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International Journal of Digital Earth 2016年第2期9卷 197-214页

作者： jane Hunter Charles Brooking Lucy Reading Sue Vink School of Information Technology and Electrical Engineering(ITEE) The University of QueenslandBrisbaneQLDAustralia Centre for Water in the Minerals Industry(CWIMI) The University of QueenslandBrisbaneQLDAustralia

The 3D Water Chemistry Atlas is an intuitive,open source,Web-based system that enables the three-dimensional(3D)sub-surface visualization of ground water monitoring data,overlaid on the local geological model(formation and aquifer strata).This paper firstly describes the results of evaluating existing virtual globe technologies,which led to the decision to use the Cesium open source WebGL Virtual Globe and Map Engine as the underlying *** it describes the backend database and search,filtering,browse and analysis tools that were developed to enable users to interactively explore the groundwater monitoring data and interpret it spatially and temporally relative to the local geological formations and aquifers via the Cesium *** result is an integrated 3D visualization system that enables environmental managers and regulators to assess groundwater conditions,identify inconsistencies in the data,manage impacts and risks and make more informed decisions about coal seam gas extraction,waste water extraction,and water reuse.

关键词： 3D sub-surface visualization groundwater geological model

Conceptualising Intangible Heritage in Urban Environments: Challenges for Implementing the HUL Recommendation

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Built Heritage 2018年第4期2卷 72-81页

作者： Harriet jane Deacon Centre for Dance Research Coventry UniversityCoventryUnited Kingdom

The Historic Urban Landscape(HUL)Recommendation(UNESCO 2011)suggests that heritage management should be holistic,integrated,people-centred and focused on sustainable development *** tangible and intangible heritage should be taken into account,allowing for appropriate change over time.A variety of stakeholders should be involved in planning processes,including all levels of government,NGOs and *** dialogue and mediation,as well as tools such as documentation,inventorying and mapping should be used to identify multiple layers of *** the Recommendation thus offers a wonderful opportunity to develop consultative,bottom-up,integrated planning for sustainable development in urban *** paper suggests that one barrier to integrating management planning for tangible and intangible heritage is a persistent confusion about what‘intangible heritage’is and why it deserves *** it the values that local communities associate with their environment(‘intangible values’),or is it cultural practices that they happen to perform in that environment(intangible cultural heritage,or ICH)?Should‘intangible heritage’be managed as an attribute attesting to the authenticity of tangible fabric,or as a subject of safeguarding in its own right?If it means all these things at the same time,why is the same concept being used for so many different ideas and what are the consequences?The paper will suggest that a clearer conceptual understanding of intangible heritage is necessary to effectively integrate it into urban management strategies under the HUL approach.

关键词： intangible heritage Historic Urban Landscape UNESCO intangible heritage convention

Coconut oil:what do we really know about it so far?

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Food Quality and Safety 2019年第2期3卷 61-72页

作者： Renan da Silva Lima jane Mara Block Department of Food Science and Technology Federal University of Santa CatarinaFlorianópolisBrazil

In recent years,coconut oil has emerged as a potential‘miracle’*** media vehicles and health specialists assure that this fat is capable of promoting health benefits,such as weight reduction,cholesterol lowering,prevention of cardiovascular diseases,and anti-inflammatory effect,among *** claims are used to market the product and boost its sales by coconut oil ***,governmental regulatory agencies in many countries are still sceptical about the benefits obtained by the consumption of coconut oil due to its high-saturated fatty acid *** light of such controversy,this review focused on analysing the published literature on the alleged health claims,in order to investigate if there is enough scientific evidence to support *** was verified that the metabolism of lauric acid,the major fatty acid in coconut oil,remains *** studies reported that the product was not efficient in weight ***,it has been reported that the consumption of coconut oil increased low-density lipoprotein cholesterol,consequently increasing the risk of cardiovascular *** general,the studies present conflicting results and there is a lack of long-term human-based clinical ***,as a saturated fat,coconut oil should be consumed with moderation and the health allegations should not be used to market the product,once they are not scientifically proven so far.

关键词： lauric acid saturated fatty acids medium-chain triglycerides LDL cholesterol cardiovascular diseases

MicroRNAs as therapeutic strategy for hepatitis B virusassociated hepatocellular carcinoma: Current status and future prospects

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World Journal of Gastroenterology 2014年第20期20卷 5973-5986页

作者： Yi Lin jane Tan Wei Ning Chen School of Chemical and Biomedical Engineering College of Engineering Nanyang Technological University Singapore 637459 Singapore

Hepatocellular carcinoma(HCC)remains to be one of the top causing cancer-related deaths *** majority of HCC cases are reported to be the result of chronic hepatitis B virus(HBV)*** treatments for HBV-related HCC revolve around the use of drugs to inhibit viral replication,as a high level of viral load and antigen in circulation often presents a poor patient ***,existing therapies are inefficient in the complete eradication of HBV,often resulting in tumour *** involvement of microRNAs(miRNAs)in important processes in HBV-related HCC makes it an important player in the progression of HCC in chronic hepatitis B infected *** this review,we discuss the key aspects of HBV infection and the important viral products that may regulate cancerrelated processes via their interaction with miRNAs or their closely related protein ***,we also look at how miRNAs may go about regulating the virus,especially in vital processes like viral *** from miRNAs acting as either oncogenes or tumour-suppressors,we also look at how miRNAs may function as biomarkers that may possibly serve as better candidates than those currently employed in the diagnosis of HBV infection or HBV-related HCC.A summary of the roles of miRNAs in HBV-related HCC will hopefully lead to a gain in understanding of the pathogenesis process and pave the way for new insights in medical therapy.

关键词： Hepatitis B virus Hepatitis B virus X protein Hepatocellular carcinoma Mechanisms MicroRNAs Profiling

Investigation of fluorescence characterization and electrochemical behavior on the catalysts of nanosized Pt-Rh/y-AI203 to oxidize gaseous ammonia

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Frontiers of Environmental Science & Engineering 2013年第3期7卷 428-434页

作者： Chang-Mao HUNG Wen-Liang LAI jane-Li LIN Department of Vehicle Engineering Yung-Ta Institute of Technology and Commerce Pingtung 909 China Department of Environmental Science and Occupational Safety and Hygiene Tajen University Pingtung 907 China

This work describes the environmentally friendly technology for oxidation of ammonia （NH3） to form nitrogen at temperatures range from 423K to 673K by selective catalytic oxidation （SCO） over a nanosized Pt- Rh/γ-A12O3 catalyst prepared by the incipient wetness impregnation method of hexachloroplatinic acid （H2PtC16） and rhodium （Ⅲ） nitrate （Rh（NO3）3） with γ-A12O3 in a tubular fixed-bed flow quartz reactor （TFBR）. The characterization of catalysts were thoroughly measured using transmission electron microscopy （TEM）, three- dimensional excitation-emission fluorescent matrix （EEFM） spectroscopy, UV-Vis absorption, dynamic light- scattering （DLS）, zeta potential meter, and cyclic voltam- metry （CV）. The results demonstrated that at a temperature of 673K and an oxygen content of4%, approximately 99% of the NH3 was removed by catalytic oxidation over the nanosized Pt-Rh/γ-A12O3 catalyst. N2 was the main product in NH3-SCO process. Further, it reveals that the oxidation of NH3 was proceeds by the over-oxidation of NH3 into NO, which was conversely reacted with the NH3 to yield N2. Therefore, the application ofnanosized Pt-Rh/γ-A12O3 catalyst can significantly enhance the catalytic activity toward NH3 oxidation. One fluorescent peak for fresh catalyst was different with that of exhausted catalyst. It indicates that EEFM spectroscopy was proven to be an appropriate and effective method to characterize the Pt clusters in intrinsic emission from nanosized Pt-Rh/γ-A12O3 catalyst. Results obtained from the CV may explain the significant catalytic activity of the catalysts.

关键词： ammonia (NH3) nanosized Pt- Rh/γ-A12O3catalyst excitation-emission fluorescent matrix (EEFM) selective catalytic oxidation (SCO) tubular fixed-bedreactor (TFBR)

Potato aphid Macrosiphum euphorbiae performance is determined by aphid genotype and not mycorrhizal fungi or water availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison jane Karley Matthew Emslie-Smith Alison Elizabeth Bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcomes modified by soil biotic and abiotic conditions. We used the potato aphid （Macrosiphum euphorbiae Thomas） feeding on cultivated Solanum tuberosum and wild Solanurn berthaulti to study the impact of water availability and plant mutualistic arbuscular mycorrhizal （AM） fungi on aphid performance and susceptibility to a parasitoid wasp （Aphidius ervi Haliday）. Plants were grown under glass with live or sterile AM fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes ofM. euphorbiae or maintained as aphidfree controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed explanta. Solarium tuberosum accumulated c. 20% more dry mass than S. berthaultii, and root mass of S. berthaultii was smallest under reduced water supply in the presence of AM fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype ＂2＂ aphids; genotype ＂1＂ aphid density was particularly reduced on S. berthaultii. Aphid genotype ＂1＂ exhibited low susceptibility to parasitism and was attacked less frequently than the other two more susceptible aphid genotypes. Neither AM fungi nor water availability affected insect performance. Our study suggests a fitness trade-offin M. euphorbiae between parasitism resistance and aphid performance on poor quality Solarium hosts that warrants further exploration, and indicates the importance of accounting for genotype identity in determining the outcome of multitrophic interactions.

关键词： Aphidius ervi arbuscular mycorrhizal fungi multitrophic interaction parasitism resistance Solanum spp.

Increased extrinsic apoptotic pathway activity in patients with hepatocellular carcinoma following transarterial embolization

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World Journal of Gastroenterology 2011年第42期17卷 4675-4681页

作者： Shih-Ho Wang Li-Mien Chen jane-Dar Lee Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial Hospital and Chang Gung UniversityCollege of Medicine Division of Hematology/Oncology Department of MedicineTaichung Armed Forces General Hospital Central Taiwan University of Science and Technology Department of Surgery Taic-hung Armed Forces General Hospital

AIM： TO determine the apoptosis pathway in residual viable hepatocellular carcinoma （HCC） tissues following transarterial embolization （TAE）.andα fetoprotein （AFP） levels after TAE. All tissue samples were taken from the residual tumors. The expression of various apoptotic proteins was evaluated via immunoblotting procedures. The results were analyzed using a Student＇s t test. RESULTS： Tumor size and the AFP level decreased by 46.2% and 55.3% after TAE, respectively. There was no significant difference detected for the Bcl-2/Bax ratio or the cleaved caspase-9 expression levels in either group. However, extrinsic apoptopic pathway-related expression of Fas and cleaved caspase-8 expression were significantly higher in the study group than in the control group （P 〈 0.05）. In addition, cleaved caspase-3 expression in the study group was higher （1.62-fold） than in control group （P 〈 0.05）. CONCLUSION： TAE is an effective palliative therapy that decreases tumor size and AFP levels via an increase in extrinsic apoptosis pathway in patients with unresectable HCC.

关键词： Apoptosis Hepatocellular carcinoma Transarterial embolization

Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis

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International Journal of Oral Science 2016年第3期8卷 138-144页

作者： jane Park Bhumika Shokeen Susan K Haake Renate Lux School of Dentistry University of California at Los Angeles Los Angeles USA

Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral biofilm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATCC 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine, galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, RadD, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and RadD, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-specific binding profile of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity.

关键词： adhesin bio?lm coaggregation Fusobacterium nucleatum Porphyromonas gingivalis

Deep Energies for Estimating Three-Dimensional Facial Pose and Expression

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Communications on Applied Mathematics and Computation 2024年第2期6卷 837-861页

作者： jane Wu Michael Bao Xinwei Yao Ronald Fedkiw Department of Computer Science Stanford University353 Jane Stanford WayStanfordCA 94305USA Epic Games 620 Crossroads BlvdCaryNC 27518USA

While much progress has been made in capturing high-quality facial performances using motion capture markers and shape-from-shading,high-end systems typically also rely on rotoscope curves hand-drawn on the *** curves are subjective and difficult to draw consistently;moreover,ad-hoc procedural methods are required for generating matching rotoscope curves on synthetic renders embedded in the optimization used to determine three-dimensional(3D)facial pose and *** propose an alternative approach whereby these curves and other keypoints are detected automatically on both the image and the synthetic renders using trained neural networks,eliminating artist subjectivity,and the ad-hoc procedures meant to mimic *** generally,we propose using machine learning networks to implicitly define deep energies which when minimized using classical optimization techniques lead to 3D facial pose and expression estimation.

关键词： Numerical optimization Neural networks Motion capture Face tracking

Newly discovered endocrine functions of the liver

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World Journal of Hepatology 2021年第11期13卷 1611-1628页

作者： jane Rhyu Run Yu Division of Endocrinology Diabetesand MetabolismUCLA David Geffen School of MedicineLos AngelesCA 90095United States

The liver,the largest solid visceral organ of the body,has numerous endocrine functions,such as direct hormone and hepatokine production,hormone metabolism,synthesis of binding proteins,and processing and redistribution of metabolic *** the last 10 years,many new endocrine functions of the liver have been *** in the classical endocrine functions include delineation of mechanisms of liver production of endocrine hormones[including 25-hydroxyvitamin D,insulin-like growth factor 1(IGF-1),and angiotensinogen],hepatic metabolism of hormones(including thyroid hormones,glucagon-like peptide-1,and steroid hormones),and actions of specific binding proteins to glucocorticoids,sex steroids,and thyroid *** studies have furthered insight into cirrhosis-associated endocrinopathies,such as hypogonadism,osteoporosis,IGF-1 deficiency,vitamin D deficiency,alterations in glucose and lipid homeostasis,and controversially relative adrenal *** novel endocrine functions of the liver have also been unraveled,elucidating the liver’s key negative feedback regulatory role in the pancreaticαcell-liver axis,which regulates pancreaticαcell mass,glucagon secretion,and circulating amino acid *** and other hepatokines,such as fetuin-A and fibroblast growth factor 21,have also been discovered to play important endocrine roles in modulating insulin sensitivity,lipid metabolism,and body *** is expected that more endocrine functions of the liver will be revealed in the near future.

关键词： Liver Endocrine function Hormone Amino acids Hepatokine Fibroblast growth factor 21