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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane traffick.ng and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, k.y regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is ak.n to atypical heme oxygenases in prok.ryotes but is not wellcharacterized in vertebrates. Prok.ryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is k.own about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOk.LAeI H.GHANDVAr e.JUMAeV S.k.ATIr T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and k.netic energies of each beam along with the work.done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Photolysis studies on HCOOH and HCOO^- in presence of TiO_2 photocatalyst as suspension in aqueous medium

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Journal of Natural Gas Chemistry 2009年第1期18卷 50-54页

作者： G. r. Dey k. N. r. Nair k. k. Pushpa radiation and Photochemistry Division Bhabha Atomic Research Centre Trombay Mumbai 400 085 India

Photolysis studies on formic acid （HCOOH） and formate ion （HCOO-） in presence of TiO2, a photocatalyst, as suspension in water were carried out separately using 350 nm ultraviolet light. The products, such as H2, CO, CO2 and CH4, generated during the experiments were monitored with varying the ambient, light exposure time, and the concentration of HCOOH/HCOO-. The yields of CO in all these systems increased with light exposure time. In aerated systems, CO yields were higher in contrast to the deoxygenated （Ar-purged） systems under identical conditions. It is proposed apparently that the formation of CO is tak.ng place during the chemical reduction of in-situ generated CO2, a photo-mineralized product of HCOOH/HCOO-, but not through the direct photodecomposition or photodehydration （CO＋H2O） of solute molecules. The rates of CO formation during 1.3 M HCOOH photolysis in presence of TiO2 photocatalyst were evaluated to be 0.21 and 0.13 μl/min in aerated and Ar-purged systems, respectively. As compared with HCOOH systems, the CO yields are lower when 0.2 M HCOONa was exposed to light under identical conditions. The CO growth rates were evaluated to be 0.07 and 0.046 μl/min^-1 for aerated and deoxygenated HCOONa systems, respectively; moreover, the trend is quite similar to that of the HCOOH system. Under these conditions, the emission of H2 was also observed, and its yield was significantly higher in Ar-purged system as compared with the CO yields. However, in aerated system, the yields of these products were just opposite. The formation of low yield of methane was observed during photolysis of HCOOH/HCOO ions. In CO2 ambient, the yields of CO and H2 varied drastically with time.

关键词： formic acid formate ion photolysis TiO2

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eXPerIMeNTAL AND NUMerICAL ANALYSIS OF LAMINAr AND LOW TUrBULeNT FLOW DISTrIBUTIONS IN INLeT DIVIDING HeADer OF SHeLL AND TUBe HeAT eXCHANGer

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Journal of Hydrodynamics 2010年第4期22卷 494-502页

作者： k.NNAN k. rUDrAMOOrTHY r. Department of Production engineering PSG College of Technology

Flow distribution headers play a major role in heat *** selection of header diameter,branch pipe diameter,branch pipe spacing *** based on the designer＇s experience and general guide *** proper selection of the header dimensions will yield uniform flow distribution in heat exchangers,which in turn will enhance the heat exchanger *** this work.the flow distribution in branch pipes and the pressure variation across the branch pipes in laminar and low turbulence region is studied with two models of the inlet dividing *** the numerical analysis has been applied,its inability to predict the no flow condition through the branch pipes is *** results are presented in the form of flow rate ratio through branch pipes and nondimensional coefficients across branch pipes which are useful to apply the existing mathematical models for the present experimental setup.

关键词： shell and tube heat exchanger inlet dividing header uniform flow distribution experimental setups numerical analysis

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Semi-relativistic Two-Body States of Spinless Particles with a Scalar-Type Interaction Potential

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Communications in Theoretical Physics 2018年第2期69卷 127-130页

作者： k. e. Thylwe k.H-Mechanics Royal institute of Technology S-100 44 Stockholm Swede

A semi-relativistic quantum approximation for mutual scalar interaction potentials is outlined and *** are consistent with two-body Dirac equations for bound states of zero total angular momentum. Two-body effects nea... 详细信息

关键词： relativistic quantum mechanics two-body effects two-body scalar potentials bound states quark.otential

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Semantic rule Based Image Visual Feature Ontology Creation

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International Journal of Automation and computing 2014年第5期11卷 489-499页

作者： r. I. Minu k. k. Thyagharajan Department of Computer Science & engineering Jerusalem College of Engineering rMD engineering College

Multimedia is one of the important communication channels for mank.nd. Due to the advancement in technology and enormous growth of mank.nd, a vast array of multimedia data is available today. This has resulted in the obvious need for some techniques for retrieving these data. This paper will give an overview of ontology-based image retrieval system for asteroideae flower family domain. In order to reduce the semantic gap between the low-level visual features of an image and the high-level domain k.owledge, we have incorporated a concept of multi-modal image ontology. So, the created asteroideae flower domain specific ontology would have the k.owledge about the domain and the visual features. The visual features used to define the ontology are prevalent color,basic intrinsic pattern and contour gradient. In prevalent color extraction, the most dominant color from the images was identified and indexed. In order to determine the texture pattern for a particular flower, basic intrinsic patterns were used. The contour gradients provide the information on the image edges with respect to the image base. These feature values are embedded in the ontology at appropriate slots with respect to the domain k.owledge. This paper also defines some of the query axioms which are used to retrieve appropriate information from the created ontology. This ontology can be used for image retrieval system in semantic web.

关键词： Information and k.owledge computer vision intelligent computing feature extraction ontology

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Distribution of Pill Millipedes (Arthrosphaera) and Associated Soil Fauna in the Western Ghats and West Coast of India

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Pedosphere 2008年第6期18卷 749-757页

作者： k. M. ASHWINI k. r. SrIDHAr Microbiology and Biotechnology Department of Biosciences Mangalore University Mangalagangotri

Seven sampling sites in each of three biomes (Western Ghats, foothills of Western Ghats and west coast) of south- western India were investigated to study the distribution, abundance and ecology of pill millipedes (Arthrosphaera) and associated fauna in relation to edaphic features. Abundance and biomass of Arthrosphaera and other millipedes were the highest in Western Ghats, while earthworms were in foothills. Arthrosphaera magna and Arthrosphaera spp. were common in Western Ghats and foothills respectively, while no Arthrosphaera were found in the west coast. None of the sampling sites consisted of more than one species of Arthrosphaera. Biomass of Arthrosphaera, other millipedes and earthworms significantly differed in Western Ghats (P = 9.48 × 10-7) and foothills (P = 1.35 × 10-8), as did the biomass of species of Arthrosphaera (P = 2.76 × 10-7) between Western Ghats and foothills. Correlation analysis revealed that biomass of Arthrosphaera was significantly (P = 0.01, r = 0.45) correlated with soil organic carbon rather than other edaphic fea- tures (pH, phosphate, calcium and magnesium). Distribution pattern, abundance, biomass and ecology of Arthrosphaera of Western Ghats in relation to soil qualities were compared with millipedes of other regions of the world.

关键词： Arthrosphaera distribution edaphic features pill millipedes Western Ghats

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Activator-assisted electroless deposition of copper nanostructured films

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 196-203页

作者： Varsha r. Mehto r. k. Pandey Department of Physics Barkatullah University NIIT University

This paper showed simple and effective synthesis of copper nanoparticles within controlled diameter using direct electroless deposition on glass substrates, following the sensitization and activation steps. electroless-deposited metals, such as Cu, Co, Ni, and Ag, and their alloys had many advantages in micro- and nanotechnologies. The structural, morphological, and optical properties of copper deposits were characterized using X-ray diffraction （XrD）, atomic force microscopy （AFM）, and UV-Vis spectroscopy. The structural data was further analyzed using the rietveld refinement program. Structural studies reveal that the deposited copper prefers a （111） orientation. AFM studies suggest the deposited materials form compact, uniform, and nanocrystalline phases with a high tendency to self-organize. The data show that the particle size can be controlled by controlling the activator concentration. The absorption spectra of the as-deposited copper nanoparticles reveal that the plasmonic peak.broadens and exhibits a blue shift with decreasing particle size.

关键词： nanostructured materials thin films copper electroless plating deposition

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Drop formation at nozzles submerged in quiescent continuous phase： an experimental study with TBP-dodecane and nitric acid system

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Nuclear Science and Techniques 2018年第6期29卷 110-118页

作者： Amitava roy MayurDarek.r k. k. Singh k. T. Shenoy r. B. Grover Homi Bhabha National Institute Anushaktinagar Mumbai 400094 India Chemical engineering Division Bhabha Atomic Research Centre Mumbai 400085 India

Solvent extraction is an important process in the nuclear fuel cycle. Tributyl phosphate(TBP) diluted with dodecane is commonly used as a solvent for extracting heavy metals from nitric acid medium. Studies on hydrodynamics of a single drop, which is the smallest mass transfer entity, are required for better understanding of the complex mass transfer and phase separation phenomena that occur in extraction equipment. In this study, drop formation at nozzles is studied using 30% TBP-dodecane as the dispersed phase and dilute nitric acid as the quiescent continuous phase. experiments are carried out to determine the drop diameter, jetting velocity, drop detachment height and drop detachment time for various dispersed phase velocities, nozzle diameters(1.91, 3.04, and 4.88 mm), and nitric acid concentrations(0.01, 1, 3 N). Drop formation is captured using high-speed imaging, which enables quantification of drop size, onset of jetting, drop detachment height, and drop detachment time. experimental data are used to propose correlations for predicting drop diameter and minimum jetting velocity. The correlations are found to be very accurate with average absolute relative errors being 5.23 and 2.97%, respectively.

关键词：试验性硝酸静止沉没系统高速度分离现象磷酸盐

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A discrete model for prediction of radon flux from fractured rock.

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Journal of rock.Mechanics and Geotechnical engineering 2018年第5期10卷 879-892页

作者： k.M. Ajayi k. Shahbazi r Tuk.araja k. k.tzenstein Department of Mechanical engineering South Dakota School of Mines and Technology Rapid City SD 57701 USA b Department of Mining engineering and Management South Dakota School of Mines and Technology Rapid City SD 57701 USA Department of Geology and Geological engineering South Dakota School of Mines and Technology Rapid City SD 57701 USA

Prediction of radon flux from the fractured zone of a propagating cave mine is basically associated with uncertainty and complexity. For instance, there is restricted access to these zones for field measure- ments, and it is quite difficult to replicate the complex nature of both natural and induced fractures in these zones in laboratory studies. Hence, a technique for predicting radon flux from a fractured rock.using a discrete fracture network.（DFN） model is developed to address these difficulties. This model quantifies the contribution of fractures to the total radon flux, and estimates the fracture density from a measured radon flux considering the effects of advection, diffusion, as well as radon generation and decay. radon generation and decay are classified as reaction processes. Therefore, the equation solved is termed as the advection-diffusion-reaction equation （ADre）. Peclet number （Pe）, a conventional dimensionless parameter that indicates the ratio of mass transport by advection to diffusion, is used to classify the transport regimes. The results show that the proposed model effectively predicts radon flux from a fractured rock. An increase in fracture density for a rock.sample with uniformly distributed radon generation rate can elevate radon flux significantly compared with another rock.sample with an equivalent increase in radon generation rate. In addition to Pe, two other independent dimensionless parameters （derived for radon transport through fractures） significantly affect radon dimensionless flux. Findings provide insight into radon transport through fractured rock. and can be used to improve radon control measures for proactive mitigation.

关键词： radon mass flux radon dimensionless flux Stochastic model Discrete fracture network.(DFN) Caving mining method Fractured rock.

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