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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 947-951页

作者： Matheus Dellamea Baldissera Nathieli Bianchin Bottari Thirssa Helena Grando Roberto Christ Vianna Santos Ana Julia Figueiro Dalcin Patrfcia Gomes Renata Platcheck Raffin Carine Eloise Prestes Zimmerman janio morais santurio Silvia Gonzalez Monteiro Aleksandro Schafer Da Silva Department of Microbiology and Parasitology Universidade Federal de Santa Maria(UFSM) Laboratory of Microbiology Centro Universitdrio Franciscano Laboratory of Nanotechnology Centro Universitdrio Franciscano Department of Animal Science Universidade do Estado de Santa Catarina(UDESC)

Objective:To verify the trypanocidal effectiveness of aescin and aescin liposomes against Trypanosoma evansi in vitro and in ***:Aescin and aescin liposomes were used in vitro on trypomastigotes at different concentrations(0.5%,1.0%and 2.0%) and exposure times(0,1,3,6 and 9 h).In vivo tests were performed using mice as the experimental *** evansi infected mice were treated with aescin and aescin liposomes with doses of 60 and 100 mg/kg during 4 ***:The three concentrations tested in free form and nanoencapsulated showed trypanocidal activity in vitro,completely eliminating the parasites in small concentration after6 h of *** treated with aescin(100 mg/kg) and aescin liposomes(100 mg/kg)showed increase in longevity,however without curative ***:Active compounds present in natural products,such as aescin,may potentiate the treatment of trypanosomosis when used in association with other trypanocidal drugs.

关键词： Surra Nanotechnology Aesculus hippocastanum Trypanosome

Update on pythiosis immunobiology and immunotherapy

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World Journal of Immunology 2014年第2期4卷 88-97页

作者： érico S Loreto Juliana SM Tondolo Régis A Zanette Sydney H Alves janio M santurio Department of Microbiology and Parasitology Universidade Federal de Santa Maria Programa de Pós-graduacao em Ciências Farmacêuticas Universidade Federal de Santa Maria

Pythiosis is an invasive, ulcerative, pyogranulomatous disease caused by Pythium insidiosum, a fungus-like oomycete that has been reported to affect humans, horses, dogs, and other mammals mainly in tropical and subtropical areas of the world. The disease is characterized by an eosinophilic granulomatous and a Th2 immune response which in turn helps to protect the fungus from the host cells. Pythiosis can present clinically in subcutaneous, gastrointestinal, and vascular tissues or in a systemically disseminated form depending on the species and site of infection. Changes in iron metabolism and anemia are commonly observed. The diagnosis is accomplished through clinical and pathological features, laboratory characteristics of cultures, serological and molecular tests. Treatment includes radical surgery, antimicrobial drugs, immunotherapy or a combination of these treatments. Immunotherapy is a practical and non-invasive alternative for treating pythiosis which is believed to promote a switch from a Th2 to Th1 immune response, resulting in a favorableclinical response. This therapy has demonstrated cure rates above 70% and 55% in horses and humans but low cure rates in dogs and cats. Despite the curative properties of this type of immunotherapy, the antibodies that are produced do not prevent host reinfection. Thus, development of effective adjuvants and new diagnostic techniques for early disease diagnosis are of utmost importance. The aim of this review was to promote pythiosis awareness and to provide an update about the immunotherapy and immunobiology of this disease.

关键词： Pythium insidiosum Treatment Pythiosis Immunotherapy Pathogenesis

Magnetic resonance imaging:Review of imaging techniques and overview of liver imaging

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World Journal of Radiology 2010年第8期2卷 309-322页

作者： Santhi Maniam janio Szklaruk Department of Diagnostic Radiology University of Texas M.D.Anderson Cancer CenterHoustonTX 77030United States

Magnetic resonance imaging(MRI) of the liver is slowly transitioning from a problem solving imaging modality to a first line imaging modality for many diseases of the *** well established advantages of MRI over other cross sectional imaging modalities may be the basis for this *** advancements in MRI that focus on producing high quality images and fast imaging,increasing diagnostic accuracy and developing newer function-specific contrast agents are essential in ensuring that MRI succeeds as a first line imaging *** imaging techniques,such as parallel imaging,are widely utilized to shorten scanning *** weighted echo planar imaging,an adaptation from neuroimaging,is fast becoming a routine part of the MRI liver protocol to improve lesion detection and characterization of focal liver *** enhanced dynamic T1 weighted imaging is crucial in complete evaluation of diseases and the merit of this dynamic imaging relies heavily on the appropriate timing of the contrast *** techniques that include fluorotriggered contrast enhanced MRI,an adaptation from 3D MRA imaging,are utilized to achieve good bolus timing that will allow for optimum *** accurate interpretation of liver diseases,good understanding of the newer imaging techniques and familiarity with typical imaging features of liver diseases are *** this review,MR sequences for a time efficient liver MRI protocol utilizing newer imaging techniques are discussed and an overview of imaging features of selected common focal and diffuse liver diseases are presented.

关键词： Magnetic resonance imaging Liver Oncology Contrast agents

Extrahepatic biliary cancer:New staging classification

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World Journal of Radiology 2012年第8期4卷 345-352页

作者： Dhakshinamoorthy Ganeshan Fanny E Moron janio Szklaruk Department of Diagnostic Radiology Division of Diagnostic ImagingThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Diagnostic Radiology Baylor College of MedicineHoustonTX 77030 United States

Tumor staging defines the point in the natural history of the malignancy when the diagnosis is made. The most common staging system for cancer is the tumor, node, metastases classification. Staging of cancers provides useful parameters in the determination of the extent of disease and prognosis. Cholangiocarcinoma are rare and refers to cancers that arise from the biliary epithelium. These tumors can occur anywhere along the biliary tree. These tumors have been previously divided into extrahepatic and intrahepatic lesions. Until recently the extrahepatic bile duct tumors have been considered as a single entity per American Joint Com- mission on Cancer (AJCC) staging classification. The most recent changes to the AJCC classification of bile duct cancers divide the tumors into two major catego- ries: proximal and distal tumors. This practical classifi- cation is based on anatomy and surgical management. High quality cross-sectional computed tomography (CT) and/or magnetic resonance (MR) imaging of the abdomen are essential information to accurately stage this tumors. Imaging plays an important role in diag-nosis, localization, staging and optimal management of cholangiocarcinoma. For example, it helps to localize the tumor to either perihilar or distal bile duct, both of which have different management. Further, it helps to accurately stage the disease and identify the presence of significant nodal and distant metastasis, which may preclude surgery. Also, it helps to identify the extent of local invasion, which has a major impact on the management. For example, extensive involvement of hepatic duct reaching up to second-order biliary radi- cals or major vascular encasement of portal vein or hepatic arteries precludes curative surgery and patient may be managed by palliative therapy. Further, imag- ing helps to identify any anatomical variations in the hepatic arterial or venous circulation and biliary ductal system, which is vital information for surgical planning. Th

关键词： American Joint Commission on Cancer Stag- ing Bile duct tumors Computed tomography Magnetic resonance

Can imaging patterns of neuroendocrine hepatic metastases predict response yttruim-90 radioembolotherapy?

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World Journal of Radiology 2013年第6期5卷 241-247页

作者： Julia Neperud Armeen Mahvash Naveen Garg Ravi Murthy janio Szklaruk Department of Diagnostic Radiology Division of Diagnostic Imaging University of Texas MD Anderson Cancer CenterHouston TX 77030 United States

AIM:To evaluate the response to treatment in patients with neuroendocrine tumor liver metastases following yttrium-90 ( 90 Y) radioembolotherapy, as a function of image patterns at presentation for 90 Y radioembolotherapy. METHODS: The study cohort consisted of patients with hepatic metastatic neuroendocrine tumors treated with 90 Y at our institution during a two-year time period. Hepatic metastases were evaluated on a pretherapy study assessing relative arterial enhancement compared to liver, lesion size, necrosis of the lesion, and associated tumor burden in the liver. We used six response criteria: Response Evaluation Criteria in Solid Tumors (RECIST) size, World Health Organization (WHO) size, European Association for the Study of the Liver (EASL) necrosis guidelines, Choi size, Choi necrosis and combination of Choi size and necrosis. RESULTS: About 65 lesions in 17 patients met study criteria and formed the cohort. Statistically significant response was found for lesions < 5 cm vs those ≥5 cm with RECIST (P = 0.04), WHO (P = 0.002) and combined Choi criteria (P = 0.02). Hyperenhancing lesions demonstrated greater response only with the Choi size criteria (P = 0.04). Lesions with ≤ 50% necrosis on the pre-scan had statistically significant greater response with the Choi necrosis criteria (P = 0.01). There was no statistical significance for response comparing lesions < 2 cm vs ≥ 2 cm or in comparing the degrees of tumor burden. CONCLUSION: Based on our findings in this study, it is suggested that initial imaging findings, as listed above, are not a good predictor of response to 90 Y radioembolization.

关键词： Yttrium-90 radioembolization Computed tomography Response Neuroendocrine Metastases Liver Predictor

Gd-EOB-DTPA based magnetic resonance imaging for predicting liver response to portal vein embolization

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World Journal of Radiology 2017年第4期9卷 199-205页

作者： janio Szklaruk Gustavo Luersen Jingfei Ma Wei Wei Michelle Underwood Department of Diagnostic Radiology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Hospital Moinhos de Vento Rua Goncalo de CarvalhoPorto AlegreRS 90035-170Brazil

AIM To evaluate the correlation between degree of kinetic growth(k GR) of the liver following portal vein embolization(PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the *** Seventeen patients were consented for the prospective *** patients had an MR of the abdomen with *** patients underwent *** correlation between the kG R of the liver and the degree of enhancement was evaluated with linear regression(strong assumptions) and Spearman's correlation test(rank based,no assumptions).The correlation was examined for the whole liver,segments I,VIII,VII,VI,V,IV,right liver and left *** There was no correlation between the degree of enhancement during the hepatobiliary phase and kG R for any segment,lobe of the liver or whole liver(P = 0.19 to 0.91 by Spearman's correlation test).CONCLUSION The relative enhancement of the liver during the hepatobiliary phase with Gd-EOB-DTPA cannot be used to predict the liver response to PVE.

关键词： Gd-EOB-DTPA Liver magnetic resonance imaging Portal vein embolization Resection Kinetic growth

Comparison of free breathing and respiratory triggered diffusion-weighted imaging sequences for liver imaging

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World Journal of Radiology 2019年第11期11卷 134-143页

作者： janio Szklaruk Jong Bum Son Wei Wei Priya Bhosale Sanaz Javadi Jingfei Ma Department of Diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Biostatistics The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Diffusion-weighted imaging(DWI)has become a useful tool in the detection,characterization,and evaluation of response to treatment of many cancers,including malignant liver *** offers higher image contrast between lesions and normal liver tissue than other *** images acquired at two or more b-values can be used to derive an apparent diffusion coefficient(ADC).DWI in the body has several technical *** include ghosting artifacts,mis-registration and susceptibility *** DWI sequences have been developed to overcome some of these *** goal is to evaluate 3 new DWI sequences for liver *** To qualitatively and quantitatively compare 3 DWI sequences for liver imaging:free-breathing(FB),simultaneous multislice(SMS),and prospective acquisition correction(PACE).METHODS Magnetic resonance imaging(MRI)was performed in 20 patients in this prospective *** MR study included 3 separate DWI sequences:FB-DWI,SMS-DWI,and *** image quality,mean ADC,standard deviations(SD)of ADC,and ADC histogram were *** signed-rank tests were used to compare qualitative image quality.A linear mixed model was used to compare the mean ADC and the SDs of the ADC *** tests were 2-sided and P values of<0.05 were considered statistically *** There were 56 lesions(50 malignant)evaluated in this *** mean qualitative image quality score of PACE-DWI was *** was significantly better than that of SMS-DWI(4.22)and FB-DWI(3.15)(P<0.05).Quantitatively,the mean ADC values from the 3 different sequences did not significantly differ for each liver ***-DWI had a markedly higher variation in the SD of the ADC values than did SMS-DWI and *** found statistically significant differences in the SDs of the ADC values for FB-DWI vs PACE-DWI(P<0.0001)and for FB-DWI vs SMS-DWI(P=0.03).The SD of the ADC values was not statistically significant for PACE-DWI and SMS-DWI(P=0.18).The quality

关键词： Diffusion Magnetic resonance imaging Liver Apparent diffusion coefficient Prospective acquisition correction Multi-slice

Advances in Health Promotion for People with Disabilities and the Laws of Brazil

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Health 2014年第18期6卷 2365-2374页

作者： Luciana Vieira de Carvalho Aline Cruz Esmeraldo Afio janio Cavalcanti Rodrigues Cristiana Brasil de Almeida Reboucas Lorita Marlena Freitag Pagliuca Department of Nursing Universidade Federal do CearáFortalezaBrazil

Brazilian laws guarantee the protection to the rights of the citizenship of people with disabilities and their participation in various social sectors which influence health promotion. One aimed at reflecting about the health promotion actions contemplated in Brazilian laws directed to people with physical, hearing and visual disabilities. Through the website of the National Secretariat for the Promotion of the Rights of People with Disabilities, one selected 14 laws whose content was articulated to the Health Promotion Charts in the process of discussion. The laws had as their main objective, the accessibility of people with disabilities to urban spaces, health, income, education, transportation and leisure, i.e. to public services that are essential for the establishment of health. It is concluded that there was a progress in the elaboration of laws that guarantee the rights and integration of this population. However, it is observed that the non-compliance of the laws makes the promotion of health impossible.

关键词： People with Disabilities Health Promotion Legislation

Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T

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World Journal of Radiology 2016年第7期8卷 707-715页

作者： Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis janio Szklaruk Department of Diagnostic Radiology the University of Texas MD Anderson Cancer Center Department of Biostatistics the University of Texas MD Anderson Cancer Center Department of Imaging Physics the University of Texas MD Anderson Cancer Center

AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE.

关键词： Liver magnetic resonance imaging Radial imaging Free-breathing magnetic resonance acquisition

Evaluation of Quality Care for Senior Citizens in Primary Health Care

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Health 2015年第9期7卷 1069-1074页

作者： Tainara Lorena dos Santos Ferreira Tiago Jose Barbosa de Andrade janio Gustavo Barbosa Iris do Ceu Clara Costa Fábia Barbosa de Andrade Nursing Faculty of Health Sciences of Trairi(FACISA)Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil University Center of Joao Pessoa(UNIPe) Joao PessoaBrazil Developer of Virtual Environments Federal University of Rio Grande do Norte(UFRN)NatalBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil

Objective: This study aimed to evaluate the quality care received by senior citizens in Primary Health Care (PHC) in the Unified Health System, with the objectives of contributing with the comprehensive implementation of humanized conduct and actions for this part of the population. Methods: This is a descriptive-exploratory study with a quantitative approach that was conducted in the city of Santa Cruz, which is located in the Brazilian state of Rio Grande do Norte, with a population of 130 senior citizens. The research was approved by the Committee for Ethics in Research at the Federal University at Rio Grande do Norte under protocol 152/2012. Results: In the results, the classification of the PHC services varied from good to reasonable. Regarding the assistance offered to the aging and comprehensive care, there were failures in accordance with how it’s recommended in the National Healthcare System. This concludes, through the perspective of the elderly user, the need for the reformulation of the activities which are offered to this population and therefore the implementation of conduct for better service in the area of Primary Health Care.

关键词： Quality of Life Health of the Elderly Nursing