检索结果-南通市图书馆

Alignment Techniques in Total Knee Arthroplasty：Where do We Stand Today?

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2024年第3期39卷 2024 Aug 5页

作者： Dhungana Hemanta jangid subhash Goyal Meghal Department of Orthopedics Fortis Hospital Gurgaon Haryana India.

Achieving optimal alignment in total knee arthroplasty (TKA) is a critical factor in ensuring optimal outcomes and long-term implant survival. Traditionally, mechanical alignment has been favored to achieve neutral post-operative joint alignment. However, contemporary approaches, such as kinematic alignments and hybrid techniques including adjusted mechanical, restricted kinematic, inverse kinematic, and functional alignments, are gaining attention for their ability to restore native joint kinematics and anatomical alignment, potentially leading to enhanced functional outcomes and greater patient satisfaction. The ongoing debate on optimal alignment strategies considers the following factors: long-term implant durability, functional improvement, and resolution of individual anatomical variations. Furthermore, advancements of computer-navigated and robotic-assisted surgery has augmented the precision in implant positioning and objective measurements of soft tissue balance. Despite ongoing debates on balancing implant longevity and functional outcomes, there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical variations. This review evaluates the spectrum of various alignment techniques in TKA, including mechanical alignment, patient-specific kinematic approaches, and emerging hybrid methods. Each technique is scrutinized based on its fundamental principles, procedural techniques, inherent advantages, and potential limitations, while identifying significant clinical gaps that underscore the need for further investigation.

关键词： alignment axes anatomical alignment functional alignment hybrid alignment kinematic alignment mechanical alignment total knee arthroplasty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

引用

Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok Ha Uk Sim Hyeyoung Shin Soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

引用

World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan Gupta Manisha Yadav subhash Yadav Bidhan Chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

冷弯带肋薄壁不锈钢管再生混凝土短柱轴压力学性能研究

引用

工程力学 2024年

作者：潘爽廖飞宇张伟杰 Pantha subhash 福建农林大学交通与土木工程学院福建农林大学数字福建智能交通技术物联网实验室

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承... 详细信息

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承载力和延性的影响规律。采用ABAQUS建立了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压性能的有限元分析模型，计算结果与试验结果吻合良好，利用有限元模型，进行了典型构件的荷载-应变曲线、荷载分配比例、不锈钢管和核心再生混凝土的纵向应力分布及其相互作用的分析。通过参数分析，研究了不锈钢屈服强度、核心再生混凝土强度、加劲肋宽度、再生骨料替代率和钢管宽厚比等参数对构件轴压受力性能的影响。最后，提出了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压承载力的简化计算公式，可为实际工程设计提供参考。

关键词：冷弯薄壁不锈钢再生骨料混凝土轴压试验有限元分析简化计算公式

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性

引用

电化学（中英文） 2024年第1期30卷 46-54页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江宁波315201 浙江启明电力集团有限公司浙江舟山316099 浙江大学舟山海洋研究中心浙江舟山316021 丹麦技术大学能源转换与储存系川麦哥本哈根

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2)和0.249Ω·cm^(2),但电堆中两个电池的电压反而分别增加了3.38 m V·kh^(-1)和3.78 m V·kh^(-1)。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr CrO_(4)物质,两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明,以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性（英文）

引用

电化学(中英文) 2024年第1期 49-57页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江启明电力集团有限公司浙江大学舟山海洋研究中心丹麦技术大学能源转换与储存系

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%kh–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.24... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%kh–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.249Ω·cm2，但电堆中两个电池的电压反而分别增加了3.38 m V·kh–1和3.78 m V·kh–1。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr Cr O4物质，两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明，以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effect of tool rotational speed on the particle distribution in friction stir welding of AA6092/17.5 SiCp-T6 composite plates and its consequences on the mechanical property of the joint

引用

Defence Technology（防务技术） 2020年第2期16卷 381-391页

作者： Uttam Acharya Barnik Saha Roy subhash Chandra Saha Department of Mechanical Engineering National Institute of Technology AgartalaBarjalaJiraniaWest Tripura799046India

This study investigates the effect of tool rotational speed(TRS)on particle distribution in nugget zone(NZ)through quantitative approach and its consequences on the mechanical property of friction stir welded joints of AA6092/17.5 SiCp-T6 composite.6 mm thick plates are welded at a constant tool tilt angle of 2°and tool traverse speed of 1 mm/s by varying the TRS at 1000 rpm,1500 rpm and 2000 rpm with a taper pin profiled *** analysis shows large quantity of uniformly shaped smaller size SiC particle with lower average particle area which are homogeneously distributed in the *** fragmentation of bigger size particles has been observed because of abrading action of the hard tool and resulting shearing effect and severe stress generation due to the rotation of *** particles occupy maximum area in the matrix compared to that of the base material(BM)due to the redistribution of broken particles as an effect of *** migration of particles towards the TMAZ-NZ transition zone has been also encountered at higher TRS(2000 rpm).The microhardness analysis depicts variation in average hardness from top to bottom of the NZ,minimum for 1500 rpm and maximum for 2000 *** impact strength at 1000 rpm and 1500 rpm remains close to that of BM(21.6 J)while 2000 rpm shows the accountable *** maximum joint efficiency has been achieved at 1500 rpm(84%)and minimum at 1000 rpm(68%)under tensile *** analysis shows mixed mode of failure for BM,1000 rpm and 1500 rpm,whereas 2000 rpm shows the brittle mode of failure.

关键词： Friction stir welding Aluminium matrix composite Tool rotational speed Particle distribution Mechanical property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observer-based Adaptive Optimal Control for Unknown Singularly Perturbed Nonlinear Systems With Input Constraints

引用

IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 48-57页

作者： Zhijun Fu Wenfang Xie subhash Rakheja Jing Na College of Mechanical Engineering Zhejiang University of Technology Department of Mechanical & Industrial Engineering Concordia University Faculty of Mechanical & Electrical Engineering Kunming University of Science & Technology

This paper introduces an observer-based adaptive optimal control method for unknown singularly perturbed nonlinear systems with input constraints. First, a multi-Time scales dynamic neural network MTSDNN observer with a novel updating law derived from a properly designed Lyapunov function is proposed to estimate the system states. Then, an adaptive learning rule driven by the critic NN weight error is presented for the critic NN, which is used to approximate the optimal cost function. Finally, the optimal control action is calculated by online solving the Hamilton-Jacobi-Bellman HJB equation associated with the MTSDNN observer and critic NN. The stability of the overall closed-loop system consisting of the MTSDNN observer, the critic NN and the optimal control action is proved. The proposed observer-based optimal control approach has an essential advantage that the system dynamics are not needed for implementation, and only the measured input U+002F output data is needed. Moreover, the proposed optimal control design takes the input constraints into consideration and thus can overcome the restriction of actuator saturation. Simulation results are presented to confirm the validity of the investigated approach. © 2014 Chinese Association of Automation.

关键词： Closed loop systems Cost functions Lyapunov functions Neural networks Nonlinear systems Optimal control systems Perturbation techniques

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative assessment of mechanical and chemical fluid diversion techniques during hydraulic fracturing in horizontal wells

引用

Petroleum Science 2023年第6期20卷 3582-3597页

作者： Maunish S.Shah subhash N.Shah Drilling Cementingand Stimulation Research CenterDepartment of Petroleum EngineeringSchool of Energy TechnologyPandit Deendayal Energy UniversityRaisanGandhinagarGujaratIndia Mewbourne School of Petroleum and Geological Engineering The University of OklahomaNormanOKUSA

The application of fluid diversion during hydraulic fracturing is an evolving technology and has become popular amongst E&P operators over the past few *** primary objective of the fluid diversion is to improve hydraulic fracturing treatment by increasing stimulated reservoir volume and improving hydrocarbon *** is possible by achieving any of the following objectives:creating uniform distribution of treatment slurry within the target zone;treating unstimulated and under-stimulated zones;or by increasing fracture density by creating a complex fracture *** fluid diversion application is also helpful in decreasing the number of stages(by increasing stage length)for multi-stage plug-n-perf(PnP)fracturing *** is also applied to prevent fracture-driven interactions between adjacent wells,which is currently a major issue,especially in *** addition,for successful refracturing treatment,the diverter application is essential for isolating the existing fractures and redirecting the treatment slurry to the desired unstimulated *** diversion methods can be broadly categorized into the mechanical and chemical *** established mechanical diversion techniques are frac plugs,expandable casing patches,expandable liners,swellable packers,straddle packer assembly,sand plugs,frac sleeves,perforation ball sealers,and limited entry *** different chemical diversion techniques are particulates,fibers,gels,surfactants,perforation pods,and composite *** paper describes the current status of established mechanical and chemical diverter technologies and examines their comparative advantages and *** techniques are suitable for diverter application,but the technique is selected based on the desired objective and conditions of the wellbore and *** general guidelines for selecting diversion techniques and operational considerations are also provided in the *** diagnosis of diversion treatme

关键词： Fluid diversion Diverter Diverting agents Multi-stage fracturing Hydraulic fracturing Horizontal well

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：