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Towards high strength cast Mg-RE based alloys:Phase diagrams and strengthening mechanisms

Journal of Magnesium and Alloys 2022年第6期10卷 1401-1427页

作者： janet M.Meier Josh Caris Alan A.Luo Department of Materials science and Engineering The Ohio State UniversityColumbusOH 43210USA Terves LLC EuclidOH 44117USA Department of Integrated systems Engineering The Ohio State UniversityColumbusOH 43210USA

Mg-rare earth(RE)based systems provide several important commercial alloys and many alloy development opportunities for high strength applications,especially in aerospace and defense *** phase diagrams,microstructure,and strengthening mechanisms of these multicomponent systems are very complex and often not well understood in *** have calculated phase diagrams of important binary,ternary,and multicomponent RE-containing alloy systems,using CALPHAD(CALculation of PHAse Diagrams).Based on these phase diagrams,this paper offers a critical overview on phase equilibria and strengthening mechanisms in these alloy systems,including precipitation,long period stacking order(LPsO),and other intermetallic *** review also summarized several promising Mg-RE based cast alloys in comparison with commercial WE54 and WE43 alloys;and explored new strategies for future alloy development for high strength *** is pointed out that the combination of precipitation and LPsO phases can lead to superior strength and ductility in Mg-RE based cast *** precipitates and LPsO phases can form a complex three-dimensional network that effectively impedes dislocation motion on the basal and non-basal *** LPsO phases can also prevent the coarsening of precipitates when they interact,thus providing good thermal stability at elevated *** research is needed to determine how the combination of these two types of phases can be used in alloy design and industrial scale applications.

关键词： Magnesium alloys Phase diagrams Precipitation strengthening Long period stacking order(LPsO) Alloy development CALPHAD

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status of precision medicine approaches to traumatic brain injury

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Neural Regeneration Research 2022年第10期17卷 2166-2171页

作者： sahithi Reddi smita Thakker-Varia janet Alder Anna O.Giarratana Department of Neuroscience and Cell Biology Rutgers Robert Wood Johnson Medical SchoolPiscatawayNJUSA

Traumatic brain injury(TBI)is a serious condition in which trauma to the head causes damage to the brain,leading to a disruption in brain *** is a significant health issue worldwide,with around 69 million people suffering from TBI each *** following the trauma,damage occurs in the acute phase of injury that leads to the primary outcomes of the *** the hours-to-days that follow,secondary damage can also occur,leading to chronic *** can range in severity from mild to severe,and can be complicated by the fact that some individuals sustain multiple TBIs,a risk factor for worse long-term *** our knowledge about the pathophysiology of TBI has increased in recent years,unfortunately this has not been translated into effective clinical *** *** and Drug Administration has yet to approve any drugs for the treatment of TBI;current clinical treatment guidelines merely offer supportive *** between individuals greatly vary,which makes the treatment for TBI so challenging.A blow of similar force can have only mild,primary outcomes in one individual and yet cause severe,chronic outcomes in *** of the reasons that have been proposed for this differential response to TBI is the underlying genetic differences across the *** to this,many researchers have begun to investigate the possibility of using precision medicine techniques to address TBI *** this review,we will discuss the research detailing the identification of genetic risk factors for worse outcomes after TBI,and the work investigating personalized treatments for these higher-risk *** highlight the need for further research into the identification of higher-risk individuals and the development of personalized therapies for TBI.

关键词： apolipoprotein E biomarkers brain injury brain-derived neurotrophic factor clinical trials personalized treatments precision medicine tau translational research traumatic brain injury

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Digestibility,Antioxidant and Anti-Inflammatory Activities of Pecan Nutshell(Carya illioinensis)Extracts

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Journal of Renewable Materials 2022年第10期10卷 2569-2580页

作者： María janeth Rodríguez-Roque Carmen Lizette Del-Toro-sánchez janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel Pérez-Pérez Esteban sánchez-Chávez Nora Aideésalas-salazar Juan Manuel soto-Parra Rey David Iturralde-García María Antonia Flores-Córdova Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de sonora Rosales y Niños Héroes S/NHermosilloSonMéxico Centro de Investigación en Alimentación y Desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

Phenolic compounds are related to high biological activity,avoiding oxidation in food and human *** are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be *** research aimed to evaluate the antioxidant(DPPH,ABTs,FRAP and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including *** showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DPPH(22.96 mmol ET),ABTs(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical *** studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems.

关键词： Anti-inflammatory activity antioxidants digestibility shell phenolic compounds

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Hypotension prediction index together with cerebral oxygenation in guiding intraoperative hemodynamic management: a case report

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The Journal of Biomedical Research 2022年第1期36卷 73-77页

作者： Yun Li janet Phan Azaam Mamoor Hong Liu Department of Anesthesiology the Second Hospital of Anhui Medical UniversityHefeiAnhui 230601China Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoCA 95817USA California Northstate University College of Medicine SacramentoCA 95757USA

Intraoperative hypotension happens in everyday clinical practice. It was suggested to have a strong association with adverse postoperative outcomes. Hypotension prediction index(HPI) was developed to predict intraoperative hypotension(mean arterial pressure ssure autoregulation also plays an important role in maintaining adequate organ perfusion/oxygenation during hypotension. A cerebral oxygenation monitor provides clinicians with the values of organ oxygenation. We reported a case that the cerebral oxygenation monitor was used together with HPI to guide intraoperative blood pressure management. We found that cerebral oxygenation was maintained in the event of hypotension during surgery. The patient had no intraoperative or postoperative adverse outcomes despite the hypotension. We believe this can provide an individualized intraoperative blood pressure management to avoid over-or under-treating hypotension.

关键词： hypotension prediction index cerebral oxygenation hemodynamic intraoperative

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Feasibility of gallbladder preservation during robotic left hepatectomy:A retrospective comparative study

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Laparoscopic, Endoscopic and Robotic surgery 2022年第3期5卷 100-105页

作者： Kit-Fai Lee Andrew KY.Fung Hon-Ting Lok janet WC.Kung Eugene YJ.Lo Charing CN.Chong John wong Kelvin KC.Ng Division of Hepatobiliary and Pancreatic surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Objective:Traditionally,gallbladder is routinely removed during left hepatectomy even if there is no gallbladder ***,adverse consequence after cholecystectomy,though rare,still occa-sionally *** study aims to evaluate the feasibility of gallbladder preservation during robotic left ***:All consecutive robotic left hepatectomy cases between December 2010 and January 2022 in Prince of Wales Hospital,the Chinese University of Hong Kong were retrieved from a prospectively collected *** gallbladder was preserved by moving the liver transection line just away from the gallbladder *** were divided into two groups:gallbladder preservation(GBP)and non-gallbladder preservation(NGBP).Operative results and long-term outcomes were compared between these two ***:There were 11 cases in the GBP group and 25 cases in the NGBP *** two groups were comparable in terms of the patient demographics and disease *** was no operative *** was no difference between the two groups in operative time(GBP 270 min *** 332 min,p=0.132),blood loss(GBP 50 mL *** 150 mL,p=0.115)or complication rate(GBP 27.3%*** 24.0%,p>0.999).There was also no difference in 5-year overall *** the GBP group,no patient developed specific symptoms or complications related to the preserved ***-up ultrasound or computed tomography revealed a normal appearance of the preserved gallbladders except in one patient who developed a 3-mm gallbladder *** the other hand,one(4%)patient in the NGBP group developed troublesome diarrhoea after ***:Gallbladder preservation is safe and feasible during robotic left *** preserved gallbladder does not lead to any symptoms,while postcholecystectomy diarrhoea can be avoided.

关键词： Robotic left hepatectomy Gallbladder preservation Cholecystectomy

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Three-dimensional impact kinetics with foot-strike manipulations during running

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Journal of sport and Health science 2017年第4期6卷 489-497页

作者： Andrew D. Nordin janet s. Dufek John A. Mercer Department of Kinesiology and Nutrition sciences University of Nevada Las Vegas NV 89154 USA

Background: Lack of an observable vertical impact peak in fore/mid-foot running has been suggested as a means of reducing lower extremity impact forces, although it is unclear if impact characteristics exist in other axes. The purpose of the investigation was to compare three-dimensional(3 D) impact kinetics among foot-strike conditions in over-ground running using instantaneous loading rate–time ***: Impact characteristics were assessed by identifying peak loading rates in each direction(medial–lateral(ML), anterior–posterior(AP),vertical, and 3 D resultant) following foot-strike instructions(fore-foot, mid-foot, subtle heel, and obvious heel strike). Kinematic and kinetic data were analyzed among 9 male participants in each foot-strike ***: Loading rate peaks were observed in each direction and foot-strike condition, differing in magnitude by direction(3 D resultant and vertical > AP > ML, p ≤ 0.031) and foot-strike: ML(fore-foot and mid-foot strike > obvious heel strike, p ≤ 0.032), AP(fore-foot and mid-foot strikes > subtle-heel and obvious heel strikes, p ≤ 0.023). In each direction, the first loading rate peak occurred later during heel strike running relative to fore-foot(p ≤ 0.019), with vertical and 3 D resultant impact durations exceeding shear(ML and AP, p ≤ 0.007) in each ***: Loading rate–time assessment identified contrasting impact characteristics in each direction and the 3 D resultant following foot-strike manipulations, with potential implications for lower extremity structures in running.

关键词： Fore-foot Heel strike Loading rate Mid-foot Overground Resultant

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Role of locoregional therapies in the management of patients with hepatocellular carcinoma

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Hepatoma Research 2022年第1期8卷 106-126页

作者： janet Wui Cheung Kung Kelvin Kwok Chai Ng Department of surgery The Chinese University of Hong KongHong Kong 999077China

Hepatocellular carcinoma(HCC)was the sixth most common cancer and the third cause of cancer-related deaths worldwide in *** resection and transplantation remain the cornerstone for patients with early-stage disease and represent the only option for potential cure in ***,fewer than 10%of patients are considered suitable for surgery at the time of *** therapies,defined as minimally invasive image-guided liver tumour-directed procedures,are integral to in the management of *** review discusses the role of locoregional therapies in HCC management in the emergence of immune and systemic treatments.

关键词： Locoregional therapy hepatocellular carcinoma ablation transarterial embolization radiation therapy

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Targeting EZH2 for the treatment of soft tissue sarcomas

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 226-241页

作者： Magdalena Karolak Ian Tracy janet shipley Zoës Walters Translational Epigenomics Team Cancer SciencesFaculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK sarcoma Molecular Pathology Team Divisions of Molecular Pathology and Cancer TherapeuticsThe Institute of Cancer ResearchLondon SM25NGUK.

soft tissue sarcomas(sTs)are a heterogenous group of rare malignancies of mesenchymal origin,affecting both children and *** majority of sTs have a poor prognosis and advanced stage at the time of *** treatments for sTs largely constitute tumour resection with chemotherapy and/or radiotherapy,and there has been little significant advancement in the application of novel therapies for treatment of these *** current multimodal approach to therapy often leads to long-term side effects,and for some patients,resistance to cytotoxic agents is associated with local recurrence and/or *** is,therefore,a need for novel therapeutic strategies for the treatment of *** advances in epigenetics have implicated the histone methyltransferase,EZH2,in the development and progression of diseases such as breast cancer,lymphoma and more recently *** we will review the current literature for EZH2 in sTs,including high expression of EZH2 in sTs and correlation of this with specific features of malignancy(metastasis,histological grade,and prognosis).The effects of targeting EZH2 using RNA interference and small molecule inhibitors will also be reviewed and the potential for the use of EZH2 inhibition in therapeutic strategies for sTs patients will be discussed.

关键词： EZH2 epigenetics therapy

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Vascular resections in minimally invasive surgery for pancreatic cancer

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Laparoscopic, Endoscopic and Robotic surgery 2022年第1期5卷 3-9页

作者： janet W.C.Kung Rowan W.Parks Division of HBP surgery Prince of Wales HospitalShatinHong KongChina Department of surgery The Chinese University of Hong KongHong KongChina HPB surgery Royal Infirmary of EdinburghEdinburghUnited Kingdom Department of Clinical surgery University of EdinburghEdinburghUnited Kingdom

Pancreatic ductal adenocarcinoma(PDAC)is characterised by poor oncological outcome and is the seventh cause of cancer-related deaths *** the advances in surgical technology,oncological treatment,and critical care,extended pancreatic resections including vascular resections have become more frequently performed in specialised ***,the boundaries of resectability continue to be pushed in order to achieve a potentially curative approach in selected patients in combination with neoadjuvant and adjuvant treatment *** review gives an overview on the current state of venous and arterial resections in PDAC surgery with particular attention given to the minimally invasive approach.

关键词： Pancreatic adenocarcinoma Minimally invasive surgery Extended pancreatic resection Vascular resection Vascular reconstruction Neoadjuvant therapy

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混合/流体润滑状态下原位离子液体添加剂的摩擦学性能研究

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摩擦学学报 2018年第3期38卷 342-348页

作者：杨淑燕 wong janet 蔡美荣周峰中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 青岛理工大学机械工程学院山东青岛266520 英国帝国理工学院机械工程系

本工作重点研究了混合/流体润滑状态下原位离子液体添加剂的摩擦学性能,选用聚乙二醇(PEG-400)作基础油,将双(三氟甲基磺酰)亚胺锂盐(Li TFsI)溶解在PEG中原位合成离子液体.利用微型牵引力试验机测量在室温、60和80℃以及不同滑滚比下... 详细信息

本工作重点研究了混合/流体润滑状态下原位离子液体添加剂的摩擦学性能,选用聚乙二醇(PEG-400)作基础油,将双(三氟甲基磺酰)亚胺锂盐(Li TFsI)溶解在PEG中原位合成离子液体.利用微型牵引力试验机测量在室温、60和80℃以及不同滑滚比下摩擦系数随卷吸速度的变化,研究离子液体添加剂的有效性以及离子液体添加剂对PEG流变行为的影响.本研究中将为深入研究离子液体的润滑机理提供一种新的研究手段,对于指导设计新型离子液体润滑材料具有较为重要的意义.

关键词：离子液体添加剂混合/流体润滑 stribeck曲线流变特性

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