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Mitigating osteonecrosis of the jaw(ONJ) through preventive dental care and understanding of risk factors

Bone Research 2020年第1期8卷 14-25页

作者： Jason TWan Douglas MSheeley Martha JSomerman janice slee National Institute of Dental and Craniofacial Research National Institutes of HealthBethesdaMDUSA Laboratory for Oral Connective Tissue Biology National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaMDUSA

It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw(ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860. The subsequent removal of yellow phosphorus from matches in the early 20 th century saw a parallel decline in "phossy jaw" until the early 2000 s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. Today, the potential side effect of ONJ associated with medications that block osteoclast activity(antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. Much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONJ, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONJ is a rare occurrence and ONJ-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dental evaluations and care prior to initiating antiresorptive therapies and by monitoring dental health during and after treatment. This review describes the current clinical management guidelines for ONJ, the critical role of dental-medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

关键词： drugs metabolism alterations

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Pedestrian walking speed at un-signalized midblock crosswalk and its impact on urban street segment performance

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第1期8卷 57-69页

作者： Albert Forde janice Daniel Division of Statewide Planning New Jersey Department of TransportationTrentonNJ 08625USA Department of Civil and Environmental Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA

The Urban Street Segment Chapter of the Highway Capacity Manual(HCM)includes a methodology for evaluating the level of service urban street segments provide to automobile *** methodology does not account for pedestrian activity at un-signalized midblock crosswalk on an urban street *** activity at un-signalized midblock crosswalk on urban street segments causes friction conditions between automobiles and *** a consequence,the average time it takes vehicles to travel along the segment is *** segment running time decreases both the travel speed of automobiles and the level of service provided to automobile *** is an inverse relationship between the delay incurred by interrupted vehicles and the speeds at which pedestrians walk while crossing at *** account for this delay,there is a need to investigate pedestrian walking speeds at un-signalized midblock *** study measured pedestrian walking speeds by age-group at two un-signalized midblock crosswalks on urban street *** first objective of this paper is to perform statistical analyses to examine the measured free-flow pedestrian walking *** second objective is to demonstrate how the findings of this study can be incorporated into the Urban Street Segment Analysis Chapter of the *** walking speeds were recorded and analyzed for 2937 *** results show teenagers walk at an average speed of 1.45 m/s,young adults walk at an average speed of 1.55 m/s,middle age pedestrians walk at a speed of 1.45 m/s,older pedestrians walk at speed of 1.09 m/s,and elderly or physically disabled pedestrians walk at a speed of 1.04 m/s.

关键词： Midblock Pedestrian Walking speed HCM Urban Street

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Cardiac resynchronisation therapy after percutaneous mitral annuloplasty

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World Journal of Clinical Cases 2016年第5期4卷 127-129页

作者： janice Swampillai Department of Cardiology Waikato Hospital

Percutaneous approaches to reduce mitral regurgitation in ischemic cardiomyopathy have stirred interest *** with ischemic cardiomyopathy and functional mitral regurgitation often meet criteria for cardiac resynchronisation therapy to improve left ventricular function as well as mitral regurgitation,and alleviate *** case shows that implantation of a pacing lead in the coronary sinus to restore synchronous left and right ventricular contraction is feasible,despite the presence of a remodeling device in the coronary sinus.

关键词： Mitral regurgitation Cardiac implantable electronic device Percutaneous mitral regurgitation Ischemic cardiomyopathy Cardiac resynchronisation therapy

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janice Drew's work on diet and cancer

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World Journal of Gastrointestinal Pathophysiology 2011年第4期2卷 61-64页

作者： janice Drew Rowett Institute of Nutrition and Health University of AberdeenGreenburn RoadBucksburnAberdeenAB21 9SBUnited Kingdom

Obesity and associated reduced consumption of plant derived foods are linked to increased risk of colon cancer as well as a number of other organ specific *** processes are a contributing factor but the precise mechanisms remain *** and cancer incidence are increasing worldwide,presenting bleak prospects for reducing,or preventing,obesity related *** incidence of these preventable cancers can be achieved with greater understanding of the molecular mechanisms linking diet and *** Drew has developed a research program over recent years to investigate molecular mechanisms related to consumption of anti-inflammatory metabolites generated from consumption of plant based diets,the impact of high fat diets and associated altered metabolism and obesity on regulation of colon inflammatory responses and processes regulating the colon *** strategies have been developed incorporating transcriptomics,including the novel gene expression technology,the GenomeLab System and proteomics,together with biochemical analyses of plasma and tissue samples to assess correlated changes in oxidative stress,inflammation and *** approaches developed have achieved success in establishing antioxidant and anti-inflammatory activity of dietary antioxidants and associated genes and pathways that interact to modulate redox status in the *** processes and genes altered in response to obesity and high fat diets have provided evidence of molecular mechanisms that are implicated in obesity related cancer.

关键词： Diet and cancer Obesity-related cancer Adipokines Leptin Phenolic acids Mitochondria Proteomics Multiplex gene expression

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HILLTOP RESIDENCE AND SITE SUSTAINABLE DESIGN

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Journal of Green Building 2011年第1期6卷 34-45页

作者： janice Olshesky Olshesky Design Group LLC American Institute of Architects National AIACenter for Building Science and Performance

Sustainability on a residential renovation can be difficult to *** this project was a complete gut renovation and two small additions,which included a new third story space,roof,and a rear addition,it was easy to investigate a wide variety of sustainable *** building envelope was improved,interior aspects modified,and the energy generation systems explored and selected to all work in unison to enhance the end result of the *** order to measure the degree of sustainability,ODG wanted to use a residential design rating *** the time this house was designed there were few recognized residential rating systems available and none appeared to be as stringent and broad reaching as the LEED Commercial Rating *** used the LEED 2.2 rating system as a *** this project began,LEED for Homes had not yet been *** Hilltop Residence project sought to infuse an existing residence with the following qualities:cost effective technology,a“not to exceed”budget,a 75-year life cycle,the client’s aesthetics,functional living,sustainable design,and allow for productive healthy *** used the LEED categories of Sustainable Sites,Water Efficiency,Materials&Resources,Energy&Atmosphere,and Indoor Air *** sustainable goals that were met affect both the building and the *** home was designed to use rapidly renewable materials,use less water,conserve energy,generate its own electricity,automate the mechanical house processes,and reduce stormwater *** renovated home conserved existing material and used new materials that are rapidly *** designing to a 75-year life cycle,materials selected were either rapidly renewable or incredibly *** designed for longer lifespans are inherently sustainable because their components will not need to be replaced as *** reduction of operating and maintenance costs will pass savings directly to the client,providing a return on investment for the costs of the

关键词： Residential renovation sustainable stack effect passive solar energy efficiency photo-voltaic panels LEED Smart Home ventilation open plan high efficiency high performance exterior envelope water efficiency

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Performance evaluation of the HCM 2010 platoon dispersion model under midblock pedestrian and truck traffic friction conditions

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第6期4卷 522-534页

作者： albert forde janice daniel new jersey department of transportation TrentonNJ 08625USA department of civil and environmental engineering new jersey institute of technologyNewarkNJ 07102USA

The urban street segment analysis chapter of the Highway Capacity Manual 2010 provides a methodology for evaluating automobile performance on street segments within an urban roadway network （TRB, 2010）. The methodology involves applying a platoon dispersion model to predict platoon arrival profiles at a downstream signalized intersection; using the predicted arrival flow profiles to compute the proportion of vehicle arrivals on green, and subsequently compute the control delay, average travel speed and level of service （LOS） of the segment. The predictive ability of the HCM 2010 platoon dispersion model has not been independently evaluated using field data. This paper, therefore, uses field data to evaluate the performance of the HCM 2010 platoon dispersion model under friction and no friction traffic conditions. The traffic friction conditions include pedestrian and vehicular interactions on urban collector street segments and the presence of trucks within the traffic stream on principal urban arterial segments. Based on the results obtained, the HCM 2010 platoon dispersion model performs relatively well in predicting platoon arrival profiles on urban street segments with no friction traffic conditions. The results, however, show the model＇s performance is limited on urban street segments with pedestrian and truck friction conditions.

关键词： Highway Capacity Manual 2010Platoon dispersionFrictionUrban street

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Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?

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Neural Regeneration Research 2024年第7期19卷 1419-1420页

作者： Muhammad N.Arshad janice R.Naegele Department of Biology Wesleyan UniversityMiddletownCTUSA Department of Neuroscience Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal *** surgical resection of the foci is an established and effective approach for controlling seizures,both temporal lobes cannot be removed,due to their prominent roles in learning and ***,seizures induce changes to the temporal lobes that contribute to hyperexcitability,including mossy fiber sprouting,astrogliosis.

关键词： epilepsy progenitor seizures

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Number matters:control of mammalian mitochondrial DNA copy number

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Journal of Genetics and Genomics 2009年第3期36卷 125-131页

作者： Laura L.Clay Montier janice J.Deng Department of Cellular and Structural Biology The Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio

Regulation of mitochondrial biogenesis is essential for proper cellular functioning. Mitochondrial DNA （mtDNA） depletion and the resulting mitochondrial malfunction have been implicated in cancer, neurodegeneration, diabetes, aging, and many other human diseases. Although it is known that the dynamics of the mammalian mitochondrial genome are not linked with that of the nuclear genome, very little is known about the mechanism of mtDNA propagation. Nevertheless, our understanding of the mode of mtDNA replication has ad- vanced in recent years, though not without some controversies. This review summarizes our current knowledge of mtDNA copy number control in mammalian cells, while focusing on both mtDNA replication and turnover. Although mtDNA copy number is seemingly in excess, we reason that mtDNA copy number control is an important aspect of mitochondrial genetics and biogenesis and is essential for normal cellular function.

关键词： mitochondria DNA copy number DNA turnover replication

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Selected dietary plant-based proteins for growth and health response of Nile tilapia Oreochromis niloticus

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Aquaculture and Fisheries 2024年第1期9卷 3-19页

作者： Tzodoq Obrero Magbanua janice Alano Ragaza Ateneo Aquatic and Fisheries Resources Laboratory Department of BiologySchool of Science and EngineeringAteneo de Manila UniversityKatipunan AvenueLoyola HeightsQuezon CityMetro Manila1108Philippines

Tilapia culture is one of the largest sectors of global *** the different species of tilapia,Nile tilapia(Oreochromis niloticus)is perhaps the top cultured *** production of Nile tilapia has been continually increasing throughout the years resulting in genetic *** tilapia strains with better growth performance and adaptive capability to survive in different culture conditions have been developed to alleviate the *** demand for Nile tilapia implies higher farming ***-based proteins are utilized as partial or complete fishmeal replacements to reduce feed ***,these proteins can adversely affect and alter growth and feed performance,carcass composition and indices,and gut and hepatic *** review discusses the use of seven plant-based proteins:namely,soybean,copra,pea,corn,palm kernel,microalgae,and seaweed as a Nile tilapia *** processing methods are employed to produce several types of plant-based *** plant-protein types,when utilized as an aquafeed ingredient,vary in its effect on the performance,hemato-immunological parameters,and gut and hepatic health of Nile *** have shown that Nile tilapia can effectively maximize plant-based protein diets based on the preparation method,type of plant source,amino acid supplementation,and inclusion levels of the plant *** readily available crops should be considered as primary protein sources for *** to the use of plant-based proteins as a main dietary protein are limiting amino acids,presence of anti-nutritional factors,and the competition between its demand as human food and as animal feed.

关键词： Nile tilapia Plant-based proteins Soybean proteins Copra proteins Pea proteins Corn proteins Palm kernel proteins Algal proteins

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Experimental and computational validation of a scaled train tunnel model using modal analysis

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Frontiers of Mechanical Engineering 2013年第4期8卷 420-428页

作者： janice B.D'SOUZA Sangarapillai KANAPATHIPILLAI School of Mechanical and Manufacturing Engineering The University of New South Wales

Acoustic engineers are faced with the challenge of minimising reverberation time in their designs so as to contribute to the health and well-being of those traveling by train and those on the *** the problem is easy to identify,it is not as simple to *** acoustical environment of a train tunnel is complex,with a variety of noise contributing factors such as train announcements,speech of commuters,ventilation systems,electrical equipment and wheel and rail *** a result,there is some difficulty in modeling the complete acoustic environment with computational or acoustic first *** this study,an experimental rig was constructed to model the acoustic behavior within a *** modal properties for the 300 Hz to 1500 Hz range,including resonances and mode shapes were identified and were shown to successfully correspond to theoretical results and a computational model created in COMSOL using Finite Element Analysis.

关键词： reverberation time acoustic environment modal properties resonances

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