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中国处方药 2010年第12期9卷 58-59页

作者： Aaron L.Nelson Eugen Dhimolea janice m.reichert 石永进

截至目前,全球共批准上市21个抗体药物,其中治疗性全人单抗药物占据了1/3,全人单抗是所有抗体药物中获批数量、研发速度和研发数量增长最快的一类。

关键词：人单克隆抗体治疗性抗体药物批准上市单抗药物研发速度人单抗

Epidemiological, Clinical Progress Aspects of Congenital Heart Disease with Neonatal Revelation at the mother-Child Hospital of Bingerville (HmE) Concerning 98 Cases from January 2021 to December 2022 (Côte d’Ivoire)

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Open Journal of Pediatrics 2024年第1期14卷 89-100页

作者： Adja Evelyne Akaffou-Gbery Richard Azagoh-Kouadio Anne-Lise Laetitia mobio Jean-Jacques Yao Atteby Serenah marie janice N’vrah Anoh Kouassi Raoul Yao Department of Paediatrics and Neonatology H&#244pital Mère-Enfant de Bingerville (HME) Bingerville C&#244te d’Ivoire Department of medical Pediatrics and Specialties CHU de Angré Abidjan C&#244te d’Ivoire

Introduction The distribution of congenital heart disease (CHD) in sub-Saharan Africa is highly imprecise and varies from one region to another due to the inequality of diagnostic facilities. The aim of this study was to determine the in-hospital prevalence of congenital heart disease in children at the mother-Child hospital of Bingerville (HmE) by specifying the diagnostic, therapeutic and evolutionary aspects. materials and methods We conducted a retrospective, descriptive, cross-sectional study at HmE of Bingerville from January 2021 to December 2022. All newborns with congenital heart disease confirmed by echocardiography were included in the study. Results Of 656 admissions to the neonatology department over the study period, congenital heart disease accounted for 14.9% (98/656) of cases. In our series, 76.7% were diagnosed before the 1st week of life, with a mean chronological age of 5.18 days and extremes of 0 and 46 days. There were as many male patients (50%) as female (50%), i.e. a sex ratio of 1. These newborns were premature in 60.2% of cases, with a mean and median gestational age of 34 weeks’ amenorrhea. most were left-right shunts (90.8%). Persistent ductus arteriosus (PDA) (48.9%) predominated, followed by atrial septal defect (38.7%), ventricular septal defect (13.3%), common trunk artery (CTA) (3.1%) and open septal pulmonary atresia (OSPA) (1%) as the primary cyanogenic heart disease. Pulmonary arterial hypertension (PAH) (50%) was primary in 38.8% and secondary (61.2%). The mortality rate was 30.6%, and all CTA patients died (100%), with a significant statistical relationship (p = 0.027). Progression under treatment was marked by clinical stabilization (68/98) in 69.4% of cases. Conclusion: Congenital heart disease is relatively common at the Bingerville HmE. Access to echocardiography should be facilitated in neonatology departments for rapid diagnosis and optimal management of congenital heart disease in newborns.

关键词： Newborn Congenital Heart Disease Côte d’Ivoire

Pedestrian walking speed at un-signalized midblock crosswalk and its impact on urban street segment performance

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第1期8卷 57-69页

作者： Albert Forde janice Daniel Division of Statewide Planning New Jersey Department of TransportationTrentonNJ 08625USA Department of Civil and Environmental Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA

The Urban Street Segment Chapter of the Highway Capacity manual(HCm)includes a methodology for evaluating the level of service urban street segments provide to automobile *** methodology does not account for pedestrian activity at un-signalized midblock crosswalk on an urban street *** activity at un-signalized midblock crosswalk on urban street segments causes friction conditions between automobiles and *** a consequence,the average time it takes vehicles to travel along the segment is *** segment running time decreases both the travel speed of automobiles and the level of service provided to automobile *** is an inverse relationship between the delay incurred by interrupted vehicles and the speeds at which pedestrians walk while crossing at *** account for this delay,there is a need to investigate pedestrian walking speeds at un-signalized midblock *** study measured pedestrian walking speeds by age-group at two un-signalized midblock crosswalks on urban street *** first objective of this paper is to perform statistical analyses to examine the measured free-flow pedestrian walking *** second objective is to demonstrate how the findings of this study can be incorporated into the Urban Street Segment Analysis Chapter of the *** walking speeds were recorded and analyzed for 2937 *** results show teenagers walk at an average speed of 1.45 m/s,young adults walk at an average speed of 1.55 m/s,middle age pedestrians walk at a speed of 1.45 m/s,older pedestrians walk at speed of 1.09 m/s,and elderly or physically disabled pedestrians walk at a speed of 1.04 m/s.

关键词： midblock Pedestrian Walking speed HCm Urban Street

Stabilization and visual analysis of video-recorded sailing sessions

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Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 258-267页

作者： Gijs m.W.reichert marcos Pieras Ricardo marroquim Anna Vilanova Computer Graphics and Visualization Technical University DelftDelft 2628CDThe Netherlands Visualization Group Technical University EindhovenEindhovenAZ 5612The Netherlands

One common way to aid coaching and seek to improve athletes’performance is by recording training sessions for posterior *** the case of sailing,coaches record videos from another boat,but usually rely on handheld devices,which may lead to issues with the footage and missing important *** the other hand,by autonomously recording the entire session with a fixed camera,the analysis becomes challenging owing to the length of the video and possible stabilization *** this work,we aim to facilitate the analysis of such full-session videos by automatically extracting maneuvers and providing a visualization framework to readily locate interesting ***,we address issues related to image ***,an evaluation of the framework points to the benefits of video stabilization in this scenario and an appropriate accuracy of the maneuver detection method.

关键词： Visualization Sports Visual-analytics

基于注意力机制与自适应特征融合的群养猪身份识别

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软件导刊 2024年第6期23卷 25-31页

作者：韩丁磊陈晨 Steibel Juan Siegford janice 韩俊杰王梦凡徐雷钧 Norton Tomas 江苏大学电气信息工程学院江苏镇江212013 Department of Animal Science Iowa State UniversityAmesIA 50010USA Animal Behaviour and Welfare Group Department of Animal ScienceMichigan State UniversityEast Lansing 48824USA Animal Behaviour and Welfare Group Department of Computational MathematicsScience and EngineeringMichigan State UniversityEast Lansing 48824USA Division of measure Model&Manage Bioresponses(M3-Biores)KU LeuvenLeuven 30001Belgium

针对群养猪攻击过程中身体形变和重叠影响猪身份识别精度的问题,开发一种基于注意力机制和自适应特征融合的深度学习方法以提高猪身份识别精度。录制猪栏中8只猪每天8小时共3天的视频,并筛选含攻击的16830帧作为数据集。首先,采用ResNe... 详细信息

针对群养猪攻击过程中身体形变和重叠影响猪身份识别精度的问题,开发一种基于注意力机制和自适应特征融合的深度学习方法以提高猪身份识别精度。录制猪栏中8只猪每天8小时共3天的视频,并筛选含攻击的16830帧作为数据集。首先,采用ResNet50提取猪的卷积神经网络(CNN)特征;然后,采用特征金字塔网络(FPN)在ResNet50中选择3层不同尺度的特征,以优化这些特征的定位和语义信息;接着,采用自注意力机制提高这些特征的区分度,并采用自适应空间特征融合(ASFF)以融合不同尺度的特征;最后,利用卷积和Sigmoid函数相结合的检测器对猪身份进行识别。使用该方法后,猪身份识别的均值平均精度(mAP)达到95.59%,速度达到37.6 f/s。结果表明,该方法能够在攻击场景下有效识别猪身份,有助于将攻击识别从群体级细化为个体级。

关键词：群养猪身份识别注意力机制特征融合深度学习

mitigating osteonecrosis of the jaw(ONJ) through preventive dental care and understanding of risk factors

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Bone Research 2020年第1期8卷 14-25页

作者： Jason TWan Douglas mSheeley martha JSomerman janice SLee National Institute of Dental and Craniofacial Research National Institutes of HealthBethesdaMDUSA Laboratory for Oral Connective Tissue Biology National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaMDUSA

It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw(ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860. The subsequent removal of yellow phosphorus from matches in the early 20 th century saw a parallel decline in "phossy jaw" until the early 2000 s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. Today, the potential side effect of ONJ associated with medications that block osteoclast activity(antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONJ, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONJ is a rare occurrence and ONJ-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dental evaluations and care prior to initiating antiresorptive therapies and by monitoring dental health during and after treatment. This review describes the current clinical management guidelines for ONJ, the critical role of dental-medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

关键词： drugs metabolism alterations

Rainfall partitioning in young clonal plantations Eucalyptus species in a subtropical environment,and implications for water and forest management

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International Soil and Water Conservation Research 2021年第3期9卷 474-484页

作者： Decio Oscar Cardoso Ferreto Josémiguel reichert Rosane Barbosa Lopes Cavalcante Raghavan Srinivasan Soils Department Universidade Federal de Santa Maria(UFSM).Avenida Romima 1000Santa MariaRSBrazil Instituto Tecnoldgico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil Department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTXUSA

Different canopy characteristics of industrial eucalyptus may lead to differences in water evaporation and availability to *** study aims to understand rainfall partitioning in a young clonal plantation(age of 2-4.5 years)of three eucalyptus species by relating tree parameters:diameter at breast height,total height,and leaf area *** measured rainfall,throughfall,stemflow and litter interception,along with the tree *** eucalyptus trees had rainfall interception varying between 22 mm(for 178 mm of rainfall)and 42 mm(for 87 mm of te rainfall),throughfall between 106 mm(for 186 mm of rainfall)and 44 mm(for 74 mm of rainfall),and stemflow between 0.5 mm(for 92 mm of rainfall)and 1.4 mm(for 24 mm of rainfall).For the three species,rainfall interception varied between 12 and 48%,throughfall between 57 and 90%,and stemflow between 0.3 and 5.4%.The coefficient of determination between interception and rainfall was 0.76,indicating interception depends on other variables,possibly including antecedent rainfall,rainfall intensity,and *** decreased with a reduction in leaf area index caused by eucalyptus *** *** had 0.75 mm of throughfall per 1 mm of rainfall,whereas in *** and E saligna,these ratios were 0.71 and 0.68,*** in *** and *** had a higher positive relationship with the diameter at breast height of the trees,whereas in *** the highest relationship was with the *** results contribute to establishing management strategies,such as choosing suitable eucalyptus species to local climate,and to improve the synchronization of crop-demand versus soil-water-supply while maintaining streamflow to fulfill ecological and production needs.

关键词： Water balance Blue-green water Forest hydrology Rainfall interception Rainfall throughfall

Financial sector development and economic growth:evidence from Cameroon

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Financial Innovation 2017年第1期3卷 381-398页

作者： janice Tieguhong Puatwoe Serge mandiefe Piabuo TTRECED-CAmEROON YaoundeCentreCameroon

For decades,African economies have embarked on financial sector ***,the empirical implications of these reforms have been *** paper investigates the impact of financial development on Economic growth using time series data in *** investigation was carried out using three common indicators of financial development(broad money,deposit/GDP and domestic credit to private sector).Using the Auto Regressive Distributive Lag(ARDL)technique of estimation,it was discovered that there exist a short-run positive relationship between monetary mass(m2),government expenditure and economic growth,a short run negative relationship between bank deposits,private investment and economic growth equally *** in the long run,all indicators of financial development show a positive and significant impact on economic *** paper thus confirms the existence of a positive and long-term impact of all the indicators of financial development on economic growth through bound *** is therefore proposed that the financial reforms in Cameroon should be pushed forward in order to boost the development of the financial sector thus an increase in its role on economic growth.

关键词： Financial development Economic growth Financial intermediation Endogenous growth

AdsorbmL: a leap in efficiency for adsorption energy calculations using generalizable machine learning potentials

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npj Computational materials 2023年第1期9卷 565-573页

作者： janice Lan Aini Palizhati muhammed Shuaibi Brandon m.Wood Brook Wander Abhishek Das matt Uyttendaele C.Lawrence Zitnick Zachary W.Ulissi Fundamental AI Research(FAIR) Meta AIMetaMenlo ParkCAUSA Department of Chemical Engineering Carnegie Mellon UniversityPittsburghPAUSA Scott Institute for Energy Innovation Carnegie Mellon UniversityPittsburghPAUSA

Computational catalysis is playing an increasingly significant role in the design of catalysts across a wide range of applications.A common task for many computational methods is the need to accurately compute the adsorption energy for an adsorbate and a catalyst surface of ***,the identification of low-energy adsorbate-surface configurations relies on heuristic methods and researcher *** the desire to perform high-throughput screening increases,it becomes challenging to use heuristics and intuition *** this paper,we demonstrate machine learning potentials can be leveraged to identify low-energy adsorbate-surface configurations more accurately and *** algorithm provides a spectrum of trade-offs between accuracy and efficiency,with one balanced option finding the lowest energy configuration 87.36%of the time,while achieving a~2000×speedup in *** standardize benchmarking,we introduce the Open Catalyst Dense dataset containing nearly 1000 diverse surfaces and~100,000 unique configurations.

关键词： adsorption configuration energy

Arsenic speciation in freshwater fish:challenges and research needs

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Food Quality and Safety 2023年第3期7卷 383-407页

作者： Karen S.Hoy Tetiana Davydiuk Xiaojian Chen Chester Lau Jordan R.m.Schofield Xiufen Lu Jennifer A.Graydon Ruth mitchell megan reichert X.Chris Le Department of Chemistry University of AlbertaEdmontonAlbertaCanada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlbertaCanada Alberta Health Health Protection BranchEdmontonAlbertaCanada

Food and water are the main sources of human exposure to *** is important to determine arsenic species in food because the toxicities of arsenic vary greatly with its chemical *** research has focused on high concentrations of arsenic species in marine *** concentrations of arsenic species in freshwater fish are much lower,and their determination presents analytical *** this review,we summarize the current state of knowledge on arsenic speciation in freshwater fish and discuss challenges and research *** samples are typically homogenized,and arsenic species are extracted using water/methanol with the assistance of sonication and enzyme *** species in the extracts are commonly separated using high-performance liquid chromatography(HPLC)and detected using inductively coupled plasma mass spectrometry(ICPmS).Electrospray ionization tandem mass spectrometry,used in combination with HPLC and ICPmS,provides complementary information for the identification and characterization of arsenic *** methods and perspectives discussed in this review,covering sample preparation,chromatography separation,and mass spectrometry detection,are directed to arsenic speciation in freshwater fish and applicable to studies of other food *** progress made in arsenic speciation analysis,a large fraction of the total arsenic in freshwater fish remains *** is challenging to identify and quantify arsenic species present in complex sample matrices at very low *** research is needed to improve the extraction efficiency,chromatographic resolution,detection sensitivity,and characterization capability.

关键词： Arsenic species environment food consumption freshwater fish human exposure identification of unknowns liquid chromatography mass spectrometry