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SARS-coV-2 variants are associated with different clinical courses in children with MIS-c

World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet jane c.burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SARS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at Rady children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SARS-coV-2 variants

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang cheng Hao Tongtong Fu Dian Yu jane Howe Kaiwen chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of chemical Engineering and Applied chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada college of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)c_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Breeding system and pollination ecology of a potentially invasive alien clematis vitalba *** Ireland

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Journal of Plant Ecology 2018年第1期11卷 56-63页

作者： conor M.Redmond jane c.Stout Faculty of Science University of South BohemiaCeske BudejoviceBranisovska 176037005 Ceske BudejoviceCzech Republic Biology centre Institute of EntomologyThe Czech Academy of SciencesBranisovska 3137005 Ceske BudejoviceCzech Republic School of Natural Sciences and Trinity centre for Biodiversity Research Trinity College DublinDublin 2Ireland

Aims Invasive alien plants can greatly affect native communities and eco-system processes but only a small fraction of alien plant species become *** to establishment and invasion include reproductive *** vitalba *** been a popular hor-ticultural species for the past century and is widely distributed and can be highly *** Ireland,it is considered naturalized and potentially *** this,little is known about its reproduc-tive *** We carried out manipulative field experiments in Ireland and com-pared fruit and seed set from a number of pollination treatments,namely cross-pollination,geitonogamy,autogamy and natural *** also recorded floral visitation to *** through a series of timed *** Findings We found that *** is capable of uniparental reproduction via geitonogamy and autonomous selfing,albeit at a reduced rate com-pared with outcrossing *** vitalba was visited by at least 10 native pollinator taxa,with hoverflies dominating *** fruit set nor seed set in our study population was pollen *** the lack of reproductive constraint,*** may easily spread in suitable *** is of concern in Ireland,given its prevalence in some of the country’s most floristically diverse regions.

关键词： clematis vitalba plant invasion invasive traits mutualism

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Reforestation Programs in Southwest china:Reported Success,Observed Failure, and the Reasons Why

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Journal of Mountain Science 2007年第4期4卷 275-292页

作者： christine jane Trac Stevan Harrell Thomas M. Hinckley Amanda c. Henck Department of Biology University of Washington Department of Anthropology Box 353010 University of Washington Seattle WA 98195 USA college of Forest Resources University of Washington Department of Earth and Space Sciences University of Washington

Ever since the disastrous floods of 1998, the chinese government has used the Natural Forest Protection and Sloping Land conversion Programs to promote afforestation and reforestation as means to reduce runoff, control erosion, and stabilize local livelihoods. These two ambitious programs have been reported as large-scale successes, contributing to an overall increase in china’s forest cover and to the stated goals of environmental stabilization. A small-scale field study at the project level of the implementation of these two programs in Baiwu Township, Yanyuan county, Sichuan, casts doubt upon the accuracy and reliability of these claims of success; ground observations revealed utter failure in some sites and only marginal success in others. Reasons for this discrepancy are posited as involving ecological, economic, and bureaucratic factors. Further research is suggested to determine whether these discrepancies are merely local aberrations or represent larger-scale failures in reforestation programs.

关键词： Forests afforestation reforestation grain-to-green natural forest protection plan china Sichuan Liangshan

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Scaffold protein MAPK8IP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity

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Asian Journal of Andrology 2023年第2期25卷 198-207页

作者： Jian Huang Wang Liu Bi-Yun Lin Jean c Li jane Lu Ben-Yi Li center for Pathological Diagnosis and Research The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001China Department of Urology The University of Kansas Medical CenterKansas CityKS 66160USA

Mitogen-activated protein kinase-8-interacting protein 2(MAPK8IP2)is a scaffold protein that modulates MAPK signal *** MAPK pathways were heavily implicated in prostate cancer progression,the regulation of MAPK8IP2 expression in prostate cancer is not yet *** assessed MAPK8IP2 gene expression in prostate cancer related to disease progression and patient survival ***8IP2 expression was analyzed using multiple genome-wide gene expression datasets derived from The cancer Genome Atlas(TcGA)RNA-sequence project and complementary DNA(cDNA)*** cox regressions and log-rank tests were used to analyze the overall survival outcome and progression-free ***8IP2 protein expression was evaluated using the immunohistochemistry *** quantitative PcR and Western blot methods analyzed androgen-stimulated MAPK8IP2 expression in LNcaP *** primary prostate cancer tissues,MAPK8IP2 mRNA expression levels were significantly higher than those in the case-matched benign prostatic *** MAPK8IP2 expression was strongly correlated with late tumor stages,lymph node invasion,residual tumors after surgery,higher Gleason scores,and preoperational serum prostate-specific antigen(PSA)***8IP2 upregulation was significantly associated with worse overall survival outcomes and progression-free *** castration-resistant prostate cancers,MAPK8IP2 expression strongly correlated with androgen receptor(AR)signaling *** cell culture-based experiments,MAPK8IP2 expression was stimulated by androgens in AR-positive prostate cancer ***,MAPK8IP2 expression was blocked by AR antagonists only in androgen-sensitive LNcaP but not castration-resistant c4-2B and 22RV1 *** results indicate that MAPK8IP2 is a robust prognostic factor and therapeutic biomarker for prostate *** potential role of MAPK8IP2 in the castration-resistant progression is under further investigation.

关键词： cell cycle regulation disease progression mitogen-activated protein kinase-8-interacting protein 2 patient survival prostate cancer

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Markov cellular automata models for chronic disease progression

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International Journal of Biomathematics 2015年第6期8卷 259-280页

作者： jane Hawkins Donna Molinek Department of Mathematics University of North carolina at chapel HillcB #3250 Chapel Hill North Carolina 27599-3250 USA Department of Mathematics and computer Science Davidson college Davidson North Carolina 28035 USA

We analyze a Markov cellular automaton that models the spread of viruses that often progress to a chronic condition, such as human immunodeficiency virus （HIV） or hep- atitis c virus （HcV）. We show that the complex dynamical system produces a Markov process at the later stages, whose eigenvectors corresponding to the eigenvalue 1 have physical significance for the long-term prognosis of the virus. Moreover we show that drug treatment leads to chronic conditions that can be modeled by Markov shifts with more optimal eigenveetors.

关键词： HIV cellular automata Markov process HcV.

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State of Science:Why Does Rework Occur in construction?What Are Its consequences?And What can be Done to Mitigate Its Occurrence?

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Engineering 2022年第11期18卷 246-258页

作者： Peter E.D.Love jane Matthews Michael c.P.Sing Stuart R.Porter Weili Fang School of civil and Mechanical Engineering Curtin UniversityPerthWA 6845Australia School of Architecture and Built Environment Deakin University Geelong Waterfront CampusGeelongVIC 3220Australia School of Architecture and Built Environment The University of NewcastleCallaghanNSW 2308Australia Department of civil and Building Systems Technische Universität BerlinBerlin 13156Germany

There has been a wealth of research that has examined the nature of rework in *** toward addressing the rework problem has been limited-it still plagues practice,adversely impacting a project’s *** all rework studies have focused on determining its proximal or root causes and therefore have overlooked the conditions that result from its *** filling this void,this paper draws upon our previous empirical studies,amongst others,to provide a much-needed theoretical framing to understand better why rework occurs,what its consequences are,and how it can be mitigated during *** theoretical framing we derive from our review provides construction organizations and their projects with a realization that the journey to mitigating rework begins with creating an error-mastery culture comprising authentic leadership,psychological safety,an errormanagement orientation,and *** suggest that,once an error-mastery culture is established within construction organizations and their projects,they will be better positioned to realize the benefits of the techniques,tools,and technologies espoused to address rework,such as the Last Planner® and building information *** also provide directions for future research and identify implications for practice so that strides toward rework mitigation in construction can be made.

关键词： construction Errors Error-mastery culture Pathogens Rework Violations

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Micromorphology of Surface crusts in the Knersvlakte,South Africa

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Journal of Mountain Science 2009年第2期6卷 189-196页

作者： Sarah-jane c.Fox Anthony J.Mills Rosa M.Poch Department of Soil Science Stellenbosch UniversityStellenbosch South Africa Department of Environment and Soil Science University of LleidaRovira Roure 191 Lleida

Soils in the Knersvlakte are particularly prone to crusting and have lower inherent infiltrability than other soils across western southern Africa. Micromorphological techniques were used to examine the structure and porosity of soil crusts in the Knersvlakte to ascertain why crusting is so intense in this region. Quantile regression using boundary lines was employed to examine the relationships between infiltrability and soil properties for all samples （n = 67）. This analysis showed that infiltrability is potentially maximal at low water- dispersible ＇clay plus silt＇ content and low silt content （r^2 = 0.72 and 0.64; respectively, n = 67）（Figure 2）. The strength of crusts, pH, Ec, clay mineralogy, and water-dispersible clay, silt and ＇clay plus silt＇ content were compared, and a pore analysis using optical microscopy was undertaken on images of six soil thin sections （n = 6）（circular and parallel polarizers）. Pore analysis was further undertaken on five horizontal slices of equal dimensions taken through each soil thin section. The porosity samples with low infiltrability （〈 100 mm·hr^-1, n = 4） had greater crust strength, lower porosity （both total and in the least porous slice） and greater water-dispersible ＇day plus silt＇ and silt content than the porosity samples with high infiltrability （〉 100mm·hr^-1, n = 2）. The porosity samples with low infiltrability showed a trend of lower pH and greater water dispersible clay percentage. Porosity varied within the porosity samples due to the presence of dense clay/silt bands （〈 0.5 mm in width） with relatively few air vesicles. The porosity samples with horizontal slices of low porosity （but large numbers of air vesicles） had low infiltrability, while those without slices of low porosity （and relatively few air vesicles） had high infiltrability. We conclude that the intense crusting and resultant low infiltrability of soils in the Knersvlakte appears to be related to the formation of thin, dense clay/silt bands in the

关键词： Infiltrability optical microscopy porosity air vesicles

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Morphology and viability of adult Fasciola gigantica(giant liver flukes) from Philippine carabaos(Bubalus bubalis) upon in vitro exposure to lead

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 491-493页

作者： Aimee caye G. chang Mary jane c. Flores Biology Department College of Science De La Salle University

Objective: To evaluate the effects of lead in the morphology and viability of Fasciola gigantica(F. gigantica)(giant liver fluke) isolated from infected livers of carabaos in vitro using the following concentrations of lead: 0, 100, 150 and 200 mg/L. Methods: In vitro viability and motility assay was conducted to evaluate the ef ects of lead using 1% methylene blue as the vital dye for assessment of the l ukes' viability. Results: Results indicate that F. gigantica can tolerate lead exposure as high as 200 mg/L with visible morphological variations. Upon exposure to lead, liver l ukes tend to curl and excrete black precipitates as a sign of physiological stress response. Furthermore, the lethal concentration(Lc50) of lead against F. gigantica in vitro was 160 mg/L. conclusions: In conclusion, tolerance of liver flukes to high levels of lead suggests its potential as a possible biomarker of environmental pollution.

关键词： Fasciola gigantica Giant liver fluke carabaos Heavy metal Lead Lc50 Philippines

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comparing posture induced intraocular pressure variations in normal subjects and glaucoma patients

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 399-404页

作者： Onyekachi jane Ireka chimdia E Ogbonnaya Obinna c Arinze Nneka Ogbu chimdi M chuka-Okosa Department of Ophthalmology Alex Ekwueme Federal University Teaching HospitalAbakalikiEbonyi State 48028Nigeria Department of Ophthalmology University of Nigeria Teaching HospitalItuku OzallaEnugu 01129Nigeria

AIM:To compare the posture-induced variations in intraocular pressure(IOP)between the primary open angle glaucoma(POAG)and non-glaucomatous ***:A case-controlled age matched study was conducted in 55 successive newly diagnosed POAG and 56 non-glaucomatous patients seen in glaucoma clinic and general outpatient eye clinic in the Alex Ekwueme University Teaching Hospital,*** IOPs of eligible correspondents were measured with Perkin’s hand-held tonometer in the sitting,supine flat and supine with pillow positions *** of IOP in each position was done after 15 min of assuming such ***:The IOP difference between the sitting and supine flat position was significantly higher in the POAG than non-glaucoma subjects(7.68±2.08 vs 4.03±0.13 mm Hg,Pce between the sitting and supine with pillow positions was 2.61±1.49 mm Hg for POAG and 1.44±0.70 mm Hg in non-glaucoma(Pce between supine flat and supine with pillow positions was 5.07±2.24 mm Hg in POAG and 2.59±0.66 mm Hg in non-glaucomatous patients(PcONcLUSION:Greater variations in posture induced IOP occurred in POAG patients than *** posture induced IOP variation is lowest in the sitting position and highest in the supine flat *** of posture induced IOP changes may be an important tool in the management of glaucoma.

关键词： primary open angle glaucoma non-glaucoma intraocular pressure sitting position supine position

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