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World Journal of Gastroenterology 2012年第18期18卷 2212-2218页

作者： Daniel R van Langenberg jane m andrews Department of Gastroenterology and Hepatology Royal Adelaide HospitalSchool of MedicineUniversity of AdelaideSouth Australia 5000Australia Department of Gastroenterology and Hepatology Eastern Health Clinical SchoolMonash UniversityVictoria 3128Australia

AIm:To assess the reasons for,and factors associated with,patient-initiated changes in treating specialist in inflammatory bowel diseases(IBD).mETHODS:Prospectively identified IBD patients(n = 256) with ≥ 1 encounter at a metropolitan hospital were surveyed,including whether they had changed treating specialist and *** reasons included loss of confidence,disagreement,and/or personality clash with the ***:Of 162 respondents,70(43%) had ever changed specialists;30/70(43%) for negative reasons,52/70(74%) in the preceding *** with negative reasons for changing(n = 30) were younger(median,35.2 years vs 45.3 years),had higher IBD knowledge(median,5.0 years vs 4.0 years),yet had lower medication adherence and satisfaction scores(median,19.0 years vs 22.0 years,14.0 years vs 16.0 years respectively,mann-Whitney tests,all P mpared to all other responders(n = 132).Patients with a recent change(for any reason) were more likely to have Crohn's disease,currently active disease,previous bowel resection and recent hospitalization [OR 2.6,95% CI(1.3-5.4),2.2(1.0-4.7),5.56(1.92-16.67),2.0(1.3-3.0),eachP mporaneous disease-related factors(recent relapse) which,where modifiable,may enhance patient-doctor relationships and therefore quality of care.

关键词： Inflammatory bowel disease Patient-doctor relationship Quality of care Disease outcomes Quality of life

Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease

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World Journal of Gastroenterology 2016年第8期22卷 2611-2620页

作者： Alice L Bennett David moore Peter A Bampton Robert V Bryant jane m andrews Department of Gastroenterology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia Department of Gastroenterology Flinders Medical Centre Flinders Drive Bedford Park SA 5042 Australia School of medicine University of Adelaide Adelaide SA 5000 Australia Department of Gastroenterology Women's and Children's Hospital Adelaide SA 5006 Australia School of medicine Flinders University Adelaide SA 5001 Australia

AIm: To describe the disease and psychosocial outcomes of an inflammatory bowel disease (IBD) transition cohort and their ***: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition ***: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance (35%), there was a very low usage (5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority (54%) felt they were not strongly prepared. A high rate (78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex (8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices (of the options offered) was a shared clinic appointment with all key ***: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans.

关键词： Transition care Crohn’ s disease Ulcerative colitis Chronic illness Inflammatory bowel disease Patient perspectives Disease outcomes

Lower esophageal sphincter relaxation is impaired in older patients with dysphagia

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World Journal of Gastroenterology 2011年第10期17卷 1326-1331页

作者： Laura K Besanko Carly m Burgstad Reme mountifi eld jane m andrews Richard Heddle Helen Checklin Robert JL Fraser Investigation and Procedures Unit Repatriation General Hospital Department of Gastroenterology and Hepatology Royal Adelaide Hospital Discipline of medicine University of Adelaide Adelaide 5000 South Australia Australia Department of medicine Flinders University of South Australia Bedford Park 5042 South Australia Australia

AIm: To characterize the effects of age on the mechanisms underlying the common condition of esophageal dysphagia in older patients, using detailed manometric analysis. mETHODS: A retrospective case-control audit was performed on 19 patients aged ≥ 80 years (mean age 85 ± 0.7 year) who underwent a manometric study for dysphagia (2004-2009). Data were compared with 19 younger dysphagic patients (32 ± 1.7 years). Detailed manometric analysis performed prospectively included basal lower esophageal sphincter pressure (BLESP), pre-swallow and nadir LESP, esophageal body pressures and peristaltic duration, during water swallows (5 mL) in right lateral (RL) and upright (UR) postures and with solids. Data are mean ± SE; a P-value mmHg; P mmHg vs 0.7 ± 0.6 mmHg, P mmHg vs 1.6 ± 0.5 mmHg, P = 0.01) with shorter relaxation after solids (7.9 ± 1.5 s vs 9.7 ± 0.4 s, P = 0.05). No age-related differences were seen in esophageal body pressures or peristalsis duration. CONCLUSION: Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients. Its contribution to dysphagia and the effects of healthy ageing require further investigation.

关键词： Dysphagia Elderly Esophageal motility Lower Esophageal Sphincter Aging

Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第12期21卷 3663-3670页

作者： Réme mountifield jane m andrews Antonina mikocka-Walus Peter Bampton Department of Gastro-enterology and Hepatology Flinders Medical Centre Flinders University of South Australia IBD Service Department of Gastroenterology and Hepatology and School of Medicine University of Adelaide at Royal Adelaide Hospital School of Nursing and midwifery University of South Australia

AIm: To examine the frequency of regular complementary and alternative therapy(CAm) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAm use across all cohorts. mETHODS: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAm use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAm use were determined using binary logistic regression analysis. RESULTS: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAm use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAm use to their doctor. Independent predictors of CAm use which confirm those reported previously were: covert conventional medication dose reduction(P ment(P medication(P = 0.043), and higher QOL(P m use by family or friends(P mmunication(P m use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAm use. Patient reluctance to discuss CAm with physicians may promote greater reliance on social contacts to influence CAm decisions.

关键词： Complementary medicine Alternative therapy Therapy

Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice

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World Journal of Gastroenterology 2017年第16期23卷 2995-3002页

作者： Shomron Ben-Horin jane m andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William moran monica Cesarini Christian D Stone Doron Schwartz marijana Protic Xavier Roblin Giulia Roda min-Hu Chen Ofir Har-Noy Charles N Bernstein Department of Gastroenterology Sheba Medical CenterSackler School of MedicineTel-Aviv UniversityRamat-Gan 52621Israel the First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510700Guangdong provinceChina Department of Gastroenterology and Hepatology Inflammatory Bowel Disease ServiceRoyal Adelaide HospitalSchool of MedicineUniversity of AdelaideAdelaideSA 5005Australia Division of Gastroenterology School of Health SciencesUniversity of IoanninaIoannina 45500Greece Department of Gastroenterology Hepatology and NutritionDigestive Disease Diseases and Surgery InstituteCleveland Clinic FoundationClevelandOH 44109United States Unit of Inflammatory Bowel Disease Hospital Israelita Albert EinsteinSao PauloSP 05652-900Brazil Department of Gastroenterology Venizeleio General HospitalHeraklion71409 CreteGreece Department of Internal medicine Yonsei University College of MedicineSeoul 03722South Korea NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of NottinghamNottingham NG7 2UHUnited Kingdom Dipartimento di medicina Interna e Specialitàmediche “Sapienza”University of Rome00185 RomaItaly Comprehensive Digestive Institute of Nevada Las VegasNV 89113United States Department of Gastroenterology and Hepatology Soroka University Medical CenterBeer-Sheva 6400111Israel Department of Gastroenterology University Hospital ZvezdaraBelgrade 11000Serbia Department of Gastroenterology University-Hospital of Saint-Etienne42100 Saint EtienneFrance Gastroenterology Unit S.Orsola-Malpighi40138 BolognaItaly IBD Clinical and Research Centre University of ManitobaWinnipegMB R3T2N2Canada

AIm To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). mETHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P milarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.

关键词： Inflammatory bowel disease Corticosteroids 5-aminosalicylates Ulcerative colitis

Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting

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World Journal of Gastroenterology 2013年第16期19卷 2514-2520页

作者： Nora B Zschau jane m andrews Richard H Holloway mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann Department of Gastroenterology and Hepatology Royal Adelaide Hospital Faculty of Health Sciences University of AdelaideAdelaide Department of Gastroenterology and Hepatology Lyell McEwin Hospital Department of Gastroenterology and Hepatology University of Queensland School of Medicine Princess Alexandra Hospital

AIm: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. mETHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) *** two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy.

关键词： Gastroesophageal reflux disease Epidemiology Proton pump inhibitor Acid suppressive therapy Endoscopy Barrett’s esophagus Functional gastrointestinal disorders

A comparative investigation on wear behaviors of physical and chemical vapor deposited bronze coatings for hydraulic piston pump

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Chinese Journal of Aeronautics 2024年第3期37卷 391-403页

作者： Wei HAO andrews LARBI Hongkang DONG Dongyun WANG Shenghu LI Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and maintenance Technology and Equipment Zhejiang Normal UniversityJinhua 321004China College of Engineering Zhejiang Normal UniversityJinhua 321004China Hangzhou Lilong Hydraulic Co. LtdHangzhou 311200China

The cylinder block/valve plate interface is one of the most critical frictional interfaces of the swashplate-type axial piston ***,the poor lubrication interface caused rapid wear and high friction loss in an elastohydrodynamic lubrication system,decreasing the pump *** resistant bronze coatings were fabricated on 38CrmoAl substrate by Physical Vapor Deposition(PVD)and Chemical Vapor Deposition(CVD),***-on-disc wear tests were performed to comparatively investigate the wear behaviors of the coatings and bulk ductile iron *** can be found that the PVD-bronze coating exhibited better wear resistance than the other two *** enhanced wear resistance was attributed to the unique composite microstructure and desired mechanical strength,which could resist to mechanical shear and spallation,decreasing friction *** appropriate hardness of(1.33±0.07)GPa could be beneficial for enhancing its wear *** PVD-bronze coating possessed a much lower and stable coefficient of friction(about 0.1)and wear rate(about 6000μm3.N-1.m-1)under the loading forces of about 100 N after 20 *** wear mechanism was the abrasive wear.

关键词： Aircraft hydraulic pump Bronze Coatings Wear resistance mechanisms

Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

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World Journal of Gastroenterology 2020年第30期26卷 4428-4441页

作者： Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi jane m andrews Gillian mahy Paola Chivers Simon Travis Ian Craig Lawrance Centre for Inflammatory Bowel Diseases St John of God HospitalSubiaco 6008Western AustraliaAustralia Translational Gastroenterology Unit NIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Inflammatory Bowel Disease Research Group Queensland institute of Medical ResearchHerston 4006QueenslandAustralia Department of Gastroenterology Mater HospitalBrisbane 4101QueenslandAustralia Department of Gastroenterology Mater HospitalSouth Brisbane 4101QueenslandAustralia of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Department of Gastroenterology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalFitzroy 3065VictoriaAustralia Department of Gastroenterology Northern HealthEpping 3076VictoriaAustralia Department of Gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalDarlinghurst 2010New South WalesAustralia Department of Gastroenterology Flinders Medical CentreBedford Park 5042South AustraliaAustralia Department of Gastroenterology Liverpool HospitalSydney 2170New South WalesAustralia Department of Gastroenterology Royal Adelaide Hospital&University of AdelaideAdelaide 5000South AustraliaAustralia Department of Gastroenterology Townsville HospitalDouglas 4814QueenslandAustralia Institute for Health Research University of Notre DameFremantle 6160Western AustraliaAustralia School of medicine and Pharmacology University of Western AustraliaCrawley 6009Western AustraliaAustralia

BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)*** To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving *** A retrospective review of Australian and Oxford,United Kingdom data for UC *** response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were *** regression models and Kaplan meier curves were performed to assess the time to remission,time to failure and the covariates influencing *** outcomes were *** Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were *** clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo ***-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%Pmo 73%vs 46%Pmo 66%vs 51%P=0.03).more Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(Pmy by 12 *** VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.

关键词： Vedolizumab Ulcerative colitis Outcomes

Non-physician endoscopists: A systematic review

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World Journal of Gastroenterology 2015年第16期21卷 5056-5071页

作者： maximilian Stephens Luke F Hourigan mark Appleyard George Ostapowicz mark Schoeman Paul V Desmond jane m andrews michael Bourke David Hewitt David A margolin Gerald J Holtmann Department of Gastroenterology and Hepatology Princess Alexandra Hospital Faculty of medicine and Biomedical Sciences University of Queensland Department of Gastroenterology and Hepatology RBWH Department of Gastroenterology and Hepatology Gold Coast Hospital QLD 4215 Department of Gastro-enterology and Hepatology Royal Adelaide Hospital and University of Adelaide St Vincent’s Hospital University of MelbourneMelbourne VIC 3010Australia Department of Gastroenterology and Hepatology Westmead HospitalUniversity of Sydney School of medicine University of Queensland Department of Gastroenterology Queensland Elizabeth II Jubilee HospitalCoopers PlainsBrisbane QLD 4108Australia Department of Colon and Rectal Surgery Ochsner Clinic Foundation Ochsner Clinical SchoolUniversity of Queensland

AIm:To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal(GI) endoscopy ***:The literature was searched for publications reporting nurse endoscopy using several databases and specific search *** were screened against eligibility criteria and for *** searches yielded 74 eligible and relevant articles; 26 of these studies were primary research articles using original datasets relating to the ability of nonphysician *** publications included a total of 28883 procedures performed by non-physician ***:The number of publications in the field of non-specialist gastrointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sigmoidoscopies,5 to upper GI endoscopy and 6 to *** studies were from metropolitan centres with nurses working under strict supervision and guidance by specialist *** distribution of publications showed the majority of research was conducted in the United States(43%),the United Kingdom(39%)and the Netherlands(7%).most studies conclude that after appropriate training nurseendoscopists safely perform ***,in relation to endoscopic competency,safety or patient satisfaction,all studies had major methodological *** were often not randomized(21/26studies)and not appropriately *** relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due largely to the increased need for subsequent endoscopies,specialist follow-up and primary care ***:Contrary to general beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence suggests the *** significant shortcomings and biases limit the validity and

关键词： Nurse endoscopist Cost-benefit Servicemodel Patient satisfaction Outcome parameter

肝细胞癌患者的症状和症状群及常用工具的整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 66-75,I0002页

作者： Thitiporn Pathomjaruwat Yaowarat matchim jane mArmer Research Unit in Palliative Care for Adults and Older Adults Faculty of NursingThammasat UniversityPathum ThaniThailand mU Sinclair School of Nursing University of MissouriColumbiaUSA

目的综合现有知识,识别肝细胞癌(hepatocellular carcinoma,HCC)患者的症状和症状群,以及相关评估工具,以最大限度地改善症状管理。方法采用Whittemore和Knafl提出的整合性综述方法框架,在Pubmed..ScienceDirect、Scopus、CINAHL和ThaiJO等数据库中对文献进行系统检索。检索文献发表时间限定为2005年一2022年,仅纳人经过同行评审及有英文摘要的文献。由2名研究员独立进行文献的筛选、提取和分析。结果共纳入14篇文献。分为3个主题:HCC患者的症状.症状评估和症状群。疲劳、乏力、胃痛或腹痛/腹胀、食欲不振、味觉改变、睡眠障碍、苦恼和悲伤是HCC患者最常见的症状。患者症状与肿瘤分期和治疗方法有关。常用的症状评估工具包括5种类型:HCC特异性症状评估癌症一般症状评估、非症状构念测量、特定症状(如疲劳、睡眠障碍、焦虑和抑郁)测量及结合临床检查的症状评估等5种。HCC患者的症状群分为5类:疼痛相关症状、胃肠道症状、神经心理症状和感觉症状.肝功能异常相关症状及其他。结论该综述对HCC患者症状、症状评估和症状群相关知识进行了综合。尽管目前有多种评估工具,但没有一种能涵盖HCC患者的所有症状。建议今后的研究纳入更大的同质化的样本,以便更准确地评估测量工具的效能,避免在将症状分类为症状群时出现歧义,提高症状管理的有效性。

关键词：肝细胞癌肝癌综述症状评估症状群