检索结果-南通市图书馆

Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis

引用

Protein & Cell 2012年第12期3卷 934-942页

作者： Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright jane peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte Gene Expression Laboratories The Salk Institute for Biological Studies10010 N.Torrey Pines Rd.La JollaCA 92037USA Sanofi US R&DEarly to Candidate UnitTucson Research Center2090 E.Innovation Park DriveTucsonAZ 85755USA Sanofi Deutschland GmbH R&DTSU Aging Quality of LifeIndustriepark HoechstFrankfurt am Main 65926Germany Sanofi R&D Early to Candidate Unit195Route d'Espagne-BP 13669ToulouseFrance Center of Regeneration Medicine Dr.Aiguader 88Barcelona 08003Spain

Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal *** of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal ***,the body does not fully repair itself from this type of degeneration,resulting in impaired ***,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage *** stem cells(MSC)have also been used as cell therapy to repair degenerated ***,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the *** repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline *** of the reasons for this is inefficient chondrogenesis by endogenous and exogenous *** that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic *** recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell *** we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis.

关键词： hESC hiPSC chondrogenesis compound screening platform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：