Background:Sul.ur mustard(SM)is a chemical.warfare vesicant that severel. injures exposed eyes,l.ngs,and *** hydrochl.ride(NM)is widel. used as an SM *** study aimed to devel.p a depil.tory doubl.-disc(DDD)NM skin bur...
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Background:Sul.ur mustard(SM)is a chemical.warfare vesicant that severel. injures exposed eyes,l.ngs,and *** hydrochl.ride(NM)is widel. used as an SM *** study aimed to devel.p a depil.tory doubl.-disc(DDD)NM skin burn model.for investigating vesicant pharmacotherapy ***:Hair removal.method(cl.pping onl. versus cl.pping fol.owed by a depil.tory),the effect of acetone in the vesicant administration vehicl.,NM dose(0.5-20μmol.,vehicl. vol.me(5-20μl.,and time course(0.5-21 days)were investigated using mal. and femal. CD-1 ***,an indicator of burn response,was assessed by biopsy skin *** ideal.NM dose to induce partial.thickness burns was assessed by edema and histopathol.gic *** optimized DDD model.was val.dated using an establ.shed reagent,NDH-4338,a cycl.oxygenase,inducibl. nitric oxide synthase,and acetyl.hol.nesterase inhibitor ***:Cl.pping/depil.tory resul.ed in a 5-fol. higher skin edematous response and was highl. reproducibl.(18-fol. l.wer%CV)compared to cl.pping *** did not affect edema *** edema occurred 24-48 h after NM administra-tion using optimized dosing methods and *** partial.thickness burns were achieved with 5μmol.of NM and responded to treatment with *** dif-ferences in burn edematous responses were observed between mal.s and ***:A highl. reproducibl. and sensitive partial.thickness skin burn model.was devel.ped for assessing vesicant pharmacotherapy *** model.pro-vides cl.nical.y rel.vant wound severity and el.minates the need for organic sol.ents that induce changes to the skin barrier function.
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