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Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

中华医学杂志(英文版) 2005年第17期 7-15页

作者： Loretta YC Yam,Alfred YF chan,Thomas MT Cheung,Eva LH Tsui,jane ck chan,Vivian CW Wong Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China

Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory *** aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this *** Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome *** rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital *** Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid *** to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid *** were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive *** Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality.

关键词： acute respiratory failure · infection control · invasive mechanical ventilation · non-invasive ventilation · severe acute respiratory syndrome

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Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

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Chinese Medical Journal 2005年第17期118卷 1413-1421页

作者： Loretta YC Yam Alfred YF chan Thomas MT Cheung Eva LH Tsui jane ck chan Vivian CW Wong Division of Respiratory and Critical Care Medicine Department of MedicinePamela Youde Nethersole Eastern HospitalHong KongChina Hong Kong Hospital Authority Head Office Hong KongChina

Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiring ventilatory *** aimed to compare the efficacy of non-invasive ventilation against invasive mechanical ventilation treating respiratory failure in this *** Retrospective analysis was conducted on all respiratory failure patients identified from the Hong Kong Hospital Authority Severe Acute Respiratory Syndrome *** rate,mortality and secondary outcome of a hospital utilizing non-invasive ventilation under standard infection control conditions(NIV Hospita1)were compared against 13 hospitals using solely invasive ventilation(IMV Hospitals).Multiple logistic regression analyses with adjustments for confounding variables were performed to test for association between outcomes and hospital *** Both hospital groups had comparable demographics and clinical profiles,but NIV Hospital(42 patients)had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid *** to IMV Hospitals(451 patients).NIV Hospital had lower adjusted odds ratios for intubation(0.36,95%C10.164-0.791,P=0.011)and death(0.235.95%C10.077-0.716,P=0.O 11),and improved earlier after pulsed steroid *** were no instances of transmission of severe acute respiratory syndrome among health care workers due to the use of non-invasive *** Compared to invasive mechanical ventilation,non-invasive ventilation as initial ventilatory support for acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated with reduced intubation need and mortality.

关键词： acute respiratory failure infection control invasive mechanical ventilation non-invasive ventilation severe acute respiratory syndrome

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Anonymous TollPass: A Blockchain-Based Privacy-Preserving Electronic Toll Payment Model

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Computers, Materials & Continua 2024年第6期79卷 3495-3518页

作者： jane Kim Soojin Lee chan Yeob Yeun Seung-Hyun Seo Department of Electronic&Electrical Engineering Graduate SchoolHanyang UniversitySeoul04763Korea Department of Electrical Engineering and Computer Science Khalifa University of Science and TechnologyAbu Dhabi127788United Arab Emirates School of Electrical Engineering Hanyang UniversityERICAAnsan15588Korea

As big data,Artificial Intelligence,and Vehicle-to-Everything(V2X)communication have advanced,Intelligent Transportation Systems(ITS)are being developed to enable efficient and safe transportation *** Toll Collection(ETC),which is one of the services included in ITS systems,is an automated system that allows vehicles to pass through toll plazas without stopping for manual *** ETC system is widely deployed on highways due to its contribution to stabilizing the overall traffic system *** ensure secure and efficient toll payments,designing a distributed model for sharing toll payment information among untrusted toll service providers is ***,the current ETC system operates under a centralized ***,both toll service providers and toll plazas know the toll usage history of *** raises concerns about revealing the entire driving routes and patterns of *** address these issues,blockchain technology,suitable for secure data management and data sharing in distributed systems,is being applied to the ETC *** enables efficient and transparent management of ETC ***,the public nature of blockchain poses a challenge where users’usage records are exposed to all *** tackle this,we propose a blockchain-based toll ticket model named AnonymousTollPass that considers the privacy of *** proposed model utilizes traceable ring signatures to provide unlinkability between tickets used by a vehicle and prevent the identity of the vehicle using the ticket from being identified among the ring members for the ***,malicious vehicles’identities can be traced when they attempt to reuse *** conducting simulations,we show the effectiveness of the proposed model and demonstrate that gas fees required for executing the proposed smart contracts are only 10%(when the ring size is 50)of the fees required in previous studies.

关键词： Blockchain electronic toll collection smart contract traceable ring signature

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Health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： Joanne Mathew Jordy Mehawej Ziyue Wang Taylor Orwig Eric Ding Andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu jane Saczynski David D.McManus Khanh-Van Tran Division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Department of Internal Medicine Central Michigan UniversityMount PleasantUSA Department of Pharmacy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BAckGROUND Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2DS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer Health Activation Index,the Generalized Anxiety Disorder questionnaire,the 12-Item Short Form Health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

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MESANGIAL IgA GLOMERULONEPHRITIS IN HONG KONG A CLINICAL REVIEW

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中华医学杂志(英文版) 1986年第11期99卷 908-909页

作者： MK chan S Kwan ck Yeunk PY CHau University of Hong Kong Queen Mary HospitalHong Kong

Mesangial IgA glomerulonephritis accounts for 12% of all primary glomerulonephritis diagnosed from renal biopsies performed at Queen Mary Hospital. The clinical features of 106 patients with biopsy proven mesangial IgA glomerulonephritis seen at the renal clinic of the Department of Medicine, University of Hong Kong, were reviewed. There were 55 males and 51 females aged from 12 to 65 years with a mean of 28 years. Six groups of presenting features were recognized. Although the commonest was asymptomatic proteinuria and/or microscopic

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Large-eddy Simulation of Ethanol Spray-Air Combustion and Its Experimental Validation

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Chinese Journal of Chemical Engineering 2014年第2期22卷 214-220页

作者：李科周力行 chan C.K Department of Engineering Mechanics Tsinghua University School of Energy and Environment Inner Mongolian University of Science and Technology Department of Applied Mathematics Hong Kong Polytecnic University

Large-eddy simulation of spray combustion is under its rapid *** combustion models were used by different ***,these models are less validated by detailed experimental *** this paper,large-eddy simulation(LES)of ethanol spray-air combustion was made using an Eulerian-Lagrangian approach,a subgrid-scale kinetic energy stress model,and a filtered finite-rate combustion model,neglecting the sub-grid scale reaction *** simulation results are compared with experimental dada in the literature and validated in *** LES obtained statistically averaged gas temperature is in much better agreement with the experimental results than Reynolds averaged(RANS)modeling using the most complex probability density function(PDF)equation combustion *** instantaneous LES results show the coherent structures of the shear region near the high-temperature flame zone and the fuel vapor concentration map,indicating that the droplets are concentrated in this shear *** instantaneous temperature,oxygen and carbon dioxide concentration maps show the close interaction between the coherent structures and the combustion reaction.

关键词： ethanol-air two-phase flow spray combustion large-eddy simulation

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QS Alex 755 nm激光对黑素细胞p16INK4a表达的影响

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中华皮肤科杂志 2004年第7期37卷 413-415页

作者：项蕾红 Henry HL chan Joseph ck Leung 复旦大学附属华山医院皮肤科上海200040 香港大学玛丽医院皮肤科

目的了解激光对黑素细胞潜在恶变作用的可能性。方法QSAlex755nm激光体外照射HTB66、Sk-mel-24和G3613种黑素瘤细胞株,照射剂量为0.85～2J/cm2,24h后收集细胞。应用流式细胞仪和RT-PCR方法分别测定p16INK4a蛋白和p16INK4amRNA在激光照... 详细信息

目的了解激光对黑素细胞潜在恶变作用的可能性。方法QSAlex755nm激光体外照射HTB66、Sk-mel-24和G3613种黑素瘤细胞株,照射剂量为0.85～2J/cm2,24h后收集细胞。应用流式细胞仪和RT-PCR方法分别测定p16INK4a蛋白和p16INK4amRNA在激光照射前后和不同剂量照射后的表达水平。结果激光照射后,HTB66细胞株(p16INK4a蛋白阳性株)的p16INK4a蛋白表达明显增加;而低水平表达的Sk-mel-24和G361细胞株无明显变化。在HTB66细胞株中虽然p16INK4a蛋白的表达上调,但对其功能的测定发现它并不能阻止细胞周期从G0/G1向S/G2M转变。HTB66细胞株的p16INK4amRNA的表达也增加。结论经研究剂量的激光照射后DNA有损伤。具有黑素瘤家族史或个人史的患者可能有p16INK4a基因的突变或丢失,不提倡用激光治疗此类患者的色素性疾病。

关键词： QS Alex 755nm激光黑素细胞 p16INK4a 黑素瘤基因突变

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Association of oral submucous fibrosis （OSF） with outcome of squamous cell carcinoma of tongue

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中国口腔颌面外科杂志 2008年第B5期6卷 123-124页

作者： Hsiao YL Poon ck chan MY Wong YK Department of Dentistry Division of Oral and MaxillofacialSurgery Taichung Veterans General Hospital TaichungTaiwan China

Background: Oral squamous cell carcinoma and oral submucous fibrosis, they both are highly associated with betel quid chewing habit。Like other potentially malignant disorders, oral submucous fibrosis has been known as 3-7% malignant transformation rate。Currently, some emerged evidences have supported that oral submucous fibrosis could be highly related with epithelial-mesenchymal transition (EMT) in oral mucosa, which possibly response to long-term injury from betel quid。Simultaneously, the EMT also seems to play a role in tumor invasion and metastasis in some malignant cells。It is reasonably believed that pathophysiological connections existed between fibrosis and cancer behavior。Purpose: To analysis the influence of oral submucous fibrosis on overall outcome of oral squamous cell carcinoma。Methods: Since 2002-2005, 65 patients were consecutively collected from Department of Oral and Maxillofacial Surgery, Taichung Veterans General Hospital, Taiwan, China。The inclusion criteria were previously untreated patients on tongue without pathological cervical metastasis。The cancer patients with submucous fibrosis were divided into mild, moderate, severe subgroups; patients without betel nut chewing as control group。The overall survival and disease-free rates of patients were analyzed by Kaplan-Meier analysis。Results: Conclusively, variables such as age, grading, tumor size, even status of cut margin all were not statistically difference between subgroups。The overall outcomes also have been not shown any difference between subgroups, such as disease-flee rate (P= 1.35) and overall survival rate (P=1.43)。Conclusion: In this prospective cohort study, the comorbidity of submucous fibrosis with tongue cancer patients should not be considered as a negative influence on overall outcomes。However, we need more long period follow-up these patients for confirming this primary conclusion。

关键词：口腔黏膜纤维化鳞状细胞癌舌癌

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生物质炭与铁钙材料对镉砷复合污染农田土壤的修复

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环境科学 2024年第1期45卷 450-458页

作者：吴秋产吴骥子赵科理连斌袁峰孙淇田欣浙江农林大学环境与资源学院杭州311300 浙江农林大学浙江省土壤污染生物修复重点实验室杭州311300

选取了铁钙材料(FC)和山核桃蒲生物质炭(BC)制备得到复合材料(BF),用于修复农田土壤中镉砷复合污染,以降低水稻糙米中的镉和砷含量.通过水稻盆栽试验,在植物生长期内,采集了土壤孔隙水、根际土壤、非根际土壤、水稻植株和水稻根表铁膜,... 详细信息

选取了铁钙材料(FC)和山核桃蒲生物质炭(BC)制备得到复合材料(BF),用于修复农田土壤中镉砷复合污染,以降低水稻糙米中的镉和砷含量.通过水稻盆栽试验,在植物生长期内,采集了土壤孔隙水、根际土壤、非根际土壤、水稻植株和水稻根表铁膜,探究了铁钙材料、生物质炭及其复合材料对土壤中镉和砷生物有效性和植株中镉和砷含量的影响及机制.结果表明,生物质炭材料能显著(Pck增加了48.5%~184.0%,根表铁膜含量增加7.5%~13.6%.与空白对照组相比,生物质炭能够有效降低水稻糙米中Cd含量(21.0%~26.1%),铁钙材料和复合材料能够同时降低糙米中Cd和As含量,其中复合材料对糙米中Cd和As降低效果最佳,降幅高达36.9%~42.0%和40.4%~44.4%,使水稻糙米Cd和As含量均低于国家标准值(GB 2762-2017).

关键词：生物质炭铁钙材料镉(Cd) 砷(As) 农田土壤

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Digital Factory-A Technology Show Case for Teaching and Research in Digital Manufacturing

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机电工程技术 2002年第6期31卷 109-111页

作者： Danny S K chan Albert ck Choi (The Hong Kong Polytechnic Univers ity The Hong Kong Polytechnic University

With the advancing digital technology and information tools in networking the core of manufacturing activities has shifted from the physical production of goods to the systematic processing of *** competitiveness of tomorrow’s manufacturing enterprise lies in the operation of such digital factory in parallel with the physical *** change in manufacturing in the digital age is taking place not only in Hong Kong but *** paper describes the development of establishing a digital factory laboratory in the Department of Industrial and Systems Engineering of The Hong Kong Polytechnic *** Digital Factory is a focus for teaching research and technology transfer in the area of digital *** paper also describes an application case of virtual manufacturing in which computer simulation models of a production line of an AC motor are developed for investigation.

关键词：数字工厂数据制造教学研究

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