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Risk factors for endophthalmitis after cataract surgery in diabetic patients: a case control study

International Journal of Ophthalmology(English edition) 2019年第3期12卷 417-423页

作者： Sukhum Silpa-archa Apichaya Papirachnart Panisa Singhanetr janine m preble Department of Ophthalmology Faculty of Medicine Rajavithi Hospital Rangsit University Wayne State University School of medicine

AIm: To identify risk factors associated with post-cataract surgery endophthalmitis(PCE) in type 2 diabetic ***: A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic patients undergoing cataract surgery in Rajavithi Hospital from January 2007 to December 2015. Fifteen patients with PCE were included as the case group and 179 patients without PCE were included as the control group. Potential factors associated with PCE among both groups including demographics, pre-operative characteristics, surgical settings and complications, were statistically analyzed using Chi-square testing and a logistic regression ***: Within the case group, 53% were females and the median age was 68 y. Univariate analysis of pre-operative characteristics, surgical settings and complications revealed that recent pre-operative fasting plasma glucose, insulin therapy, presence of diabetic retinopathy, and severe non-proliferative or proliferative diabetic retinopathy were significantly associated with PCE. In a multivariate analysis adjusting for blood glucose level, insulin treatment was the only significant factor associated with an increased risk of PCE(OR 3.9, 95%CI 1.0-15.0, P=0.04) compared to patients without insulin treatment. The most common causative organisms were gram-positive bacteria(89%). Staphylococcus species represented the most common group(67%). median best corrected visual acuity at 1-month and 3-month follow-up was equal at 0.7 logmAR(20/100).CONCLUSION: The authors identify insulin treatment as the only risk factor associated with endophthalmitis after cataract surgery in type 2 diabetic patients. Further studies with serum levels of pre-operative glycated hemoglobin(HbA_(1c)) and post-operative fasting plasma glucose level are essential to truly demonstrate the role of peri-operative glycemic markers as a risk factor for PCE.

关键词： endophthalmitis cataract surgery diabetic patients insulin fasting plasma glucose

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Poor prognostic factors in post-traumatic endophthalmitis following open globe injury

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1968-1975页

作者： Sukhum Silpa-archa Akkaranisorn Dejkong Kwanchanoke Kumsiang Peranut Chotcomwongse janine m preble C.Stephen Foster Department of Ophthalmology Faculty of MedicineRajavithi HospitalRangsit UniversityBangkok 10400Thailand Department of Ophthalmology Kresge Eye Institute Wayne State University School of MedicineDetroitMichigan 48201USA massachusetts Eye Research and Surgery Institution Massachusetts 02451USA Ocular Immunology&Uveitis Foundation WalthamMassachusetts 02451USA Harvard medical School BostonMassachusetts 02115USAWalthamMassachusetts 02451USABostonMassachusetts 02115USA

AIm:To demonstrate prognostic factors for poor visual outcome in patients with post-traumatic endophthalmitis(PTE)following open globe ***:A retrospective study was conducted on 66 patients(66 eyes)with PTE following open globe injury from 2005 to *** factors accounting for good and poor visual outcome were statistically analyzed by Chisquare test and Logistic regression ***:In 66 cases,39 cases(59%)had a poor visual *** and multivariate Logistic regression analysis identified retained intraocular foreign body(IOFB)as the only factor significantly associated with poor visual outcome[adjusted odds ratio,4.62;95%confidence interval(1.04-20.53);P=0.04].The most common causative agents were gram-positive organisms(83%),of which Bacillus cereus(33%),was the most common *** cases received intravitreal antibiotic *** ciprofloxacin was the most used systemic antibiotic(33%).Pars plana vitrectomy was performed in 83%(55/66)of *** 6 mo follow-up,mean BCVA was 1.74±0.72 log mAR ***:In patients with PTE following open globe injury,the only predictor of poor visual outcome is the presence of *** cereus is the most isolated microorganism.

关键词： post-traumatic endophthalmitis open globe injury intraocular foreign body

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Intrahepatic cholangiocarcinoma: Introducing the preoperative prediction score based on preoperative imaging

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 262-270页

作者： Fabian Bartsch Felix Hahn Lukas müller janine Baumgart maria Hoppe-Lotichius Roman Kloeckner Hauke Lang Department of General Visceral and Transplant SurgeryUniversity Medical Center of the Johannes Gutenberg-University MainzLangenbeckst155131 MainzGermany Department of Diagnostic and Interventional Radiology University Medical Center of the Johannes Gutenberg-University MainzLangenbeckst155131 MainzGermany

Background: Intrahepatic cholangiocarcinoma(ICC) still has a poor long-term outcome, even after complete resection. We investigated different parameters gathered in preoperative imaging and analyzed their influence on resectability, recurrence, and survival. methods: All patients who underwent exploration due to ICC between January 2008 and June 2018 were analyzed retrospectively. Kaplan-meier model, log-rank test and Cox regression were used. Results: Out of 184 patients, 135(73.4%) underwent curative intended resection. median overall survival(OS) was 22.2 months with a consecutive 1-, 3-and 5-year OS of 73%, 29%, and 17%. median recurrencefree survival(RFS) was 9.3 months with a consecutive 1-, 3-and 5-year RFS of 36%, 15%, and 11%. Site of tumor, parenchymal localization, tumor configuration/dissemination, and estimated tumor volume had significant influence on resectability. Univariate analyses showed that site of tumor, tumor configuration/dissemination, number of nodules, and estimated tumor volume had predictive values for OS and RFS. Together with tumor size the preoperative prediction(POP) score was created showing significance for OS and RFS(all Pmultivariate analysis, POP score(HR=1.779;95% CI: 1.26 8-2.4 95;P=0.001), T stage(HR=1.255;95% CI: 1.040-1.514;P=0.018) and N stage(HR=1.334;95% CI: 1.081-1.645;P=0.007) were the independent predictors for OS. For RFS, POP score(HR=1.733;95% CI: 1.30 0-2.311;Pm stage(HR=3.036;95% CI: 1.376-6.697;P=0.006) were the independent predictors. Conclusions: The POP score showed to have a highly significant influence on OS and RFS. The score is easy to assess through preoperative imaging. For patients in the high risk group at least staging laparoscopy or preoperative chemotherapy should be evaluated, because they showed equal outcome compared to the irresectable group.

关键词： Intrahepatic cholangiocarcinoma Cholangiocarcinoma Liver surgery Preoperative imaging Survival

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Cholesterol crystal embolism leading to perforation of the gallbladder

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 653-655页

作者： janine Tappenden Simon K. Suvarna Roger Ackroyd Badri m. Shrestha Northern General Hospital Herries Road Sheffield S5 7AU UK

BACKGROUND: Cholesterol crystal embolism (CCE) from atherosclerotic arterial disease leading to perforation of the gallbladder is rare. We describe our experience of managing a patient with perforation of gallbladder caused by CCE. mETHODS: A 64-year-old man was admitted to this hospital because of acute abdominal pain with clinical features suggestive of peritonitis. He was known to suffer from atherosclerotic peripheral arterial disease and had undergone aortobifemoral bypass 17 years ago. A CT scan showed a collection of peri-hepatic fluid. The gallbladder was normal in appearance but contained multiple calculi. At laparotomy, free bile was observed in the peritoneal cavity, leaking from a pin-hole size peroration of the fundus of the gallbladder. Hence cholecystectomy was performed. RESULTS: The patient made an uneventful recovery. Histological study of the gallbladder showed chronic cholecystitis and obliteration of the lumen of the mural arteries with cholesterol crystals within, indicating CCE. CONCLUSIONS: Although perforation of the gallbladder following CCE of its mural arteries is rare, the diagnosis should be considered in patients with abdominal pain and known atherosclerotic arterial disease. management should include an early recognition of this condition, prompt institution of treatment, prevention of further insults by discontinuing or avoiding predisposing factors, and modification of cardiovascular risk factors.

关键词： cholesterol crystal embolism perforation gallbladder peritonitis

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Real-world treatment attrition rates in advanced esophagogastric cancer

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World Journal of Gastroenterology 2020年第39期26卷 6027-6036页

作者： Erica S Tsang Howard J Lim Daniel J Renouf janine m Davies Jonathan m Loree Sharlene Gill Department of medicine BC CancerVancouver V5Z 4E6Canada Division of medical Oncology University of British ColumbiaVancouver V5Z 4E6Canada

BACKGROUND Over the last decade,multiple agents have demonstrated efficacy for advanced esophagogastric cancer(EGC).Despite the availability of later lines of therapy,there remains limited real-world data about the treatment attrition rates between lines of *** To characterize the use and attrition rates between lines of therapy for patients with advanced *** We identified patients who received at least one cycle of chemotherapy for advanced EGC between July 1,2017 and July 31,2018 across six regional centers in British Columbia(BC),***,treatment,and outcomes data were *** Of 245 patients who received at least one line of therapy,median age was 66 years(IQR 58.2-72.3)and 186(76%)were male,Eastern Cooperative Oncology Group(ECOG)performance status 0/1(80%),gastric vs GEJ(36%vs 64%).Histologies included adenocarcinoma(78%),squamous cell carcinoma(8%),and signet ring(14%),with 31%HER2 positive.72%presented with de novo disease,and 25%had received previous *** was a high level of treatment attrition,with patients receiving only one line of therapy n=122,50%),two lines n=83,34%),three lines n=34,14%),and four lines n=6,2%).Kaplan-meier analysis demonstrated improved survival with increasing lines of therapy(median overall survival 7.7 vs 16.6 vs 22.8 vs 40.4 mo,Pmultivariable Cox regression,improved survival was associated with better baseline ECOG and increased lines of therapy(Pmet need for more efficacious early-line treatment options for patients with advanced EGC.

关键词： Esophagogastric cancer Gastric cancer Treatment attrition Systemic therapy Treatment outcomes Real-world evidence

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A Quadrature-Based Kinetic model for Dilute Non-Isothermal Granular Flows

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Communications in Computational Physics 2011年第6期10卷 216-252页

作者： Alberto Passalacqua janine E.Galvin Prakash Vedula Christine m.Hrenya Rodney O.Fox Department of Chemical and Biological Engineering Iowa State UniversityAmesIA 50011-2230USA United States Department of Energy National Energy Technology Laboratory MorgantownWV 26507-0880USA School of Aerospace and mechanical Engineering University of OklahomaNormanOK 73019-0601USA Department of Chemical and Biological Engineering University of ColoradoBoulderCO 80309-0424USA.

A moment method with closures based on Gaussian quadrature formulas is proposed to solve the Boltzmann kinetic equation with a hard-sphere collision kernel for mono-dispersed *** orders of accuracy in terms of the moments of the velocity distribution function are considered,accounting for moments up to seventh ***-based closures for four different models for inelastic collisionthe Bhatnagar-Gross-Krook,ES-BGK,the maxwell model for hard-sphere collisions,and the full Boltzmann hard-sphere collision integral-are derived and *** approach is validated studying a dilute non-isothermal granular flow of inelastic particles between two stationary maxwellian *** obtained from the kinetic models are compared with the predictions of molecular dynamics(mD)simulations of a nearly equivalent system with finite-size *** influence of the number of quadrature nodes used to approximate the velocity distribution function on the accuracy of the predictions is *** for constitutive quantities such as the stress tensor and the heat flux are provided,and show the capability of the quadrature-based approach to predict them in agreement with the mD simulations under dilute conditions.

关键词： Kinetic equation quadrature-based moment method granular gas collision integral BGK-type model

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High-throughput computational discovery of In_(2)mn_(2)O_(7) as a high Curie temperature ferromagnetic semiconductor for spintronics

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npj Computational materials 2019年第1期5卷 529-535页

作者： Wei Chen janine George Joel B.Varley Gian-marco Rignanese Geoffroy Hautier Institute of Condensed matter and Nanoscicence(ImCN) Universitécatholique de Louvain1348 Louvain-la-NeuveBelgium Lawrence Livermore National Laboratory LivermoreCA 94550USA

materials combining strong ferromagnetism and good semiconducting properties are highly desirable for spintronic applications(e.g.,in spin-filtering devices).In this work,we conduct a search for concentrated ferromagnetic semiconductors through highthroughput computational *** screening reveals the limited availability of semiconductors combining ferromagnetism and a low effective *** identify the manganese pyrochlore oxide In_(2)mn_(2)O_(7) as especially promising for spin transport as it combines low electron effective mass(0.29m0),a large exchange splitting of the conduction band(1.1 eV),stability in air,and a Curie temperature(about 130 K)among the highest of concentrated ferromagnetic *** rationalise the high performance of In_(2)mn_(2)O_(7) by the unique combination of a pyrochlore lattice favouring ferromagnetism with an adequate alignment of O–2p,mn–3d,and In–5s forming a dispersive conduction band while enhancing the Curie temperature.

关键词： temperature ferromagnetic semiconductors

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A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

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Burns & Trauma 2018年第2期6卷 129-139页

作者： janine m.Duke Sean m.Randall James H.Boyd mark W.Fear Suzanne Rea Fiona m.Wood Burn Injury Research Unit Faculty Health and Medical SciencesThe University of Western AustraliaPerthWAAustralia Centre for Data Linkage Curtin UniversityPerthWAAustralia Burns Service of Western Australia Fiona Stanley Hospital and Princess Margaret HospitalPerthWAAustralia.

Background: Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data. methods: A retrospective longitudinal study using linked health data of all patients admitted with burns in Western Australia (n = 30,997), 1980–2012, and age and gender frequency matched cohorts of people with non-burn trauma (n = 28,647) and no injury admissions (n = 123,399). Analyses included direct standardisation, negative binomial regression and Cox proportional hazards regression. Results: Annual age-standardised infectious disease admission rates were highest for the burn cohort, followed by the non-burn trauma and uninjured cohorts. Age-standardised admission rates by decade showed different patterns across major categories of infectious diseases, with the lower respiratory and skin and soft tissue infections the most common for those with burns and other open trauma. Compared with the uninjured, those with burns had twice the admission rate for infectious disease after discharge (incident rate ratio (IRR), 95% confidence interval (CI): 2.04, 1.98–2.11) while non-burn trauma experienced 1.74 times higher rates (95%CI: 1.68–1.81). The burn cohort experienced 10% higher rates of first-time admissions after discharge when compared with the non-burn trauma (hazard ratio (HR), 95%CI: 1.10, 1.05–1.15). Compared with the uninjured cohort, incident admissions were highest during the first 30 days after discharge for burns (HR, 95%CI: 5.18, 4.15–6.48) and non-burn trauma (HR, 95%CI: 5.06, 4.03–6.34). While incident rates remained high over the study period, the magnitude decreased with increasing time from discharge: burn vs uninjured: HR, 95%CI: 30 days to 1 year: 1.69, 1.53–1.87;1 to 10 years: 1.40, 1.33–1.47;10 years to end of study period: 1.16, 1.08–1.24;non-burn trauma vs uninjured: HR, 95%CI: 30 days to 1 year: 1.71, 1.55–1.90;

关键词： Burn Non-burn trauma No injury Infectious diseases Cohort Population-based

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Counting Steps in Research: A Comparison of Accelerometry and Pedometry

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Open Journal of Preventive medicine 2011年第1期1卷 1-7页

作者： melody Oliver Hannah m Badland janine Shepherd Grant m Schofield 不详

The objective of this study was to assess the validity of the step count functions in Actical accelerometers and activPAL inclinometers, compared with pedome-ter-derived step count data. Firstly, directly observed step counts over 3 treadmill speeds were compared with steps collected from 3 pedometers, accelerometers, and inclinometers in 10 adults. Secondly, step count data were derived from 22 participants who wore a pedome-ter, accelerometer, and inclinometer over 48 hours. Agreement between measurement tools was determined. All monitors appropriately measured steps in the labo-ratory conditions. In free living conditions, the mean percentage differences with pedometer-determined step counts were -7.3% and 7.0% for the Actical and ac-tivPAL monitors, respectively. With the exception of slow walking for the Actical units (ICC mill speeds, and across units during the free living condition. The 95% prediction interval ranges were wide, ranging from -68.8% to 54.2% for the Acticals, and from -39.1% to 53.2% for the activPALs. Step counts gathered from Actical and activPAL units should not be used interchangeably with pedometer-derived step count data.

关键词： Physical activity measurement Pedometer Inclinometer Accelerometer Validation Reliability

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Human primary muscle stem cells regenerate injured urethral sphincter in athymic rats

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Animal models and Experimental medicine 2022年第5期5卷 453-460页

作者： Biniam m.Bekele Verena Schöwel-Wolf janine Kieshauer Andreas marg Andreas Busjahn Sarah Davis Gayle Nugent Anne-Karoline Ebert Simone Spuler muscle Research Unit Experimental and Clinical Research Centera cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and the CharitéUniversitätsmedizin BerlinBerlinGermany CharitéUniversitätsmedizin BerlinGermany max-Delbrück-Center for molecular medicine in the Helmholtz Association BerlinGermany Berlin Institute of Health at CharitéUniversitätsmedizin BelrinGermany HealthTwist GmbH BerlinGermany Charles River Laboratories MattawanMichiganUSA Department of Urology and Pediatric Urology University Hospital UlmUlmGermany

Background:The aim of the study was to demonstrate the efficacy of human muscle stem cells(muSCs)isolated using innovative technology in restoring internal urinary sphincter function in a preclinical animal ***:Colonies of pure human muSCs were obtained from muscle biopsy *** rats were subjected to internal urethral sphincter damage by *** days after injury,2×105 muscle stem cells or medium as control were injected into the area of sphincter damage(n=5 in each group).Peak bladder pressure and rise in pressure were chosen as outcome *** repeatedly obtain the necessary pressure values,telemetry sensors had been implanted into the rat bladders 10 days prior to ***:There was a highly significant improvement in the ability to build up peak pressure as well as a pressure rise in animals that had received muscle stem cells as compared to control(p=0.007)3 weeks after the cells had been *** mini-mal histologic evidence of scarring was observed in treated ***:Primary human muscle stem cells obtained using innovative technology functionally restore internal urethral sphincter function after *** into use in clinical settings is foreseeable.

关键词： human muscle stem cells sphincter injury telemetry urinary incontinence urodynamics

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