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Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells

Cell Regeneration 2012年第1期1卷 11-18页

作者： Curtis C Hughey Maria P Alfaro Darrell D Belke Jeffery N Rottman Pampee P Young David H Wasserman jane shearer Department of Biochemistry and Molecular Biology Faculty of MedicineUniversity of CalgaryCalgaryABCanadaT2N 1N4 Department of Pathology School of MedicineVanderbilt UniversityNashvilleTNUSA37232 Faculty of Kinesiology University of CalgaryCalgaryABCanadaT2N 1N4 Department of Medicine Division of Cardiovascular MedicineSchool of MedicineVanderbilt UniversityNashvilleTNUSA37240 Department of Veterans Affairs Medical Center NashvilleTNUSA37232 Department of Molecular Physiology and Biophysics School of MedicineVanderbilt UniversityNashvilleTNUSA37240 University of Calgary KNB Rm 3318.2500 University Dr.NWCalgaryABCanadaT2N 1N4.

Background:Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial *** this,ischemia-induced death of transplanted cells remains a major hurdle to the efficacy of treatment.‘Superhealer’MRL/MpJ mesenchymal stem cells(MRL-MSCs)have been reported to exhibit increased engraftment resulting in reduced infarct size and enhanced contractile *** study determines whether intrinsic differences in mitochondrial oxidative phosphorylation(OXPHOS)assist in explaining the enhanced cellular survival and engraftment of ***:Compared to wild type MSCs(WT-MSCs),mitochondria from intact MRL-MSCs exhibited an increase in routine respiration and maximal electron transport capacity by 2.0-and 3.5-fold,*** routine oxygen utilization is expressed as a portion of maximal cellular oxygen flux,the MRL-MSCs have a greater spare respiratory ***,glutamate/malate-and succinate-supported oxygen consumption in permeabilized cells was elevated approximately 1.25-and 1.4-fold in the MRL-MSCs,***:The results from intact and permeabilized MSCs indicate MRL-MSCs exhibit a greater reliance on and capacity for aerobic *** greater capacity for oxidative metabolism may provide a protective effect by increasing ATP synthesis per unit substrate and prevent glycolysis-mediated acidosis and subsequent cell death upon transplantation into the glucose-and oxygen-deprived environment of the infarcted heart.

关键词： Energetics Mitochondria Oxidative phosphorylation Stem cells

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