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Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography

International Journal of Ophthalmology(English edition) 2020年第7期13卷 1109-1114页

作者： Wen-Ying Fan Alan Fleming Gavin Robertson Akihito Uji jano van hemert Michael Singer Min Sagong Michael Ip SriniVas R.Sadda Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Sciences Key LaboratoryCapital Medical UniversityBeijing 100730China Doheny Image Reading Center Doheny Eye InstituteLos AngelesCA 90086USA Department of Ophthalmology David Geffen School of Medicine at UCLALos AngelesCA 90095USA Optos PLC Dunfermline KY118GRUnited Kingdom Department of Ophthalmology Medical Center Ophthalmology AssociatesSan AntonioTX 78258USA

AIM: To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field(UWF) fluorescein angiography(FA).METHODS: Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200 Tx. Images obtained at different gaze angles stereographically projected and montaged. The early-phase UWF FA frames were processed to segment the retinal vasculature and the results were exported as binary masks. The fractal dimension(FD) was calculated using the box-counting ***: The global FD for the entire retina was 1.6±0.04, with no difference between males and females(1.59±0.04 vs 1.61±0.04, P=0.084) or between right and left eyes(1.6±0.04 vs 1.6±0.05, P=0.61). FD was nonuniformly distributed among four quadrants(P0.05).CONCLUSION: Fractal geometry is non-uniformly distributed across the retina in normal eyes and decreases from the fovea to the far-periphery. Subjects with an older age tend to have a smaller FD, however, the FD in the farperiphery does not appear to be influenced by age.

关键词： fractal analysis retina ultra-wide field fluorescein angiography normal subject

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Influence of the Multispecies Probiotic Ecologic^(■) BARRIER on Parameters of Intestinal Barrier Function

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Food and Nutrition Sciences 2014年第18期5卷 1739-1745页

作者： Saskia van hemert Geline Ormel Research and Development Winclove Probiotics AmsterdamThe Netherlands

The intestinal epithelium is a single cell layer that forms the largest and most important barrier against the external environment. A proper functioning of the intestinal barrier is essential for maintaining optimal health. A disrupted intestinal barrier function has been associated with the development of autoimmune and inflammatory diseases. Probiotics are live microorganisms that confer a health benefit to the host and have been associated with prevention of diseases such as antibiotic-associated diarrhea, irritable bowel syndrome and inflammatory bowel disease. Probiotics can improve and restore the intestinal barrier function in diverse ways and effects are thought to be species- and even strain-specific. With this research the influence of probiotic bacteria in Ecologic? BARRIER on parameters of intestinal barrier function was investigated. The results show that each bacterial strain in Ecologic?BARRIER is in vitro capable to improve the epithelial barrier in diverse ways.

关键词： Probiotics Ecologic^(■) BARRIER Intestinal Barrier Function

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Clinical Studies Evaluating Effects of Probiotics on Parameters of Intestinal Barrier Function

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Advances in Microbiology 2013年第2期3卷 212-221页

作者： Saskia van hemert Jurre Verwer Burkhard Schütz Winclove Probiotics Amsterdam the Netherlands

The intestinal barrier is important in preventing translocation of bacteria, toxins and antigens from the lumen of the gut into the body. Enhanced permeability, or gut leakiness, has been associated with different diseases. Probiotics can, strain-specifically, improve the epithelial barrier function. However, so far most researches have used cell lines or animal models due to the difficulty of measuring the effects of products on the epithelial barrier function in vivo in humans. Here a systematic literature search was performed to find articles addressing the effects of probiotics on the barrier function in human trials. The Pubmed database was searched (January 2013) to identify human in vivo studies with probiotic products in which parameters for epithelial barrier function were measured. In total 29 studies were identified, but patients, bacterial characteristics and methods to measure intestinal barrier function caused large heterogeneity among these studies. About half of the studies showed positive results of probiotics on the epithelial barrier function, indicating a clear potential of probiotics in this field. In a case series of 14 patients using Ecologica825, a probiotic food supplement with known effect on epithelial barrier function, different markers of intestinal integrity improved significantly. Further studies in this field should consider strain(s), dose and duration of the probiotic supplementation as well as the markers used to measure epithelial barrier function. Besides the lactulose/mannitol test, zonulin and α1-antitrypsin might be valuable markers to measure epithelial barrier function in future experiments.

关键词： Bacteria Epithelial Barrier Gut Permeability Intestinal Barrier Function Intestinal Integrity Probiotics Review Vivo Studies

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一种用于去除医学影像资料身份验证的开放式工具包

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国际医学放射学杂志 2010年第5期 504-505页

作者： D.R.González T.Carpenter J.I.van hemert J.Wardlaw 尚全良 National e-Science Centre School of InformaticsUniversity of Edinburgh

关键词：医学数字影像传输隐私权资料保护行动去除身份识别匿名工具包假名

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