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Application of artifcial intelligence in cataract management:current and future directions

Eye and Vision 2024年第1期10卷 21-30页

作者： Laura Gutierrez jane.sujuan lim Li Lian Foo Wei Yan Ng Michelle Yip Gilbert Yong San lim Melissa Hsing Yi Wong Allan Fong Mohamad Rosman Jodhbir Singth Mehta Haotian Lin Darren Shu Jeng Ting Daniel Shu Wei Ting Singapore Eye Research Institute SingaporeSingapore Singapore National Eye Center 11 Third Hospital AvenueSingapore 168751Singapore Academic Ophthalmology School of MedicineUniversity of NottinghamNottinghamUK Zhongshan Ophthalmic Center Sun Yet Sen UniversityGuangzhouChina

The rise of artifcial intelligence(AI)has brought breakthroughs in many areas of *** ophthalmology,AI has delivered robust results in the screening and detection of diabetic retinopathy,age-related macular degeneration,glaucoma,and retinopathy of *** management is another feld that can beneft from greater AI *** is the leading cause of reversible visual impairment with a rising global clinical *** diagnosis,monitoring,and surgical management are necessary to address this *** addition,patients in large developing countries often sufer from limited access to tertiary care,a problem further exacerbated by the ongoing COVID-19 *** on the other hand,can help transform cataract management by improving automation,efcacy and overcoming geographical ***,AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus *** utilizes a deep-learning,convolutional neural network(CNN)to detect and classify referable cataracts ***,some of the latest intraocular lens formulas have used AI to enhance prediction accuracy,achieving superior postoperative refractive results compared to traditional ***,AI can be used to augment cataract surgical skill training by identifying diferent phases of cataract surgery on video and to optimize operating theater workfows by accurately predicting the duration of surgical ***,some AI CNN models are able to efectively predict the progression of posterior capsule opacifcation and eventual need for YAG laser *** advances in AI could transform cataract management and enable delivery of efcient ophthalmic *** key challenges include ethical management of data,ensuring data security and privacy,demonstrating clinically acceptable performance,improving the generalizability of AI models across heterogeneous populations,and improving the trust of e

关键词： Artifcial intelligence Telemedicine Cataract Cataract screening Cataract surgery IOL calculations Biometry Machine learning

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Risk factors and outcomes associated with alcohol relapse after liver transplantation

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World Journal of Hepatology 2017年第17期9卷 771-780页

作者： jane lim Michael P Curry Vinay Sundaram Department of Medicine Cedars Sinai Medical Center Department of Medicine Beth Israel Deaconess Medical Center Division of Gastroenterology and Compre-hensive Transplant Center Cedars--Sinai Medical Center

Alcoholic liver disease(ALD) is the second most common indication for liver transplantation(LT) in the United States and Europe. Unlike other indications for LT, transplantation for ALD may be controversial due to the concern for alcohol relapse and non-compliance after LT. However, the overall survival in patients transplanted for ALD is comparable or higher than in patients transplanted for other etiologies of liver disease. While the rate of alcohol use after liver transplantation does not differ among various etiologies of liver disease, alcohol relapse after transplantation for ALD has been associated with complications such as graft rejection, graft loss, recurrent alcoholic cirrhosis and reduced long-term patient survival. Given these potential complications, our review aimed to discuss risk factors associated with alcohol relapse and the efficacy of various interventions attempted to reduce the risk of alcohol relapse. We also describe the impact of alcohol relapse on post-transplant outcomes including graft and patient survival. Overall, alcohol liver disease remains an appropriate indication for liver transplantation, and long-term mortality in this group of patients is primarily attributed to cardiovascular disease or de novo malignancies rather than alcohol related hepatic complications, among those who relapse.

关键词： Cirrhosis Relapse prevention Recidivism

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Regulation and role of the ER chaperone BiP

Regulation and role of the ER chaperone BiP

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Mary-jane Gething Leon Helfenbaum Amanda lim Carolyn McNees Susan Shahin Department of Biochemistry and Molecular Biology University of MelbourneParkvilleVictoria 3052Australia

The major stress-responsive protein in the endoplasmic reticulum (ER) is BiP, an HSP70 molecular chaperone required both for translocatinn of nascent proteins across the ER membrane and for their subsequent folding and assembly. Nuclear transcription of the genes encoding BiP and other ER chaperones is increased many fold when unfolded proteins accumulate within the ER. The promoters of these genes all contain an unfolded protein response element (UPRE). Thus a novel intracellular sensing system exists that monitors events in the

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Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi

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Molecular Plant 2008年第3期1卷 496-509页

作者： Francisco Llorente Paul M usksktt Andrea Sanchez-Vallet Gemma Lopez Brisa Ramos Clara Sanchez-Rodriguez Lucia Jorda jane Parker Antonio Molina Centro de Biotecnologia y Genbmica de Plantas (CBGP) Departamento de Biotecnologia-UPM ETS Ingenieros Agrbnomos Avda Complutense E-28040Madrid Spain Department of Plant-Microbe Interactions Max Planck Institute for Plant Breeding Research Carl-von-Linne Weg 10 50829 Cologne Germany

In plants, resistance to necrotrophic pathogens depends on the interplay between different hormone systems, such as those regulated by salicylic acid （SA）, jasmonic acid （JA）, ethylene, and abscisic acid. Repression of auxin signaling by the SA pathway was recently shown to contribute to antibacterial resistance. Here, we demonstrate that Arabidopsis auxin signaling mutants axrl, axr2, and axr6 that have defects in the auxin-stimulated SCF （Skpl-Cullin- F-box） ubiquitination pathway exhibit increased susceptibility to the necrotrophic fungi Plectosphaerella cucumerina and Botrytis cinerea. Also, stabilization of the auxin transcriptional repressor AXR3 that is normally targeted for removal by the SCF-ubiquitin/proteasome machinery occurs upon P. cucumerina infection. Pharmacological inhibition of auxin transport or proteasome function each compromise necrotroph resistance of wild-type plants to a similar extent as in non-treated auxin response mutants. These results suggest that auxin signaling is important for resistance to the necrotro- phic fungi P. cucumerina and B. cinerea. SGTlb （one of two Arabidopsis SGT1 genes encoding HSP90/HSC70 co-chaperones） promotes the functions of SCF E3-ubiquitin ligase complexes in auxin and JA responses and resistance conditioned by certain Resistance （R） genes to biotrophic pathogens. We find that sgtlb mutants are as resistant to P. cucumerina as wild-type plants. Conversely, auxin/SCF signaling mutants are uncompromised in RPP4-triggered resistance to the obligate biotrophic oomycete, Hyaloperonospora parasitica. Thus, the predominant action of SGTlb in R gene-conditioned resis- tance to oomycetes appears to be at a site other than assisting SCF E3-ubiquitin ligases. However, genetic additivity of sgtlb axrl double mutants in susceptibility to H. parasitica suggests that SCF-mediated ubiquitination contributes to lim- iting biotrophic pathogen colonization once plant-pathogen compatibility is established.

关键词： plant defense innate immunity necrotrophic fungi auxin signaling proteasome.

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Never Accept Failure

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Women of China 1996年第3期 18-19页

作者： JENNIFER lim

TWO famous western novels, Pride and Prejudice by jane Austen and Presumption by Julia Barrett, have been introduced to Chinese readers by two generations of one family, Wang Keyi and his daughter, Wang Lei. Pride and Prejudice was translated in 1953 before the daughter was born; Presumption was translated in 1995 after the father had passed away. This father and

关键词： Never Accept Failure

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音乐集市

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现代装饰 2022年第2期 146-151页

作者： Amelia Borg Nick Braun jane Caught Qianyi lim Timothy Moore Rafid Hai John Tanner Lauren Crockett Peter Bennetts(摄影) 郭映琴(译) 不详

本案位于澳大利亚墨尔本,集工作、学习、表演、合作于一体,是澳大利亚当代音乐的新型文化社交空间。为了促进音乐与商业的融合,本中心汇聚了多家澳大利亚顶尖的音乐机构,包括:维多利亚音乐、维多利亚音乐发展办公室以及The Push音乐慈... 详细信息

本案位于澳大利亚墨尔本,集工作、学习、表演、合作于一体,是澳大利亚当代音乐的新型文化社交空间。为了促进音乐与商业的融合,本中心汇聚了多家澳大利亚顶尖的音乐机构,包括:维多利亚音乐、维多利亚音乐发展办公室以及The Push音乐慈善机构,同时也容纳了一系列共享办公、教育以及表演空间。项目坐落于科林伍德院新区的两栋19世纪学校建筑内,是音乐与创业的结合体。落成后的项目与周边的建筑、附近的住户以及号称“墨尔本岩石之家”的Tote酒店形成了良好的互动关系,有效地鼓励了当地社区创意型产业的融合。室内涵盖了多种功能空间,包括作曲室、教育空间、走廊、会议室以及社交空间,其能够为不同类型的活动及表演提供场所,接纳人们随时迸发的表演灵感,而可移动的墙壁与窗帘则进一步增强了空间的灵活性。多功能空间体现了空间项目与使用者的融合,大门与吧台闪烁的灯光吸引着人们。与大多数文化社交中心相同,室内的照明系统在使用和空间配置上都非常灵活:设有可移动隔断的会议空间在日程结束后可变身为激动人心的演出现场。

关键词：科林伍德演出现场功能空间空间配置照明系统澳大利亚慈善机构当代音乐

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提高啤酒发酵度的方法探讨

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中国酿造 2014年第11期33卷 118-121页

作者：闫素娟李红贾士儒天津科技大学生物工程学院天津300457 中国食品发酵工业研究院北京100015

从发酵原理出发,尝试向麦汁中添加可发酵性糖,通过葡萄糖、果糖、蔗糖以及麦芽糖四种糖的添加,研究高发酵性糖对发酵度的影响。结果表明,当麦汁与相同浓度的蔗糖溶液以2∶5的比例混合时,麦汁极限发酵度提高至85%以上。同时,通过添加氯化... 详细信息

从发酵原理出发,尝试向麦汁中添加可发酵性糖,通过葡萄糖、果糖、蔗糖以及麦芽糖四种糖的添加,研究高发酵性糖对发酵度的影响。结果表明,当麦汁与相同浓度的蔗糖溶液以2∶5的比例混合时,麦汁极限发酵度提高至85%以上。同时,通过添加氯化铵0.93 g/L,成功解决了添加可发酵性糖后麦汁中α-氨基氮含量不足的问题。

关键词：可发酵性糖氮源发酵度 α-氨基氮

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