair of Statistical Methods and Econometrics Karlsruhe Institute of Technology(KIT)Bluecherstr.1776185KarlsruheGermany Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Solar Energy Research Institute of Singapore(SERIS) National University of Singapore(NUS)Singapore117574Singapore UK Power Networks LondonSE61NPUK China Meteorological Administration Beijing100081China Heilongjiang Meteorological Bureau Harbin150001China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111BudapestHungary

Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,*** such,forecast calibration tools have become *** those tools,quantile regression(QR)is highly competitive in terms of both flexibility and predictive ***,a long-standing problem of QR is quantile crossing,which greatly limits the interpretability of QR-calibrated *** this point,this study proposes a non-crossing quantile regression neural network(NCQRNN),for calibrating ensemble NWP forecasts into a set of reliable quantile forecasts without *** overarching design principle of NCQRNN is to add on top of the conventional QRNN structure another hidden layer,which imposes a non-decreasing mapping between the combined output from nodes of the last hidden layer to the nodes of the output layer,through a triangular weight matrix with positive *** empirical part of the work considers a solar irradiance case study,in which four years of ensemble irradiance forecasts at seven locations,issued by the European Centre for Medium-Range Weather Forecasts,are calibrated via NCQRNN,as well as via an eclectic mix of benchmarking models,ranging from the naïve climatology to the state-of-the-art deep-learning and other non-crossing *** and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the maximum sharpness subject to calibration,amongst all ***,the proposed conception to resolve quantile crossing is remarkably simple yet general,and thus has broad applicability as it can be integrated with many shallow-and deep-learning-based neural networks.

关键词： ensemble weather forecasting forecast calibration non-crossing quantile regression neural network CORP reliability diagram post-processing

Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis: Gastric tonometry revisited

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World Journal of Gastroenterology 2006年第30期12卷 4892-4896页

作者： Gabor C Kovacs Geza Telek janos Hamar Jozsef Furesz janos Regoly-Merei 3rd Department of Surgery Semmelweis University Budapest Hungary Department of Experimental Research National Institute of Traumatology Budapest Hungary Institute of Health Protection Hungarian Defense Forces Budapest Hungary

AIM： To evaluate whether multiple determinations of intramucosal pH （pHi） in acute pancreatitis （AP） patients could provide additional information of the disease severity during early hospitalization. METHODS： Twenty-one patients suffering from acute pancreatitis were monitored by gastric tonometry in the first 72 h after hospital admission. RESULTS： In the survivor group （n = 15） the initially low phi values returned to normal level （pHi ≥ 7.32） within 48 h （median pHi： d 1： 7.21; d 2： 7.32; d 3： 7.33）. In contrast, pHi values in the non-survivor group n = 6） were persistently either below or in the low normal range （median pHi 7.12; 7.12; 7.07 respectively）, but pHi differences between the two groups reached significance only after 24 h （P 〈 0.01）. Mucosal acidosis detected at any time during the monitored period was associated with the emergence of single or multiple organ dysfunction （P 〈 0.01）. CONCLUSION： Prolonged gastric mucosal acidosis was associated with remote organ dysfunction and failure in Acute Pancreatitis, however, correlation with the fatal outcome became significant only 24 h after admission. Due to its non-invasive nature gastric tonometry may supplement the pro-inflammatory markers to achieve a multi-faceted monitoring of the disease.

关键词： Acute pancreatitis Human studies Intramucosal pH Mucosal barrier dysfunction Septic complications Bacterial translocation Multiple organ dysfunction

Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing

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World Journal of Gastroenterology 2007年第19期13卷 2727-2732页

作者： janos Papp Marietta E Kovacs Edith Olah Department of Molecular Genetics National Institute of Oncology Rath Gy. u. 7-9 H-1122 Budapest Hungary

AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one ***: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population.

关键词： Germline mutation Hereditary non-polyposis colorectal cancer MLH1 MSH2 Rearrangement

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适用于放大自发辐射平滑光束的脉宽压缩方法

强激光与粒子束 2012年第6期24卷 1381-1384页

作者：向益淮汤秀章 S.Szatmari B.janos 中国原子能科学研究院高功率准分子激光实验室北京102413 Department of Experimental Physics University of Szeged

为了增加靶上的功率密度和耦合效率,基于饱和增益开关原理,发展了一种适用于放大自发辐射平滑光束的脉宽压缩方法。利用该方法,在赛格德大学的一台放电泵浦KrF准分子激光器上进行了实验,将该激光器输出的脉宽为14.5ns的放大自发辐射光... 详细信息

为了增加靶上的功率密度和耦合效率,基于饱和增益开关原理,发展了一种适用于放大自发辐射平滑光束的脉宽压缩方法。利用该方法,在赛格德大学的一台放电泵浦KrF准分子激光器上进行了实验,将该激光器输出的脉宽为14.5ns的放大自发辐射光束压缩到了7.5ns,并且保持了光束原有的均匀性。

关键词： KrF准分子激光放大自发辐射脉宽压缩光束均匀性

人体筋膜网络的综合研究能更好地了解中医治疗机制——2009年筋膜大会会议纪要(英文)

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中西医结合学报 2010年第2期8卷 199-200页

作者： janos PALHALMI 白宇原林 East-West Bio Medicine Ltd. 南方医科大学解剖学教研室广东广州510515

The second Fascia Congress was an interdisciplinary event, organized for promoting the connections between the societies of researchers and clinicians working in the field of alternative medicine and traditional Oriental medicine. The organizers and participants introduced several aspects of the connective tissue matrix or so called fascial network of the human and mammalian body related to integrative biomedical sciences.

关键词：人体筋膜中医治疗症状临床分析

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中子束流相空间标定技术介绍

核电子学与探测技术 2012年第12期32卷 1376-1379页

作者：王姝驭李润东唐彬 janos Fuzi 中国工程物理研究院核物理与化学研究所四川绵阳621900 匈牙利布达佩斯固体物理与光学研究所

为了在中子射线装置调试与安装过程中了解上游部件或者中子源情况,应用中子束流相空间标定技术进行了相关的研究,通过采用二维位敏探测器,小孔与飞行时间装置相结合的办法,可以得到中子束流的发散、源强度分布以及上游部件的安装情况,... 详细信息

为了在中子射线装置调试与安装过程中了解上游部件或者中子源情况,应用中子束流相空间标定技术进行了相关的研究,通过采用二维位敏探测器,小孔与飞行时间装置相结合的办法,可以得到中子束流的发散、源强度分布以及上游部件的安装情况,为下游部件的设计、安装与调试提供必要输入参数。

关键词：中子束流相空间二维位敏探测器小孔飞行时间