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prognostic Factors for Mortality in Severe Traumatic Brain Injury at HGZ 46, Villahermosa, Tabasco, period from March 1, 2021 to December 31, 2022

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Open Journal of Emergency Medicine 2024年第1期12卷 1-9页

作者： América del Carmen flores Jiménez Eduardo Guillermo Aguilar López Rafael Blanco De La Vega p.rez Juan Manuel Hernández Vázquez Emergency Room at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico Intensive Care Unit at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico

Introduction: A traumatic brain injury (TBI) is caused by a forceful bump, blow, or jolt to the head or body, or by an object that pierces the skull and interrupts the normal function of the brain. Severe TBI is estimated at 73 cases per 100,000 people. The mortality of severe TBI can be reduced if a timely diagnosis and treatment of the injuries are made through prognostic factors. Objective: To determine the prognostic factors related to mortality in severe traumatic brain injury at the Hospital General de Zona No. 46. Material and Methods: Retrospective, cross-sectional and descriptive study in beneficiaries admitted to the Hospital General de Zona (HGZ) No. 46 of the Mexican Institute of Social Security (IMSS by its acronym in Spanish), with a diagnosis of severe TBI;the possible prognostic factors related to mortality of severe TBI were obtained from their records. Measures of central tendency and chi square were used for data analysis. Results: The study sample consisted of 60 subjects diagnosed with severe traumatic brain injury, of which 5 (8%) were women and 55 (92%) were men, and all 60 (100%) patients died. The average age of the sample was 26 with a standard deviation of 9 years. The variables that had a p value less than or equal to 0.05 were: Mydriasis, seizures, Hyperglycemia, Normoglycemia, Hypothermia and Hypotension. This means that these variables were associated with mortality. Conclusion: Statistical significance is demonstrated in prognostic factors of mortality in severe traumatic brain injury with p perglycemia, normoglycemia, hypothermia and hypotension.

关键词： Traumatic Brain Injury prognostic Factors Mortality Severity

Overweight/Obesity in University Students from Mexico: Comparison Using Different Indices

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Journal of Biosciences and Medicines 2024年第7期12卷 151-159页

作者： Gabriel Medrano-Donlucas Claudia Carolina Hernández-peña Ricardo Juárez-Lozano Cecilia López-López Santiago C. Sigrist flores Rafael Villalobos-Molina Itzell A. Gallardo-Ortíz Instituto de Ciencias Biomdicas Universidad Autnoma de Ciudad Jurez Ciudad Jurez Mxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autnoma de Mxico Tlalnepantla de Baz Mxico

The goal was to compare body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), and relative fat mas (RFM), to identify the best predictor of overweight and obesity in university students from Mexico. This is a cross-sectional survey with 697 university students from northern and central Mexico (448 women, and 249 men aged 18 - 19 years). Data was collected during 2018. Overweight and obesity were calculated from those indices and for both, female and male students, the order of correlation between a pair of indices were WHtR vs. RFM > WHtR vs. WC > RFM vs. WC > WHtR vs. BMI > BMI vs. WC > RFM vs. BMI. It is concluded to use the WHtR and the RFM to better predict overweight and obesity in young Mexican university students.

关键词： Overweight and Obesity Anthropometry Anthropometry Indices

Effect of Ultraviolet Radiation on Hsp70 protein Expression in HaCaT Cells

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World Journal of Nuclear Science and Technology 2024年第1期14卷 59-71页

作者： Sergio Hugo Sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez Kevin Said Ramírez Dávila Luis Martín García Ortiz Germán flores Cortés Luz Elena Vidales Rodríguez Jesús Adrián López David Alejandro García López Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de MicroRNAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by pAGE-SDS and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A Light (UVA) Ultraviolet B Light (UVB) Ultraviolet C Light (UVC) Heat Shock protein 70 (Hsp70) HaCaT

pharmacokinetics of sildenafil in children with pulmonary arterial hypertension

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World Journal of pediatrics 2017年第6期13卷 588-592页

作者： Hugo Juárez Olguín Hector Osnaya Martínez Carmen flores p.rez Blanca Ramírez Mendiola Liliana Rivera Espinosa Juan Luis Chávez pacheco janett flores p.rez Ignacio Mora Maga(n)a Laboratory of pharmacology National Institute of PediatricsMexico CityMexico Department of pharmacology Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Service of Cardiology National Institute of PediatricsMexico CityMexico Laboratory of pharmacology National Institute of PediatricsMexico CityMexico Subdirection of Teaching and Educational programming National Institute of PediatricsMexico CityMexico

Background:Recently,sildenafil was introduced to treat pulmonary arterial hypertension (pAH);however,there are currently few studies on the pharmacokinetics of sildenalfil in ***,we aimed to carry out a pharmacokinetic study of sildenafil in children with pAH using a single ***:Twelve children diagnosed with pAH,consisting of with ten males and two females,were recruited for the study after obtaining written consent from their parents or *** samples were obtained predose and at 0.25,0.5,1,2,4,8 and 12 hours after the oral administration of 1 mg/kg of sildenafil using an extemporal pediatric formulation developed in our *** samples were analyzed using a previously validated high performance liquid chromatography ***:A pharmacokinetic analysis using the WinNonlin 3.1 program that considered the Akaike information criterion (AIC) for sdecting a more adjustable model was *** following pharmacokinetic parameters were obtained:maximal concentration (Cmax):366+179 ng/mL,time to maximal concentration:0.92±0.30 hours,elimination half-life (t1/2):2.41±1.18 hours,total clearance (CLto/F):5.85±2.81 L/hour,volume of distribution (Vd/F):20.13±14.5 L,absorption rate constants (Ka):0.343 hour-1,elimination rate (Ke):0.35 hour-1,area under curve from zero to infinity:2061±618 ng/mL/*** data of all patients adjusted to the model of one compartment were corroborated using ***:The parameters Ka,Ke and t1/2 were found to be similar to those reported in adults;however,the values of Cmax and Vd/F were significantly *** on these findings,we propose that treatment regimen of sildenafil be adjusted in children with pAH.

关键词： pharmacokinetics pulmonary arterial hypertension sildenafil

Digestibility,Antioxidant and Anti-Inflammatory Activities of pecan Nutshell(Carya illioinensis)Extracts

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Journal of Renewable Materials 2022年第10期10卷 2569-2580页

作者： María Janeth Rodríguez-Roque Carmen Lizette Del-Toro-Sánchez Janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel p.rez-p.rez Esteban Sánchez-Chávez Nora AideéSalas-Salazar Juan Manuel Soto-parra Rey David Iturralde-García María Antonia flores-Córdova Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de Sonora Rosales y Niños Héroes S/NHermosilloSonMéxico Centro de Investigación en Alimentación y Desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

phenolic compounds are related to high biological activity,avoiding oxidation in food and human *** are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be *** research aimed to evaluate the antioxidant(DppH,ABTS,FRAp and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including *** showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DppH(22.96 mmol ET),ABTS(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical *** studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems.

关键词： Anti-inflammatory activity antioxidants digestibility shell phenolic compounds

Use of δ^(18)O, δ^(13)C and NO_(3)^(-) to identify hydrogeochemical processes related to contamination in an aquifer located in central Mexico

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Acta Geochimica 2022年第3期41卷 367-392页

作者： JoséIván Morales-Arredondo María Aurora Armienta Hernández Fátima Juárez-Aparicio Jorge Federico Landa-Arreguín Itzamna Zaknite flores-Ocampo Natural Resources Department Institute of GeophysicsNational Autonomous University of MexicoCiudad Universitaria No.3000Col.Copilco UniversidadCoyoacan Delegation04360 MexicoCDMXMexico Earth Sciences postgraduate program University National Autonomous of MexicoUniversity City No.3000Col.Copilco UniversityCoyoacán Delegation04510 MexicoCDMXMexico

In this work,an isotopic analysis of δ^(18)O,δ^(13)C,and NO_(3)^(-) concentrations was carried out to identify the origin and the processes related to the contamination of an aquifer located in the state of Guanajuato,*** research identified the possible sources of δ^(13)C in *** groundwater flow,CO_(2) participates in different hydrogeochemical reactions in which the dissolution of carbonates or biochemical processes related to biodegradation stand *** data of δ^(13)C,δ^(18)O,and the hydrogeochemical behavior of NO_(3)^(-) and HCO_(3)^(-) in water,in addition to isotopic data and the chemical composition of limestones in the study area,were determined to establish the isotopic signature and the processes undergone by the *** isotopic signature of rock and water samples indicated that metamorphic limestones contributed with carbon dioxide to deep groundwater,while in the upper aquifer,bacterial metabolic reactions during nitrification–denitrification could modify the isotopic signature of δ^(13)C in some wells,although atmospheric contribution also plays a *** modification of the carbon isotopic component is related to the precipitation of calcite in specific regions of the study area,input of atmospheric CO_(2),and soil(*** possible participation of C4-type plants in the assimilation-release of carbon).This process is not confirmed or completely ruled out in this study since agriculture is excessively developed throughout the *** joint interpretation of isotopic values and the hydrogeochemical behavior of major and conservative elements help in identifying possible pollution processes in which different carbon sources are related.

关键词： ^(18)O and^(13)C isotopes Groundwater pollution Nitrate Limestone

Application of two forms of silicon and their impact on the postharvest and the content of bioactive compounds in cucumber(Cucumis sativus L.)fruits

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BIOCELL 2022年第11期46卷 2497-2506页

作者： YOLANDA GONZÁLEZ-GARCÍA VALERIA flores-ROBLES GREGORIO CADENAS-pLIEGO ADALBERTO BENAVIDES-MENDOZA MARCELINO CABRERA DE LA FUENTE ALBERTO SANDOVAL-RANGEL ANTONIO JUÁrez-MALDONADO Departamento de Botánica Universidad Autónoma Agraria Antonio NarroSaltillo25315México Maestría en Ciencias en Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Centro de Investigación en Química Aplicada Saltillo25294México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México

The metabolic activity of the fruits continues even after harvest,which results in the loss of bioactive compounds,a decrease in the quality of the fruits,softening and browning,among other negative *** use of certain elements such as silicon can improve postharvest quality,since it is involved in the metabolic,physiological and structural activity of plants,moreover can increase the quality of the *** addition,nanotechnology has had a positive impact on crop yield,nutritional value,fruit quality and can improve antioxidant *** these reasons,the use of beneficial elements such as silicon in the form of nanoparticles can be a viable option to improve the characteristics of the *** the present study was evaluated the application of potassium silicate(125,250 and 500 mg L^(−1))and SiO_(2) nanoparticles(125,250 and 500 mg L^(−1))during the development of the *** results showed that the application of silicon(potassium silicate and silicon nanoparticles)increased the content of total soluble solids(up to 15.6%higher than control),titratable acidity(up to 38.8%higher than control),vitamin C(up to 78.2%higher than control),phenols(up to 22%higher than control),flavonoids(up to 64.6%higher than control),and antioxidant activity in lipophilic compounds(up to 56.2%higher than control).This study suggests that the use of silicon can be a good option to increase the content of bioactive compounds in cucumber fruits when they are applied during the development of the crop.

关键词： Fruit quality Nanotechnology Silicon nanoparticles potassium silicate Antioxidant compounds Antioxidant capacity

particulate matter geochemistry of a highly industrialized region in the Caribbean:Basis for future toxicological studies

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Geoscience Frontiers 2022年第1期13卷 376-387页

作者： Luis F.O.Silva Ismael L.Schneider paulo Artaxo Yuleisy Núñez-Blanco Diana pinto Érico M.M.flores Leandro Gómez-plata Omar Ramírez Guilherme L.Dotto Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia Department of Applied physics Institute of PhysicsUniversity of São PauloBrazil Department of Chemistry Universidade Federal de Santa MariaRSBrazil Universidad Militar Nueva Granada(UMNG) Faculty of EngineeringEnvironmental EngineeringKm 2 Cajicá-ZipaquiráColombia Chemical Engineering Department Federal University of Santa Maria-UFSM1000Roraima Avenue97105-900 Santa MariaRSBrazil

Air pollution has become an important issue,especially in Caribbean urban areas,and,particulate matter(pM)emitted by different natural and anthropogenic sources causes environmental and health *** this work,we studied the concentrations of pM_(10) and pM_(2.5) sources in an industrial and port urban area in the Caribbean region of *** samples were collected within 48-h periods between April and October 2018 by using a partisol 2000 i-D *** geochemical characterization was performed by X-ray fluorescence(XRF)***,ionic species and black carbon(BC)were quantified by ion chromatography and reflectance spectroscopy,*** the positive Matrix Factorization(pMF)receptor model,the contributions of pM sources were *** average concentration of pM_(10) was 46.6±16.2μg/m^(3),with high concentrations of Cl and *** pM_(2.5),the average concentration was 12.0±3.2μg/m^(3),and the most abundant components were BC,S,and *** receptor model identified five sources for pM_(10) and pM_(2.5).For both fractions,the contributions of marine sea spray,re-suspended soil,and vehicular traffic were *** addition,pM_(2.5) included two mixed sources were found to be fuel oil combustion with fertilizer industry emissions,and secondary aerosol sources with building construction ***,pM_(10) was found to also include building construction emissions with re-suspended soil,and metallurgical industry *** obtained geochemical atmospheric results are important for the implementation of strategies for the continuous improvement of the air quality of the Caribbean region.

关键词： Urban air pollution particulate matter Geochemical composition Aerosol source apportionment Receptor models pMF

Recent Advances in Synthesis and properties of Hybrid Halide perovskites for photovoltaics

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Nano-Micro Letters 2018年第4期10卷 167-200页

作者： C.C.Vidyasagar Blanca M.Muoz flores Víctor M.Jimnez p.rez Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Ciudad Universitaria School of Basic Sciences and Research in Chemistry Rani Channamma University

The progress made by the scientific community in emerging photovoltaic technologies over the past two decades has been outstanding. Numerous methods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum deposition technique. A serious concern is the toxicity of the materials. In this review, several methods aimed at resolving these problems to some extent have been compiled, including eco-friendly synthesis. Further efficiency enhancements are expected following optimization, and a better fundamental understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a simple low-cost model called‘‘dispersed photovoltaic cells' ' is presented.

关键词： perovskites Solar cells Organic–inorganic perovskites Synthetic routes Fluorescence