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Targeted therapy in gastroesophageal cancers:past,present and future

Gastroenterology Report 2015年第4期3卷 316-329,I0002页

作者： janghee woo Stacey A.Cohen Jonathan E.Grim Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA Division of Medical Oncology University of WashingtonSeattleWAUSA Hospital and Specialty Medicine VA Puget Sound Health Care SystemSeattleWAUSA

Gastroesophageal cancer is a significant global problem that frequently presents at an incurable stage and has very poor survival with standard chemotherapy *** review will examine the epidemiology and molecular biology of gastroesophageal cancer and will focus on the key deregulated signaling pathways that have been targeted in the clinic.A comprehensive overview of clinical data highlighting successes and failures with targeted agents will be *** notably,HER2-targeted therapy with the monoclonal antibody trastuzumab has proven beneficial in first-line therapy and has been incorporated into standard *** the VEGF pathway has also proven beneficial,and the VEGFR-targeted monoclonal antibody ramucirumab is now approved for second-line *** contrast to these positive results,agents targeting the EGFR and MET pathways have been evaluated extensively in gastroesophageal cancer but have repeatedly failed to show *** increased understanding of the molecular predictors of response to targeted therapies is sorely *** the future,improved molecular pathology approaches should subdivide this heterogeneous disease entity to allow individualization of cancer therapy based on integrated and global identification of deregulated signaling *** patient selection,rational combinations of targeted therapies and incorporation of emerging immunotherapeutic approaches should further improve the treatment of this deadly disease.

关键词： esophageal cancer gastric cancer targeted therapy molecular oncology

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