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Chinese Jour.al of Cancer.r.sear.h 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu jane.Shi Jinjing Xia Guangdong Lung Cancer.Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer.Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Depar.ment of r.spir.tion Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Depar.ment of Thor.cic Oncology and Sur.er. the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Depar.ment of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Depar.ment of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Depar.ment of Pulmonar. Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Depar.ment of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Depar.ment of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Depar.ment of Thor.cic Oncology Beijing Cancer HospitalBeijing 100142China Pr.duct Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower.10(NCT02813785) explor.d the efficacy and safety of single-agent atezolizumab *** as second-line tr.atment for.advanced non-small cell lung cancer.NSCLC) in east Asian ***: Key eligibility cr.ter.a for.this phase Ⅲ, open-label, r.ndomized study included age ≥18 year.;histologically documented advanced NSCLC per.the Union for.Inter.ational Cancer.Contr.l/Amer.can Joint Committee on Cancer.staging system(7th edition);easter. Cooper.tive Oncology Gr.up per.or.ance status of 0 or.1;and disease pr.gr.ssion following platinum-based chemother.py for.advanced or.metastatic NSCLC. Patients wer. r.ndomized 2:1 to r.ceive either.atezolizumab(1,200 mg) or.docetaxel(75 mg/m^(2)). The pr.mar. study endpoint was over.ll sur.ival(OS) in the intention-to-tr.at(ITT) population with wild-type epider.al gr.wth factor.r.ceptor.expr.ssion(ITT eGFr.WT) and in the over.ll ITT ***: Median OS in the ITT eGFr.WT population(n=467) was 12.3 [95% confidence inter.al(95% CI),10.3-13.8] months in the atezolizumab ar.(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel ar.[n=155;str.tified hazar. r.tio(Hr., 0.82;95% CI, 0.66-1.03]. Median OS in the over.ll ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab tr.atment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel tr.atment(n=188;str.tified Hr. 0.87;95% CI, 0.71-1.08). Gr.de 3/4 tr.atment-r.lated adver.e events(Tr.es) occur.ed in 18.4% of patients in the atezolizumab ar. and 50.0% of patients in the docetaxel ***: IMpower.10 did not meet its pr.mar. efficacy endpoint of OS in the ITT eGFr.WT or.over.ll ITT populations. Atezolizumab was compar.tively mor. toler.ble than docetaxel, with a lower.incidence of gr.de3/4 Tr.es.

关键词： Atezolizumab east Asia non-small cell lung cancer pr.gr.mmed death-ligand 1 inhibitor. monoclonal antibody

Did pediatr.c dr.g development advance epilepsy tr.atment in young patients?It is time for.new r.sear.h goals

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Wor.d Jour.al of Methodology 2024年第2期14卷 65-74页

作者： ear. B ettienne emilio r.sso Pasquale Str.ano jane.M Gr.nt-Kels Klaus r.se College of Phar.acy Howard University College of PharmacyWashingtonDC 20059United States Depar.ment of Health Sciences School of MedicineRussoUniversity"Magna Graecia"of CatanzaroCatanzaro 88100Italy Ir.CS Istituto Giannina Gaslini Genova 16148Italy Depar.ment of Der.atology University of Connecticut Health CenterFarmingtonCT 06032United States klausr.se Consulting Pediatric Drug Development and moreMedical ScienceCH-4125 RiehenSwitzerland

Moder. dr.gs have changed epilepsy,which affects people of all ***,for.young people with epilepsy,the fr.mewor. of dr.g development has *** the wake of the thalidomide catastr.phe,the misconception emer.ed that for.peopleear. of age dr.gs,including antiseizur. medications(ASMs),need separ.te pr.of of efficacy and safety,over.ll called"pediatr.c dr.g development".For.ASMs,this has changed to some *** now accept that ASMs ar. effective inear. as well,but they still r.quir."extr.polation of efficacy,"as if minor. wer. another.*** a r.sult,some of the pediatr.c clinical epilepsy r.sear.h over.the past decades was *** mor. impor.antly,this has hamper.d r.sear.h on meaningful r.sear.h *** do not need to confir. that ASMs wor. befor. as they do after.the 18th ***,we need to lear. how to pr.vent br.in damage in young patients by pr.venting seizur.s and optimize ASMs’*** we discuss how to pr.ceed in this endeavor.

关键词： epilepsy Pediatr.c dr.g development Ther.peutic or.hans Antiseizur. medications Pediatr.c investigation plan Clinical phar.acology

Application of ar.ifcial intelligence in catar.ct management:cur.ent and futur. dir.ctions

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eye and Vision 2024年第1期10卷 21-30页

作者： Laur. Gutier.ez jane.Sujuan Lim Li Lian Foo Wei Yan Ng Michelle Yip Gilber. Yong San Lim Melissa Hsing Yi Wong Allan Fong Mohamad r.sman Jodhbir.Singth Mehta Haotian Lin Dar.en Shu Jeng Ting Daniel Shu Wei Ting Singapor. eye r.sear.h Institute SingaporeSingapore Singapor. National eye Center 11 Third Hospital AvenueSingapore 168751Singapore Academic Ophthalmology School of MedicineUniversity of NottinghamNottinghamUK Zhongshan Ophthalmic Center Sun Yet Sen UniversityGuangzhouChina

The r.se of ar.ifcial intelligence(AI)has br.ught br.akthr.ughs in many ar.as of *** ophthalmology,AI has deliver.d r.bust r.sults in the scr.ening and detection of diabetic r.tinopathy,age-r.lated macular.degener.tion,glaucoma,and r.tinopathy of *** management is another.feld that can beneft fr.m gr.ater.AI *** is the leading cause of r.ver.ible visual impair.ent with a r.sing global clinical *** diagnosis,monitor.ng,and sur.ical management ar. necessar. to addr.ss this *** addition,patients in lar.e developing countr.es often sufer.fr.m limited access to ter.iar. car.,a pr.blem fur.her.exacer.ated by the ongoing COVID-19 *** on the other.hand,can help tr.nsfor. catar.ct management by impr.ving automation,efcacy and over.oming geogr.phical ***,AI can be applied as a telediagnostic platfor. to scr.en and diagnose patients with catar.ct using slit-lamp and fundus *** utilizes a deep-lear.ing,convolutional neur.l networ.(CNN)to detect and classify r.fer.ble catar.cts ***,some of the latest intr.ocular.lens for.ulas have used AI to enhance pr.diction accur.cy,achieving super.or.postoper.tive r.fr.ctive r.sults compar.d to tr.ditional ***,AI can be used to augment catar.ct sur.ical skill tr.ining by identifying difer.nt phases of catar.ct sur.er. on video and to optimize oper.ting theater.wor.fows by accur.tely pr.dicting the dur.tion of sur.ical ***,some AI CNN models ar. able to efectively pr.dict the pr.gr.ssion of poster.or.capsule opacifcation and eventual need for.YAG laser.*** advances in AI could tr.nsfor. catar.ct management and enable deliver. of efcient ophthalmic *** key challenges include ethical management of data,ensur.ng data secur.ty and pr.vacy,demonstr.ting clinically acceptable per.or.ance,impr.ving the gener.lizability of AI models acr.ss heter.geneous populations,and impr.ving the tr.st of e

关键词： Ar.ifcial intelligence Telemedicine Catar.ct Catar.ct scr.ening Catar.ct sur.er. IOL calculations Biometr. Machine lear.ing

Unveiling Global Human Tr.fficking Tr.nds: A Compr.hensive Analysis

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Jour.al of Data Analysis and Infor.ation Pr.cessing 2024年第1期12卷 49-75页

作者： Somtobe Olisah Clement Odooh Oghenekome efijemue echezona Obunadike jane.Onwuchekwa Omoshola Owolabi Saheed Akintayo Callistus Obunadike Depar.ment of Computer.Science Austin Peay State University Clarkesville TN USA Depar.ment of Data Science Carolina University Winston-Salem NC USA

This paper.pr.sents a compr.hensive analysis of global human tr.fficking tr.nds over.a twenty-year.per.od, lever.ging a r.bust dataset fr.m the Counter.Tr.fficking Data Collabor.tive (CTDC). The study unfolds in a systematic manner. beginning with a detailed data collection phase, wher. ethical and legal standar.s for.data usage and pr.vacy ar. str.ctly obser.ed. Following collection, the data under.oes a r.gor.us pr.pr.cessing stage, involving cleaning, integr.tion, tr.nsfor.ation, and nor.alization to ensur. accur.cy and consistency for.analysis. The analytical phase employs time-ser.es analysis to delineate histor.cal tr.nds and utilizes pr.dictive modeling to for.cast futur. tr.jector.es of human tr.fficking using the advanced analytical capabilities of Power.BI. A compar.tive analysis acr.ss r.gions—Afr.ca, the Amer.cas, Asia, and eur.pe—is conducted to identify and visualize the distr.bution of human tr.fficking, dissecting the data by victim demogr.phics, types of exploitation, and dur.tion of victimization. The findings of this study not only offer.a descr.ptive and pr.dictive outlook on tr.fficking patter.s but also pr.vide insights into the r.gional nuances that influence these tr.nds. The ar.icle under.cor.s the pr.valence and per.istence of human tr.fficking, identifies factor. contr.buting to its evolution, and discusses the implications for.policy and law enfor.ement. By integr.ting a methodological appr.ach with quantitative analysis, this r.sear.h contr.butes to the str.tegic planning and r.sour.e allocation for.combating human tr.fficking. It highlights the necessity for.continued r.sear.h and inter.ational cooper.tion to effectively addr.ss and mitigate this global issue. The implications of this r.sear.h ar. significant, offer.ng actionable insights for.policymaker., law enfor.ement, and advocates in the ongoing battle against human tr.fficking.

关键词： Human Tr.fficking Global Tr.nds Data Analysis Victim Demogr.phics Policy Implications Technological Advancements Socioeconomic Factor. For.casting r.gional Dispar.ties Tr.nsnational Cr.me

专访西班牙NACAr.略设计公司:展望明天,让它在今天发生

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包装与设计 2024年第4期 32-51页

作者：无 Jaume jane.Ber. Donadeu 《包装&设计》西班牙NACAr.略设计公司

“在设计中我们会优先考虑极简主义、人体工程学和模块化,以促进用户对产品的使用和情感互动。”来自西班牙的NACAr.略设计公司称得上是iF设计奖的“获奖专业户”,几乎每年都会获得好几个iF设计奖。就在今年,NACAr.口气夺得三枚iF设... 详细信息

“在设计中我们会优先考虑极简主义、人体工程学和模块化,以促进用户对产品的使用和情感互动。”来自西班牙的NACAr.略设计公司称得上是iF设计奖的“获奖专业户”,几乎每年都会获得好几个iF设计奖。就在今年,NACAr.口气夺得三枚iF设计奖。迄今为止,他们已累计获得26个iF设计奖!

关键词：人体工程学极简主义情感互动设计奖 NACA 模块化西班牙专业户

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简·鲍恩:从名流肖像到温柔街拍

旅游世界 2024年第8期 36-50页

作者：崔霁云 jane.Bown(图) 不详

2006年2月某日,一位小个儿老太太独自进了白金汉宫,她的包里装着最爱的奥林巴斯OM-1相机。这是80岁的摄影师简·鲍恩(jane.Bown),来为英国女王伊丽莎白二世80岁生日拍摄肖像。简·鲍恩,20世纪最著名的肖像摄影师之一,1925年出生。她的... 详细信息

2006年2月某日,一位小个儿老太太独自进了白金汉宫,她的包里装着最爱的奥林巴斯OM-1相机。这是80岁的摄影师简·鲍恩(jane.Bown),来为英国女王伊丽莎白二世80岁生日拍摄肖像。简·鲍恩,20世纪最著名的肖像摄影师之一,1925年出生。她的摄影简单直接,但塑造的画面却让许多摄影师为之赞叹。在曾由男性主宰的英国媒体界,简·鲍恩毫无疑问是一个传奇。

关键词：英国女王伊丽莎白二世鲍恩媒体界肖像摄影师奥林巴斯

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为应对AI能源危机低功耗芯片市场崛起

商业周刊（中文版） 2024年第6期 18-19页

作者： jane.Lanhee Lee 永年(译) 不详

为了理解人工智能(AI)需要如此多能量的一个关键原因,我们可以想象一下:好比一个计算机芯片是当地图书馆的某个部分,一套人工智能算法是拥有借阅特权的研究人员,每当算法需要数据时,它就会去到图书馆(存储芯片),检查数据并将其带到另一... 详细信息

为了理解人工智能(AI)需要如此多能量的一个关键原因,我们可以想象一下:好比一个计算机芯片是当地图书馆的某个部分,一套人工智能算法是拥有借阅特权的研究人员,每当算法需要数据时,它就会去到图书馆(存储芯片),检查数据并将其带到另一个芯片(处理器),以执行某个功能。

关键词：计算机芯片检查数据能源危机存储芯片人工智能算法图书馆处理器

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繁花小镇伊瓦尔法兰西的优雅时光和唯美浪漫

环球人文地理 2024年第5期 144-152页

作者：袁莘捷 jane.flickr.unsplash

布满岁月痕迹的石头城堡与历经风雨的繁花交织，蔚蓝宁静的湖面倒映着一艘艘渔船，这就是伊瓦尔小镇日常而美丽的画面。伊瓦尔(Yvoir.)是一个古老的中世纪小镇，位于法国东部萨瓦省边界，阿尔卑斯山脚下，紧邻西欧最大的自然湖泊莱芒湖...

布满岁月痕迹的石头城堡与历经风雨的繁花交织，蔚蓝宁静的湖面倒映着一艘艘渔船，这就是伊瓦尔小镇日常而美丽的画面。伊瓦尔(Yvoir.)是一个古老的中世纪小镇，位于法国东部萨瓦省边界，阿尔卑斯山脚下，紧邻西欧最大的自然湖泊莱芒湖（日内瓦湖），被评为“法国最美丽的乡村”之一。小镇与瑞士隔湖相望，距离极近，居民坐船20分钟便可抵达。镇内面积不大，

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Changes in Soil Physicochemical Pr.per.ies under.Selected Climate-Smar. Agr.cultur.l Pr.ctices in Centr.l Afr.can r.public

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Open Jour.al of Soil Science 2024年第1期14卷 97-114页

作者： Julie Léancy Gougodo De Mon-Zoni Ar.auld Dave Bangane Konzoba jane.Akoth Omenda Mohammad Zaman ephr.m Kosh-Komba Plant and Fungal Biodiver.ity Labor.tor. Faculty of Sciences University of Bangui Central African Republic Centr.l Afr.can Institute for.Agr.cultur.l r.sear.h (ICr.) Bangui Central African Republic Labor.toir. of Geoscience Faculty of Sciences University of Bangui Bangui Central African Republic Depar.ement of Water.& Agr.cultur.l r.sour.es Management University of Embu Embu Kenya Inter.ational Atomic ener.y Agency (IAeA) Vienna Austria Labor.tor. of Biological and Agr.nomical Sciences for.Development Faculty of Sciences University of Bangui Bangui Central African Republic

Soil nutr.ent depletion as a r.sult of continuous cultivation with insufficient exter.al nutr.ent r.plenishment is a major.challenge in sub-Sahar.n Afr.ca (SSA). A tr.al using the or.anic and miner.l fer.ilizer.was established in the cassava cr.pping system of the Pissa and Damar. ar.as to addr.ss the declining soil fer.ility. The study aimed to evaluate the effect of cow manur. and miner.l fer.ilizer.in combination or.sole application on soil physico-chemical pr.per.ies and macr.nutr.ents. The exper.mental tr.al adopted a r.ndomized complete block design (r.BD) r.plicated four.times. The tr.atments compr.sed of;T1 (Contr.l), T2 (Peasant pr.ctice), T3 (sole NPK), and T4 (Cow manur. + NPK). The data on soil physicochemical analysis was subjected to a one-way analysis of var.ance in SAS 9.4 and the mean was separ.ted by Tukey’s HSD test at p e soil pH values r.nged fr.m 4.20 to 4.91;and 4.53 to 5.28 in Pissa and Damar. r.spectively. Accor.ing to the tr.atments, a low pH value is obser.ed in T3 (4.13) in the Pissa. Combined use of cow manur. and the miner.l fer.ilizer.r.sulted in higher.Mg K and N in the Pissa r.gion and higher.soil pH in Damar.. The use of sole NPK (T3) gave a higher.soil car.on and CN r.tio. In the Pissa r.gion the CeC, Cu, Fe, and Zn wer. higher.in the tr.atments with miner.l fer.ilizer.compar.d to the contr.l. Conclusively, the use of miner.l fer.ilizer.and cow manur. can be used with optimum r.tes to impr.ve soil physico-chemical pr.per.ies on a sustainable basis.

关键词： Cow Manur. Physicochemical Nutr.ents Agr.ecology Nutr.ent Management