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The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals:A nationwide multicenter study

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Infectious Medicine 2022年第4期1卷 229-235页

作者： Allen Widysanto Ignatius Bima Prasetya Tandry Meriyanti Veli Sungono Diane Lukito Setiawan Edy Gunawan Bayu Adiputra jane olivia lorens Theresia Santi Cindy Meidy Leony Pradhana Irawan Yusuf Catherine Gunawan Siloam Hospitals Lippo Village BantenIndonesia Faculty of Medicine Pelita Harapan UniversityBantenIndonesia Siloam Hospitals Surabaya East JavaIndonesia Clinical Research Department Siloam Hospitals Group BantenIndonesia Siloam Hospitals Lippo Cikarang West JavaIndonesia Mochtar Riady Institute for Nanotechnology BantenIndonesia

Background:Several vaccines have been approved against COVID-19,and 5 have been used in *** to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac,healthcare workers received the third booster of mRNA vaccine(mRNA-1273)to increase the antibody *** study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare ***:This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-12736 months after the second *** samples were obtained 2nd,6th,12th,and 24th weeks after the second dose of CoronaVac vaccine administration,with mRNA-1273 booster on week *** measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S *** identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression ***:This study comprised 576 participants aged 32 years old,72.05%female,and 45.84%from high-risk occupation *** median antibodies titer level on the 2nd,6th,12th,and 24th weeks after the second vaccine dose administration were 40.99 u/mL,42.01 u/mL,54.78 u/mL,and 23,225 u/*** levels trended highest in female and younger age group(20-29 years old).Conclusions:The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.

关键词： Antibodies titer COVID-19 Immune response S-RBD IgG Vaccine

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