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Obesity: Nutrition and Genetics—A Short Narrative Review

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Health 2018年第12期10卷 1779-1788页

作者： José M. tallon janine Narciso Ana Barros Ana Pereira Aldo M. Costa António J. Silva University of trás-os-Montes e Alto Douro Vila Real Portugal University of Beira Interior Covilh&#227 Portugal Polytechnic Institute of Setúbal Superior School of Education Setúbal Portugal Research Centre in Sports Health and Human Development CIDESD Vila Real Portugal Health Science Research Center CICS-UBI Covilh&#227 Portugal

Obesity has become a major global health challenge and it is a risk factor for the development of several comorbid conditions. Additionally, obesity has considerable economic consequences. Obesity is a multifactorial condition that arises from independent influences of genetic and social-environmental factors on food intake and physical activity. It has been difficult to establish clear associations between weight status and the intake of single foods or food groups. In most people, the predisposition to obesity has a polygenic basis, which means that obesity will develop if an individual has several polygenic variants that increase body weight. the FtO gene was the first GWAS-identified obesity-susceptibility gene and since then other polygenic variants that are associated with BMI and dietary intake have also been identified. However, this is still an active area of research as more polygenetic variants await discovery.

关键词： Obesity Nutrition Genetics

Differential regulation of the anthocyanin profile in purple kiwifruit(Actinidia species)

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Horticulture Research 2019年第1期6卷 1746-1761页

作者： Yongyan Peng Kui Lin-Wang janine M.Cooney tianchi Wang Richard V.Espley Andrew C.Allan School of Biological Sciences University of AucklandAucklandNew Zealand the New Zealand Institute for Plant and Food Research Limited Mt AlbertAucklandNew Zealand the New Zealand Institute for Plant and Food Research Limited East Street3214 HamiltonNew Zealand

Anthocyanins are a group of secondary metabolites that colour fruit and flowers orange,red,purple or blue depending on a number of factors,such as the basic structure,co-pigmentation,metal ion complexation and vacuolar *** biosynthesis of anthocyanin is regulated at the transcriptional level by a group of transcription factors,the MYB–bHLH–WD40(MBW)*** this study,the purple colouration in several kiwifruit(Actinidia)species was identified and characterised as red cyanidin-based and blue delphinidin-based *** differential pigmentation in the skin and flesh can be attributed to the differential ratio of cyanidin and delphinidin derivatives accumulated in the total anthocyanin *** expression of anthocyanin biosynthetic genes chalcone synthase(CHS),flavonoid 3-O-glucosyltransferase(F3Gt),flavonoid 3′-hydroxylase(F3′H)and flavonoid 3′5′-hydroxylase(F3′5′H)is crucial for anthocyanin ***,the balance of expression of the F3′H and F3′5′H genes appears responsible for the ratio of cyanidin and delphinidin derivatives,while a lack of CHS,F3Gt and MYB110 expression is responsible for a lack of total *** transcriptional regulation of the F3′H and F3′5′H promoters by the R2R3 MYB transcription factor MYB110 is markedly different in tobacco transient *** kiwifruit MYB10 or MYB110 are over-expressed in Actinidia chinensis both cyanidin-based and delphinidin-based anthocyanins are elevated,but F3′H and F3′5′H genes are not strongly correlated with MYB *** results suggest that the core kiwifruit anthocyanin pathway genes are dependent on characterised MYB transcription factors,while other regulatory proteins are more directly responsible for the expression of the F3′H and F3′5′H genes.

关键词： Actinidia orange flowers

Genetic Divergence among Progenies Resulting from the Crossing of Groups Coffee timor Hybrid and Dilla ＆ Alghe

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Journal of Agricultural Science and technology(B) 2013年第12期3卷 865-872页

作者： janine Magalhaes Guedes Juliana Costa Rezende Joao Marcos Rodrigues Andrade Lara Samuel Pereira Carvalho Antonio Alves Pereira Alex Mendonca de Carvalho Department of Agriculture-UFLA Federal University of Lavras DAG-Cx. P. 3037-37.200-000 Lavras MG Brazil Agricultural Research Company of Minas Gerais-technological Center in South of Minas Campus UFLA Cx P. 179 37200-000Lavras MG Brazil Agricultural Research Company of Minas Gerais -technological Center in Zona da Mata Campus UFV Cx P. 216 - 36571-000Vigosa MG Brazil

this study aimed to agronomically and morphologically characterize, as well as analyze the genetic divergence of Dilla ＆ Alghe x timor hybrid progenies of the coffee germplasm bank of Minas Gerais in Brazil to improve the breeding and management schemes of the hybrids. Forty-two morpho-agronomic traits were evaluated and the generalized Mahalanobis distance was used to quantify the genetic divergence among progenies. tocher clustering, unweighted pair-group method using arithmetic averages （UPGMA） method and canonical variation analysis were employed as clustering strategies. the tocher and UPGMA methods have been separated the progenies into eight and five groups, respectively. Analysis of the relative contribution of each characteristic to genetic dissimilarity highlighted the characteristics of production in liters in 2009, production notes in 2009, and average uniformity of maturation in 2009 as those that contributed most to obtaining genetic divergence. the authors observed that the first three canonical variables accounted for over 99% of the total variance observed in the full set of analyzed characteristics. High variability was observed among the 15 progenies of Dilla ＆ Alghe × timor hybrid progenies. the progenies MG0589 and MG0592, MG0593 and MG0589, MG0591 and MG0589, MG0589 and MG0588, MG0589 and MG0583 were the most suitable crosses for exploring the genetic variability in Dilla ＆ Alghe × timor hybrid generated from the germplasm bank of Minas Gerais. through these crossovers, it is expected to get new coffee cultivars with desirable agronomic characteristics, as resistant to Pseudomonas xyringae pv. garcae and some breeds ofHemileia vastatrix.

关键词： Coffea arabica multivariate analysis germplasm bank genetic improvement morpho-agronomic traits.

A population-based comparison study of the mental health of patients with intentional and unintentional burns

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Burns & trauma 2018年第4期6卷 287-296页

作者： thirthar P Vetrichevvel Sean M Randall Fiona M Wood Suzanne Rea James H Boyd janine M Duke Burn Injury Research Unit Faculty of Health and Medical SciencesThe University of Western AustraliaM318 35 Stirling HighwayCrawleyPerthWestern Australia 6009Australia Curtin Medical School Curtin UniversityPerthAustralia Centre for Data Linkage Curtin UniversityPerthWestern AustraliaAustralia Burns Service of Western Australia Fiona Stanley Hospital and Princess Margaret HospitalPerthWestern AustraliaAustralia

Background:A number of studies report high prevalence of mental health conditions among burn patients. However there is a need to understand differences in the temporal relationship between mental health conditions and intentional and unintentional burns to hasten psychological prevention and intervention. this study aims to compare the socio-demographic profile, burn characteristics and pre-and post-burn psychiatric morbidity of burn patients by intent-of-injury. Methods:De-identified linked hospital, death and mental health (MH) case registry data of burn patients hospitalised in Western Australia between 1 January 1980 and 30 June 2012 were analysed. Crude (observed) post-burn rates of mental health admissions were generated by burn intent-of-injury. Descriptive statistics were performed to compare the characteristics of the burn patients. Results:A total of 30,997 individuals were hospitalised for a first burn;360 (1.2%) had self-harm burns and 206 (0.7%) assault burns. Over the study period, admission rates for assault burns increased by 4.8%per year (95%confidence interval (CI) 3.1–6.5%) and self-harm burns increased 6.9%per year (95%CI 4.8–9.1%). Self-harm and assault burns occurred mainly among those aged 15 to 44 years (median age, interquartile range (IQR):self-harm 30 years, 22–40;assault 31 years, 23–38). those with self-harm burns had a longer index hospital stay (median (IQR):self-harm 15 days (5–35) vs 4 days (1–11) assault vs 4 days (1–10) unintentional) and higher in-hospital mortality (7.2%self-harm vs 1.9%assault burns vs 0.8%unintentional). More than half (55.0%) of self-harm burns had a prior hospitalisation (5-year lookback) for a MH condition vs 10.7%of assault burns and 2.8%of unintentional burns. Crude post-burn rates of MH admissions per 100 person-years (PY) by intent-of-burn subgroups:self-harm 209 per 100 PY, assault burns 11 per 100 PY and unintentional burns 3 per 100 PY. Conclusions:Intentional burn patients experienced significantly

关键词： Intentional burns Mental health Self-harm burns Assault burns Epidemiology

Contribution to the Improvement of transfusion Safety: Assessment of the Pre-Donation Hemoglobin Level at the Yamoussoukro Blood transfusion Center in Cote d’Ivoire

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Open Journal of Blood Diseases 2023年第2期13卷 78-82页

作者： Renaude janine Amon Boukalo Guillaume Zaminan Martial Bama Saydou Kaboré Sidonie Gooré Kouamenan Issaka tiembré Jean-Jacques Dadié Bosso Sekongo Yassongui Mamadou National Center for Blood transfusion Abidjan C&#244te d’Ivoire National Institute of Public Hygiene Abidjan C&#244te d’Ivoire Blood transfusion Center Yamoussoukro C&#244te d’Ivoire

Introduction: Despite the progress recorded at the level of transfusion safety in Côte d’Ivoire, much remains to be done, particularly at the level of the medical selection of blood donors. the objective of the study was to make an assessment of the pre-donation capillary hemoglobin dosage for the year 2020 of the fixed collection, of the Blood transfusion Center of Yamoussoukro. Method: this is a retrospective study that took place at the Yamoussoukro Blood transfusion Center. the data collection related to all old and new blood donors were deemed suitable for the fixed collection of the year 2020. the method chosen for the pre-donation control is that of the portable hemoglobinometer of the HémoCue® type, more precisely 201+. Results: Of the 1160 blood donors in the study, the pre-donation hemoglobin level was not measured in 787 (67.8%) subjects of either sex. Of the subjects who had a pre-donation hemoglobin level performed, 97 (26%) blood donors had a sub-standard hemoglobin level, including 15 females and 82 males. Conclusion: Pre-donation hemoglobin testing of blood donors is effective in Yamoussoukro. However, efforts must still be made to improve the quality of the blood collected and to protect blood donors.

关键词： Blood Donation Medical Selection Pre-Donation Hemoglobin Fixed Collection Yamoussoukro

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Culinary Diplomacy

China International Business 2010年第9期 51-51页

作者： janine COUGHLIN tHE PERSONAL CHEFS tO KINGS PRINCES AND PRESIDENTSFROM AROUND THE WORLD GATHER IN BEIJING FOR A MEETINGOF THE CLUB DES CHEFS DES CHEFS

Members of the most exclusive gastronomic club in the world came to China last month to explore first-hand the complexities of Chinese cuisine. the 30-member Club Des Chefs Des Chefs d＇Etat is comprised of the personal chefs to heads of state from around the world. the group was started 33 years ago by Gilles Bragard, known as ＂courtier of the chefs＂ when he realized that many of the chefs to heads of state did not know each other.

关键词：烹饪国家元首俱乐部厨师复杂性世界美食中餐

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公共服务交由谁做应视情况而定 004

中国政府采购报

作者： John Alford janine O’Flynn 朱颖

当政府在决定把公共服务项目交由谁来做时，精明的政府改革者们不再抱持“私人的永远是最好的”或“公共的永远是最好的”这样绝对的观点，相反，他们很可能会说“这一切都需视情况而定”。对于公共机构与私营或非盈利供应商签订合同...

当政府在决定把公共服务项目交由谁来做时，精明的政府改革者们不再抱持“私人的永远是最好的”或“公共的永远是最好的”这样绝对的观点，相反，他们很可能会说“这一切都需视情况而定”。对于公共机构与私营或非盈利供应商签订合同或产生伙伴关系这一领域，现在虽有

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产后甲状腺炎

英国医学杂志中文版 2021年第12期24卷 726-731页

作者： Riley Epp janine Malcolm Khiera Jolin-Dahel Michaela Clermont Erin Keely 赵茵(译) Department of Medicine University of Ottawa OttawaOntarioCanada Division of Endocrinology and Metabolism The Ottawa HospitalOttawaOntarioCanada Department of Family Medicine University of OttawaOttawaOntarioCanada Ottawa OntarioCanada 华中科技大学同济医学院附属协和医院

一名27岁的1型糖尿病经产妇,孕期及分娩期无并发症,第二次分娩后4个月,出现脱发、焦虑、易怒和失眠。据她回忆,她在初次生产后就逐渐出现疲劳、虚弱、睡眠中断、奶量不足以及产后3周体重停止下降。根据这些症状她被诊断为产后抑郁症,并... 详细信息

一名27岁的1型糖尿病经产妇,孕期及分娩期无并发症,第二次分娩后4个月,出现脱发、焦虑、易怒和失眠。据她回忆,她在初次生产后就逐渐出现疲劳、虚弱、睡眠中断、奶量不足以及产后3周体重停止下降。根据这些症状她被诊断为产后抑郁症,并使用抗抑郁药进行治疗。几个月的抗抑郁药试验性治疗无效,并发现患者存在促甲状腺激素(tSH)水平的升高。给予左旋甲状腺素替代治疗后症状改善。患者这次生产后的表现又被诊断为产后抑郁症,并进行了抗抑郁治疗。然而,该治疗再次无效,同时发现患者tSH水平下降,提示甲状腺毒症。

关键词：产后抑郁症甲状腺毒症试验性治疗抗抑郁治疗经产妇产后甲状腺炎抗抑郁药症状改善