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Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases:A mini-review

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BIOCELL 2023年第8期47卷 1703-1708页

作者： AN-soo jang Division of Allergy and Respiratory Medicine Department of Internal MedicineSoonchunhyang University Bucheon Hospital170 Jomaru-roBucheon-siGyeonggi-do14584Korea

Exposure to air pollutants such as PM_(10),PM_(2.5),PM_(0.1),O_(3),CO,NO2,and SO_(2),and biological pollutants are important factors causing the evolution and furtherance of obstructive lung diseases(OLD),including asthma and chronic obstructive pulmonary disease(COPD).Asthma is the most frequent chronic inflammatory airway disease,characterized by breathlessness,wheezing,chest tightness,and cough,together with the presence of exaggerated expiratory airflow fluctuation that varies over *** is a heterogeneous lung condition characterized by chronic respiratory symptoms such as dyspnea,cough,expectoration,and/or exacerbations due to abnormalities of the airways and/or alveoli that cause persistent,often progressive,airflow *** the molecular mechanisms and cellular processes based on the development of OLD on exposure to air pollutants will provide insights into the solution of pathogenesis,prevention,and treatment of these *** molecular mechanisms and cellular process involved in signal transduction pathway plays a role in the binding of extracellular signaling molecules and ligands to receptors placed on the cell surface or on the inner side cell that trigger inflammation that occurs,especially when something important enters the cell to bring into a cascade *** binding then alters the cell metabolism,shape,and gene expression in the *** review aimed to reveal the effect of air pollutants on the molecular mechanisms and cellular processes involved in the signal transduction pathways in OLD.

关键词： Air pollutants Obstructive lung diseases Signal pathway

Comparative pollen morphology of Glechoma and Marmoritis(Nepetinae,Lamiaceae)

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Journal of Systematics and Evolution 2010年第6期48卷 464-473页

作者： Tae-soo jang Suk-Pyo HONG Laboratory of Plant Systematics Department of BiologyInstitute of Basic SciencesKyung Hee University

The pollen morphology of 13 taxa(34 specimens) of the genera Glechoma L.,and Marmoritis *** investigated in detail using light,scanning electron,and transmission electron *** grains of all studied taxa are small to large in size(P = 32.5-60.4 μm,E = 20.2-50.5 μm),prolate-spheroidal to prolate in shape and mostly hexacolpate(the amb more or less circular or rarely ellipsoid) with granular *** sexine ornamentation of Glechoma is bireticulate;the muri of the primary reticulum are irregularly circled,and lumen size is *** contrast,the sexine surfaces of the Marmoritis pollen tend to more elongate or wider at the muri of the primary reticulum than those of the *** pollen wall stratification of selected taxa(three from Glechoma and one from Marmoritis) is characterized by unbranched columellae,and continuous or distinctly discontinuous endexine based on transmission electron microscopy *** results of Glechoma and Marmoritis reveal rather similar pollen morphological features,however,fine details of sexine ornamentation are characteristic to differentiate the pollen *** these differences may be useful in establishing the taxonomic boundary between two genera,they are too weak to segregate diagnostic characters.

关键词： Glechoma Lamiaceae Marmoritis Nepetinae pollen morphology scanning electron microscope sexine ornamentation transmission electron microscope.

Endovascular treatment of a ruptured pseudoaneurysm of the internal carotid artery in a patient with nasopharyngeal cancer:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9121-9126页

作者： Jung-soo Park Hyoung Gyu jang Department of Neurosurgery Jeonbuk National University Medical School and HospitalJeonju 54907South Korea

BACKGROUND Radiation therapy(RT)for nasopharyngeal cancer can cause several *** rare cases,an internal carotid artery pseudoaneurysm can occur,which can be *** report the experience of a nasopharyngeal cancer patient who underwent radiation therapy and subsequently developed a fatal pseudoaneurysm of the petrous internal carotid *** SUMMARY A 39-year-old man was diagnosed with nasopharyngeal cancer 2 years ago(American Joint Committee on Cancer Stage T3N2M0)and received concurrent chemoradiation *** subsequently relapsed and received *** week after the 4th cycle of chemotherapy,he was admitted to the emergency room of our hospital because of massive epistaxis accompanied by a headache.A pseudoaneurysm of the petrous internal carotid artery was confirmed by digital subtraction angiography(DSA).Stent-assisted endovascular coil embolization was performed and complete occlusion was *** pseudoaneurysm was observed on DSA after coil embolization;however,intermittent epistaxis was maintained even after coil *** seven days,a diagnostic laryngoscopy was *** bleeding occurred after aspiration of the blood clot during the laryngoscopy and the patient died of hypovolemic *** this case,epistaxis may have been a sign of pseudoaneurysm;therefore,treatment such as embolization should be performed promptly,and careful management should be undertaken after *** This case highlights a rare,serious complication of RT in nasopharyngeal cancer and how it should be recognized and treated.

关键词： Pseudoaneurysm Nasopharyngeal cancer Radiation therapy Epistaxis Carotid artery pseudoaneurysm Case report

Hydrogen Generation from the Dissociation of Water Using Microwave Plasmas

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Chinese Physics Letters 2013年第6期30卷 144-147页

作者： Yong Ho Jung soo Ouk jang Hyun Jong You Plasma Technology Research Center National Fusion Research InstituteJeonbuk 573-540Korea

Hydrogen is produced by direct dissociation of water vapor,i.e.,splitting water molecules by the electrons in water plasma at low pressure(<10–50 Torr)using microwave plasma *** condition generates a high electron te... 详细信息

Hydrogen is produced by direct dissociation of water vapor,i.e.,splitting water molecules by the electrons in water plasma at low pressure(oh line intensity.

关键词： microwave dissociation utilizing

Vacuum-free lamination via controlled polymer adhesion for selective photogeneration and photodetection

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Carbon Energy 2024年第7期6卷 205-218页

作者： Min soo Kim Jihyun Lim Woongsik jang Dong Hwan Wang Department of Intelligent Semiconductor Engineering Chung-Ang UniversitySeoulRepublic of Korea School of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea

This study attempts to develop a reproducible thin-film formation technique called vacuum-free(VF)lamination,which transfers thin films using elastomeric polymer-based laminating ***,by controlling the interface characteristics of the mediator based on the work of adhesion,VF lamination is successfully performed for various thicknesses(from 20 to 240 nm)of a conjugated photoactive material composed of poly[(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo[1,2-b:4,5-bʹ]dithiophene))-alt-(5,5-(1ʹ,3ʹ-di-2-thienyl-5ʹ,7ʹ-bis(2-ethylhexyl)benzo[1ʹ,2ʹ-c:4ʹ,5ʹ-cʹ]dithiophene-4,8-dione)](a polymer donor)and 2,2ʹ-((2Z,2ʹZ)-((12,13-bis(2-butyloctyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2ʹʹ,3ʹʹ:4ʹ,5ʹ]thieno[2ʹ,3ʹ:4,5]pyrrolo[3,2-g]thieno[2ʹ,3ʹ:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(a nonfullerene acceptor).Interestingly,the organic photovoltaic and photodetecting applications,prepared by the VF lamination process,showed superior performance compared to those of devices prepared by conventional *** is due to the overturned surface morphology,which led to enhanced charge transport ability and blocking of the externally injected ***,the reproducible VF lamination process,exploiting an adhesion-based elastomeric polymer mediator,is a promising thin-film formation technique for developing efficient next-generation organic optoelectronic materials consistent with the solution process.

关键词： conjugated nonfullerene acceptor photodetectors photovoltaics polymer vacuum-free lamination

Development of 3D bicontinuous metal-intermetallic composites through subsequent alloying process after liquid metal dealloying

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Journal of Magnesium and Alloys 2023年第11期11卷 4274-4281页

作者： Jee Eun jang Jihye Seong soo-Hyun Joo Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Dankook UniversityCheonan 31116Republic of Korea

This study presents a novel process for the fabrication of metal-intermetallic composites with a 3D bicontinuous structure, achieved through a combination of liquid metal dealloying(LMD) and subsequent alloying. Initially, porous Ti structures are produced using the LMD process, followed by immersion in a molten Mg-3Al(wt%) metal. Due to the higher thermodynamic miscibility of Al with Ti compared to Mg, the concentration of Al in the Ti matrix increases as the immersion time increases. This results in a sequential phase transition within the Ti matrix: α-Ti → Ti_(3)Al → Ti Al. The phase transition considerably affects the hardness and strength of the composite material,with the Mg-Ti_(3)Al-Ti Al composite exhibiting a maximum hardness nearly twice as high as that of the conventional Mg-Ti composite. This innovative process holds potential for the development of various bicontinuous metal-intermetallic composites.

关键词： Liquid metal dealloying Subsequent alloying Metal–intermetallic composite 3D bicontinuous structure Hardness

Development of genome engineering technologies in cattle: from random to specific

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Journal of Animal Science and Biotechnology 2018年第2期9卷 285-293页

作者： soo-Young Yum Ki-Young Youn Woo-Jae Choi Goo jang Department of Veterinary Clinical Science College of Veterinary Medicine and the Research Institute of Veterinary Science Seoul National University Farm Animal Clinical Training and Research Center Institute of Green Bio Science Technology Seoul National University Emergence Center for Food-Medicine Personalized Therapy System Advanced Institutes of Convergence Technology Seoul National University College of Veterinary Medicine Seoul National University

The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the ***, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.

关键词： Cattle CRISPR-Cas9 Genome engineering technologies Transgenesis Transposon

Memristive Devices Based on Two-Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第4期14卷 29-58页

作者： Ki Chang Kwon Ji Hyun Baek Kootak Hong soo Young Kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Two-dimensional(2D)transition metal chalcogenides(TMC)and their heterostructures are appealing as building blocks in a wide range of electronic and optoelectronic devices,particularly futuristic memristive and synaptic devices for brain-inspired neuromorphic computing *** distinct properties such as high durability,electrical and optical tunability,clean surface,flexibility,and LEGO-staking capability enable simple fabrication with high integration density,energy-efficient operation,and high *** review provides a thorough examination of high-performance memristors based on 2D TMCs for neuromorphic computing applications,including the promise of 2D TMC materials and heterostructures,as well as the state-of-the-art demonstration of memristive *** challenges and future prospects for the development of these emerging materials and devices are also *** purpose of this review is to provide an outlook on the fabrication and characterization of neuromorphic memristors based on 2D TMCs.

关键词： Two-dimensional materials Memristors Neuromorphic computing Artificial synapses Transition metal chalcogenides

Statistical estimations for Plasmodium vivax malaria in South Korea

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 169-175页

作者： Youngsaeng Lee Hyeongap jang Jeong Ae Rhee Jeong-soo Park Department of Statistics Chonnam National University JW LEE Center for Global Medicine College of MedicineSeoul National University Department of Preventive Medicine Chonnam National University

Objective:To calculate the numbers of weekly infections and prevalence of malaria,and to predict future trend of malaria incidences in South ***:Weekly incidences of malaria for 13 years from the period 2001-2013 in South Korea were *** backcalculation equations were used with incubation period *** maximum likelihood estimation for Poisson model was also *** confidence intervals of the estimates were obtained by a bootstrap method.A regression model for time series of malaria incidences over13 years was fitted by the non-linear least squares method,and used to predict ***:The estimated infection curve is narrower and more concentrated in the summer than in the incidence *** started around the 19 th week and was over around the41 st *** maximum weekly infection 110 was obtained at the 29 th *** prevalence at the first week was around 496 persons,the minimum number was 366 at 22 nd week,and the maximum prevalence was 648 at 34 th *** drops in late spring with people that falling ill and had had long incubation periods and rose in the summer with new *** future forecast based on the regression model was that an increase at year 2014 compared to 2013 may reach a peak(at maximum about 70 weekly cases) at year *** a decreasing trend after ***:This work shows that back-calculation methods could work well in estimating the infection rates and the prevalence of *** obtained results can be useful in establishing an efficient preventive program for malaria *** method presented here can be used in other countries where incidence data and incubation period are available.

关键词： Back calculation Incidence Incubation period Infection Poisson model Prevalence Regression model